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John Paul Middleton

Professor of Medicine
Medicine, Nephrology
Duke Box 2747, Durham, NC 27705
2424 Erwin Road, Suite 605, Durham, NC 27705

Selected Grants


Patiromer Efficacy to Reduce Episodic Hyperkalemia in End Stage Renal Disease Patients Treated with Hemodialysis (PEARL-HD)

Clinical TrialPrincipal Investigator · Awarded by Vifor Pharma, Inc · 2019 - 2025

Duke Training Grant in Nephrology

Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 1995 - 2023

A Randomized Trial of Fistula vs. Graft Arteriovenous Vascular Access in Older Adults with End-Stage Kidney Disease on Hemodialysis: The AV ACCESS Trial

Clinical TrialPrincipal Investigator · Awarded by Wake Forest University School Of Medicine · 2021 - 2023

Preventing Cognitive Decline by Reducing BP Target Trial (PCOT)

ResearchCo Investigator · Awarded by University of Texas - Southwestern · 2020 - 2021

Oral Sodium Bicarbonate to Slow Chronic Kidney Disease Progression

ResearchPrincipal Investigator · Awarded by University of Utah · 2017 - 2018

Data Coordinating Center for Pilot Studies of Candidate Therapies for CKD

ResearchPrincipal Investigator · Awarded by Cleveland Clinic Lerner College of Medicine · 2013 - 2018

Risk Factors for Sudden Cardiac Death in Patients with Chronic Kidney Disease

ResearchCo-Mentor · Awarded by National Institutes of Health · 2014 - 2017

Computational Approach To Personalized Anemia Management

ResearchPrincipal Investigator · Awarded by University of Louisville · 2012 - 2016

BMS CV202-010-0055

Clinical TrialPrincipal Investigator · Awarded by Bristol-Myers Squibb · 2013 - 2015

IPA - Kimberly B. Gitter

ResearchPrincipal Investigator · Awarded by Veterans Administration Medical Center · 2008 - 2010

Hemodialysis Vascular Access Clinical Trials Consortium

ResearchCo Investigator · Awarded by National Institutes of Health · 2000 - 2009

External Relationships


  • AstraZeneca
  • National Institutes of Health
  • NephroNet
  • Novo Nordisk
  • Raleigh Radiology
  • Relypsa/Vifor

This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.