James Martin Harris

Journal Article Can J Ophthalmol · July 29, 2025 OBJECTIVE: To investigate whether specific findings on optical coherence tomography (OCT) in patients with endophthalmitis are correlated with visual prognosis. DESIGN: A single-center, retrospective, consecutive series. PARTICIPANTS: Patients with endopht ... Full text Link to item Cite

The Role of Inflammation in Age-Related Macular Degeneration.

Journal Article Int Ophthalmol Clin · July 1, 2025 Age-related macular degeneration (AMD) is a common neurodegenerative disease that results in significant morbidity and economic cost to patients and society. While advances in our understanding of the mechanisms of neovascularization have led to breakthrou ... Full text Link to item Cite

Ocular effects of Rho kinase (ROCK) inhibition: a systematic review.

Journal Article Eye (Lond) · December 2024 Topical therapies targeting Rho-associated protein kinase (ROCK) signalling, including netarsudil (Rhopressa®) and ripasudil (Glanatec®), have become widely adopted as part of standard clinical practice to lower intraocular pressure (IOP) in patients with ... Full text Link to item Cite

Vision Loss and Difficulty Walking in a Pediatric Sexual Assault Victim.

Journal Article J Neuroophthalmol · September 1, 2024 Full text Link to item Cite

Optogenetic axon guidance in embryonic zebrafish.

Journal Article STAR Protoc · December 17, 2021 Axons form the long-range connections of biological neuronal networks, which are built through the developmental process of axon guidance. Here, we describe a protocol to precisely and non-invasively control axonal growth trajectories in live zebrafish emb ... Full text Link to item Cite

Post-operative intracranial gas migration with optic nerve infiltration and atrophy following retinal detachment repair.

Journal Article Am J Ophthalmol Case Rep · December 2020 PURPOSE: To report a patient with post-operative gas migration into the optic nerve and lateral ventricles after retinal detachment repair. OBSERVATIONS: A 78-year-old pseudophakic man developed a temporal visual field cut in his non-operative, right eye 3 ... Full text Link to item Cite

Effective treatment of a normal-tension glaucoma patient with bilateral ab externo XEN Gel Stent implantation.

Journal Article Am J Ophthalmol Case Rep · December 2020 PURPOSE: To provide the first report of effective use of bilateral XEN Gel Stent implantation using an ab externo open-conjunctival approach designed to improve bleb function and meet the uniquely low intraocular pressure requirements of a Japanese patient ... Full text Link to item Cite

Long-Range Optogenetic Control of Axon Guidance Overcomes Developmental Boundaries and Defects.

Journal Article Dev Cell · June 8, 2020 Axons connect neurons together, establishing the wiring architecture of neuronal networks. Axonal connectivity is largely built during embryonic development through highly constrained processes of axon guidance, which have been extensively studied. However ... Full text Link to item Cite

Building blocks of the cerebral cortex: from development to the dish.

Journal Article Wiley Interdiscip Rev Dev Biol · 2015 Since Ramon y Cajal's examination of the cellular makeup of the cerebral cortex, it has been appreciated that this tissue exhibits some of the greatest degrees of cellular heterogeneity in the entire nervous system. This intricate structure emerges during ... Full text Link to item Cite

Estrogen defines the dorsal-ventral limit of VEGF regulation to specify the location of the hemogenic endothelial niche.

Journal Article Dev Cell · May 27, 2014 Genetic control of hematopoietic stem and progenitor cell (HSPC) function is increasingly understood; however, less is known about the interactions specifying the embryonic hematopoietic niche. Here, we report that 17β-estradiol (E2) influences production ... Full text Link to item Cite

Prostaglandin E2 regulates liver versus pancreas cell-fate decisions and endodermal outgrowth.

Journal Article Dev Cell · February 24, 2014 The liver and pancreas arise from common endodermal progenitors. How these distinct cell fates are specified is poorly understood. Here we describe prostaglandin E2 (PGE2) as a regulator of endodermal fate specification during development. Modulating PGE2 ... Full text Link to item Cite

Glucose metabolism impacts the spatiotemporal onset and magnitude of HSC induction in vivo.

Journal Article Blood · March 28, 2013 Many pathways regulating blood formation have been elucidated, yet how each coordinates with embryonic biophysiology to modulate the spatiotemporal production of hematopoietic stem cells (HSCs) is currently unresolved. Here, we report that glucose metaboli ... Full text Link to item Cite

Rargb regulates organ laterality in a zebrafish model of right atrial isomerism.

Journal Article Dev Biol · December 15, 2012 Developmental signals determine organ morphology and position during embryogenesis. To discover novel modifiers of liver development, we performed a chemical genetic screen in zebrafish and identified retinoic acid as a positive regulator of hepatogenesis. ... Full text Link to item Cite

Deficiency of the cytoskeletal protein SPECC1L leads to oblique facial clefting.

Journal Article Am J Hum Genet · July 15, 2011 Genetic mutations responsible for oblique facial clefts (ObFC), a unique class of facial malformations, are largely unknown. We show that loss-of-function mutations in SPECC1L are pathogenic for this human developmental disorder and that SPECC1L is a criti ... Full text Link to item Cite

Prostaglandin E2 enhances human cord blood stem cell xenotransplants and shows long-term safety in preclinical nonhuman primate transplant models.

Journal Article Cell Stem Cell · April 8, 2011 Hematopoietic stem cells (HSCs) are used in transplantation therapy to reconstitute the hematopoietic system. Human cord blood (hCB) transplantation has emerged as an attractive alternative treatment option when traditional HSC sources are unavailable; how ... Full text Link to item Cite

Differential gene expression during compensatory sprouting of dendrites in the auditory system of the cricket Gryllus bimaculatus.

Journal Article Insect Mol Biol · August 2009 Neurones that lose their presynaptic partners because of injury usually retract or die. However, when the auditory interneurones of the cricket Gryllus bimaculatus are denervated, dendrites respond by growing across the midline and forming novel synapses w ... Full text Link to item Cite

Hematopoietic stem cell development is dependent on blood flow.

Journal Article Cell · May 15, 2009 During vertebrate embryogenesis, hematopoietic stem cells (HSCs) arise in the aorta-gonads-mesonephros (AGM) region. We report here that blood flow is a conserved regulator of HSC formation. In zebrafish, chemical blood flow modulators regulated HSC develo ... Full text Link to item Cite