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Alzheimer's disease: genetic aspects and associated clinical disorders.

Publication ,  Journal Article
Heyman, A; Wilkinson, WE; Hurwitz, BJ; Schmechel, D; Sigmon, AH; Weinberg, T; Helms, MJ; Swift, M
Published in: Ann Neurol
November 1983

Genetic aspects and associated clinical disorders were studied in a consecutive series of 68 men and women in whom Alzheimer's disease appeared at or before age 70. Secondary cases of dementia were found in 17 (25%) of the families, affecting 22 of the probands' siblings and parents. The cumulative incidence of Alzheimer's disease in these relatives was approximately 14% at age 75. An increased frequency of Down's syndrome was observed among relatives of the probands: a rate of 3.6 per 1,000, as compared with an expected rate of 1.3 per 1,000. A history of thyroid disease was established in 9 (19.6%) of the 46 female probands, a frequency greater than that reported in the general population. There was no excess of hematological malignancies among the blood relatives, and parental age at the time of birth of the probands did not differ from the norm. The results of this study indicate that early-onset Alzheimer's disease is associated with a genetic factor manifested in a substantial familial aggregation of dementia, a probable excess of Down's syndrome in the probands' relatives, and a possible association with thyroid dysfunction in women with this form of dementia.

Duke Scholars

Published In

Ann Neurol

DOI

ISSN

0364-5134

Publication Date

November 1983

Volume

14

Issue

5

Start / End Page

507 / 515

Location

United States

Related Subject Headings

  • Thyroid Diseases
  • Risk
  • Pedigree
  • Neurology & Neurosurgery
  • Middle Aged
  • Maternal Age
  • Male
  • Leukemia
  • Humans
  • Female
 

Citation

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Heyman, A., Wilkinson, W. E., Hurwitz, B. J., Schmechel, D., Sigmon, A. H., Weinberg, T., … Swift, M. (1983). Alzheimer's disease: genetic aspects and associated clinical disorders. Ann Neurol, 14(5), 507–515. https://doi.org/10.1002/ana.410140503
Heyman, A., W. E. Wilkinson, B. J. Hurwitz, D. Schmechel, A. H. Sigmon, T. Weinberg, M. J. Helms, and M. Swift. “Alzheimer's disease: genetic aspects and associated clinical disorders.Ann Neurol 14, no. 5 (November 1983): 507–15. https://doi.org/10.1002/ana.410140503.
Heyman A, Wilkinson WE, Hurwitz BJ, Schmechel D, Sigmon AH, Weinberg T, et al. Alzheimer's disease: genetic aspects and associated clinical disorders. Ann Neurol. 1983 Nov;14(5):507–15.
Heyman, A., et al. “Alzheimer's disease: genetic aspects and associated clinical disorders.Ann Neurol, vol. 14, no. 5, Nov. 1983, pp. 507–15. Pubmed, doi:10.1002/ana.410140503.
Heyman A, Wilkinson WE, Hurwitz BJ, Schmechel D, Sigmon AH, Weinberg T, Helms MJ, Swift M. Alzheimer's disease: genetic aspects and associated clinical disorders. Ann Neurol. 1983 Nov;14(5):507–515.

Published In

Ann Neurol

DOI

ISSN

0364-5134

Publication Date

November 1983

Volume

14

Issue

5

Start / End Page

507 / 515

Location

United States

Related Subject Headings

  • Thyroid Diseases
  • Risk
  • Pedigree
  • Neurology & Neurosurgery
  • Middle Aged
  • Maternal Age
  • Male
  • Leukemia
  • Humans
  • Female