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Two biochemical markers in lymphocyte subpopulations.

Publication ,  Journal Article
Huang, AT; Logue, GL; Engelbrecht, GL
Published in: Br J Haematol
December 1976

Human blood lymphocytes can be separated into two populations according to the presence of surface complement receptors. Lymphocytes containing complement receptors (CR+) were found to have a high rate of RNA synthesis or turnover accompanied by increased protein synthesis. Lymphocytes not containing complement receptors (CR-) while maintaining a low profile in RNA synthesis, had a 10-12-fold greater activity in adenosine deaminase enzyme which is believed to be related to lymphocyte-immune responses and cell-mediated immunity. These two biochemical characteristics can be useful tools for future studies in lymphocyte functions. By using these two biochemical markers, we found that CLL lymphocytes were predominantly of the CR+ type, had high active RNA synthesis, and very low adenosine deaminase level. Lymphocytes from two patients with X-linked agammaglobulinaemia showed a picture opposite to that of CLL.

Duke Scholars

Published In

Br J Haematol

DOI

ISSN

0007-1048

Publication Date

December 1976

Volume

34

Issue

4

Start / End Page

631 / 638

Location

England

Related Subject Headings

  • RNA
  • Lymphocytes
  • Leukemia, Lymphoid
  • Immunology
  • Humans
  • Complement System Proteins
  • Cell Separation
  • Binding Sites, Antibody
  • Agammaglobulinemia
  • Adenosine Deaminase
 

Citation

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Huang, A. T., Logue, G. L., & Engelbrecht, G. L. (1976). Two biochemical markers in lymphocyte subpopulations. Br J Haematol, 34(4), 631–638. https://doi.org/10.1111/j.1365-2141.1976.tb03610.x
Huang, A. T., G. L. Logue, and G. L. Engelbrecht. “Two biochemical markers in lymphocyte subpopulations.Br J Haematol 34, no. 4 (December 1976): 631–38. https://doi.org/10.1111/j.1365-2141.1976.tb03610.x.
Huang AT, Logue GL, Engelbrecht GL. Two biochemical markers in lymphocyte subpopulations. Br J Haematol. 1976 Dec;34(4):631–8.
Huang, A. T., et al. “Two biochemical markers in lymphocyte subpopulations.Br J Haematol, vol. 34, no. 4, Dec. 1976, pp. 631–38. Pubmed, doi:10.1111/j.1365-2141.1976.tb03610.x.
Huang AT, Logue GL, Engelbrecht GL. Two biochemical markers in lymphocyte subpopulations. Br J Haematol. 1976 Dec;34(4):631–638.
Journal cover image

Published In

Br J Haematol

DOI

ISSN

0007-1048

Publication Date

December 1976

Volume

34

Issue

4

Start / End Page

631 / 638

Location

England

Related Subject Headings

  • RNA
  • Lymphocytes
  • Leukemia, Lymphoid
  • Immunology
  • Humans
  • Complement System Proteins
  • Cell Separation
  • Binding Sites, Antibody
  • Agammaglobulinemia
  • Adenosine Deaminase