Henry Yin
Professor of Psychology and Neuroscience
I am interested in understanding the neural mechanisms underlying goal-directed actions. For the first time in history, advances in psychology and neurobiology have made it feasible to pursue the detailed neural mechanisms underlying goal-directed and voluntary actions--how they are driven by the needs and desires of the organism and controlled by cognitive processes that provide a rich representation of the self and the world. My approach to this problem is highly integrative, combining behavioral analysis with electrophysiological techniques as well as tools from molecular biology. In the near future three techniques will be emphasized. 1) Dissecting reward-guided behavior using analytical behavioral assays. 2) In vivo recording from cerebral cortex, thalamus, midbrain, and basal ganglia in awake behaving rodents. Up to hundreds of neurons can be recorded from multiple brain areas that form a functional neural network in a single animal. 3) In vitro (and ex vivo) whole-cell patch-clamp recording in brain slices, with the aid of genetic tools for visualization of distinct neuronal populations. Ultimately, I hope to characterize goal-directed actions at multiple levels of analysis--from molecules to neural networks. This knowledge will provide us with insight into various pathological conditions characterized by impaired goal-directed behaviors, such as drug addiction, obsessive-compulsive disorder, Parkinson's disease, and Huntington's disease.
Current Appointments & Affiliations
- Professor of Psychology and Neuroscience, Psychology & Neuroscience, Trinity College of Arts & Sciences 2020
- Associate Professor in Neurobiology, Neurobiology, Basic Science Departments 2017
- Faculty Network Member of the Duke Institute for Brain Sciences, Duke Institute for Brain Sciences, University Institutes and Centers 2011
- Affiliate of the Duke Regeneration Center, Regeneration Next Initiative, Basic Science Departments 2021
Contact Information
- GSRB II Rm 3012, Box 91050, Durham, NC 27708
- GSRB II, Box 91050, Durham, NC 27708-0086
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hy43@duke.edu
(919) 660-5781
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http://www.duke.edu/~hy43
- Background
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Education, Training, & Certifications
- Ph.D., University of California - Los Angeles 2004
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Previous Appointments & Affiliations
- Associate Professor in the Department of Psychology and Neuroscience, Psychology & Neuroscience, Trinity College of Arts & Sciences 2015 - 2019
- Assistant Professor in Neurobiology, Neurobiology, Basic Science Departments 2010 - 2017
- Assistant Professor of Psychology and Neuroscience, Psychology & Neuroscience, Trinity College of Arts & Sciences 2008 - 2015
- Recognition
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In the News
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MAR 31, 2020 Duke Institute for Brain Sciences -
JAN 21, 2020 -
NOV 24, 2015 -
OCT 9, 2014 Duke Research Blog -
DEC 17, 2013
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- Research
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Selected Grants
- Dissecting basal ganglia circuit mechanisms underlying instrumental learning awarded by National Institutes of Health 2016 - 2027
- The Role of Opponent Basal Ganglia Outputs in Behavior awarded by National Institutes of Health 2017 - 2026
- The role of parafascicular thalamic circuits in action generation awarded by National Institutes of Health 2021 - 2026
- Neuron-Microglia Crosstalk in Development: A new role for the neuron-derived cytokine IL34 in microglial function awarded by National Institutes of Health 2022 - 2025
- Neural Circuit Control of Postnatal Quiescent Neural Stem Cell Activation awarded by National Institutes of Health 2014 - 2025
- Neurobiology Training Program awarded by National Institutes of Health 2019 - 2024
- Linking Neuron-Astrocyte Communication to Long-Term Changes in Neural Circuit Function and Behavior awarded by Salk Institute Biotechnology/Industrial Associatio 2021 - 2023
- Striatal Microcircuit Drivers of Adaptive Learning in Habit Formation awarded by National Institutes of Health 2018 - 2023
- Genes, Neural Circuits, and Behavior awarded by University of Tennessee Health Science Center 2019 - 2023
- Heat Shock Factors and Protein Misfolding Disease awarded by National Institutes of Health 2018 - 2023
- Influence of prenatal exposure to air pollution and maternal stress on microglial sculpting of neural circuits awarded by National Institutes of Health 2021 - 2023
- Dissecting Striatal Micro-circuits Underlying Goal Pursuit awarded by National Institutes of Health 2017 - 2022
- The Regulation of Synaptic Connectivity and Homeostasis by Huntingtin awarded by National Institutes of Health 2016 - 2020
- Taking DISCO Live: Dual pathway Imaging of Striatal Circuit Output in vivo awarded by National Institutes of Health 2017 - 2019
- Genes, Neural Circuits, and Behavior awarded by National Institutes of Health 2018 - 2019
- Analysis of Shank3 Complete and Temporal and Spatial Specific Knockout Mice awarded by National Institutes of Health 2012 - 2018
- Basic predoctoral training in neuroscience awarded by National Institutes of Health 1992 - 2018
- Neural-Glial Interactions and Opioid Abuse: Modulation by Early-Life Experience awarded by National Institutes of Health 2013 - 2018
- From Good Habit to Bad: Examining the relationship between habit learning and compulsivity awarded by McKnight Endowment Fund for Neuroscience 2014 - 2017
- Neural Mechanisms of Habit Formation and Maintenance awarded by National Institutes of Health 2011 - 2016
- Training in Fundamental &Translational Neuroscience awarded by National Institutes of Health 2005 - 2016
- Physiological Effects of Ethanol on Neural Circuits Mediating Habit Formation awarded by National Institutes of Health 2008 - 2013
- Ethanol Effects on Neostriatal Function awarded by National Institutes of Health 2008 - 2011
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External Relationships
- Harbour International Education Technology
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Petter, Elijah A., Isabella P. Fallon, Ryan N. Hughes, Glenn D. R. Watson, Warren H. Meck, Francesco Paolo Ulloa Severino, and Henry H. Yin. “Elucidating a locus coeruleus-dentate gyrus dopamine pathway for operant reinforcement.” Elife 12 (April 2023): e83600. https://doi.org/10.7554/elife.83600.Full Text
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Zhang, Jinyong, Ryan N. Hughes, Namsoo Kim, Isabella P. Fallon, Konstantin Bakhurin, Jiwon Kim, Francesco Paolo Ulloa Severino, and Henry H. Yin. “A one-photon endoscope for simultaneous patterned optogenetic stimulation and calcium imaging in freely behaving mice.” Nature Biomedical Engineering 7, no. 4 (April 2023): 499–510. https://doi.org/10.1038/s41551-022-00920-3.Full Text
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Yu, Chunxiu, Tony Tianlun Jiang, Charles T. Shoemaker, David Fan, Mark A. Rossi, and Henry H. Yin. “Striatal mechanisms of turning behaviour following unilateral dopamine depletion in mice.” The European Journal of Neuroscience 56, no. 5 (September 2022): 4529–45. https://doi.org/10.1111/ejn.15764.Full Text
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Kim, Sunwhi, Yong-Eun Kim, Inuk Song, Yusuke Ujihara, Namsoo Kim, Yong-Hui Jiang, Henry H. Yin, Tae-Ho Lee, and Il Hwan Kim. “Neural circuit pathology driven by Shank3 mutation disrupts social behaviors.” Cell Reports 39, no. 10 (June 2022): 110906. https://doi.org/10.1016/j.celrep.2022.110906.Full Text
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Bakhurin, Konstantin I., and Henry H. Yin. “Closing the loop on models of interval timing.” Nature Neuroscience 25, no. 3 (March 2022): 270–71. https://doi.org/10.1038/s41593-022-01015-7.Full Text
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Barter, J. W., and H. H. Yin. “Achieving natural behavior in a robot using neurally inspired hierarchical perceptual control.” Iscience 24, no. 9 (September 24, 2021). https://doi.org/10.1016/j.isci.2021.102948.Full Text
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Hughes, Ryan N., Glenn D. R. Watson, Elijah A. Petter, Namsoo Kim, Konstantin I. Bakhurin, and Henry H. Yin. “Precise coordination of three-dimensional rotational kinematics by ventral tegmental area GABAergic neurons.” Current Biology : Cb 31, no. 9 (May 2021): 2037. https://doi.org/10.1016/j.cub.2021.04.008.Full Text
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Li, Haofang E., Mark A. Rossi, Glenn D. R. Watson, H Gregory Moore, Min Tong Cai, Namsoo Kim, Katrina A. Vokt, et al. “Hypothalamic-Extended Amygdala Circuit Regulates Temporal Discounting.” The Journal of Neuroscience : The Official Journal of the Society for Neuroscience 41, no. 9 (March 2021): 1928–40. https://doi.org/10.1523/jneurosci.1836-20.2020.Full Text
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Watson, Glenn D. R., Ryan N. Hughes, Elijah A. Petter, Isabella P. Fallon, Namsoo Kim, Francesco Paolo Ulloa Severino, and Henry H. Yin. “Thalamic projections to the subthalamic nucleus contribute to movement initiation and rescue of parkinsonian symptoms.” Science Advances 7, no. 6 (February 2021): eabe9192. https://doi.org/10.1126/sciadv.abe9192.Full Text
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Bakhurin, Konstantin I., Ryan N. Hughes, Joseph W. Barter, Jinyong Zhang, and Henry H. Yin. “Protocol for Recording from Ventral Tegmental Area Dopamine Neurons in Mice while Measuring Force during Head-Fixation.” Star Protocols 1, no. 2 (September 2020): 100091. https://doi.org/10.1016/j.xpro.2020.100091.Full Text
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Lusk, Nicholas, Warren H. Meck, and Henry H. Yin. “Mediodorsal Thalamus Contributes to the Timing of Instrumental Actions.” The Journal of Neuroscience : The Official Journal of the Society for Neuroscience 40, no. 33 (August 2020): 6379–88. https://doi.org/10.1523/jneurosci.0695-20.2020.Full Text
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Kim, Il Hwan, Namsoo Kim, Sunwhi Kim, Koji Toda, Christina M. Catavero, Jamie L. Courtland, Henry H. Yin, and Scott H. Soderling. “Dysregulation of the Synaptic Cytoskeleton in the PFC Drives Neural Circuit Pathology, Leading to Social Dysfunction.” Cell Rep 32, no. 4 (July 28, 2020): 107965. https://doi.org/10.1016/j.celrep.2020.107965.Full Text Link to Item
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Hughes, Ryan N., Konstantin I. Bakhurin, Elijah A. Petter, Glenn D. R. Watson, Namsoo Kim, Alexander D. Friedman, and Henry H. Yin. “Ventral Tegmental Dopamine Neurons Control the Impulse Vector during Motivated Behavior.” Current Biology : Cb 30, no. 14 (July 2020): 2681-2694.e5. https://doi.org/10.1016/j.cub.2020.05.003.Full Text
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Bakhurin, Konstantin I., Xiaoran Li, Alexander D. Friedman, Nicholas A. Lusk, Glenn Dr Watson, Namsoo Kim, and Henry H. Yin. “Opponent regulation of action performance and timing by striatonigral and striatopallidal pathways.” Elife 9 (April 2020): e54831. https://doi.org/10.7554/elife.54831.Full Text
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Burrus, Caley J., Spencer U. McKinstry, Namsoo Kim, M Ilcim Ozlu, Aditya V. Santoki, Francia Y. Fang, Annie Ma, et al. “Striatal Projection Neurons Require Huntingtin for Synaptic Connectivity and Survival.” Cell Rep 30, no. 3 (January 21, 2020): 642-657.e6. https://doi.org/10.1016/j.celrep.2019.12.069.Full Text Link to Item
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Hughes, Ryan N., Konstantin I. Bakhurin, Joseph W. Barter, Jinyong Zhang, and Henry H. Yin. “A Head-Fixation System for Continuous Monitoring of Force Generated During Behavior.” Frontiers in Integrative Neuroscience 14 (January 2020): 11. https://doi.org/10.3389/fnint.2020.00011.Full Text
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Hughes, Ryan N., Glenn D. R. Watson, Elijah A. Petter, Namsoo Kim, Konstantin I. Bakhurin, and Henry H. Yin. “Precise Coordination of Three-Dimensional Rotational Kinematics by Ventral Tegmental Area GABAergic Neurons.” Current Biology : Cb 29, no. 19 (October 2019): 3244-3255.e4. https://doi.org/10.1016/j.cub.2019.08.022.Full Text
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Yang, Rui, Kathryn K. Walder-Christensen, Namsoo Kim, Danwei Wu, Damaris N. Lorenzo, Alexandra Badea, Yong-Hui Jiang, Henry H. Yin, William C. Wetsel, and Vann Bennett. “ANK2 autism mutation targeting giant ankyrin-B promotes axon branching and ectopic connectivity.” Proc Natl Acad Sci U S A 116, no. 30 (July 23, 2019): 15262–71. https://doi.org/10.1073/pnas.1904348116.Full Text Link to Item
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Kim, Namsoo, Haofang E. Li, Ryan N. Hughes, Glenn D. R. Watson, David Gallegos, Anne E. West, Il Hwan Kim, and Henry H. Yin. “A striatal interneuron circuit for continuous target pursuit.” Nat Commun 10, no. 1 (June 20, 2019): 2715. https://doi.org/10.1038/s41467-019-10716-w.Full Text Link to Item
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Risher, W Christopher, Namsoo Kim, Sehwon Koh, Ji-Eun Choi, Petar Mitev, Erin F. Spence, Louis-Jan Pilaz, et al. “Thrombospondin receptor α2δ-1 promotes synaptogenesis and spinogenesis via postsynaptic Rac1.” J Cell Biol 217, no. 10 (October 1, 2018): 3747–65. https://doi.org/10.1083/jcb.201802057.Full Text Link to Item
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Tan, Shawn, Yixin Xiao, Henry H. Yin, Albert I. Chen, Tuck Wah Soong, and H Shawn Je. “Postnatal TrkB ablation in corticolimbic interneurons induces social dominance in male mice.” Proceedings of the National Academy of Sciences of the United States of America 115, no. 42 (October 2018): E9909–15. https://doi.org/10.1073/pnas.1812083115.Full Text
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Rodriguez, Erica, Katsuyasu Sakurai, Jennie Xu, Yong Chen, Koji Toda, Shengli Zhao, Bao-Xia Han, et al. “Publisher Correction: A craniofacial-specific monosynaptic circuit enables heightened affective pain.” Nat Neurosci 21, no. 6 (June 2018): 896. https://doi.org/10.1038/s41593-018-0103-7.Full Text Link to Item
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Bey, Alexandra L., Xiaoming Wang, Haidun Yan, Namsoo Kim, Rebecca L. Passman, Yilin Yang, Xinyu Cao, et al. “Brain region-specific disruption of Shank3 in mice reveals a dissociation for cortical and striatal circuits in autism-related behaviors.” Transl Psychiatry 8, no. 1 (April 27, 2018): 94. https://doi.org/10.1038/s41398-018-0142-6.Full Text Link to Item
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O’Hare, Justin, Nicole Calakos, and Henry H. Yin. “Recent Insights into Corticostriatal Circuit Mechanisms underlying Habits: Invited review for Current Opinions in Behavioral Sciences.” Curr Opin Behav Sci 20 (April 2018): 40–46. https://doi.org/10.1016/j.cobeha.2017.10.001.Full Text Link to Item
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Toda, Koji, Nicholas A. Lusk, Glenn D. R. Watson, Namsoo Kim, Dongye Lu, Haofang E. Li, Warren H. Meck, and Henry H. Yin. “Nigrotectal Stimulation Stops Interval Timing in Mice.” Current Biology : Cb 27, no. 24 (December 2017): 3763-3770.e3. https://doi.org/10.1016/j.cub.2017.11.003.Full Text
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Rodriguez, Erica, Katsuyasu Sakurai, Jennie Xu, Yong Chen, Koji Toda, Shengli Zhao, Bao-Xia Han, et al. “A craniofacial-specific monosynaptic circuit enables heightened affective pain.” Nat Neurosci 20, no. 12 (December 2017): 1734–43. https://doi.org/10.1038/s41593-017-0012-1.Full Text Open Access Copy Link to Item
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Pappas, Andrea L., Alexandra L. Bey, Xiaoming Wang, Mark Rossi, Yong Ho Kim, Haidun Yan, Fiona Porkka, et al. “Deficiency of Shank2 causes mania-like behavior that responds to mood stabilizers.” Jci Insight 2, no. 20 (October 19, 2017). https://doi.org/10.1172/jci.insight.92052.Full Text Link to Item
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O’Hare, Justin K., Haofang Li, Namsoo Kim, Erin Gaidis, Kristen Ade, Jeff Beck, Henry Yin, and Nicole Calakos. “Striatal fast-spiking interneurons selectively modulate circuit output and are required for habitual behavior.” Elife 6 (September 5, 2017). https://doi.org/10.7554/eLife.26231.Full Text Link to Item
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Yin, Henry H. “The Basal Ganglia in Action.” The Neuroscientist : A Review Journal Bringing Neurobiology, Neurology and Psychiatry 23, no. 3 (June 2017): 299–313. https://doi.org/10.1177/1073858416654115.Full Text
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Wang, Xiaoming, Alexandra L. Bey, Brittany M. Katz, Alexandra Badea, Namsoo Kim, Lisa K. David, Lara J. Duffney, et al. “Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism.” Nat Commun 7 (May 10, 2016): 11459. https://doi.org/10.1038/ncomms11459.Full Text Open Access Copy Link to Item
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Yin, H. H. “The role of opponent basal ganglia outputs in behavior.” Future Neurology 11, no. 2 (May 1, 2016): 149–69. https://doi.org/10.2217/fnl.16.6.Full Text
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Rossi, Mark A., Haofang E. Li, Dongye Lu, Il Hwan Kim, Ryan A. Bartholomew, Erin Gaidis, Joseph W. Barter, et al. “A GABAergic nigrotectal pathway for coordination of drinking behavior.” Nat Neurosci 19, no. 5 (May 2016): 742–48. https://doi.org/10.1038/nn.4285.Full Text Link to Item
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Bartholomew, Ryan A., Haofang Li, Erin J. Gaidis, Michelle Stackmann, Charles T. Shoemaker, Mark A. Rossi, and Henry H. Yin. “Striatonigral control of movement velocity in mice.” The European Journal of Neuroscience 43, no. 8 (April 2016): 1097–1110. https://doi.org/10.1111/ejn.13187.Full Text
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O’Hare, Justin K., Kristen K. Ade, Tatyana Sukharnikova, Stephen D. Van Hooser, Mark L. Palmeri, Henry H. Yin, and Nicole Calakos. “Pathway-Specific Striatal Substrates for Habitual Behavior.” Neuron 89, no. 3 (February 3, 2016): 472–79. https://doi.org/10.1016/j.neuron.2015.12.032.Full Text Link to Item
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Berglund, Ken, Kara Clissold, Haofang E. Li, Lei Wen, Sung Young Park, Jan Gleixner, Marguerita E. Klein, et al. “Luminopsins integrate opto- and chemogenetics by using physical and biological light sources for opsin activation.” Proceedings of the National Academy of Sciences of the United States of America 113, no. 3 (January 2016): E358–67. https://doi.org/10.1073/pnas.1510899113.Full Text
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Koh, Sehwon, Namsoo Kim, Henry H. Yin, Ian R. Harris, Nadine S. Dejneka, and Cagla Eroglu. “Human Umbilical Tissue-Derived Cells Promote Synapse Formation and Neurite Outgrowth via Thrombospondin Family Proteins.” J Neurosci 35, no. 47 (November 25, 2015): 15649–65. https://doi.org/10.1523/JNEUROSCI.1364-15.2015.Full Text Link to Item
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Kim, Il Hwan, Mark A. Rossi, Dipendra K. Aryal, Bence Racz, Namsoo Kim, Akiyoshi Uezu, Fan Wang, et al. “Spine pruning drives antipsychotic-sensitive locomotion via circuit control of striatal dopamine.” Nat Neurosci 18, no. 6 (June 2015): 883–91. https://doi.org/10.1038/nn.4015.Full Text Link to Item
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Barter, J. W., S. Li, D. Lu, R. A. Bartholomew, M. A. Rossi, C. T. Shoemaker, D. Salas-Meza, E. Gaidis, and H. H. Yin. “Beyond reward prediction errors: The role of dopamine in movement kinematics.” Frontiers in Integrative Neuroscience 9, no. MAY (May 27, 2015). https://doi.org/10.3389/fnint.2015.00039.Full Text
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Rossi, M. A., and H. H. Yin. “Elevated dopamine alters consummatory pattern generation and increases behavioral variability during learning.” Frontiers in Integrative Neuroscience 9, no. MAY (May 15, 2015). https://doi.org/10.3389/fnint.2015.00037.Full Text
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Rossi, Mark A., Nicole Calakos, and Henry H. Yin. “Spotlight on movement disorders: What optogenetics has to offer.” Mov Disord 30, no. 5 (April 15, 2015): 624–31. https://doi.org/10.1002/mds.26184.Full Text Link to Item
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Barter, Joseph W., Suellen Li, Tatyana Sukharnikova, Mark A. Rossi, Ryan A. Bartholomew, and Henry H. Yin. “Basal ganglia outputs map instantaneous position coordinates during behavior.” The Journal of Neuroscience : The Official Journal of the Society for Neuroscience 35, no. 6 (February 2015): 2703–16. https://doi.org/10.1523/jneurosci.3245-14.2015.Full Text
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Jenkins, Paul M., Namsoo Kim, Steven L. Jones, Wei Chou Tseng, Tatyana M. Svitkina, Henry H. Yin, and Vann Bennett. “Giant ankyrin-G: a critical innovation in vertebrate evolution of fast and integrated neuronal signaling.” Proc Natl Acad Sci U S A 112, no. 4 (January 27, 2015): 957–64. https://doi.org/10.1073/pnas.1416544112.Full Text Link to Item
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Rossi, Mark A., Vinson Go, Tracy Murphy, Quanhai Fu, James Morizio, and Henry H. Yin. “A wirelessly controlled implantable LED system for deep brain optogenetic stimulation.” Frontiers in Integrative Neuroscience 9 (January 2015): 8. https://doi.org/10.3389/fnint.2015.00008.Full Text Open Access Copy
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Kim, Namsoo, Joseph W. Barter, Tatyana Sukharnikova, and Henry H. Yin. “Striatal firing rate reflects head movement velocity.” The European Journal of Neuroscience 40, no. 10 (November 2014): 3481–90. https://doi.org/10.1111/ejn.12722.Full Text
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McKinstry, Spencer U., Yonca B. Karadeniz, Atesh K. Worthington, Volodya Y. Hayrapetyan, M Ilcim Ozlu, Karol Serafin-Molina, W Christopher Risher, et al. “Huntingtin is required for normal excitatory synapse development in cortical and striatal circuits.” J Neurosci 34, no. 28 (July 9, 2014): 9455–72. https://doi.org/10.1523/JNEUROSCI.4699-13.2014.Full Text Open Access Copy Link to Item
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Barter, Joseph W., Stephen Castro, Tatyana Sukharnikova, Mark A. Rossi, and Henry H. Yin. “The role of the substantia nigra in posture control.” The European Journal of Neuroscience 39, no. 9 (May 2014): 1465–73. https://doi.org/10.1111/ejn.12540.Full Text
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Leblond, Mona, Tatyana Sukharnikova, Chunxiu Yu, Mark A. Rossi, and Henry H. Yin. “The role of pedunculopontine nucleus in choice behavior under risk.” The European Journal of Neuroscience 39, no. 10 (May 2014): 1664–70. https://doi.org/10.1111/ejn.12529.Full Text
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Hayrapetyan, Volodya, Stephen Castro, Tatyana Sukharnikova, Chunxiu Yu, Xinyu Cao, Yong-Hui Jiang, and Henry H. Yin. “Region-specific impairments in striatal synaptic transmission and impaired instrumental learning in a mouse model of Angelman syndrome.” The European Journal of Neuroscience 39, no. 6 (March 2014): 1018–25. https://doi.org/10.1111/ejn.12442.Full Text
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Yin, Henry H. “Action, time and the basal ganglia.” Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 369, no. 1637 (March 2014): 20120473. https://doi.org/10.1098/rstb.2012.0473.Full Text
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Leblond, M., T. Sukharnikova, C. Yu, M. A. Rossi, and H. H. Yin. “The role of pedunculopontine nucleus in choice behavior under risk.” European Journal of Neuroscience, 2014.
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Yin, H. H. “Cortico-Basal Ganglia Networks and the Neural Substrates of Actions,” January 1, 2014, 29–47. https://doi.org/10.1016/B978-0-12-405941-2.00002-X.Full Text
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Rossi, Mark A., David Fan, Joseph W. Barter, and Henry H. Yin. “Bidirectional modulation of substantia nigra activity by motivational state.” Plos One 8, no. 8 (January 2013): e71598. https://doi.org/10.1371/journal.pone.0071598.Full Text
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Rossi, Mark A., Tatyana Sukharnikova, Volodya Y. Hayrapetyan, Lucie Yang, and Henry H. Yin. “Operant self-stimulation of dopamine neurons in the substantia nigra.” Plos One 8, no. 6 (January 2013): e65799. https://doi.org/10.1371/journal.pone.0065799.Full Text
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Barter, J. W., M. A. Rossi, and H. H. Yin. “Waiting for rewards: neural adaptation in substantia nigra neurons under fixed interval feedback (In preparation).” Journal of Neuroscience, 2013.
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Rossi, Mark A., Volodya Y. Hayrapetyan, Benjamin Maimon, Krystal Mak, H Shawn Je, and Henry H. Yin. “Prefrontal cortical mechanisms underlying delayed alternation in mice.” Journal of Neurophysiology 108, no. 4 (August 2012): 1211–22. https://doi.org/10.1152/jn.01060.2011.Full Text
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Rossi, M. A. “Methods for studying habitual behavior in mice.” Current Protocols in Neuroscience, July 2012.
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Fan, David, Mark A. Rossi, and Henry H. Yin. “Mechanisms of action selection and timing in substantia nigra neurons.” The Journal of Neuroscience : The Official Journal of the Society for Neuroscience 32, no. 16 (April 2012): 5534–48. https://doi.org/10.1523/jneurosci.5924-11.2012.Full Text
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Yu, Chunxiu, David Fan, Alberto Lopez, and Henry H. Yin. “Dynamic changes in single unit activity and γ oscillations in a thalamocortical circuit during rapid instrumental learning.” Plos One 7, no. 11 (January 2012): e50578. https://doi.org/10.1371/journal.pone.0050578.Full Text
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Barter, J. W., S. Castro, T. Sukharnikova, M. A. Rossi, and W. Ebenstein. “The role of the substantia nigra in posture control (Submitted).” Journal of Neuroscience, 2012.
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Rossi, M. A., and D. Fan. “Mechanisms of action selection and timing in substantia nigra neurons.” Journal of Neuroscience 2, no. 16 (2012).
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Rossi, M. A., and H. H. Yin. “The role of the dorsal striatum in instrumental conditioning.” Neuromethods 62 (October 24, 2011): 55–69. https://doi.org/10.1007/978-1-61779-301-1_4.Full Text
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Leblond, Mona, David Fan, Julia K. Brynildsen, and Henry H. Yin. “Motivational state and reward content determine choice behavior under risk in mice.” Plos One 6, no. 9 (January 2011): e25342. https://doi.org/10.1371/journal.pone.0025342.Full Text
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Fan, David, Dylan Rich, Tahl Holtzman, Patrick Ruther, Jeffrey W. Dalley, Alberto Lopez, Mark A. Rossi, et al. “A wireless multi-channel recording system for freely behaving mice and rats.” Plos One 6, no. 7 (January 2011): e22033. https://doi.org/10.1371/journal.pone.0022033.Full Text Open Access Copy
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Russo, A. L. de, D. Fan, J. Gupta, O. Shelest, R. M. Costa, and H. H. Yin. “Instrumental uncertainty as a determinant of behavior under interval schedules of reinforcement.” Frontiers in Integrative Neuroscience 4 (December 1, 2010). https://doi.org/10.3389/fnint.2010.00017.Full Text
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Yin, Henry H. “The sensorimotor striatum is necessary for serial order learning.” The Journal of Neuroscience : The Official Journal of the Society for Neuroscience 30, no. 44 (November 2010): 14719–23. https://doi.org/10.1523/jneurosci.3989-10.2010.Full Text
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YU, C., J. Gupta, and H. H. Yin. “The role of mediodorsal thalamus in temporal differentiation of reward-guided actions.” Frontiers in Integrative Neuroscience, no. MAY 2010 (May 1, 2010). https://doi.org/10.3389/fnint.2010.00014.Full Text
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DeRusso, A. L., D. Fan, J. Gupta, O. Shelest, R. M. Costa, and H. H. Yin. “Instrumental uncertainty as a determinant of behavior under interval schedules of reinforcement.” Frontiers in Integrative Neuroscience, no. MAY 2010 (2010).
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Yu, C., J. Gupta, J. F. Chen, and H. H. Yin. “Genetic deletion of A2A adenosine receptors in the striatum selectively impairs habit formation.” Journal of Neuroscience 29, no. 48 (December 2009).
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Yin, H. H. “The role of the murine motor cortex in action duration and order.” Frontiers in Integrative Neuroscience 3, no. OCT (October 9, 2009). https://doi.org/10.3389/neuro.07.023.2009.Full Text
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Yin, H. H. “The role of the murine motor cortex in action duration and order.” Frontiers in Integrative Neuroscience 3, no. 23 (October 2009).
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Yin, H. “From actions to habits.” Alcohol Research and Health 31, no. 4 (May 20, 2009): 340–44.
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Yin, Henry H., Shweta Prasad Mulcare, Monica R. F. Hilário, Emily Clouse, Terrell Holloway, Margaret I. Davis, Anita C. Hansson, David M. Lovinger, and Rui M. Costa. “Dynamic reorganization of striatal circuits during the acquisition and consolidation of a skill.” Nature Neuroscience 12, no. 3 (March 2009): 333–41. https://doi.org/10.1038/nn.2261.Full Text
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Yin, H. H. “Neuroadaptations leading to alcohol addiction and dependence.” Alcohol Research and Health 31, no. 4 (2009): 340–44.
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Yin, Henry H., Sean B. Ostlund, and Bernard W. Balleine. “Reward-guided learning beyond dopamine in the nucleus accumbens: the integrative functions of cortico-basal ganglia networks.” The European Journal of Neuroscience 28, no. 8 (October 2008): 1437–48. https://doi.org/10.1111/j.1460-9568.2008.06422.x.Full Text
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Yin, H. “The elephantine shape of addiction.” Behavioral and Brain Sciences 31, no. 4 (August 1, 2008): 461. https://doi.org/10.1017/S0140525X08004974.Full Text
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Yin, Henry H. “From actions to habits: neuroadaptations leading to dependence.” Alcohol Research & Health : The Journal of the National Institute on Alcohol Abuse and Alcoholism 31, no. 4 (January 2008): 340–44.
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Yin, Henry H., Louise Adermark, and David M. Lovinger. “Neurotensin reduces glutamatergic transmission in the dorsolateral striatum via retrograde endocannabinoid signaling.” Neuropharmacology 54, no. 1 (January 2008): 79–86. https://doi.org/10.1016/j.neuropharm.2007.06.004.Full Text
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Hilário, M. R. F., E. Clouse, H. H. Yin, and R. M. Costa. “Endocannabinoid signaling is critical for habit formation.” Frontiers in Integrative Neuroscience 1, no. NOV (November 2, 2007). https://doi.org/10.3389/neuro.07.006.2007.Full Text
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Yin, Henry H., Brian S. Park, Louise Adermark, and David M. Lovinger. “Ethanol reverses the direction of long-term synaptic plasticity in the dorsomedial striatum.” The European Journal of Neuroscience 25, no. 11 (June 2007): 3226–32. https://doi.org/10.1111/j.1460-9568.2007.05606.x.Full Text
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Hilario, M., E. Clouse, H. H. Yin, and R. M. Costa. “Endocannabinoid signaling is required for habit formation.” Frontiers in Integrative Neuroscience 1(6) (2007).
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Yin, Henry H., Margaret I. Davis, Jennifer A. Ronesi, and David M. Lovinger. “The role of protein synthesis in striatal long-term depression.” The Journal of Neuroscience : The Official Journal of the Society for Neuroscience 26, no. 46 (November 2006): 11811–20. https://doi.org/10.1523/jneurosci.3196-06.2006.Full Text
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Dang, Mai T., Fumiaki Yokoi, Henry H. Yin, David M. Lovinger, Yanyan Wang, and Yuqing Li. “Disrupted motor learning and long-term synaptic plasticity in mice lacking NMDAR1 in the striatum.” Proceedings of the National Academy of Sciences of the United States of America 103, no. 41 (October 2006): 15254–59. https://doi.org/10.1073/pnas.0601758103.Full Text
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Yin, Henry H., and Barbara J. Knowlton. “The role of the basal ganglia in habit formation.” Nature Reviews. Neuroscience 7, no. 6 (June 2006): 464–76. https://doi.org/10.1038/nrn1919.Full Text
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Wang, Zhongfeng, Li Kai, Michelle Day, Jennifer Ronesi, Henry H. Yin, Jun Ding, Tatiana Tkatch, David M. Lovinger, and D James Surmeier. “Dopaminergic control of corticostriatal long-term synaptic depression in medium spiny neurons is mediated by cholinergic interneurons.” Neuron 50, no. 3 (May 2006): 443–52. https://doi.org/10.1016/j.neuron.2006.04.010.Full Text
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Yin, Henry H., Xiaoxi Zhuang, and Bernard W. Balleine. “Instrumental learning in hyperdopaminergic mice.” Neurobiology of Learning and Memory 85, no. 3 (May 2006): 283–88. https://doi.org/10.1016/j.nlm.2005.12.001.Full Text
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Yin, Henry H., and David M. Lovinger. “Frequency-specific and D2 receptor-mediated inhibition of glutamate release by retrograde endocannabinoid signaling.” Proceedings of the National Academy of Sciences of the United States of America 103, no. 21 (May 2006): 8251–56. https://doi.org/10.1073/pnas.0510797103.Full Text
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Yin, H. H., B. J. Knowlton, and B. W. Balleine. “Reversible inactivation of dorsolateral striatum enhances sensitivity to changes in action-outcome contingency in instrumental conditioning.” Behavioural Brain Research 66, no. 2 (2006): 189–96.
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Yin, Henry H., Barbara J. Knowlton, and Bernard W. Balleine. “Inactivation of dorsolateral striatum enhances sensitivity to changes in the action-outcome contingency in instrumental conditioning.” Behavioural Brain Research 166, no. 2 (January 2006): 189–96. https://doi.org/10.1016/j.bbr.2005.07.012.Full Text
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Yin, Henry H., Barbara J. Knowlton, and Bernard W. Balleine. “Blockade of NMDA receptors in the dorsomedial striatum prevents action-outcome learning in instrumental conditioning.” The European Journal of Neuroscience 22, no. 2 (July 2005): 505–12. https://doi.org/10.1111/j.1460-9568.2005.04219.x.Full Text
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Yin, Henry H., Sean B. Ostlund, Barbara J. Knowlton, and Bernard W. Balleine. “The role of the dorsomedial striatum in instrumental conditioning.” The European Journal of Neuroscience 22, no. 2 (July 2005): 513–23. https://doi.org/10.1111/j.1460-9568.2005.04218.x.Full Text
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Yin, Henry H., and Barbara J. Knowlton. “Contributions of striatal subregions to place and response learning.” Learning & Memory (Cold Spring Harbor, N.Y.) 11, no. 4 (July 2004): 459–63. https://doi.org/10.1101/lm.81004.Full Text
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Yin, H. H., B. J. Knowlton, and B. W. Balleine. “Lesions of the dorsolateral striatum abolish habits and preserve goal expectancy.” European Journal of Neuroscience 19 (2004): 1–9.
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Yin, Henry H., Barbara J. Knowlton, and Bernard W. Balleine. “Lesions of dorsolateral striatum preserve outcome expectancy but disrupt habit formation in instrumental learning.” The European Journal of Neuroscience 19, no. 1 (January 2004): 181–89. https://doi.org/10.1111/j.1460-9568.2004.03095.x.Full Text
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Yin, Henry, Mark E. Bardgett, and John G. Csernansky. “Kainic acid lesions disrupt fear-mediated memory processing.” Neurobiology of Learning and Memory 77, no. 3 (May 2002): 389–401. https://doi.org/10.1006/nlme.2001.4037.Full Text
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Yin, H. H., and B. J. Knowlton. “Reinforcer devaluation abolishes conditioned cue preference: evidence for stimulus-stimulus associations.” Behavioral Neuroscience 116, no. 1 (February 2002): 174–77. https://doi.org/10.1037//0735-7044.116.1.174.Full Text
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Kwong-yin Fock, H. “Retail outlet location decision maker – franchisor or franchisee?” Marketing Intelligence &Amp; Planning 19, no. 3 (June 1, 2001): 171–79. https://doi.org/10.1108/02634500110391717.Full Text
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Book Sections
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Yin, H. “The crisis in neuroscience.” In The Interdisciplinary Handbook of Perceptual Control Theory: Living Control Systems IV, 23–48, 2020. https://doi.org/10.1016/B978-0-12-818948-1.00003-4.Full Text
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Yin, H. H. “Restoring purpose in behavior.” In Computational and Robotic Models of the Hierarchical Organization of Behavior, 9783642398759:319–47, 2013. https://doi.org/10.1007/978-3-642-39875-9_14.Full Text
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Yin, H. H., and B. J. Knowlton. “Addiction and learning in the brain.” In Handbook of Implicit Cognition and Addiction, 167–84, 2005. https://doi.org/10.4135/9781412976237.n12.Full Text
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Conference Papers
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Yin, H. H., B. J. Knowlton, and B. W. Balleine. “From habits to actions: Dorsolateral striatum lesions alter the content of learning.” In Iconip 2002 Proceedings of the 9th International Conference on Neural Information Processing: Computational Intelligence for the E Age, 3:1579–81, 2002. https://doi.org/10.1109/ICONIP.2002.1202887.Full Text
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- Teaching & Mentoring
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Recent Courses
- NEUROSCI 211: Brain and Behavior: Translating Neuroscience 2023
- NEUROSCI 391: Neuroscience Independent Scholarship 1: Advanced Topics 2023
- NEUROSCI 478S: Motivation, Action, Choice: Neural and Behavioral Mechanisms 2023
- NEUROSCI 493: Research Independent Study 1 2023
- NEUROSCI 494: Research Independent Study 2 2023
- PSY 276: Brain and Behavior: Translating Neuroscience 2023
- PSY 478S: Motivation, Action, Choice: Neural and Behavioral Mechanisms 2023
- NEUROSCI 493: Research Independent Study 1 2022
- NEUROSCI 494: Research Independent Study 2 2022
- NEUROSCI 495: Research Independent Study 3 2022
- NEUROSCI 496: Research Independent Study 4 2022
- NEUROSCI 773S: Reward and the Brain 2022
- PSY 773S: Reward and the Brain 2022
- NEUROBIO 393: Research Independent Study 2021
- NEUROBIO 793: Research in Neurobiology 2021
- NEUROSCI 211: Brain and Behavior: Translating Neuroscience 2021
- NEUROSCI 478S: Motivation, Action, Choice: Neural and Behavioral Mechanisms 2021
- NEUROSCI 493: Research Independent Study 1 2021
- NEUROSCI 494: Research Independent Study 2 2021
- PSY 276: Brain and Behavior: Translating Neuroscience 2021
- PSY 478S: Motivation, Action, Choice: Neural and Behavioral Mechanisms 2021
- PSY 746S: Teaching Practicum 2021
- Scholarly, Clinical, & Service Activities
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Presentations & Appearances
- The role of opponent basal ganglia outputs in behavior. December 10, 2014 2014
- The role of dopamine in behavior. April 1, 2014 2014
- The role of opponent basal ganglia outputs in behavior. February 18, 2014 2014
- The role of dopamine in behavior. January 1, 2014 2014
- Habit formation and addiction. June 1, 2013 2013
- Beyond reward prediction errors: the role of dopamine in behavior. May 1, 2013 2013
- The role of dopamine in behavior. May 1, 2013 2013
- The role of dopamine in behavior. March 1, 2013 2013
- The integrative functions of the basal ganglia. November 18, 2012 2012
- Electrophysiological and optogenetic elucidation of dopamine function. November 9, 2012 2012
- Prefrontal and striatal mechanisms underlying working memory. October 19, 2012 2012
- The integrative function of the basal ganglia: from synapse to behavior. December 15, 2011 2011
- The integrative function of the basal ganglia. December 9, 2011 2011
- Control in operant conditioning. July 30, 2011 2011
- Goals and actions: the integrative function of the basal ganglia. November 9, 2010 2010
- Decision under risk in mice. July 8, 2010 2010
- The integrative function of the basal ganglia. May 17, 2010 2010
- Goals and actions: the integrative function of the striatum. October 18, 2009 2009
- The integrative function of the dorsal striatum. March 18, 2009 2009
- University of North Carolina at Chapel Hill. September 9, 2008 2008
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