Scholars@Duke

• Background
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  Education, Training, & Certifications

  • Ph.D., Florida International University 2009
• Recognition
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  In the News

  • AUG 27, 2019

    School of Medicine Magnify Magazine

    How Do Whales Fight Off Cancer?
• Research
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  Selected Grants

  • Targeting convergent oncogenic signaling during AR inhibition to overcome metastasis and immune evasion in prostate cancer awarded by National Institutes of Health 2019 - 2024
  • Targeting convergent mechanisms of castration resistant prostate cancer therapy resistance, metastasis, and immune evasion with AR-LDDs 2019 - 2022
  • Targeting the p38/Snail/PD-L1 axis in hormone-therapy resistance and metastasis awarded by Department of Defense 2018 - 2021
  • An integrated comparative physiology and genomics approach to understand dolphin adaptation to hypoxia 2020 - 2021
  • An integrated comparative physiology and genomics approach to understand dolphin adaptation to hypoxia 2020 - 2021
  • Bioengineering Plastic-Degrading Microbes To Eliminate Plastic Waste 2018 - 2020
  • Targeting Convergent Mechanisms of Therapy Resistance, Metastasis, and Immune Evasion with CBP inhibitors 2018 - 2020
  • Validation and interrogation of differentially expressed and alternatively spliced genes in African American prostate ca awarded by Department of Defense 2014 - 2020
  • Development of Circulating Molecular Predictors of Chemotherapy and Novel Hormonal Therapy Benefit in Men with Metastatic Castration Resistant Prostate Cancer (mCRPC) 2014 - 2020
  • Marine Mammals Point the Way Toward New Therapies to Prevent Hypoxia 2019 - 2020
  • Scholars in Marine Medicine: Mentored Research at the Nexus of the Marine Environment and Human Health. 2019 - 2020
  • Testing the efficacy of AR degrading compounds in enzalutamide-resistant prostate cancer 2017 - 2019
• Publications & Artistic Works
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  Selected Publications

  • Academic Articles

    • Yuan, Fuwen, William Hankey, Dayong Wu, Hongyan Wang, Jason Somarelli, Andrew J. Armstrong, Jiaoti Huang, Zhong Chen, and Qianben Wang. “Molecular determinants for enzalutamide-induced transcription in prostate cancer..” Nucleic Acids Res 47, no. 19 (November 4, 2019): 10104–14. https://doi.org/10.1093/nar/gkz790.
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    • Sheth, M. U., S. K. Kwartler, E. R. Schmaltz, S. M. Hoskinson, E. J. Martz, M. M. Dunphy-Daly, T. F. Schultz, A. J. Read, W. C. Eward, and J. A. Somarelli. “Bioengineering a Future Free of Marine Plastic Waste.” Frontiers in Marine Science 6 (October 11, 2019). https://doi.org/10.3389/fmars.2019.00624.
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    • Tuohy, Joanne L., Jason A. Somarelli, Luke B. Borst, William C. Eward, B Duncan X. Lascelles, and Jonathan E. Fogle. “Immune dysregulation and osteosarcoma: Staphylococcus aureus downregulates TGF-β and heightens the inflammatory signature in human and canine macrophages suppressed by osteosarcoma..” Vet Comp Oncol, August 17, 2019. https://doi.org/10.1111/vco.12529.
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    • Jolly, Mohit Kumar, Kathryn E. Ware, Shengnan Xu, Shivee Gilja, Samantha Shetler, Yanjun Yang, Xueyang Wang, et al. “E-Cadherin Represses Anchorage-Independent Growth in Sarcomas through Both Signaling and Mechanical Mechanisms..” Mol Cancer Res 17, no. 6 (June 2019): 1391–1402. https://doi.org/10.1158/1541-7786.MCR-18-0763.
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    • Armstrong, Andrew J., Susan Halabi, Jun Luo, David M. Nanus, Paraskevi Giannakakou, Russell Z. Szmulewitz, Daniel C. Danila, et al. “Prospective Multicenter Validation of Androgen Receptor Splice Variant 7 and Hormone Therapy Resistance in High-Risk Castration-Resistant Prostate Cancer: The PROPHECY Study..” J Clin Oncol 37, no. 13 (May 1, 2019): 1120–29. https://doi.org/10.1200/JCO.18.01731.
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    • Lazarides, Alexander L., David L. Kerr, Daniel P. Nussbaum, R Timothy Kreulen, Jason A. Somarelli, Dan G. Blazer, Brian E. Brigman, and William C. Eward. “Soft Tissue Sarcoma of the Extremities: What Is the Value of Treating at High-volume Centers?.” Clin Orthop Relat Res 477, no. 4 (April 2019): 718–27. https://doi.org/10.1097/01.blo.0000533623.60399.1b.
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    • Xu, Shengnan, Kathryn E. Ware, Yuantong Ding, So Young Kim, Maya U. Sheth, Sneha Rao, Wesley Chan, et al. “An Integrative Systems Biology and Experimental Approach Identifies Convergence of Epithelial Plasticity, Metabolism, and Autophagy to Promote Chemoresistance..” J Clin Med 8, no. 2 (February 7, 2019). https://doi.org/10.3390/jcm8020205.
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    • Jolly, Mohit Kumar, Jason A. Somarelli, Maya Sheth, Adrian Biddle, Satyendra C. Tripathi, Andrew J. Armstrong, Samir M. Hanash, Sharmila A. Bapat, Annapoorni Rangarajan, and Herbert Levine. “Hybrid epithelial/mesenchymal phenotypes promote metastasis and therapy resistance across carcinomas..” Pharmacol Ther 194 (February 2019): 161–84. https://doi.org/10.1016/j.pharmthera.2018.09.007.
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    • Armstrong, Andrew J., Santosh Gupta, Patrick Healy, Gabor Kemeny, Beth Leith, Michael R. Zalutsky, Charles Spritzer, et al. “Pharmacodynamic study of radium-223 in men with bone metastatic castration resistant prostate cancer..” Plos One 14, no. 5 (2019). https://doi.org/10.1371/journal.pone.0216934.
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    • George, Jason T., Mohit Kumar Jolly, Shengnan Xu, Jason A. Somarelli, and Herbert Levine. “Survival Outcomes in Cancer Patients Predicted by a Partial EMT Gene Expression Scoring Metric..” Cancer Res 77, no. 22 (November 15, 2017): 6415–28. https://doi.org/10.1158/0008-5472.CAN-16-3521.
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    • Jolly, Mohit Kumar, Kathryn E. Ware, Shivee Gilja, Jason A. Somarelli, and Herbert Levine. “EMT and MET: necessary or permissive for metastasis?.” Molecular Oncology 11, no. 7 (July 2017): 755–69. https://doi.org/10.1002/1878-0261.12083.
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    • Jolly, Mohit Kumar, Satyendra C. Tripathi, Jason A. Somarelli, Samir M. Hanash, and Herbert Levine. “Epithelial/mesenchymal plasticity: how have quantitative mathematical models helped improve our understanding?.” Molecular Oncology 11, no. 7 (July 2017): 739–54. https://doi.org/10.1002/1878-0261.12084.
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    • Ware, Kathryn E., Shivee Gilja, Shenghan Xu, Samantha Shetler, Mohit K. Jolly, Xueyang Wang, Suzanne Bartholf Dewitt, et al. “Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells..” J Vis Exp, no. 122 (April 7, 2017). https://doi.org/10.3791/55520.
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    • Somarelli, Jason A., Kathryn E. Ware, Rumen Kostadinov, Jeffrey M. Robinson, Hakima Amri, Mones Abu-Asab, Nicolaas Fourie, Rui Diogo, David Swofford, and Jeffrey P. Townsend. “PhyloOncology: Understanding cancer through phylogenetic analysis..” Biochimica Et Biophysica Acta. Reviews on Cancer 1867, no. 2 (April 2017): 101–8. https://doi.org/10.1016/j.bbcan.2016.10.006.
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    • Gupta, Santosh, Jing Li, Gabor Kemeny, Rhonda L. Bitting, Joshua Beaver, Jason A. Somarelli, Kathryn E. Ware, Simon Gregory, and Andrew J. Armstrong. “Whole Genomic Copy Number Alterations in Circulating Tumor Cells from Men with Abiraterone or Enzalutamide-Resistant Metastatic Castration-Resistant Prostate Cancer..” Clin Cancer Res 23, no. 5 (March 1, 2017): 1346–57. https://doi.org/10.1158/1078-0432.CCR-16-1211.
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    • Somarelli, Jason A., Samantha Shetler, Mohit K. Jolly, Xueyang Wang, Suzanne Bartholf Dewitt, Alexander J. Hish, Shivee Gilja, et al. “Mesenchymal-Epithelial Transition in Sarcomas Is Controlled by the Combinatorial Expression of MicroRNA 200s and GRHL2..” Mol Cell Biol 36, no. 19 (October 1, 2016): 2503–13. https://doi.org/10.1128/MCB.00373-16.
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    • Somarelli, J. A., D. Schaeffer, M. S. Marengo, T. Bepler, D. Rouse, K. E. Ware, A. J. Hish, et al. “Distinct routes to metastasis: plasticity-dependent and plasticity-independent pathways..” Oncogene 35, no. 33 (August 18, 2016): 4302–11. https://doi.org/10.1038/onc.2015.497.
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    • Ware, Kathryn E., Jason A. Somarelli, Daneen Schaeffer, Jing Li, Tian Zhang, Sally Park, Steven R. Patierno, et al. “Snail promotes resistance to enzalutamide through regulation of androgen receptor activity in prostate cancer..” Oncotarget 7, no. 31 (August 2, 2016): 50507–21. https://doi.org/10.18632/oncotarget.10476.
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    • Somarelli, Jason A., Mary-Keara Boss, Jonathan I. Epstein, Andrew J. Armstrong, and Mariano A. Garcia-Blanco. “Carcinosarcomas: tumors in transition?.” Histol Histopathol 30, no. 6 (June 2015): 673–87. https://doi.org/10.14670/HH-30.673.
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    • Schaeffer, Daneen, Jason A. Somarelli, Gabi Hanna, Gregory M. Palmer, and Mariano A. Garcia-Blanco. “Cellular migration and invasion uncoupled: increased migration is not an inexorable consequence of epithelial-to-mesenchymal transition..” Mol Cell Biol 34, no. 18 (September 15, 2014): 3486–99. https://doi.org/10.1128/MCB.00694-14.
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    • Bitting, Rhonda L., Daneen Schaeffer, Jason A. Somarelli, Mariano A. Garcia-Blanco, and Andrew J. Armstrong. “The role of epithelial plasticity in prostate cancer dissemination and treatment resistance..” Cancer Metastasis Rev 33, no. 2–3 (September 2014): 441–68. https://doi.org/10.1007/s10555-013-9483-z.
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    • Somarelli, Jason A., Annia Mesa, Carol E. Rodriguez, Shalini Sharma, and Rene J. Herrera. “U1 small nuclear RNA variants differentially form ribonucleoprotein particles in vitro..” Gene 540, no. 1 (April 25, 2014): 11–15. https://doi.org/10.1016/j.gene.2014.02.054.
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    • Somarelli, Jason A., Daneen Schaeffer, Reggie Bosma, Vivian I. Bonano, Jang Wook Sohn, Gabor Kemeny, Abhinav Ettyreddy, and Mariano A. Garcia-Blanco. “Fluorescence-based alternative splicing reporters for the study of epithelial plasticity in vivo..” Rna 19, no. 1 (January 2013): 116–27. https://doi.org/10.1261/rna.035097.112.
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    • Evsyukova, Irina, Jason A. Somarelli, Simon G. Gregory, and Mariano A. Garcia-Blanco. “Alternative splicing in multiple sclerosis and other autoimmune diseases..” Rna Biol 7, no. 4 (July 2010): 462–73. https://doi.org/10.4161/rna.7.4.12301.
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• Teaching & Mentoring
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  Recent Courses

  • BIOLOGY 278LA: Comparative Physiology of Marine Animals 2019
  • ENERGY 395: Connections in Energy: Interdisciplinary Team Projects 2019
  • ENERGY 795: Connections in Energy: Interdisciplinary Team Projects 2019
  • ENVIRON 278LA: Comparative Physiology of Marine Animals 2019

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