Scholars@Duke
Barrie James Hurwitz

Barrie James Hurwitz

Associate Professor Emeritus of Medicine
Neurology
hurwi003@mc.duke.edu
Box 3184 Med Ctr, Durham, NC 27710
122 Baker House, Durham, NC 27710

Selected Publications

Analysis of current multiple sclerosis registries.

Journal Article Neurology · January 4, 2011 BACKGROUND: Patient registries are valuable because they provide data that cannot be captured in any other way. Observations from registry studies are particularly informative if multiple registries confirm similar findings. A selection of multiple scleros ... Full text Link to item Cite

Registry studies of long-term multiple sclerosis outcomes: description of key registries.

Journal Article Neurology · January 4, 2011 BACKGROUND: Multiple sclerosis (MS) registries can provide valuable insights into the natural history of MS. Key observational findings of the registries include MS patient disability progression rate, predictors of increased disability, and changes in lif ... Full text Link to item Cite

MR imaging in multiple sclerosis: review and recommendations for current practice.

Journal Article AJNR Am J Neuroradiol · June 2010 MR imaging is widely used for the diagnosis and monitoring of patients with MS. Applications and protocols for MR imaging continue to evolve, prompting a need for continual reassessments of the optimal use of this technique in clinical practice. This artic ... Full text Link to item Cite

The diagnosis of multiple sclerosis and the clinical subtypes.

Journal Article Ann Indian Acad Neurol · October 2009 The diagnosis of multiple sclerosis (MS) requires objective findings referable to the central nervous system. A wide differential diagnosis often has to be considered. Magnetic resonance imaging and electrophysiologic and cerebrospinal fluid studies can al ... Full text Link to item Cite

Optimizing outcomes in multiple sclerosis - A consensus initiative

Journal Article Multiple Sclerosis · April 27, 2009 Background: Initiation of immunomodulators in patients experiencing a clinically isolated syndrome (CIS) may delay progression to clinically definite MS. However, lack of consensus remains on many issues affecting optimal management of MS. Method: A panel ... Full text Cite

Important sources of variability in clinical studies of neutralizing antibodies against interferon beta.

Journal Article J Neurol Sci · September 15, 2008 Interferon (IFN) beta treatment of relapsing-remitting multiple sclerosis (RRMS) stimulates production of neutralizing antibodies (NAbs) in some patients. However, clinical data supporting the hypothesis that NAbs to IFN beta adversely affect patient outco ... Full text Link to item Cite

Tolerability and safety profile of 12- to 28-week treatment with interferon beta-1b 250 and 500 microg QOD in patients with relapsing-remitting multiple sclerosis: a multicenter, randomized, double-blind, parallel-group pilot study.

Journal Article Clin Ther · June 2008 BACKGROUND: It is not known whether the currently available treatment regimen of interferon beta-1b (IFNbeta-1b) 250 microg provides the maximum benefit possible in the treatment of relapsing-remitting multiple sclerosis (RRMS), or whether higher doses of ... Full text Link to item Cite

Neutralizing antibodies to interferon β-1b are not associated with disease worsening in multiple sclerosis

Journal Article Journal of International Medical Research · January 1, 2007 The clinical impact of neutralizing antibodies (NAbs) on interferon beta (IFNβ) efficacy was studied in three large patient cohorts comprising 6698 multiple sclerosis (MS) patients receiving IFNβ-1b across North America, Europe, and Australia. In North Ame ... Full text Cite

A randomized, multicentre, open-label, parallel-group trial of the tolerability of interferon beta-1a (Rebif) administered by autoinjection or manual injection in relapsing-remitting multiple sclerosis.

Journal Article Mult Scler · October 2005 Injection site reactions (ISRs) are a common side effect of subcutaneous interferon beta therapy, particularly during initiation of therapy. Retrospective analysis of two clinical trials showed that patients using an autoinjector experienced fewer ISRs tha ... Full text Link to item Cite

Comparative tolerance of IFN beta-1a regimens in patients with relapsing multiple sclerosis. The EVIDENCE study.

Journal Article J Neurol · January 2005 The EVIDENCE study was a direct comparative study of two dose regimens of interferon (IFN) beta-1a used in the treatment of relapsing-remitting multiple sclerosis (RRMS): 30 mcg intramuscularly once weekly (qw; n=338) and 44 mcg subcutaneously three times ... Full text Link to item Cite

Jugular bulb saturation and cognitive dysfunction after cardiopulmonary bypass.

Journal Article Ann Thorac Surg · December 1994 Inadequate cerebral oxygenation during cardiopulmonary bypass may lead to postoperative cognitive dysfunction in patients undergoing cardiac operations. A psychological test battery was administered to 255 patients before cardiac operation and just before ... Full text Link to item Cite

Effect of aging on cerebral autoregulation during cardiopulmonary bypass. Association with postoperative cognitive dysfunction.

Journal Article Circulation · November 1994 BACKGROUND: Age is a predictor of cognitive dysfunction after cardiac surgery, but the mechanism is unknown. The purpose of our study was to determine whether age-related decrements in cognition are associated with cerebral blood flow (CBF) autoregulation ... Link to item Cite

Effect of aging on cerebral autoregulation during cardiopulmonary bypass: Association with postoperative cognitive dysfunction

Journal Article Circulation · November 1, 1994 Background: Age is a predictor of cognitive dysfunction after cardiac surgery, but the mechanism is unknown. The purpose of our study was to determine whether age-related decrements in cognition are associated with cerebral blood flow (CBF) autoregulation ... Cite

Multiple sclerosis, retroviruses, and PCR. The HTLV-MS Working Group.

Journal Article Neurology · March 1991 Previously reported serologic and polymerase chain reaction (PCR)-based findings have suggested an association between the human retrovirus, HTLV-I, and multiple sclerosis (MS). Due to the inherent ability of PCR to produce false-positive results, we devel ... Full text Link to item Cite

Efficacy and toxicity of cyclosporine in chronic progressive multiple sclerosis: a randomized, double-blinded, placebo-controlled clinical trial. The Multiple Sclerosis Study Group.

Journal Article Ann Neurol · June 1990 Patients with clinically definite multiple sclerosis, mild to moderately severe neurological disability (entry score on the Expanded Disability Status Scale (EDSS) between 3.0 and 7.0), and a progressive course defined by an increase in the EDSS of between ... Full text Link to item Cite

Detection of sequences homologous to human retroviral DNA in multiple sclerosis by gene amplification.

Journal Article Proc Natl Acad Sci U S A · April 1989 Twenty-one patients with multiple sclerosis, chronic progressive type, were examined for DNA sequences homologous to a human retrovirus. Genomic DNA from peripheral blood mononuclear cells was analyzed for the presence of homologous sequences to the human ... Full text Link to item Cite

Risk of multiple sclerosis exacerbation during pregnancy and breast-feeding.

Journal Article JAMA · June 17, 1988 Studies in the past have reported an increased risk of exacerbations in multiple sclerosis during the postpartum period; it is not known whether breast-feeding alters this risk. We interviewed 435 women regarding pregnancy and breast-feeding history, provi ... Link to item Cite

Magnetic resonance imaging in multiple sclerosis: decreased signal in thalamus and putamen.

Journal Article Ann Neurol · October 1987 High-field strength (1.5 Tesla) magnetic resonance imaging in 15 patients with multiple and extensive white-matter lesions and clinically definite multiple sclerosis delineated a previously undescribed finding of abnormally decreased signal intensity on T2 ... Full text Link to item Cite

Early-onset Alzheimer's disease: clinical predictors of institutionalization and death.

Journal Article Neurology · June 1987 Follow-up observations were made of 92 white patients with early-onset Alzheimer's disease to determine the demographic, clinical, and neuropsychological factors predictive of institutionalization or death. The cumulative mortality rate 5 years after entry ... Full text Link to item Cite

Reduced signal intensity on MR images of thalamus and putamen in multiple sclerosis: Increased iron content?

Journal Article American Journal of Roentgenology · January 1, 1987 High-field-strength (1.5-T) MR imaging was used to evaluate 47 patients with definite multiple sclerosis and 42 neurologically normal control patients. Abnormal, multiple foci of increased signal intensity on T2-weighted images, most prominent in the periv ... Full text Cite

Reduced signal intensity on MR images of thalamus and putamen in multiple sclerosis: Increased iron content?

Journal Article American Journal of Neuroradiology · January 1, 1987 High-field-strength (1.5-T) MR imaging was used to evaluate 47 patients with definite multiple sclerosis and 42 neurologically normal control patients. Abnormal, multiple foci of increased signal intensity on T2-weighted images, most prominent in the periv ... Cite

Atrial septal aneurysm: association with cerebrovascular and peripheral embolic events.

Journal Article Stroke · 1987 Patient records in 36 consecutively identified patients with typical echocardiographic findings of atrial septal aneurysm were reviewed. Ten of the 36 (28%) had cerebrovascular events. Of these 10, 5 had completed strokes of definite embolic origin on the ... Full text Link to item Cite

Comparison of amaurosis fugax and transient cerebral ischemia: a prospective clinical and arteriographic study.

Journal Article Ann Neurol · December 1985 We compared the clinical associations, arteriographic findings, and long-term outcome of 93 patients with amaurosis fugax and 212 patients with focal cerebral ischemia (transient ischemic attacks [TIAs]). The group of patients with cerebral TIAs included a ... Full text Link to item Cite

Risk of ischemic heart disease in patients with TIA.

Journal Article Neurology · May 1984 A prospective study was made of the morbidity and mortality from ischemic heart disease in 390 patients with focal TIA caused by atherosclerotic vascular disease. The 5-year cumulative rate of myocardial infarction or sudden death in these patients was 21. ... Full text Link to item Cite

Dysautonomia in Guillain-Barré syndrome with dorsal root ganglioneuropathy, wallerian degeneration, and fatal myocarditis.

Journal Article Ann Neurol · January 1984 An acute Guillain-Barré syndrome presenting as dysautonomia is described in a 12-year-old boy. The patient died of intractable cardiac arrhythmias and cardiac failure. A severe myocarditis with destruction of dorsal root ganglion cells and wallerian degene ... Full text Link to item Cite

Alzheimer's disease: genetic aspects and associated clinical disorders.

Journal Article Ann Neurol · November 1983 Genetic aspects and associated clinical disorders were studied in a consecutive series of 68 men and women in whom Alzheimer's disease appeared at or before age 70. Secondary cases of dementia were found in 17 (25%) of the families, affecting 22 of the pro ... Full text Link to item Cite

GENETIC-STUDIES OF ALZHEIMERS-DISEASE

Conference ANNALS OF NEUROLOGY · January 1, 1983 Link to item Cite

Degeneration of the central nervous system associated with celiac disease.

Journal Article J Neurol Sci · January 1982 The following report describes a 57-year-old man with celiac disease who developed a progressive and fatal neurologic disorder despite intensive medical and nutritional care. The clinical and pathological CNS findings in this patient are compared with thos ... Full text Link to item Cite

TIA WITH BENIGN OUTCOME

Conference STROKE · January 1, 1982 Link to item Cite

Progressive sensory neuropathy in patients without carcinoma: a disorder with distinctive clinical and electrophysiological findings.

Journal Article Ann Neurol · March 1981 Seven patients with severe progressive impairment of kinesthetic sense, mild dysfunction of cutaneous sense, and sparing of motor function were examined during a 3-year period. The clinical and electrophysiological findings are described in detail. None of ... Full text Link to item Cite

The effect of oral glycerol on intraventricular pressure in man.

Journal Article Neurology · July 1977 Oral glycerol was administered to eight patients with meningeal carcinomatosis or acute leukemia in whom ventricular catheters and Ommaya reservoirs had been implanted for the purpose of intrathecal chemotherapy or chemoprophylaxis. Intraventricular pressu ... Full text Link to item Cite