Jamie Rae Privratsky | Scholars@Duke

Jamie Rae Privratsky
Assistant Professor of Anesthesiology

Current Research Interests

Acute kidney injury (AKI) dramatically increases morbidity and mortality and is one of the most common forms of organ failure in perioperative and critically ill patients. Unresolved AKI leads to ongoing renal injury, fibrosis, and subsequent chronic kidney disease (CKD), which is a major risk factor for future cardiovascular events. Although AKI is not always preventable, interventions designed to promote renal healing and prevent CKD can improve long-term renal and cardiovascular health. My long-term goal is to develop targeted immunomodulatory therapies for acute kidney injury (AKI) to prevent its transition to chronic kidney disease (CKD) and induction of remote organ failure. Currently, we study mechanisms of injury and repair in mouse models of AKI. We use a variety of genetically floxed mice in order to explore the mechanisms by which cytokines, chemokines, and specific immune cells modulate kidney injury and remote organ dysfunction. Current projects include:

Examining the role of IL-1 receptor signaling in toxic AKI
Deciphering how IL-1 receptor signaling in renal macrophages contributes to renal injury and healing
Elucidating the role of dendritic cells in renal injury and repair.

Current Appointments & Affiliations

Assistant Professor of Anesthesiology, Anesthesiology, Critical Care Medicine, Anesthesiology 2017

Contact Information

2301 Erwin Rd, DUMC Box 3094, Durham, NC 27710
DUMC Box 3094, Durham, NC 27710
jamie.privratsky@duke.edu
LinkedIn for Jamie Privratsky

Background
Education, Training, & Certifications
- Anesthesiology, Duke University 2016 - 2017
- Anesthesiology, Duke University 2013 - 2016
- M.D., Medical College of Wisconsin 2012
- Ph.D., Medical College of Wisconsin 2010
Medical Licensure
- 2016-02185. North Carolina. 2016
Expertise
Subject Headings
Research
Selected Grants
- The Role of the IL-1 Receptor in the AKI to CKD transition awarded by National Institutes of Health 2019 - 2024
- The role of macrophage IL-1 signaling in acute kidney injury and recovery awarded by International Anesthesia Research Society 2017 - 2019
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Cherry, Anne D., Jennifer N. Hauck, Benjamin Y. Andrew, Yi-Ju Li, Jamie R. Privratsky, Lakshmi D. Kartha, Alina Nicoara, Annemarie Thompson, Joseph P. Mathew, and Mark Stafford-Smith. “Intraoperative renal resistive index threshold as an acute kidney injury biomarker..” J Clin Anesth 61 (May 2020). https://doi.org/10.1016/j.jclinane.2019.109626.
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  - Lu, Xiaohan, Nathan P. Rudemiller, Jamie R. Privratsky, Jiafa Ren, Yi Wen, Robert Griffiths, and Steven D. Crowley. “Classical Dendritic Cells Mediate Hypertension by Promoting Renal Oxidative Stress and Fluid Retention..” Hypertension 75, no. 1 (January 2020): 131–38. https://doi.org/10.1161/HYPERTENSIONAHA.119.13667.
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  - Ren, Jiafa, Nathan P. Rudemiller, Yi Wen, Xiaohan Lu, Jamie R. Privratsky, and Steven D. Crowley. “The transcription factor Twist1 in the distal nephron but not in macrophages propagates aristolochic acid nephropathy..” Kidney Int 97, no. 1 (January 2020): 119–29. https://doi.org/10.1016/j.kint.2019.07.016.
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  - Wen, Yi, Nathan P. Rudemiller, Jiandong Zhang, Taylor Robinette, Xiaohan Lu, Jiafa Ren, Jamie R. Privratsky, Sergei A. Nedospasov, and Steven D. Crowley. “TNF-α in T lymphocytes attenuates renal injury and fibrosis during nephrotoxic nephritis..” Am J Physiol Renal Physiol 318, no. 1 (January 1, 2020): F107–16. https://doi.org/10.1152/ajprenal.00347.2019.
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  - Lu, Xiaohan, Nathan P. Rudemiller, Yi Wen, Jiafa Ren, Gianna E. Hammer, Robert Griffiths, Jamie R. Privratsky, Bo Yang, Matthew A. Sparks, and Steven D. Crowley. “A20 in Myeloid Cells Protects Against Hypertension by Inhibiting Dendritic Cell-Mediated T-Cell Activation..” Circ Res 125, no. 12 (December 6, 2019): 1055–66. https://doi.org/10.1161/CIRCRESAHA.119.315343.
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  - Lu, Xiaohan, Nathan P. Rudemiller, Jiafa Ren, Yi Wen, Bo Yang, Robert Griffiths, Jamie R. Privratsky, Babita Madan, David M. Virshup, and Steven D. Crowley. “Opposing actions of renal tubular- and myeloid-derived porcupine in obstruction-induced kidney fibrosis..” Kidney Int 96, no. 6 (December 2019): 1308–19. https://doi.org/10.1016/j.kint.2019.06.020.
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  - Wen, Yi, Xiaohan Lu, Jiafa Ren, Jamie R. Privratsky, Bo Yang, Nathan P. Rudemiller, Jiandong Zhang, et al. “KLF4 in Macrophages Attenuates TNFα-Mediated Kidney Injury and Fibrosis..” J Am Soc Nephrol 30, no. 10 (October 2019): 1925–38. https://doi.org/10.1681/ASN.2019020111.
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  - Ren, Jiafa, Jiandong Zhang, Nathan P. Rudemiller, Robert Griffiths, Yi Wen, Xiaohan Lu, Jamie R. Privratsky, Michael D. Gunn, and Steven D. Crowley. “Twist1 in Infiltrating Macrophages Attenuates Kidney Fibrosis via Matrix Metallopeptidase 13-Mediated Matrix Degradation..” J Am Soc Nephrol 30, no. 9 (September 2019): 1674–85. https://doi.org/10.1681/ASN.2018121253.
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  - Yang, Bo, Lili Fu, Jamie R. Privratsky, Xiaohan Lu, Jiafa Ren, Changlin Mei, and Steven D. Crowley. “Interleukin-1 receptor activation aggravates autosomal dominant polycystic kidney disease by modulating regulated necrosis..” Am J Physiol Renal Physiol 317, no. 2 (August 1, 2019): F221–28. https://doi.org/10.1152/ajprenal.00104.2019.
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  - Wen, Yi, Nathan P. Rudemiller, Jiandong Zhang, Alexander D. Jeffs, Robert Griffiths, Xiaohan Lu, Jiafa Ren, Jamie Privratsky, and Steven D. Crowley. “Stimulating Type 1 Angiotensin Receptors on T Lymphocytes Attenuates Renal Fibrosis..” Am J Pathol 189, no. 5 (May 2019): 981–88. https://doi.org/10.1016/j.ajpath.2019.02.004.
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  - “Corrigendum.” American Journal of Physiology Renal Physiology 316, no. 5 (May 1, 2019): F1090–F1090. https://doi.org/10.1152/ajprenal.zh2-8545-corr.2019.
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  - Privratsky, Jamie R., Nian Wang, Yi Qi, Jiafa Ren, Benjamin T. Morris, John C. Hunting, G Allan Johnson, and Steven D. Crowley. “Dynamic contrast-enhanced MRI promotes early detection of toxin-induced acute kidney injury..” Am J Physiol Renal Physiol 316, no. 2 (February 1, 2019): F351–59. https://doi.org/10.1152/ajprenal.00416.2018.
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  - Privratsky, Jamie R., Vanessa T. Schroder, Nazish Hashmi, and Yuriy S. Bronshteyn. “Initial Evaluation for Low-Pressure Cardiac Tamponade Using Focused Cardiac Ultrasound..” A a Pract 11, no. 12 (December 15, 2018): 356–58. https://doi.org/10.1213/XAA.0000000000000822.
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  - Privratsky, Jamie R., Jiandong Zhang, Xiaohan Lu, Nathan Rudemiller, Qingqing Wei, Yen-Rei Yu, Michael D. Gunn, and Steven D. Crowley. “Interleukin 1 receptor (IL-1R1) activation exacerbates toxin-induced acute kidney injury..” Am J Physiol Renal Physiol 315, no. 3 (September 1, 2018): F682–91. https://doi.org/10.1152/ajprenal.00104.2018.
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  - Privratsky, Jamie R., Sebastian Diaz, Alina Nicoara, and Mani A. Daneshmand. “In reply to: "Intra-aortic balloon pump protects against hydrostatic pulmonary oedema during peripheral venoarterial-extracorporeal membrane oxygenation"..” Eur Heart J Acute Cardiovasc Care, May 1, 2018. https://doi.org/10.1177/2048872618779772.
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  - Zhang, Jiandong, Nathan P. Rudemiller, Mehul B. Patel, QingQing Wei, Norah S. Karlovich, Alexander D. Jeffs, Min Wu, et al. “Competing Actions of Type 1 Angiotensin II Receptors Expressed on T Lymphocytes and Kidney Epithelium during Cisplatin-Induced AKI..” J Am Soc Nephrol 27, no. 8 (August 2016): 2257–64. https://doi.org/10.1681/ASN.2015060683.
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  - Privratsky, J. R., S. L. McCartney, T. K. Allen, and A. S. Habib. “Management of persistent cerebrospinal fluid leak using tissue adhesive..” Int J Obstet Anesth 24, no. 1 (February 2015): 87–88. https://doi.org/10.1016/j.ijoa.2014.07.007.
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  - Privratsky, Jamie R., and Peter J. Newman. “PECAM-1: regulator of endothelial junctional integrity..” Cell Tissue Res 355, no. 3 (March 2014): 607–19. https://doi.org/10.1007/s00441-013-1779-3.
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  - Privratsky, Jamie R., Sarah B. Tilkens, Debra K. Newman, and Peter J. Newman. “PECAM-1 dampens cytokine levels during LPS-induced endotoxemia by regulating leukocyte trafficking..” Life Sci 90, no. 5–6 (January 30, 2012): 177–84. https://doi.org/10.1016/j.lfs.2011.11.002.
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  - Privratsky, Jamie R., Nima Almassi, Michael L. Guralnick, Bradley J. Anderson, and R Corey O’Connor. “Outcomes of grafted bulbar urethroplasty in men with class II or III obesity..” Urology 78, no. 6 (December 2011): 1420–23. https://doi.org/10.1016/j.urology.2011.07.1429.
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  - Privratsky, Jamie R., Cathy M. Paddock, Oliver Florey, Debra K. Newman, William A. Muller, and Peter J. Newman. “Relative contribution of PECAM-1 adhesion and signaling to the maintenance of vascular integrity..” J Cell Sci 124, no. Pt 9 (May 1, 2011): 1477–85. https://doi.org/10.1242/jcs.082271.
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  - Privratsky, Jamie R., Debra K. Newman, and Peter J. Newman. “PECAM-1: conflicts of interest in inflammation..” Life Sci 87, no. 3–4 (July 17, 2010): 69–82. https://doi.org/10.1016/j.lfs.2010.06.001.
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  - Privratsky, Jamie R., Benjamin E. Tourdot, Debra K. Newman, and Peter J. Newman. “The anti-inflammatory actions of platelet endothelial cell adhesion molecule-1 do not involve regulation of endothelial cell NF-kappa B..” J Immunol 184, no. 6 (March 15, 2010): 3157–63. https://doi.org/10.4049/jimmunol.0901944.
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  - Ceylan-Isik, Asli F., Kelly K. Guo, Edward C. Carlson, Jamie R. Privratsky, Song-Jie Liao, Lu Cai, Alex F. Chen, and Jun Ren. “Metallothionein abrogates GTP cyclohydrolase I inhibition-induced cardiac contractile and morphological defects: role of mitochondrial biogenesis..” Hypertension 53, no. 6 (June 2009): 1023–31. https://doi.org/10.1161/HYPERTENSIONAHA.108.123422.
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  - Ren, Jun, Jamie R. Privratsky, Xiaoping Yang, Feng Dong, and Edward C. Carlson. “Metallothionein alleviates glutathione depletion-induced oxidative cardiomyopathy in murine hearts..” Crit Care Med 36, no. 7 (July 2008): 2106–16. https://doi.org/10.1097/CCM.0b013e31817bf925.
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  - Wold, Loren E., Asli F. Ceylan-Isik, Cindy X. Fang, Xiaoping Yang, Shi-Yan Li, Nair Sreejayan, Jamie R. Privratsky, and Jun Ren. “Metallothionein alleviates cardiac dysfunction in streptozotocin-induced diabetes: role of Ca2+ cycling proteins, NADPH oxidase, poly(ADP-Ribose) polymerase and myosin heavy chain isozyme..” Free Radic Biol Med 40, no. 8 (April 15, 2006): 1419–29. https://doi.org/10.1016/j.freeradbiomed.2005.12.009.
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  - Li, Shi-Yan, Kish L. Golden, Yang Jiang, Guei-Jane Wang, Jamie R. Privratsky, Xiaochun Zhang, Anna R. Eason, Bruce Culver, and Jun Ren. “Inhibition of sarco(endo)plasmic reticulum Ca2+-ATPase differentially regulates contractile function in cardiac myocytes from normotensive and spontaneously hypertensive rats: role of Ca2+ regulatory proteins..” Cell Biochem Biophys 42, no. 1 (2005): 1–12. https://doi.org/10.1385/CBB:42:1:001.
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  - Aberle, Nicholas S., Jamie R. Privratsky, Larry Burd, and Jun Ren. “Combined acetaldehyde and nicotine exposure depresses cardiac contraction in ventricular myocytes: prevention by folic acid..” Neurotoxicol Teratol 25, no. 6 (November 2003): 731–36. https://doi.org/10.1016/j.ntt.2003.07.008.
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  - Privratsky, Jamie R., Loren E. Wold, James R. Sowers, Mark T. Quinn, and Jun Ren. “AT1 blockade prevents glucose-induced cardiac dysfunction in ventricular myocytes: role of the AT1 receptor and NADPH oxidase..” Hypertension 42, no. 2 (August 2003): 206–12. https://doi.org/10.1161/01.HYP.0000082814.62655.85.
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- Conference Papers
  - Privratsky, Jamie R., Jiafa Ren, Benjamin T. Morris, and Steven D. Crowley. “INFLAMMATORY PROFILE OF MURINE SEPTIC AKI: ROLE OF CD11C+/CX3CR1+ANTIGEN PRESENTING CELLS.” In Shock, 51:56–56. LIPPINCOTT WILLIAMS & WILKINS, 2019.
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  - Privratsky, Jamie R., Benjamin E. Tourdot, Debra K. Newman, and Peter J. Newman. “The Anti-inflammatory Actions of PECAM-1 Do Not Involve Regulation of Endothelial Cell NF kappa B.” In Arteriosclerosis Thrombosis and Vascular Biology, 30:E257–E257. LIPPINCOTT WILLIAMS & WILKINS, 2010.
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  - Privratsky, Jamie R., Cathy M. Paddock, and Peter J. Newman. “Relative Contribution of PECAM-1 Adhesion and Signaling to the Maintenance of Vascular Integrity.” In Arteriosclerosis Thrombosis and Vascular Biology, 30:E304–E304. LIPPINCOTT WILLIAMS & WILKINS, 2010.
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  - Privratsky, J. R., E. C. Carlson, and J. Ren. “Cardiac-specific overexpression of metallothionein prevents glutathione depletion-induced oxidative cardiomyopathy in isolated ventricular myocytes.” In Circulation, 106:201–2. LIPPINCOTT WILLIAMS & WILKINS, 2002.
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  - Privratsky, Jamie R., Loren E. Wold, and Jun Ren. “06 AT1A receptor blockade by L-158,809 prevents the development of high [glucose]-induced diabetic cardiomyopathy: Role of NADPH oxidase.” In Journal of Molecular and Cellular Cardiology, 34:A12–A12. Elsevier BV, 2002. https://doi.org/10.1016/s0022-2828(02)90112-4.
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Teaching & Mentoring
Teaching Activities
- Critical Care Fellow Lecture series: block leader 2017-2018
Scholarly, Clinical, & Service Activities
Clinical Activities
- I am an intensivist in the Duke Regional Hospital Critical Care Unit and the Duke University Hospital Surgical Intensive Care Unit. I also am an anesthesiologist in the General, Vascular, Transplant division of the Department of Anesthesiology.

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Education, Training, & Certifications

Medical Licensure

Subject Headings

Selected Grants

Selected Publications

Academic Articles

Conference Papers

Teaching Activities

Clinical Activities