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Effects of high-dose cancer chemotherapy on the absorption of digoxin in two different formulations.

Publication ,  Journal Article
Bjornsson, TD; Huang, AT; Roth, P; Jacob, DS; Christenson, R
Published in: Clin Pharmacol Ther
January 1986

The oral absorption of digoxin in tablet form has been reported to be reduced after cancer chemotherapy and radiation therapy because of cancer treatment-induced damage to the intestinal epithelium. We investigated possible differences in the effects of high-dose cancer chemotherapy on the relative bioavailability of digoxin administered in tablet form (Lanoxin; Burroughs Wellcome Co.) and in solution-in-capsule form (Lanoxicaps; Burroughs Wellcome Co.). Each subject received a single oral dose of either 0.5 mg Lanoxin (six subjects) or 0.4 mg Lanoxicaps (seven subjects) both before and after chemotherapy. For Lanoxin, there was a significant reduction in the AUC after chemotherapy to 54.4% +/- 35.5% (mean +/- SD) of the value before chemotherapy (P = 0.02), whereas for Lanoxicaps there was an insignificant reduction in AUC to 85.1% +/- 42.7% of the value before chemotherapy. These findings show that changes in the oral dosage formulation of digoxin from a tablet to a solution-in-capsule form can overcome the adverse effects of high-dose cancer chemotherapy on drug absorption, and suggest a similar approach may be successful for other drugs.

Duke Scholars

Published In

Clin Pharmacol Ther

DOI

ISSN

0009-9236

Publication Date

January 1986

Volume

39

Issue

1

Start / End Page

25 / 28

Location

United States

Related Subject Headings

  • Tablets
  • Random Allocation
  • Radioimmunoassay
  • Pharmacology & Pharmacy
  • Neoplasms
  • Middle Aged
  • Male
  • Kinetics
  • Humans
  • Female
 

Citation

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Bjornsson, T. D., Huang, A. T., Roth, P., Jacob, D. S., & Christenson, R. (1986). Effects of high-dose cancer chemotherapy on the absorption of digoxin in two different formulations. Clin Pharmacol Ther, 39(1), 25–28. https://doi.org/10.1038/clpt.1986.4
Bjornsson, T. D., A. T. Huang, P. Roth, D. S. Jacob, and R. Christenson. “Effects of high-dose cancer chemotherapy on the absorption of digoxin in two different formulations.Clin Pharmacol Ther 39, no. 1 (January 1986): 25–28. https://doi.org/10.1038/clpt.1986.4.
Bjornsson TD, Huang AT, Roth P, Jacob DS, Christenson R. Effects of high-dose cancer chemotherapy on the absorption of digoxin in two different formulations. Clin Pharmacol Ther. 1986 Jan;39(1):25–8.
Bjornsson, T. D., et al. “Effects of high-dose cancer chemotherapy on the absorption of digoxin in two different formulations.Clin Pharmacol Ther, vol. 39, no. 1, Jan. 1986, pp. 25–28. Pubmed, doi:10.1038/clpt.1986.4.
Bjornsson TD, Huang AT, Roth P, Jacob DS, Christenson R. Effects of high-dose cancer chemotherapy on the absorption of digoxin in two different formulations. Clin Pharmacol Ther. 1986 Jan;39(1):25–28.
Journal cover image

Published In

Clin Pharmacol Ther

DOI

ISSN

0009-9236

Publication Date

January 1986

Volume

39

Issue

1

Start / End Page

25 / 28

Location

United States

Related Subject Headings

  • Tablets
  • Random Allocation
  • Radioimmunoassay
  • Pharmacology & Pharmacy
  • Neoplasms
  • Middle Aged
  • Male
  • Kinetics
  • Humans
  • Female