Barrie James Hurwitz
Associate Professor Emeritus of Medicine
The general focus of my work is clinical neurology and teaching, including the diagnosis of neurologic conditions and their specific treatment.
I am not engaged in any laboratory research.
I am involved in the following clinical trials: (1) Principal investigator of double-blind, placebo-controlled research study on the safety and efficacy of Betaseron in patients with secondary progressive multiple sclerosis; (2) principal investigator of compassionate administration of open label Ropinirole in the treatment of Parkinson's disease; (3) NORG neurology consultant; and (4) investigator for the collaborative study of hereditary basis of Parkinson's disease with Dr. Allen Roses.
My academic work is as a clinical neurologist with special interests in Parkinson's disease, multiple sclerosis and cerebrovascular disease.
Current Appointments & Affiliations
- Associate Professor Emeritus of Medicine, Neurology, Clinical Science Departments 2011
Contact Information
- 122 Baker House, Durham, NC 27710
- Box 3184 Med Ctr, Durham, NC 27710
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hurwi003@mc.duke.edu
(919) 684-4126
- Background
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Education, Training, & Certifications
- M.B.B.Ch., University of Witwatersrand (South Africa) 1968
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Previous Appointments & Affiliations
- Associate Professor of Community and Family Medicine, Family Medicine and Community Health, Clinical Science Departments 1994 - 2011
- Associate Professor of Medicine, Neurology, Clinical Science Departments 1985 - 2010
- Research
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Selected Grants
- Aging And Cognitive After Cardiac Surgery awarded by National Institutes of Health 1996 - 1999
- Aging And Cognition After Cardiac Surgery awarded by National Institutes of Health 1994 - 1999
- Aging And Cognition After Cardiac Surgery awarded by National Institutes of Health 1991 - 1999
- Antiarrhythmic Mechanisms In Ischemic Myocardium awarded by National Institutes of Health 1988 - 1991
- Antiarrhythmic Mechanisms In Ischemic Myocardium awarded by National Institutes of Health 1985 - 1990
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Hurwitz, Barrie J. “Analysis of current multiple sclerosis registries.” Neurology 76, no. 1 Suppl 1 (January 4, 2011): S7-13. https://doi.org/10.1212/WNL.0b013e31820502f6.Full Text Link to Item
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Hurwitz, Barrie J. “Registry studies of long-term multiple sclerosis outcomes: description of key registries.” Neurology 76, no. 1 Suppl 1 (January 4, 2011): S3–6. https://doi.org/10.1212/WNL.0b013e3182050225.Full Text Link to Item
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Lövblad, K. -. O., N. Anzalone, A. Dörfler, M. Essig, B. Hurwitz, L. Kappos, S. -. K. Lee, and M. Filippi. “MR imaging in multiple sclerosis: review and recommendations for current practice.” Ajnr Am J Neuroradiol 31, no. 6 (June 2010): 983–89. https://doi.org/10.3174/ajnr.A1906.Full Text Link to Item
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Hurwitz, Barrie J. “The diagnosis of multiple sclerosis and the clinical subtypes.” Ann Indian Acad Neurol 12, no. 4 (October 2009): 226–30. https://doi.org/10.4103/0972-2327.58276.Full Text Link to Item
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Coyle, P., B. Arnason, B. Hurwitz, and F. Lublin. “Optimizing outcomes in multiple sclerosis - A consensus initiative.” Multiple Sclerosis 15, no. SUPPL. 2 (April 27, 2009). https://doi.org/10.1177/1352458508101134.Full Text
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Hurwitz, B. J. “Important sources of variability in clinical studies of neutralizing antibodies against interferon beta.” J Neurol Sci 272, no. 1–2 (September 15, 2008): 8–19. https://doi.org/10.1016/j.jns.2008.05.004.Full Text Link to Item
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Hurwitz, Barrie J., Douglas Jeffery, Barry Arnason, Kim Bigley, Patricia Coyle, Douglas Goodin, Samer Kaba, et al. “Tolerability and safety profile of 12- to 28-week treatment with interferon beta-1b 250 and 500 microg QOD in patients with relapsing-remitting multiple sclerosis: a multicenter, randomized, double-blind, parallel-group pilot study.” Clin Ther 30, no. 6 (June 2008): 1102–12. https://doi.org/10.1016/j.clinthera.2008.06.013.Full Text Link to Item
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Goodin, D. S., B. Hurwitz, and A. Noronha. “Neutralizing antibodies to interferon β-1b are not associated with disease worsening in multiple sclerosis.” Journal of International Medical Research 35, no. 2 (January 1, 2007): 173–87. https://doi.org/10.1177/147323000703500202.Full Text
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Mikol, D., M. Lopez-Bresnahan, S. Taraskiewicz, P. Chang, J. Rangnow, and J. Rebiject Study Group. “A randomized, multicentre, open-label, parallel-group trial of the tolerability of interferon beta-1a (Rebif) administered by autoinjection or manual injection in relapsing-remitting multiple sclerosis.” Mult Scler 11, no. 5 (October 2005): 585–91. https://doi.org/10.1191/1352458505ms1197oa.Full Text Link to Item
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Hurwitz, Barrie. “Editorial: Licensing and Use of New Therapies in MS: Where Are We Going?” Int Ms J 12, no. 2 (August 2005): 39–41.Link to Item
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Sandberg-Wollheim, M., C. Bever, J. Carter, M. Färkkilä, B. Hurwitz, Y. Lapierre, P. Chang, G. S. Francis, and G. S. EVIDENCE Study Group. “Comparative tolerance of IFN beta-1a regimens in patients with relapsing multiple sclerosis. The EVIDENCE study.” J Neurol 252, no. 1 (January 2005): 8–13. https://doi.org/10.1007/s00415-005-0589-2.Full Text Link to Item
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Croughwell, N. D., M. F. Newman, J. A. Blumenthal, W. D. White, J. B. Lewis, P. E. Frasco, L. R. Smith, E. A. Thyrum, B. J. Hurwitz, and B. J. Leone. “Jugular bulb saturation and cognitive dysfunction after cardiopulmonary bypass.” Ann Thorac Surg 58, no. 6 (December 1994): 1702–8. https://doi.org/10.1016/0003-4975(94)91666-7.Full Text Link to Item
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NEWMAN, M. F., N. D. CROUGHWELL, J. A. BLUMENTHAL, W. D. WHITE, J. B. LEWIS, L. R. SMITH, P. FRASCO, et al. “EFFECT OF AGING ON CEREBRAL AUTOREGULATION DURING CARDIOPULMONARY BYPASS - ASSOCIATION WITH POSTOPERATIVE COGNITIVE DYSFUNCTION.” Circulation 90, no. 5 (November 1, 1994): 243–49.Link to Item
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Newman, M. F., N. D. Croughwell, J. A. Blumenthal, W. D. White, J. B. Lewis, L. R. Smith, P. Frasco, E. A. Towner, R. M. Schell, and B. J. Hurwitz. “Effect of aging on cerebral autoregulation during cardiopulmonary bypass. Association with postoperative cognitive dysfunction.” Circulation 90, no. 5 Pt 2 (November 1994): II243–49.Link to Item
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Newman, M. F., N. D. Croughwell, J. A. Blumenthal, W. D. White, J. B. Lewis, L. R. Smith, P. Frasco, et al. “Effect of aging on cerebral autoregulation during cardiopulmonary bypass: Association with postoperative cognitive dysfunction.” Circulation 90, no. 5 II (November 1, 1994).
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Cavazos, J. E., J. B. Caress, V. R. Chilukuri, T. Devlin, L. Gray, and B. J. Hurwitz. “Sumatriptan-induced stroke in sagittal sinus thrombosis.” Lancet 343, no. 8905 (April 30, 1994): 1105–6. https://doi.org/10.1016/s0140-6736(94)90220-8.Full Text Link to Item
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Ondo, W. G., and B. J. Hurwitz. “Tardive dyskinesia and pseudo-parkinsonism. In a nursing home patient who itched.” N C Med J 54, no. 11 (November 1993): 605–7.Link to Item
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Ehrlich, G. D., J. B. Glaser, V. Bryz-Gornia, J. Maese, T. A. Waldmann, B. J. Poiesz, and S. J. Greenberg. “Multiple sclerosis, retroviruses, and PCR. The HTLV-MS Working Group.” Neurology 41, no. 3 (March 1991): 335–43. https://doi.org/10.1212/wnl.41.3.335.Full Text Link to Item
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Morgenlander, J. C., B. J. Hurwitz, and E. W. Massey. “Capsaicin for the treatment of pain in Guillain-Barré syndrome.” Ann Neurol 28, no. 2 (August 1990): 199. https://doi.org/10.1002/ana.410280222.Full Text Link to Item
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“Efficacy and toxicity of cyclosporine in chronic progressive multiple sclerosis: a randomized, double-blinded, placebo-controlled clinical trial. The Multiple Sclerosis Study Group.” Ann Neurol 27, no. 6 (June 1990): 591–605. https://doi.org/10.1002/ana.410270603.Full Text Link to Item
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Greenberg, S. J., G. D. Ehrlich, M. A. Abbott, B. J. Hurwitz, T. A. Waldmann, and B. J. Poiesz. “Detection of sequences homologous to human retroviral DNA in multiple sclerosis by gene amplification.” Proc Natl Acad Sci U S A 86, no. 8 (April 1989): 2878–82. https://doi.org/10.1073/pnas.86.8.2878.Full Text Link to Item
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Greenberg, S. J., L. Marcon, B. J. Hurwitz, T. A. Waldmann, and D. L. Nelson. “Elevated levels of soluble interleukin-2 receptors in multiple sclerosis.” N Engl J Med 319, no. 15 (October 13, 1988): 1019–20. https://doi.org/10.1056/NEJM198810133191517.Full Text Link to Item
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Nelson, L. M., G. M. Franklin, and M. C. Jones. “Risk of multiple sclerosis exacerbation during pregnancy and breast-feeding.” Jama 259, no. 23 (June 17, 1988): 3441–43.Link to Item
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Drayer, B. P., P. Burger, B. Hurwitz, D. Dawson, J. Cain, J. Leong, R. Herfkens, and G. A. Johnson. “Magnetic resonance imaging in multiple sclerosis: decreased signal in thalamus and putamen.” Ann Neurol 22, no. 4 (October 1987): 546–50. https://doi.org/10.1002/ana.410220418.Full Text Link to Item
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Heyman, A., W. E. Wilkinson, B. J. Hurwitz, M. J. Helms, C. S. Haynes, C. M. Utley, and L. P. Gwyther. “Early-onset Alzheimer's disease: clinical predictors of institutionalization and death.” Neurology 37, no. 6 (June 1987): 980–84. https://doi.org/10.1212/wnl.37.6.980.Full Text Link to Item
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Hurwitz, B. J., A. Heyman, P. C. Burger, and B. P. Drayer. “Subcortical arteriosclerotic encephalopathy (Binswanger's disease). Report of a case simulating psychiatric disease and normal pressure hydrocephalus.” N C Med J 48, no. 4 (April 1987): 182–86.Link to Item
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Drayer, B., P. Burger, B. Hurwitz, D. Dawson, and J. Cain. “Reduced signal intensity on MR images of thalamus and putamen in multiple sclerosis: Increased iron content?” American Journal of Roentgenology 149, no. 2 (January 1, 1987): 357–63. https://doi.org/10.2214/ajr.149.2.357.Full Text
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Drayer, B., P. Burger, and B. Hurwitz. “Reduced signal intensity on MR images of thalamus and putamen in multiple sclerosis: Increased iron content?” American Journal of Neuroradiology 8, no. 3 (January 1, 1987): 413–19.
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Belkin, R. N., B. J. Hurwitz, and J. Kisslo. “Atrial septal aneurysm: association with cerebrovascular and peripheral embolic events.” Stroke 18, no. 5 (1987): 856–62. https://doi.org/10.1161/01.str.18.5.856.Full Text Link to Item
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Hurwitz, B. J., A. Heyman, W. E. Wilkinson, C. S. Haynes, and C. M. Utley. “Comparison of amaurosis fugax and transient cerebral ischemia: a prospective clinical and arteriographic study.” Ann Neurol 18, no. 6 (December 1985): 698–704. https://doi.org/10.1002/ana.410180612.Full Text Link to Item
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Heyman, A., W. E. Wilkinson, B. J. Hurwitz, C. S. Haynes, C. M. Utley, R. A. Rosati, J. G. Burch, and T. B. Gore. “Risk of ischemic heart disease in patients with TIA.” Neurology 34, no. 5 (May 1984): 626–30. https://doi.org/10.1212/wnl.34.5.626.Full Text Link to Item
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Hodson, A. K., B. J. Hurwitz, and R. Albrecht. “Dysautonomia in Guillain-Barré syndrome with dorsal root ganglioneuropathy, wallerian degeneration, and fatal myocarditis.” Ann Neurol 15, no. 1 (January 1984): 88–95. https://doi.org/10.1002/ana.410150116.Full Text Link to Item
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Heyman, A., W. E. Wilkinson, B. J. Hurwitz, D. Schmechel, A. H. Sigmon, T. Weinberg, M. J. Helms, and M. Swift. “Alzheimer's disease: genetic aspects and associated clinical disorders.” Ann Neurol 14, no. 5 (November 1983): 507–15. https://doi.org/10.1002/ana.410140503.Full Text Link to Item
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Kinney, H. C., P. C. Burger, B. J. Hurwitz, J. C. Hijmans, and J. P. Grant. “Degeneration of the central nervous system associated with celiac disease.” J Neurol Sci 53, no. 1 (January 1982): 9–22. https://doi.org/10.1016/0022-510x(82)90076-4.Full Text Link to Item
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Kaufman, M. D., L. C. Hopkins, and B. J. Hurwitz. “Progressive sensory neuropathy in patients without carcinoma: a disorder with distinctive clinical and electrophysiological findings.” Ann Neurol 9, no. 3 (March 1981): 237–42. https://doi.org/10.1002/ana.410090306.Full Text Link to Item
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Rottenberg, D. A., B. J. Hurwitz, and J. B. Posner. “The effect of oral glycerol on intraventricular pressure in man.” Neurology 27, no. 7 (July 1977): 600–608. https://doi.org/10.1212/wnl.27.7.600.Full Text Link to Item
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Hurwitz, B. J., and J. B. Posner. “Cerebral infarction complicating subclavian vein catheterization .” Ann Neurol 1, no. 3 (March 1977): 253–54. https://doi.org/10.1002/ana.410010310.Full Text Link to Item
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Hurwitz, B. J., and D. A. Rottenberg. “Letter: Impaired clycerol clearance in obesity.” Lancet 2, no. 7941 (November 8, 1975): 933. https://doi.org/10.1016/s0140-6736(75)92179-0.Full Text Link to Item
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Hurwitz, B. J., and D. A. Rottenberg. “Letter: Glycerol, cerebral oedema, and diabetes.” Lancet 2, no. 7930 (August 23, 1975): 369. https://doi.org/10.1016/s0140-6736(75)92815-9.Full Text Link to Item
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Other Articles
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Harshaw-Ellis, Karol. “Letter to the Editor,” n.d. https://doi.org/10.1016/j.nurpra.2021.04.006.Full Text Open Access Copy
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Conference Papers
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Goodin, D. S., A. Noronha, and B. J. Hurwitz. “Neutralising antibodies to interferon-beta-1b have no impact on clinical response in multiple sclerosis.” In Multiple Sclerosis, 12:S205–S205. SAGE PUBLICATIONS LTD, 2006.Link to Item
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Kirzinger, S. S., B. J. Hurwitz, B. G. Arnason, G. K. Bigley, P. K. Coyle, D. S. Goodin, D. R. Jeffery, et al. “First phase of the BEYOND programme: 1-year interim analysis of an open-label, extension study comparing 500 mcg and 250 mcg interferon beta-1b.” In Journal of Neurology, 252:126–27. DR DIETRICH STEINKOPFF VERLAG, 2005.Link to Item
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BELKIN, R. N., B. J. HURWITZ, and J. KISSLO. “ATRIAL SEPTAL ANEURYSM - ASSOCIATION WITH CEREBROVASCULAR AND PERIPHERAL EMBOLIC EVENTS.” In Circulation, 74:178–178. AMER HEART ASSOC, 1986.Link to Item
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HEYMAN, A., W. E. WILKINSON, B. J. HURWITZ, and D. E. SCHMECHEL. “GENETIC-STUDIES OF ALZHEIMERS-DISEASE.” In Annals of Neurology, 14:150–51. LIPPINCOTT-RAVEN PUBL, 1983.Link to Item
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HEYMAN, A., T. GORE, W. E. WILKINSON, B. J. HURWITZ, J. G. BURCH, C. S. HAYNES, and C. M. UTLEY. “TIA WITH BENIGN OUTCOME.” In Stroke, 13:112–112. AMER HEART ASSOC, 1982.Link to Item
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