Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., Florida International University 2009
• Research
• 

  Selected Grants

  • Targeting the p38/Snail/PD-L1 axis in hormone-therapy resistance and metastasis awarded by Department of Defense 2018 - 2021
  • Targeting Convergent Mechanisms of Therapy Resistance, Metastasis, and Immune Evasion with CBP inhibitors awarded by FORMA Therapeutics, Inc. 2018 - 2020
  • Marine Mammals Point the Way Toward New Therapies to Prevent Hypoxia awarded by Dolphin Quest 2019 - 2020
  • Scholars in Marine Medicine: Mentored Research at the Nexus of the Marine Environment and Human Health. awarded by Dolphin Quest 2019 - 2020
  • Bioengineering Plastic-Degrading Microbes To Eliminate Plastic Waste awarded by SeaWorld & Busch Gardens Conservation Fund 2018 - 2019
  • Development of Circulating Molecular Predictors of Chemotherapy and Novel Hormonal Therapy Benefit in Men with Metastatic Castration Resistant Prostate Cancer (mCRPC) awarded by Prostate Cancer Foundation 2014 - 2019
  • Testing the efficacy of AR degrading compounds in enzalutamide-resistant prostate cancer awarded by Arvinas Inc. 2017 - 2019
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Jolly, MK, Ware, KE, Xu, S, Gilja, S, Shetler, S, Yang, Y, Wang, X, Austin, RG, Runyambo, D, Hish, AJ, Bartholf DeWitt, S, George, JT, Kreulen, RT, Boss, M-K, Lazarides, AL, Kerr, DL, Gerber, DG, Sivaraj, D, Armstrong, AJ, Dewhirst, MW, Eward, WC, Levine, H, and Somarelli, JA. "E-cadherin represses anchorage-independent growth in sarcomas through both signaling and mechanical mechanisms." Molecular Cancer Research : Mcr (March 12, 2019).  Full Text
    • Xu, S, Ware, KE, Ding, Y, Kim, SY, Sheth, MU, Rao, S, Chan, W, Armstrong, AJ, Eward, WC, Jolly, MK, and Somarelli, JA. "An Integrative Systems Biology and Experimental Approach Identifies Convergence of Epithelial Plasticity, Metabolism, and Autophagy to Promote Chemoresistance." Journal of Clinical Medicine 8, no. 2 (February 7, 2019).  Full Text
    • Jolly, MK, Somarelli, JA, Sheth, M, Biddle, A, Tripathi, SC, Armstrong, AJ, Hanash, SM, Bapat, SA, Rangarajan, A, and Levine, H. "Hybrid epithelial/mesenchymal phenotypes promote metastasis and therapy resistance across carcinomas." Pharmacology & Therapeutics 194 (February 2019): 161-184. (Review)  Full Text
    • Jolly, MK, Tripathi, SC, Somarelli, JA, Hanash, SM, and Levine, H. "Epithelial/mesenchymal plasticity: how have quantitative mathematical models helped improve our understanding?." Molecular Oncology 11, no. 7 (July 2017): 739-754.  Full Text
    • Jolly, MK, Ware, KE, Gilja, S, Somarelli, JA, and Levine, H. "EMT and MET: necessary or permissive for metastasis?." Molecular Oncology 11, no. 7 (July 2017): 755-769.  Full Text
    • Ware, KE, Gilja, S, Xu, S, Shetler, S, Jolly, MK, Wang, X, Bartholf Dewitt, S, Hish, AJ, Jordan, S, Eward, W, Levine, H, Armstrong, AJ, and Somarelli, JA. "Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells." Journal of visualized experiments : JoVE , no. 122 (April 7, 2017).  Full Text
    • Somarelli, JA, Ware, KE, Kostadinov, R, Robinson, JM, Amri, H, Abu-Asab, M, Fourie, N, Diogo, R, Swofford, D, and Townsend, JP. "PhyloOncology: Understanding cancer through phylogenetic analysis." Biochimica Et Biophysica Acta (Bba) Reviews on Cancer 1867, no. 2 (April 2017): 101-108.  Full Text
    • Gupta, S, Li, J, Kemeny, G, Bitting, RL, Beaver, J, Somarelli, JA, Ware, KE, Gregory, S, and Armstrong, AJ. "Whole Genomic Copy Number Alterations in Circulating Tumor Cells from Men with Abiraterone or Enzalutamide-Resistant Metastatic Castration-Resistant Prostate Cancer." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research 23, no. 5 (March 2017): 1346-1357.  Full Text
    • Somarelli, JA, Shetler, S, Jolly, MK, Wang, X, Bartholf Dewitt, S, Hish, AJ, Gilja, S, Eward, WC, Ware, KE, Levine, H, Armstrong, AJ, and Garcia-Blanco, MA. "Mesenchymal-Epithelial Transition in Sarcomas Is Controlled by the Combinatorial Expression of MicroRNA 200s and GRHL2." Molecular and cellular biology 36, no. 19 (October 2016): 2503-2513.  Full Text  Open Access Copy
    • Somarelli, JA, Schaeffer, D, Marengo, MS, Bepler, T, Rouse, D, Ware, KE, Hish, AJ, Zhao, Y, Buckley, AF, Epstein, JI, Armstrong, AJ, Virshup, DM, and Garcia-Blanco, MA. "Distinct routes to metastasis: plasticity-dependent and plasticity-independent pathways." Oncogene 35, no. 33 (August 2016): 4302-4311.  Full Text  Open Access Copy
    • Ware, KE, Somarelli, JA, Schaeffer, D, Li, J, Zhang, T, Park, S, Patierno, SR, Freedman, J, Foo, W-C, Garcia-Blanco, MA, and Armstrong, AJ. "Snail promotes resistance to enzalutamide through regulation of androgen receptor activity in prostate cancer." Oncotarget 7, no. 31 (August 2016): 50507-50521.  Full Text  Open Access Copy
    • Somarelli, JA, Boss, M-K, Epstein, JI, Armstrong, AJ, and Garcia-Blanco, MA. "Carcinosarcomas: tumors in transition?." Histology and histopathology 30, no. 6 (June 2015): 673-687. (Review)  Full Text
    • Schaeffer, D, Somarelli, JA, Hanna, G, Palmer, GM, and Garcia-Blanco, MA. "Cellular migration and invasion uncoupled: increased migration is not an inexorable consequence of epithelial-to-mesenchymal transition." Molecular and Cellular Biology 34, no. 18 (September 2014): 3486-3499.  Full Text
    • Somarelli, JA, Mesa, A, Rodriguez, CE, Sharma, S, and Herrera, RJ. "U1 small nuclear RNA variants differentially form ribonucleoprotein particles in vitro." Gene 540, no. 1 (April 2014): 11-15.  Full Text
    • "The role of epithelial plasticity in prostate cancer dissemination and treatment resistance." Cancer and Metastasis Reviews 33, no. 2-3 (January 1, 2014): 441-468.  Full Text
    • Somarelli, JA, Schaeffer, D, Bosma, R, Bonano, VI, Sohn, JW, Kemeny, G, Ettyreddy, A, and Garcia-Blanco, MA. "Fluorescence-based alternative splicing reporters for the study of epithelial plasticity in vivo." RNA 19, no. 1 (January 2013): 116-127.  Full Text  Link to Item
    • Evsyukova, I, Somarelli, JA, Gregory, SG, and Garcia-Blanco, MA. "Alternative splicing in multiple sclerosis and other autoimmune diseases." RNA Biol 7, no. 4 (July 2010): 462-473. (Review)  Open Access Copy  Link to Item
• Teaching & Mentoring
• 

  Recent Courses

  • BIOLOGY 278LA: Comparative Physiology of Marine Animals 2019
  • ENERGY 395: Connections in Energy: Interdisciplinary Team Projects 2019
  • ENERGY 795: Connections in Energy: Interdisciplinary Team Projects 2019
  • ENVIRON 278LA: Comparative Physiology of Marine Animals 2019

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