Scholars@Duke
J. Matthew Brennan

J. Matthew Brennan

Associate Professor of Medicine
Medicine, Cardiology
j.matthew.brennan@duke.edu
1821 Hillandale Road, Suite 25C, Durham, NC 27705

Selected Publications

Association Between Patient Survival and Clinician Variability in Treatment Rates for Aortic Valve Stenosis.

Journal Article J Am Heart Assoc · August 17, 2021 Background Patients with symptomatic severe aortic stenosis (ssAS) have a high mortality risk and compromised quality of life. Surgical/transcatheter aortic valve replacement (AVR) is a Class I recommendation, but it is unclear if this recommendation is un ... Full text Link to item Cite

Sex disparities in patients with symptomatic severe aortic stenosis.

Journal Article Am Heart J · July 2021 BACKGROUND: We evaluated whether there is equitable distribution across sexes of treatment and outcomes for aortic valve replacement (AVR), via surgical (SAVR) or transcatheter (TAVR) methods, in symptomatic severe aortic stenosis (ssAS) patients. METHODS: ... Full text Link to item Cite

Ablation of atrial fibrillation during coronary artery bypass grafting: Late outcomes in a Medicare population.

Conference J Thorac Cardiovasc Surg · April 2021 BACKGROUND: This study compares outcomes of patients with preoperative atrial fibrillation undergoing coronary artery bypass grafting (CABG) with or without concomitant atrial fibrillation ablation in a nationally representative Medicare cohort. OBJECTIVES ... Full text Link to item Cite

Reply: Redo SAVR After Primary TAVR, A Dangerous Sequence?

Journal Article JACC Cardiovasc Interv · September 28, 2020 Full text Link to item Cite

Racial Differences in the Use of Aortic Valve Replacement for Treatment of Symptomatic Severe Aortic Valve Stenosis in the Transcatheter Aortic Valve Replacement Era.

Journal Article J Am Heart Assoc · August 18, 2020 Background Aortic valve replacement (AVR) is a life-saving treatment for patients with symptomatic severe aortic valve stenosis. We sought to determine whether transcatheter AVR has resulted in a more equitable treatment rate by race in the United States. ... Full text Link to item Cite

Reoperation After Transcatheter Aortic Valve Replacement: An Analysis of the Society of Thoracic Surgeons Database.

Journal Article JACC Cardiovasc Interv · July 13, 2020 OBJECTIVES: This study sought to report the largest series of patients receiving a surgical reoperation after transcatheter aortic valve replacement (TAVR) using the Society of Thoracic Surgeons (STS) Adult Cardiac Surgery Database. BACKGROUND: TAVR has be ... Full text Link to item Cite

Association of postoperative complications and outcomes following coronary artery bypass grafting.

Journal Article Am Heart J · April 2020 BACKGROUND: The long-term effects of postoperative complications following coronary artery bypass grafting (CABG) are unknown. METHODS: Medicare-linked records from the Society of Thoracic Surgeons Adult Cardiac Surgery Database were queried for isolated C ... Full text Link to item Cite

Claims-based cardiovascular outcome identification for clinical research: Results from 7 large randomized cardiovascular clinical trials.

Journal Article Am Heart J · December 2019 BACKGROUND: Medicare insurance claims may provide an efficient means to ascertain follow-up of older participants in clinical research. We sought to determine the accuracy and completeness of claims- versus site-based follow-up with clinical event committe ... Full text Link to item Cite

Clinical Practice Patterns in Temporary Mechanical Circulatory Support for Shock in the Critical Care Cardiology Trials Network (CCCTN) Registry.

Journal Article Circ Heart Fail · November 2019 BACKGROUND: Temporary mechanical circulatory support (MCS) devices provide hemodynamic assistance for shock refractory to pharmacological treatment. Most registries have focused on single devices or specific etiologies of shock, limiting data regarding ove ... Full text Link to item Cite

Robotic Mitral Valve Repair in Older Individuals: An Analysis of The Society of Thoracic Surgeons Database.

Journal Article Ann Thorac Surg · November 2018 BACKGROUND: National outcomes of robotic mitral valve repair (rMVr) compared with sternotomy (sMVr) in older patients are currently unknown. METHODS: From 2011 to 2014, all patients aged 65 years and older undergoing MVr in The Society of Thoracic Surgeons ... Full text Open Access Link to item Cite

Outcomes after coronary artery bypass grafting in patients with myocardial infarction, cardiogenic shock and unresponsive neurological state: analysis of the Society of Thoracic Surgeons Database.

Conference Eur J Cardiothorac Surg · October 1, 2018 OBJECTIVES: Previous studies have demonstrated a 20% mortality rate among patients undergoing isolated coronary artery bypass grafting (CABG) for cardiogenic shock. However, outcomes following CABG for cardiogenic shock in patients who are neurologically u ... Full text Link to item Cite

Predicting Quality of Life at 1 Year After Transcatheter Aortic Valve Replacement in a Real-World Population.

Journal Article Circ Cardiovasc Qual Outcomes · October 2018 Background Among clinical trial patients at high surgical risk, a model has been developed and externally validated to estimate patient risk for poor outcomes after transcatheter aortic valve replacement (TAVR). How this model performs in lower risk and un ... Full text Link to item Cite

The Incidence and Consequence of Prosthesis-Patient Mismatch After Surgical Aortic Valve Replacement.

Journal Article Ann Thorac Surg · July 2018 BACKGROUND: The goal of this study was to determine the relationship of prosthesis-patient mismatch (PPM) with long-term survival and to assess whether growing concern about PPM has resulted in a decreased incidence over time. METHODS: Using The Society of ... Full text Link to item Cite

Burden of preoperative atrial fibrillation in patients undergoing coronary artery bypass grafting.

Journal Article J Thorac Cardiovasc Surg · June 2018 BACKGROUND: This study compares early and late outcomes in patients undergoing coronary artery bypass grafting with and without preoperative atrial fibrillation in a contemporary, nationally representative Medicare cohort. METHODS: In the Medicare-Linked S ... Full text Link to item Cite

Associations Between Surgical Ablation and Operative Mortality After Mitral Valve Procedures.

Journal Article Ann Thorac Surg · June 2018 BACKGROUND: Surgical ablation (SA) for atrial fibrillation (AF) concomitant to mitral valve repair/replacement (MVRR) improves longitudinal sinus rhythm. However, the risk of adding SA remains a clinical question. This study examined whether the addition o ... Full text Link to item Cite

Inclusion of Functional Status Measures in the Risk Adjustment of 30-Day Mortality After Transcatheter Aortic Valve Replacement: A Report From the Society of Thoracic Surgeons/American College of Cardiology TVT Registry.

Journal Article JACC Cardiovasc Interv · March 26, 2018 OBJECTIVES: The aim of this study was to develop and validate a risk adjustment model for 30-day mortality after transcatheter aortic valve replacement (TAVR) that accounted for both standard clinical factors and pre-procedural health status and frailty. B ... Full text Link to item Cite

Association Between Left Atrial Appendage Occlusion and Readmission for Thromboembolism Among Patients With Atrial Fibrillation Undergoing Concomitant Cardiac Surgery.

Journal Article JAMA · January 23, 2018 IMPORTANCE: The left atrial appendage is a key site of thrombus formation in atrial fibrillation (AF) and can be occluded or removed at the time of cardiac surgery. There is limited evidence regarding the effectiveness of surgical left atrial appendage occ ... Full text Link to item Cite

Contemporary management and outcomes of acute type A aortic dissection: An analysis of the STS adult cardiac surgery database.

Journal Article J Card Surg · January 2018 PURPOSE: Management of acute type A aortic dissection (AAAD) is challenging and operative strategies are varied. We used the STS Adult Cardiac Surgery Database (STS ACSD) to describe contemporary surgical strategies and outcomes for AAAD. METHODS: Between ... Full text Link to item Cite

Predicting risk of cardiac events among ST-segment elevation myocardial infarction patients with conservatively managed non-infarct-related artery coronary artery disease: An analysis of the Duke Databank for Cardiovascular Disease.

Journal Article Am Heart J · December 2017 BACKGROUND: Recent randomized evidence has demonstrated benefit with complete revascularization during the index hospitalization for multivessel coronary artery disease ST-segment elevation myocardial infarction (STEMI) patients; however, this benefit like ... Full text Link to item Cite

Conversion From Off-Pump Coronary Artery Bypass Grafting to On-Pump Coronary Artery Bypass Grafting.

Journal Article Ann Thorac Surg · October 2017 BACKGROUND: Off-pump coronary artery bypass grafting (OPCAB) has been shown to be an effective strategy for surgical revascularization. The purpose of this study was to define the incidence of intraoperative conversion from OPCAB to on-pump coronary artery ... Full text Link to item Cite

Hypothermia and cerebral protection strategies in aortic arch surgery: a comparative effectiveness analysis from the STS Adult Cardiac Surgery Database.

Journal Article Eur J Cardiothorac Surg · September 1, 2017 OBJECTIVES: Hypothermic circulatory arrest is essential to aortic arch surgery, although consensus regarding optimal cerebral protection strategy remains lacking. We evaluated the current use and comparative effectiveness of hypothermia/cerebral perfusion ... Full text Link to item Cite

Transcatheter Versus Surgical Aortic Valve Replacement: Propensity-Matched Comparison.

Journal Article J Am Coll Cardiol · July 25, 2017 BACKGROUND: Randomized trials support the use of transcatheter aortic valve replacement (TAVR) for the treatment of aortic stenosis in high- and intermediate-risk patients, but the generalizability of those results in clinical practice has been challenged. ... Full text Link to item Cite

Complete versus culprit-only revascularisation in ST elevation myocardial infarction with multi-vessel disease.

Journal Article Cochrane Database Syst Rev · May 3, 2017 BACKGROUND: Multi-vessel coronary disease in people with ST elevation myocardial infarction (STEMI) is common and is associated with worse prognosis after STEMI. Based on limited evidence, international guidelines recommend intervention on only the culprit ... Full text Link to item Cite

The Society of Thoracic Surgeons National Database 2016 Annual Report.

Journal Article Ann Thorac Surg · December 2016 The art and science of outcomes analysis, quality improvement, and patient safety continue to evolve, and cardiothoracic surgery leads many of these advances. The Society of Thoracic Surgeons (STS) National Database is one of the principal reasons for this ... Full text Link to item Cite

Variation in Warfarin Use at Hospital Discharge After Isolated Bioprosthetic Mitral Valve Replacement: An Analysis of the Society of Thoracic Surgeons Adult Cardiac Surgery Database.

Journal Article Chest · September 2016 BACKGROUND: Anticoagulation with warfarin following bioprosthetic mitral valve replacement (BMVR) is recommended by multiple practice guidelines. We assessed practice variability and patient characteristics associated with warfarin prescription following B ... Full text Link to item Cite

Variation in Hospital Risk-Adjusted Mortality Rates Following Transcatheter Aortic Valve Replacement in the United States: A Report From the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry.

Journal Article Circ Cardiovasc Qual Outcomes · September 2016 BACKGROUND: The use of transcatheter aortic valve replacement (TAVR) to treat aortic stenosis in the United States is growing, yet little is known about the variation in procedural outcomes in community practice. We developed a TAVR in-hospital mortality r ... Full text Link to item Cite

Gait Speed and Operative Mortality in Older Adults Following Cardiac Surgery.

Journal Article JAMA Cardiol · June 1, 2016 IMPORTANCE: Prediction of operative risk is a critical step in decision making for cardiac surgery. Existing risk models may be improved by integrating a measure of frailty, such as 5-m gait speed, to better capture the heterogeneity of the older adult pop ... Full text Link to item Cite

Gait Speed Predicts 30-Day Mortality After Transcatheter Aortic Valve Replacement: Results From the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry.

Journal Article Circulation · April 5, 2016 BACKGROUND: Surgical risk scores do not include frailty assessments (eg, gait speed), which are of particular importance for patients with severe aortic stenosis considering transcatheter aortic valve replacement. METHODS AND RESULTS: We assessed the assoc ... Full text Link to item Cite

Development and Validation of a Risk Prediction Model for In-Hospital Mortality After Transcatheter Aortic Valve Replacement.

Journal Article JAMA Cardiol · April 1, 2016 IMPORTANCE: Patient selection for transcatheter aortic valve replacement (TAVR) should include assessment of the risks of TAVR compared with surgical aortic valve replacement (SAVR). Existing SAVR risk models accurately predict the risks for the population ... Full text Link to item Cite

Search for new phenomena in dijet mass and angular distributions from pp collisions at √s=13 TeV with the ATLAS detector

Journal Article Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics · March 10, 2016 This Letter describes a model-agnostic search for pairs of jets (dijets) produced by resonant and non-resonant phenomena beyond the Standard Model in 3.6 fb−1 of proton–proton collisions with a centre-of-mass energy of s=13 TeV recorded by the ATLAS detect ... Full text Cite

Clinical Characteristics and Outcomes of Patients With Myocardial Infarction and Cardiogenic Shock Undergoing Coronary Artery Bypass Surgery: Data From The Society of Thoracic Surgeons National Database.

Journal Article Ann Thorac Surg · February 2016 BACKGROUND: Acute myocardial infarction complicated by cardiogenic shock (AMI-CS) is associated with substantial mortality. We evaluated outcomes of patients in The Society of Thoracic Surgeons Adult Cardiac Surgery Database who underwent coronary artery b ... Full text Link to item Cite

Invited Commentary.

Journal Article Ann Thorac Surg · February 2016 Full text Link to item Cite

Safety and clinical effectiveness of drug-eluting stents for saphenous vein graft intervention in older individuals: Results from the medicare-linked National Cardiovascular Data Registry(®) CathPCI Registry(®) (2005-2009).

Journal Article Catheter Cardiovasc Interv · January 1, 2016 OBJECTIVES: To evaluate the safety of drug-eluting stents (DES) when treating patients with failing saphenous vein grafts (SVG). BACKGROUND: DES reduce target vessel revascularization in patients with failing SVGs; however, compared with bare metal stents ... Full text Link to item Cite

Penetration, Completeness, and Representativeness of The Society of Thoracic Surgeons Adult Cardiac Surgery Database.

Journal Article Ann Thorac Surg · January 2016 BACKGROUND: The Society of Thoracic Surgeons (STS) Adult Cardiac Surgery Database (ACSD) has been successfully linked to the Centers for Medicare and Medicaid (CMS) Medicare database, thereby facilitating comparative effectiveness research and providing in ... Full text Link to item Cite

Data quality assessment and anomaly detection via map/reduce and linked data: A case study in the medical domain

Conference Proceedings - 2015 IEEE International Conference on Big Data, IEEE Big Data 2015 · December 22, 2015 Recent technological advances in modern healthcare have lead to the ability to collect a vast wealth of patient monitoring data. This data can be utilised for patient diagnosis but it also holds the potential for use within medical research. However, these ... Full text Cite

Early invasive versus conservative strategy for non-infarct related artery lesions in ST elevation myocardial infarction with multi-vessel disease

Journal Article Cochrane Database of Systematic Reviews · December 17, 2015 This is the protocol for a review and there is no abstract. The objectives are as follows: To assess the effects of early invasive compared to conservative (medical management) strategy for treating non-infarct related artery lesions in ST elevation myocar ... Full text Cite

Evaluation of The Society of Thoracic Surgeons Online Risk Calculator for Assessment of Risk in Patients Presenting for Aortic Valve Replacement After Prior Coronary Artery Bypass Graft: An Analysis Using the STS Adult Cardiac Surgery Database.

Journal Article Ann Thorac Surg · December 2015 BACKGROUND: Accurate risk assessment in patients presenting for aortic valve replacement (AVR) after prior coronary artery bypass grafting (CABG) is essential for appropriate selection of surgical versus percutaneous therapy. METHODS: We included 6,534 pat ... Full text Link to item Cite

Outcomes of Patients With Severe Chronic Lung Disease Who Are Undergoing Transcatheter Aortic Valve Replacement.

Journal Article Ann Thorac Surg · December 2015 BACKGROUND: In this study, we sought to determine the clinical outcomes after transcatheter aortic valve replacement (TAVR) among patients with chronic lung disease (CLD) and to evaluate the safety of transaortic versus transapical alternate access approac ... Full text Link to item Cite

Introduction to the STS National Database Series: Outcomes Analysis, Quality Improvement, and Patient Safety.

Journal Article Ann Thorac Surg · December 2015 The Society of Thoracic Surgeons (STS) National Database is the foundation for most of the Society's quality, research, and patient safety activities. Beginning in January 2016 and repeating each year, The Annals of Thoracic Surgery will publish a monthly ... Full text Link to item Cite

Detecting insider threats using ben-ware: Beneficial intelligent software for identifying anomalous human behaviour

Journal Article Journal of Wireless Mobile Networks, Ubiquitous Computing, and Dependable Applications · December 1, 2015 The insider threat problem is a significant and ever present issue faced by any organisation. While security mechanisms can be put in place to reduce the chances of external agents gaining access to a system, either to steal assets or alter records, the is ... Cite

Transapical and Transaortic Transcatheter Aortic Valve Replacement in the United States.

Journal Article Ann Thorac Surg · November 2015 BACKGROUND: When transcatheter aortic valve replacement (TAVR) cannot be carried out through transfemoral access, alternative access TAVR is indicated. The purpose of this study was to explore inhospital and 1-year outcomes of patients undergoing alternati ... Full text Link to item Cite

Contemporary Outcomes of Repeat Aortic Valve Replacement: A Benchmark for Transcatheter Valve-in-Valve Procedures.

Journal Article Ann Thorac Surg · October 2015 BACKGROUND: Reoperative aortic valve replacement (re-AVR) after previous AVR is a complex procedure involving redo sternotomy and removal of a previous prosthesis. With increasing use of valve-in-valve transcatheter aortic valve replacement for failed aort ... Full text Link to item Cite

Clinical outcomes at 1 year following transcatheter aortic valve replacement.

Journal Article JAMA · March 10, 2015 IMPORTANCE: Introducing new medical devices into routine practice raises concerns because patients and outcomes may differ from those in randomized trials. OBJECTIVE: To update the previous report of 30-day outcomes and present 1-year outcomes following tr ... Full text Link to item Cite

The impact of high-risk cases on hospitals' risk-adjusted coronary artery bypass grafting mortality rankings.

Journal Article Ann Thorac Surg · March 2015 BACKGROUND: Risk-adjusted mortality (RAM) models are increasingly used to evaluate hospital performance, but the validity of the RAM method has been questioned. Providers are concerned that these methods might not adequately account for the highest levels ... Full text Link to item Cite

Three-year outcomes associated with embolic protection in saphenous vein graft intervention: results in 49 325 senior patients in the Medicare-linked National Cardiovascular Data Registry CathPCI Registry.

Journal Article Circ Cardiovasc Interv · March 2015 BACKGROUND: Information is limited on contemporary use and outcomes of embolic protection devices (EPDs) in saphenous vein graft interventions. METHODS AND RESULTS: We formed a longitudinal cohort (2005-2009; n=49 325) by linking National Cardiovascular Da ... Full text Link to item Cite

The impact of extreme-risk cases on hospitals' risk-adjusted percutaneous coronary intervention mortality ratings.

Journal Article JACC Cardiovasc Interv · January 2015 OBJECTIVES: The goal of this study was to examine the calibration of a validated risk-adjustment model in very high-risk percutaneous coronary intervention (PCI) cases and assess whether sites' case mix affects their performance ratings. BACKGROUND: There ... Full text Link to item Cite

Long-Term Clinical Outcomes of Silzone Era St. Jude Medical Mechanical Heart Valves.

Journal Article J Heart Valve Dis · January 2015 BACKGROUND AND AIM OF THE STUDY: Since the voluntary recall of St. Jude Medical (SJM) Silzone impregnated heart valves, no large-scale study has examined their long-term outcomes. METHODS: Using Medicare-linked records from the Society of Thoracic Surgeons ... Link to item Cite

The association of chronic lung disease with early mortality and respiratory adverse events after aortic valve replacement.

Journal Article Ann Thorac Surg · December 2014 BACKGROUND: We studied the association between components of chronic lung disease (CLD) assessment and operative outcomes in patients undergoing aortic valve replacement (AVR) for aortic stenosis. METHODS: From 2011 to 2012, 9,177 patients included in The ... Full text Link to item Cite

The association of transcatheter aortic valve replacement availability and hospital aortic valve replacement volume and mortality in the United States.

Journal Article Ann Thorac Surg · December 2014 BACKGROUND: Whether the introduction of transcatheter aortic valve replacement (TAVR) has affected hospitals' surgical aortic valve replacement (SAVR) and overall aortic valve replacement (AVR) case volumes and outcomes in the United States is unknown. MET ... Full text Link to item Cite

Practice patterns and clinical outcomes after hybrid coronary revascularization in the United States: an analysis from the society of thoracic surgeons adult cardiac database.

Journal Article Circulation · September 9, 2014 BACKGROUND: Hybrid coronary revascularization (HCR) involves a combination of surgical and percutaneous techniques, which in selected patients may present an alternative to conventional coronary artery bypass grafting (CABG). METHODS AND RESULTS: Patients ... Full text Link to item Cite

Examination of the treatment selection process in a multicenter observational study.

Journal Article Circ Cardiovasc Qual Outcomes · September 2014 BACKGROUND: Many multicenter clinical trials use permuted-block randomization to create balanced treatment allocations within clinical centers. Unlike randomized trials, observational studies do not control treatment allocation, and statistical models are ... Full text Link to item Cite

Outcomes and prosthesis choice for active aortic valve infective endocarditis: analysis of the Society of Thoracic Surgeons Adult Cardiac Surgery Database.

Journal Article Ann Thorac Surg · September 2014 BACKGROUND: National prosthesis use in active aortic valve infective endocarditis (IE) is unreported. Prosthesis usage and outcomes in patients undergoing an aortic valve operation with active IE was evaluated. METHODS: The Society of Thoracic Surgeons Adu ... Full text Link to item Cite

Endoscopic harvesting device type and outcomes in patients undergoing coronary artery bypass surgery.

Journal Article Ann Surg · August 2014 OBJECTIVE: To evaluate angiographic and clinical outcomes associated with open and closed dissection tunnel endoscopic vein harvesting (EVH) devices. BACKGROUND: A previous PREVENT-IV (PRoject of Ex-vivo Vein graft ENgineering via Transfection IV) analysis ... Full text Link to item Cite

Mitral procedure selection in patients on dialysis: does mitral repair influence outcomes?

Journal Article J Thorac Cardiovasc Surg · July 2014 OBJECTIVE: To examine the likelihood of mitral valve repair among dialysis patients and the influence of mitral procedure selection on surgical outcomes in this cohort. METHODS: Among patients undergoing isolated primary mitral valve surgery in the Society ... Full text Link to item Cite

Concomitant tricuspid valve surgery during implantation of continuous-flow left ventricular assist devices: a Society of Thoracic Surgeons database analysis.

Journal Article J Heart Lung Transplant · June 2014 BACKGROUND: Performing concomitant tricuspid valve procedures (TVPs) in left ventricular assist device (LVAD) patients with significant pre-operative tricuspid regurgitation (TR) is controversial, and no studies have been large enough to definitively guide ... Full text Link to item Cite

The STS AVR+CABG composite score: a report of the STS Quality Measurement Task Force.

Journal Article Ann Thorac Surg · May 2014 BACKGROUND: The Society of Thoracic Surgeons (STS) is developing a portfolio of composite performance measures for the most commonly performed adult cardiac procedures. This manuscript describes the third composite measure in this series, aortic valve repl ... Full text Link to item Cite

The expanding role of mitral valve repair in triple valve operations: contemporary North American outcomes in 8,021 patients.

Journal Article Ann Thorac Surg · May 2014 BACKGROUND: Although the operative risk of multivalve operations has historically been high, current outcomes are poorly understood. We sought to evaluate factors influencing contemporary results of triple-valve operations using The Society of Thoracic Sur ... Full text Link to item Cite

Insurance status is associated with acuity of presentation and outcomes for thoracic aortic operations.

Journal Article Circ Cardiovasc Qual Outcomes · May 2014 BACKGROUND: Nonelective procedure status is the greatest risk factor for postoperative morbidity and mortality in patients undergoing thoracic aortic operations. We hypothesized that uninsured patients were more likely to require nonelective thoracic aorti ... Full text Link to item Cite

Comparative effectiveness of drug-eluting stents on long-term outcomes in elderly patients treated for in-stent restenosis: a report from the National Cardiovascular Data Registry.

Journal Article Catheter Cardiovasc Interv · February 2014 OBJECTIVE: We assessed the long-term outcomes of elderly patients who had in-stent restenosis (ISR) treated with drug-eluting stents (DES) compared with other treatment strategies. BACKGROUND: Elderly patients with ISR represent a vulnerable group of which ... Full text Link to item Cite

Status quo of hybrid coronary revascularization for multi-vessel coronary artery disease.

Journal Article Ann Thorac Surg · December 2013 Hybrid coronary revascularization (HCR) combines bypass grafting of the left anterior descending (LAD) coronary artery with percutaneous coronary intervention (PCI) of non-LAD vessels. HCR has been performed as an alternative to CABG or multi-vessel PCI in ... Full text Link to item Cite

Outcomes following transcatheter aortic valve replacement in the United States.

Journal Article JAMA · November 20, 2013 IMPORTANCE: Transcatheter aortic valve replacement (TAVR) was approved by the US Food and Drug Administration for the treatment of severe, symptomatic aortic stenosis and inoperable status (in 2011) and high-risk but operable status (starting in 2012). A n ... Full text Link to item Cite

Isolated mitral valve surgery risk in 77,836 patients from the Society of Thoracic Surgeons database.

Journal Article Ann Thorac Surg · November 2013 BACKGROUND: Understanding the operative outcomes of mitral valve (MV) surgery across the spectrum of predicted risk of mortality (PROM) is necessary to determine the best use of novel percutaneous approaches. METHODS: The Society of Thoracic Surgeons Adult ... Full text Link to item Cite

The society of thoracic surgeons national database.

Journal Article Heart · October 2013 AIMS: The Society of Thoracic Surgeons (STS) National Database collects detailed clinical information on patients undergoing adult cardiac, paediatric and congenital cardiac, and general thoracic surgical operations. These data are used to support risk-adj ... Full text Link to item Cite

Enhanced mortality risk prediction with a focus on high-risk percutaneous coronary intervention: results from 1,208,137 procedures in the NCDR (National Cardiovascular Data Registry).

Journal Article JACC Cardiovasc Interv · August 2013 OBJECTIVES: This study sought to update and validate a contemporary model for inpatient mortality following percutaneous coronary intervention (PCI), including variables indicating high clinical risk. BACKGROUND: Recently, new variables were added to the C ... Full text Link to item Cite

Variation in warfarin thromboprophylaxis after mitral valve repair: does equipoise exist and is a randomized trial warranted?

Journal Article Ann Thorac Surg · June 2013 BACKGROUND: There are limited data available to inform decision making regarding warfarin thromboprophylaxis early after mitral valve repair. METHODS: We studied 13,082 patients from The Society of Thoracic Surgeons Adult Cardiac Surgery Database (STS ACSD ... Full text Link to item Cite

Long-term safety and effectiveness of mechanical versus biologic aortic valve prostheses in older patients: results from the Society of Thoracic Surgeons Adult Cardiac Surgery National Database.

Journal Article Circulation · April 23, 2013 BACKGROUND: There is a paucity of long-term data comparing biological versus mechanical aortic valve prostheses in older individuals. METHODS AND RESULTS: We performed follow-up of patients aged 65 to 80 years undergoing aortic valve replacement with a bio ... Full text Link to item Cite

Effect of race and ethnicity on outcomes with drug-eluting and bare metal stents: results in 423 965 patients in the linked National Cardiovascular Data Registry and centers for Medicare & Medicaid services payer databases.

Journal Article Circulation · April 2, 2013 BACKGROUND: Black, Hispanic, and Asian patients have been underrepresented in percutaneous coronary intervention clinical trials; therefore, there are limited data available on outcomes for these race/ethnicity groups. METHODS AND RESULTS: We examined outc ... Full text Link to item Cite

Long-term outcomes of older diabetic patients after percutaneous coronary stenting in the United States: a report from the National Cardiovascular Data Registry, 2004 to 2008.

Journal Article J Am Coll Cardiol · December 4, 2012 OBJECTIVES: The purpose of this study was to characterize long-term outcomes of percutaneous coronary intervention (PCI) in elderly diabetic patients in routine practice. BACKGROUND: Although drug-eluting stent (DES) implantation in diabetic patients is co ... Full text Link to item Cite

Longitudinal outcome of isolated mitral repair in older patients: results from 14,604 procedures performed from 1991 to 2007.

Journal Article Ann Thorac Surg · December 2012 BACKGROUND: Mitral valve (MV) repair is performed with less frequency than MV replacement in older persons, with referral often delayed until symptoms are severe. Surgical practice in this population remains inconsistent in the absence of national MV repai ... Full text Link to item Cite

Long-term outcomes after transmyocardial revascularization.

Journal Article Ann Thorac Surg · November 2012 BACKGROUND: Two independent reports documented substantially higher operative mortality associated with transmyocardial revascularization (TMR) when used in isolation than that reported in the premarket clinical trials. To clarify the state of the art, thi ... Full text Link to item Cite

Evaluating the impact of public health notification: Duke clopidogrel experience.

Journal Article Circ Cardiovasc Qual Outcomes · November 2012 BACKGROUND: Provider and public health interventions in the late 2006 sought to change the duration of clopidogrel use after drug-eluting stent (DES) implantation. We evaluated whether public health interventions were associated with changes in patient-rep ... Full text Link to item Cite

Short- and long-term outcomes of coronary stenting in women versus men: results from the National Cardiovascular Data Registry Centers for Medicare & Medicaid services cohort.

Journal Article Circulation · October 30, 2012 BACKGROUND: Conflicting evidence exists on sex-based outcomes after coronary stenting. METHODS AND RESULTS: Data on 426 996 patients ≥65 years old (42.3% women) from the National Cardiovascular Data Registry CathPCI Registry (2004-2008) were linked to Medi ... Full text Link to item Cite

Comparative effectiveness of drug-eluting versus bare-metal stents in elderly patients undergoing revascularization of chronic total coronary occlusions: results from the National Cardiovascular Data Registry, 2005-2008.

Journal Article JACC Cardiovasc Interv · October 2012 OBJECTIVES: This study sought to investigate the long-term effectiveness of drug-eluting stents (DES) versus bare-metal stents (BMS). BACKGROUND: Improved recanalization techniques have increased interest in percutaneous coronary intervention (PCI) for chr ... Full text Link to item Cite

Long-term survival after aortic valve replacement among high-risk elderly patients in the United States: insights from the Society of Thoracic Surgeons Adult Cardiac Surgery Database, 1991 to 2007.

Journal Article Circulation · September 25, 2012 BACKGROUND: Surgical aortic valve replacement (AVR) remains the standard of care for the treatment of operable, symptomatic aortic valve disease; however, to date, there are limited national data on the contemporary long-term outcomes after AVR in older in ... Full text Link to item Cite

Early anticoagulation of bioprosthetic aortic valves in older patients: results from the Society of Thoracic Surgeons Adult Cardiac Surgery National Database.

Journal Article J Am Coll Cardiol · September 11, 2012 OBJECTIVES: The aim of this study was to evaluate the risks and benefits of short-term anticoagulation in patients receiving aortic valve bioprostheses. BACKGROUND: Patients receiving aortic valve bioprostheses have an elevated early risk of thromboembolic ... Full text Link to item Cite

Association between endoscopic vs open vein-graft harvesting and mortality, wound complications, and cardiovascular events in patients undergoing CABG surgery.

Journal Article JAMA · August 1, 2012 CONTEXT: The safety and durability of endoscopic vein graft harvest in coronary artery bypass graft (CABG) surgery has recently been called into question. OBJECTIVE: To compare the long-term outcomes of endoscopic vs open vein-graft harvesting for Medicare ... Full text Link to item Cite

Off-pump versus on-pump coronary artery bypass grafting outcomes stratified by preoperative renal function.

Journal Article J Am Soc Nephrol · August 2012 Clinical trials of off-pump coronary artery bypass grafting (CABG) have largely excluded patients with CKD. Here, we sought to determine whether pump status affects outcomes in patients with CKD. Using a nonrandomized cohort of 742,909 non-emergent, isolat ... Full text Link to item Cite

Characteristics and long-term outcomes of percutaneous revascularization of unprotected left main coronary artery stenosis in the United States: a report from the National Cardiovascular Data Registry, 2004 to 2008.

Journal Article J Am Coll Cardiol · February 14, 2012 OBJECTIVES: This study sought to assess percutaneous coronary intervention (PCI) for unprotected left main coronary artery (ULMCA) stenosis in routine U.S. clinical practice. BACKGROUND: Percutaneous coronary intervention for ULMCA stenosis is controversia ... Full text Link to item Cite

Percutaneous coronary intervention and drug-eluting stent use among patients ≥85 years of age in the United States.

Journal Article J Am Coll Cardiol · January 10, 2012 OBJECTIVES: This study assessed the comparative effectiveness of drug-eluting stents (DES) versus bare-metal stents (BMS) among patients ≥85 years of age. BACKGROUND: Despite an aging population, little is known about the comparative effectiveness of DES v ... Full text Link to item Cite

Patterns of anticoagulation following bioprosthetic valve implantation: observations from ANSWER.

Journal Article J Heart Valve Dis · January 2012 BACKGROUND AND AIM OF THE STUDY: The American College of Cardiology/American Heart Association (ACC/AHA) guidelines recommend a three-month administration of warfarin following bioprosthetic valve replacement (BVR). However, strong evidence supporting this ... Link to item Cite

Linking the National Cardiovascular Data Registry CathPCI Registry with Medicare claims data: validation of a longitudinal cohort of elderly patients undergoing cardiac catheterization.

Journal Article Circ Cardiovasc Qual Outcomes · January 2012 BACKGROUND: The National Cardiovascular Data Registry CathPCI Registry was recently linked with longitudinal Centers for Medicare & Medicaid (CMS) claims data. The degree to which this linked cohort is representative of the overall CathPCI Registry and CMS ... Full text Link to item Cite

Safety and efficacy of drug-eluting stents in older patients with chronic kidney disease: a report from the linked CathPCI Registry-CMS claims database.

Journal Article J Am Coll Cardiol · October 25, 2011 OBJECTIVES: The purpose of this study was to determine the safety and efficacy of drug-eluting stents (DES) compared with bare-metal stents (BMS) in older patients with chronic kidney disease (CKD). BACKGROUND: DES may be associated with late death and myo ... Full text Link to item Cite

Outcomes for endocarditis surgery in North America: a simplified risk scoring system.

Journal Article J Thorac Cardiovasc Surg · January 2011 OBJECTIVE: Operation for infective endocarditis is associated with the highest mortality of any valve disease, with overall rates of in-hospital mortality exceeding 20%. The Society of Thoracic Surgeons Adult Cardiac Surgery Database was examined to develo ... Full text Link to item Cite

Predictors of mitral valve repair: clinical and surgeon factors.

Journal Article Ann Thorac Surg · December 2010 BACKGROUND: Mitral valve repair is acknowledged as desirable and superior to replacement for virtually all mitral pathology. Utilizing The Society of Thoracic Surgeons (STS) Adult Cardiac Surgery Database (ACSD), a multivariable model was created that incl ... Full text Link to item Cite

Successful linking of the Society of Thoracic Surgeons adult cardiac surgery database to Centers for Medicare and Medicaid Services Medicare data.

Journal Article Ann Thorac Surg · October 2010 BACKGROUND: The Centers for Medicare and Medicaid Services (CMS) Medicare database complements The Society of Thoracic Surgeons (STS) database by providing information about long-term outcomes and cost. This study demonstrates the feasibility of linking ST ... Full text Link to item Cite

Contemporary mortality risk prediction for percutaneous coronary intervention: results from 588,398 procedures in the National Cardiovascular Data Registry.

Journal Article J Am Coll Cardiol · May 4, 2010 OBJECTIVES: We sought to create contemporary models for predicting mortality risk following percutaneous coronary intervention (PCI). BACKGROUND: There is a need to identify PCI risk factors and accurately quantify procedural risks to facilitate comparativ ... Full text Link to item Cite

Low diagnostic yield of elective coronary angiography.

Journal Article N Engl J Med · March 11, 2010 BACKGROUND: Guidelines for triaging patients for cardiac catheterization recommend a risk assessment and noninvasive testing. We determined patterns of noninvasive testing and the diagnostic yield of catheterization among patients with suspected coronary a ... Full text Link to item Cite

Use of hand carried ultrasound, B-type natriuretic peptide, and clinical assessment in identifying abnormal left ventricular filling pressures in patients referred for right heart catheterization.

Journal Article J Card Fail · January 2010 BACKGROUND: The estimation of left ventricular filling pressure (LVFP) remains a critical component in the management of patients with known or suspected acute heart failure syndromes. Although right heart catheterization (RHC) remains the gold standard, s ... Full text Link to item Cite

Clinical effectiveness of coronary stents in elderly persons: results from 262,700 Medicare patients in the American College of Cardiology-National Cardiovascular Data Registry.

Journal Article J Am Coll Cardiol · May 5, 2009 OBJECTIVES: The aim of this study was to compare outcomes in older individuals receiving drug-eluting stents (DES) and bare-metal stents (BMS). BACKGROUND: Comparative effectiveness of DES relative to BMS remains unclear. METHODS: Outcomes were evaluated i ... Full text Link to item Cite

Usefulness of hand-carried ultrasound to predict elevated left ventricular filling pressure.

Journal Article Am J Cardiol · January 15, 2009 Detection of increased left ventricular filling pressure (LVFP) is paramount in the evaluation and treatment of patients with left heart failure, yet difficult to assess directly at the bedside. Although inferior vena cava (IVC) examination can detect incr ... Full text Link to item Cite

Comparison of hand-carried ultrasound assessment of the inferior vena cava and N-terminal pro-brain natriuretic peptide for predicting readmission after hospitalization for acute decompensated heart failure.

Journal Article JACC Cardiovasc Imaging · September 2008 OBJECTIVES: We sought to compare the value of serial assessment with hand-carried ultrasound (HCU) of the inferior vena cava (IVC) with brain natriuretic peptide (BNP) to identify patients with acute decompensated heart failure (ADHF) who will be readmitte ... Full text Link to item Cite

Early intervention: which patients and how early?

Journal Article Curr Cardiol Rep · July 2008 Despite advances in preventive therapy, acute coronary syndromes (ACS) remain a significant cause of morbidity and mortality. Patient risk varies widely along a spectrum from unstable angina to ST-segment elevation myocardial infarctions (STEMIs) and can b ... Full text Link to item Cite

Reappraisal of the use of inferior vena cava for estimating right atrial pressure.

Journal Article J Am Soc Echocardiogr · July 2007 Estimation of right atrial pressure (RAP) using echocardiographic measurement of the inferior vena caval (IVC) size along with its respirophasic variation is commonly performed despite the paucity of data that critically evaluates this technique. In this s ... Full text Link to item Cite

A comparison by medicine residents of physical examination versus hand-carried ultrasound for estimation of right atrial pressure.

Journal Article Am J Cardiol · June 1, 2007 Physicians' ability to accurately estimate right atrial (RA) pressure from bedside evaluation of the jugular venous waveform is poor, particularly when performed by physicians in training. Conventional ultrasound measurement of the inferior vena cava (IVC) ... Full text Link to item Cite

Radial artery pulse pressure variation correlates with brachial artery peak velocity variation in ventilated subjects when measured by internal medicine residents using hand-carried ultrasound devices.

Journal Article Chest · May 2007 BACKGROUND: Rapid prediction of the effect of volume expansion is crucial in unstable patients receiving mechanical ventilation. Both radial artery pulse pressure variation (DeltaPP) and change of aortic blood flow peak velocity are accurate predictors but ... Full text Link to item Cite

Handcarried ultrasound measurement of the inferior vena cava for assessment of intravascular volume status in the outpatient hemodialysis clinic.

Journal Article Clin J Am Soc Nephrol · July 2006 Accurate intravascular volume assessment is critical in the treatment of patients who receive chronic hemodialysis (HD) therapy. Clinically assessed dry weight is a poor surrogate of intravascular volume; however, ultrasound assessment of the inferior vena ... Full text Link to item Cite

Acute platelet inhibition with abciximab does not reduce in-stent restenosis (ERASER study). The ERASER Investigators.

Journal Article Circulation · August 24, 1999 BACKGROUND: Although stents reduce restenosis compared with balloon angioplasty, their long-term efficacy is limited by neointimal hyperplasia. Platelet and alpha(v)beta(3) integrin receptor inhibition limits neointimal proliferation in animal models of ar ... Full text Link to item Cite