Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., Florida International University 2009
• 

  Previous Appointments & Affiliations

  • Assistant Professor in Medicine, Medicine, Medical Oncology, Medicine 2020
  • Medical Instructor in the Department of Medicine, Medicine, Medical Oncology, Medicine 2017 - 2019
• Recognition
• 

  In the News

  • APR 21, 2021

    Bass Connections

    Two Faculty Receive Inaugural Bass Connections Leadership Award

  • AUG 27, 2019

    School of Medicine Magnify Magazine

    How Do Whales Fight Off Cancer?
• Research
• 

  Selected Grants

  • Targeting convergent oncogenic signaling during AR inhibition to overcome metastasis and immune evasion in prostate cancer awarded by National Institutes of Health 2019 - 2025
  • DIRECT - Diversifying Research and Experiential Learning in Cancer Training awarded by Emerson Collective 2021 - 2024
  • Modeling tumor heterogeneity and therapy resistance in osteosarcoma using patient-derived organoids awarded by Hyundai Hope on Wheels 2021 - 2023
  • Dolphin Quest: An integrated comparative physiology and genomics approach to understand dolphin adaptation to hypoxia awarded by Dolphin Quest 2020 - 2023
  • Dolphin Quest: Scholars - An integrated comparative physiology and genomics approach to understand dolphin adaptation to hypoxia awarded by Dolphin Quest 2020 - 2023
  • An integrated physiology and genomics analysis to define molecular adaptations to diving awarded by Dolphin Quest 2022
  • The Duke University Marine Laboratory Scholars Program: Enhancing mentored research experiences for undergraduates awarded by Henry David Thoreau Foundation 2021 - 2022
  • Targeting Convergent Mechanisms of Therapy Resistance, Metastasis, and Immune Evasion with CBP inhibitors awarded by FORMA Therapeutics, Inc. 2020 - 2022
  • Targeting convergent mechanisms of castration resistant prostate cancer therapy resistance, metastasis, and immune evasion with AR-LDDs awarded by Celgene Corporation 2019 - 2022
  • Targeting the p38/Snail/PD-L1 axis in hormone-therapy resistance and metastasis awarded by Department of Defense 2018 - 2022
  • Identifying novel CRM1 inhibitor combination therapies to treat sarcomas awarded by Karyopharm Therapeutics 2021 - 2022
  • Systems Analysis of Epigenomic Architecture in Cancer Progression (Outreach Core) awarded by University of Texas Health Science Center at San Antonio 2019 - 2022
  • Bioengineering Plastic-Degrading Microbes To Eliminate Plastic Waste awarded by SeaWorld & Busch Gardens Conservation Fund 2018 - 2020
  • Targeting Convergent Mechanisms of Therapy Resistance, Metastasis, and Immune Evasion with CBP inhibitors awarded by FORMA Therapeutics, Inc. 2018 - 2020
  • Validation and interrogation of differentially expressed and alternatively spliced genes in African American prostate cancer awarded by Department of Defense 2014 - 2020
  • Development of Circulating Molecular Predictors of Chemotherapy and Novel Hormonal Therapy Benefit in Men with Metastatic Castration Resistant Prostate Cancer (mCRPC) awarded by Prostate Cancer Foundation 2014 - 2020
  • Marine Mammals Point the Way Toward New Therapies to Prevent Hypoxia awarded by Dolphin Quest 2019 - 2020
  • Scholars in Marine Medicine: Mentored Research at the Nexus of the Marine Environment and Human Health. awarded by Dolphin Quest 2019 - 2020
  • Testing the efficacy of AR degrading compounds in enzalutamide-resistant prostate cancer awarded by Arvinas Inc. 2017 - 2019
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Palencia-Madrid, Leire, Miriam Baeta, Tamara Kleinbielen, Nerea Toro-Delgado, Patricia Villaescusa, Elena Sanchez-Bustamante, Marian M. de Pancorbo, et al. “Post-Austronesian migrational wave of West Polynesians to Micronesia.” Gene 823 (May 20, 2022): 146357. https://doi.org/10.1016/j.gene.2022.146357.
       Full Text  Link to Item
    • Brown, Landon C., Susan Halabi, Jason A. Somarelli, Michael Humeniuk, Yuan Wu, Taofik Oyekunle, Lauren Howard, et al. “A phase 2 trial of avelumab in men with aggressive-variant or neuroendocrine prostate cancer.” Prostate Cancer Prostatic Dis, March 15, 2022. https://doi.org/10.1038/s41391-022-00524-7.
       Full Text  Link to Item
    • Evans, Daniel R., Alexander L. Lazarides, Mark M. Cullen, Jason A. Somarelli, Dan G. Blazer, Julia D. Visguass, Brian E. Brigman, and William C. Eward. “Identifying Modifiable and Non-modifiable Risk Factors of Readmission and Short-Term Mortality in Chondrosarcoma: A National Cancer Database Study.” Ann Surg Oncol 29, no. 2 (February 2022): 1392–1408. https://doi.org/10.1245/s10434-021-10802-8.
       Full Text  Link to Item
    • Evans, Daniel R., Alexander L. Lazarides, Mark M. Cullen, Jason A. Somarelli, Dan G. Blazer, Julia D. Visguass, Brian E. Brigman, and William C. Eward. “ASO Visual Abstract: Identifying Modifiable and Non-Modifiable Risk Factors of Readmission and Short-Term Mortality in Chondrosarcoma: A National Cancer Database Study.” Ann Surg Oncol 29, no. 2 (February 2022): 1411–12. https://doi.org/10.1245/s10434-021-10892-4.
       Full Text  Link to Item
    • Lazarides, Alexander L., Jason A. Somarelli, Brian E. Brigman, Julia D. Visgauss, and William C. Eward. “ASO Author Reflections: Identifying Modifiable and Non-Modifiable Risk Factors of Readmission and Short-Term Mortality in Chondrosarcoma.” Ann Surg Oncol 29, no. 2 (February 2022): 1409–10. https://doi.org/10.1245/s10434-021-10904-3.
       Full Text  Link to Item
    • Gunady, Ella F., Kathryn E. Ware, Sarah Hoskinson Plumlee, Nicolas Devos, David Corcoran, Joseph Prinz, Hrvoje Misetic, et al. “Exome sequencing of hepatocellular carcinoma in lemurs identifies potential cancer drivers: A pilot study.” Evol Med Public Health 10, no. 1 (2022): 221–30. https://doi.org/10.1093/emph/eoac016.
       Full Text  Link to Item
    • Rao, Sneha R., Alexander L. Lazarides, Bruce L. Leckey, Whitney O. Lane, Julia D. Visgauss, Jason A. Somarelli, David G. Kirsch, et al. “Extent of tumor fibrosis/hyalinization and infarction following neoadjuvant radiation therapy is associated with improved survival in patients with soft-tissue sarcoma.” Cancer Med 11, no. 1 (January 2022): 194–206. https://doi.org/10.1002/cam4.4428.
       Full Text  Link to Item
    • Evans, Daniel R., Alexander L. Lazarides, Mark M. Cullen, Julia Dawn Visgauss, Jason A. Somarelli, Dan Blazer, Brian E. Brigman, and William C. Eward. “ASO Visual Abstract: Identifying Modifiable and Non-Modifiable Risk Factors of Readmission and Short-Term Mortality in Osteosarcoma-A National Cancer Database Study.” Ann Surg Oncol 28, no. Suppl 3 (December 2021): 449–50. https://doi.org/10.1245/s10434-021-10131-w.
       Full Text  Link to Item
    • Evans, Daniel R., Alexander L. Lazarides, Mark M. Cullen, Julia D. Visgauss, Jason A. Somarelli, Dan G. Blazer, Brian E. Brigman, and William C. Eward. “Identifying Modifiable and Non-modifiable Risk Factors of Readmission and Short-Term Mortality in Osteosarcoma: A National Cancer Database Study.” Ann Surg Oncol 28, no. 12 (November 2021): 7961–72. https://doi.org/10.1245/s10434-021-10099-7.
       Full Text  Link to Item
    • Dasari, K., J. A. Somarelli, S. Kumar, and J. P. Townsend. “The somatic molecular evolution of cancer: Mutation, selection, and epistasis.” Progress in Biophysics and Molecular Biology 165 (October 1, 2021): 56–65. https://doi.org/10.1016/j.pbiomolbio.2021.08.003.
       Full Text
    • Subbalakshmi, A. R., S. Sahoo, I. McMullen, A. N. Saxena, S. K. Venugopal, J. A. Somarelli, and M. K. Jolly. “Klf4 induces mesenchymal–epithelial transition (Met) by suppressing multiple emt‐inducing transcription factors.” Cancers 13, no. 20 (October 1, 2021). https://doi.org/10.3390/cancers13205135.
       Full Text
    • Visgauss, Julia D., Alexander Lazarides, Brendan Dickson, Diana Cardona, Maya Sheth, Suzanne Bartholf DeWitt, Jason A. Somarelli, and William C. Eward. “Treatment of Chondroblastoma with Denosumab: A Case Report with a Correlative Analysis of Effect on the RANK Signaling Pathway.” Jbjs Case Connect 11, no. 2 (May 17, 2021). https://doi.org/10.2106/JBJS.CC.20.00178.
       Full Text  Link to Item
    • Somarelli, J. A. “The Hallmarks of Cancer as Ecologically Driven Phenotypes.” Frontiers in Ecology and Evolution 9 (April 28, 2021). https://doi.org/10.3389/fevo.2021.661583.
       Full Text
    • Zhang, Tian, Anika Agarwal, R Garland Almquist, Daniella Runyambo, Sally Park, Elizabeth Bronson, Rengasamy Boominathan, et al. “Expression of immune checkpoints on circulating tumor cells in men with metastatic prostate cancer.” Biomark Res 9, no. 1 (February 18, 2021): 14. https://doi.org/10.1186/s40364-021-00267-y.
       Full Text  Link to Item
    • Boss, Mary-Keara, Rebecca E. Oberley-Deegan, Ines Batinic-Haberle, Geoffrey A. Talmon, Jason A. Somarelli, Shengnan Xu, Elizabeth A. Kosmacek, et al. “Manganese Porphyrin and Radiotherapy Improves Local Tumor Response and Overall Survival in Orthotopic Murine Mammary Carcinoma Models.” Radiat Res 195, no. 2 (February 1, 2021): 128–39. https://doi.org/10.1667/RADE-20-00109.1.
       Full Text  Link to Item
    • Dayanidhi, D. L., B. C. Thomas, J. S. Osterberg, M. Vuong, G. Vargas, S. K. Kwartler, E. Schmaltz, et al. “Exploring the Diversity of the Marine Environment for New Anti-cancer Compounds.” Frontiers in Marine Science 7 (January 21, 2021). https://doi.org/10.3389/fmars.2020.614766.
       Full Text
    • Chakraborty, Priyanka, Emily L. Chen, Isabelle McMullen, Andrew J. Armstrong, Mohit Kumar Jolly, and Jason A. Somarelli. “Analysis of immune subtypes across the epithelial-mesenchymal plasticity spectrum.” Comput Struct Biotechnol J 19 (2021): 3842–51. https://doi.org/10.1016/j.csbj.2021.06.023.
       Full Text  Link to Item
    • Allen, Tyler A., Mark M. Cullen, Nathan Hawkey, Hiroyuki Mochizuki, Lan Nguyen, Elyse Schechter, Luke Borst, et al. “A Zebrafish Model of Metastatic Colonization Pinpoints Cellular Mechanisms of Circulating Tumor Cell Extravasation.” Front Oncol 11 (2021): 641187. https://doi.org/10.3389/fonc.2021.641187.
       Full Text  Link to Item
    • Blawas, Ashley M., Kathryn E. Ware, Emma Schmaltz, Larry Zheng, Jacob Spruance, Austin S. Allen, Nicole West, et al. “An integrated comparative physiology and molecular approach pinpoints mediators of breath-hold capacity in dolphins.” Evol Med Public Health 9, no. 1 (2021): 420–30. https://doi.org/10.1093/emph/eoab036.
       Full Text  Link to Item
    • Klionsky, Daniel J., Amal Kamal Abdel-Aziz, Sara Abdelfatah, Mahmoud Abdellatif, Asghar Abdoli, Steffen Abel, Hagai Abeliovich, et al. “Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.” Autophagy 17, no. 1 (January 2021): 1–382. https://doi.org/10.1080/15548627.2020.1797280.
       Full Text  Link to Item
    • Somarelli, Jason A., Roham Salman Roghani, Ali Sanjari Moghaddam, Beatrice C. Thomas, Gabrielle Rupprecht, Kathryn E. Ware, Erdem Altunel, et al. “A Precision Medicine Drug Discovery Pipeline Identifies Combined CDK2 and 9 Inhibition as a Novel Therapeutic Strategy in Colorectal Cancer.” Mol Cancer Ther 19, no. 12 (December 2020): 2516–27. https://doi.org/10.1158/1535-7163.MCT-20-0454.
       Full Text  Link to Item
    • Somarelli, Jason A., Gabrielle Rupprecht, Erdem Altunel, Etienne M. Flamant, Sneha Rao, Dharshan Sivaraj, Alexander L. Lazarides, et al. “A Comparative Oncology Drug Discovery Pipeline to Identify and Validate New Treatments for Osteosarcoma.” Cancers (Basel) 12, no. 11 (November 11, 2020). https://doi.org/10.3390/cancers12113335.
       Full Text  Link to Item
    • Schmaltz, Emma, Emily C. Melvin, Zoie Diana, Ella F. Gunady, Daniel Rittschof, Jason A. Somarelli, John Virdin, and Meagan M. Dunphy-Daly. “Plastic pollution solutions: emerging technologies to prevent and collectmarineplastic pollution.” Environ Int 144 (November 2020): 106067. https://doi.org/10.1016/j.envint.2020.106067.
       Full Text  Link to Item
    • Evans, Daniel R., Alexander L. Lazarides, Julia D. Visgauss, Jason A. Somarelli, Dan G. Blazer, Brian E. Brigman, and William C. Eward. “Limb salvage versus amputation in patients with osteosarcoma of the extremities: an update in the modern era using the National Cancer Database.” Bmc Cancer 20, no. 1 (October 14, 2020): 995. https://doi.org/10.1186/s12885-020-07502-z.
       Full Text  Link to Item
    • Reddy, Gireesh B., David L. Kerr, Ivan Spasojevic, Artak Tovmasyan, David S. Hsu, Brian E. Brigman, Jason A. Somarelli, David Needham, and William C. Eward. “Preclinical Testing of a Novel Niclosamide Stearate Prodrug Therapeutic (NSPT) Shows Efficacy Against Osteosarcoma.” Mol Cancer Ther 19, no. 7 (July 2020): 1448–61. https://doi.org/10.1158/1535-7163.MCT-19-0689.
       Full Text  Open Access Copy  Link to Item
    • Altunel, Erdem, Roham S. Roghani, Kai-Yuan Chen, So Young Kim, Shannon McCall, Kathryn E. Ware, Xiling Shen, Jason A. Somarelli, and David S. Hsu. “Development of a precision medicine pipeline to identify personalized treatments for colorectal cancer.” Bmc Cancer 20, no. 1 (June 24, 2020): 592. https://doi.org/10.1186/s12885-020-07090-y.
       Full Text  Link to Item
    • Gupta, Santosh, Daniel H. Hovelson, Gabor Kemeny, Susan Halabi, Wen-Chi Foo, Monika Anand, Jason A. Somarelli, et al. “Discordant and heterogeneous clinically relevant genomic alterations in circulating tumor cells vs plasma DNA from men with metastatic castration resistant prostate cancer.” Genes Chromosomes Cancer 59, no. 4 (April 2020): 225–39. https://doi.org/10.1002/gcc.22824.
       Full Text  Link to Item
    • Hao, Yue, Hyuk Jin Lee, Michael Baraboo, Katherine Burch, Taylor Maurer, Jason A. Somarelli, and Gavin C. Conant. “Baby Genomics: Tracing the Evolutionary Changes That Gave Rise to Placentation.” Genome Biol Evol 12, no. 3 (March 1, 2020): 35–47. https://doi.org/10.1093/gbe/evaa026.
       Full Text  Link to Item
    • Tuohy, Joanne L., Jason A. Somarelli, Luke B. Borst, William C. Eward, B Duncan X. Lascelles, and Jonathan E. Fogle. “Immune dysregulation and osteosarcoma: Staphylococcus aureus downregulates TGF-β and heightens the inflammatory signature in human and canine macrophages suppressed by osteosarcoma.” Vet Comp Oncol 18, no. 1 (March 2020): 64–75. https://doi.org/10.1111/vco.12529.
       Full Text  Link to Item
    • Somarelli, Jason A., Heather Gardner, Vincent L. Cannataro, Ella F. Gunady, Amy M. Boddy, Norman A. Johnson, Jeffrey Nicholas Fisk, et al. “Molecular Biology and Evolution of Cancer: From Discovery to Action.” Mol Biol Evol 37, no. 2 (February 1, 2020): 320–26. https://doi.org/10.1093/molbev/msz242.
       Full Text  Link to Item
    • Somarelli, Jason A., Amy M. Boddy, Heather L. Gardner, Suzanne Bartholf DeWitt, Joanne Tuohy, Kate Megquier, Maya U. Sheth, et al. “Improving Cancer Drug Discovery by Studying Cancer across the Tree of Life.” Mol Biol Evol 37, no. 1 (January 1, 2020): 11–17. https://doi.org/10.1093/molbev/msz254.
       Full Text  Link to Item
    • Rao, Sneha R., Jason A. Somarelli, Erdem Altunel, Laura E. Selmic, Mark Byrum, Maya U. Sheth, Serene Cheng, et al. “From the Clinic to the Bench and Back Again in One Dog Year: How a Cross-Species Pipeline to Identify New Treatments for Sarcoma Illuminates the Path Forward in Precision Medicine.” Front Oncol 10 (2020): 117. https://doi.org/10.3389/fonc.2020.00117.
       Full Text  Link to Item
    • Yuan, Fuwen, William Hankey, Dayong Wu, Hongyan Wang, Jason Somarelli, Andrew J. Armstrong, Jiaoti Huang, Zhong Chen, and Qianben Wang. “Molecular determinants for enzalutamide-induced transcription in prostate cancer.” Nucleic Acids Res 47, no. 19 (November 4, 2019): 10104–14. https://doi.org/10.1093/nar/gkz790.
       Full Text  Open Access Copy  Link to Item
    • Sheth, M. U., S. K. Kwartler, E. R. Schmaltz, S. M. Hoskinson, E. J. Martz, M. M. Dunphy-Daly, T. F. Schultz, A. J. Read, W. C. Eward, and J. A. Somarelli. “Bioengineering a Future Free of Marine Plastic Waste.” Frontiers in Marine Science 6 (October 11, 2019). https://doi.org/10.3389/fmars.2019.00624.
       Full Text
    • Jolly, Mohit Kumar, Kathryn E. Ware, Shengnan Xu, Shivee Gilja, Samantha Shetler, Yanjun Yang, Xueyang Wang, et al. “E-Cadherin Represses Anchorage-Independent Growth in Sarcomas through Both Signaling and Mechanical Mechanisms.” Mol Cancer Res 17, no. 6 (June 2019): 1391–1402. https://doi.org/10.1158/1541-7786.MCR-18-0763.
       Full Text  Link to Item
    • Palencia-Madrid, Leire, Miriam Baeta, Patricia Villaescusa, Carolina Nuñez, Marian M. de Pancorbo, Javier Rodriguez Luis, Karima Fadhlaoui-Zid, Jason Somarelli, Ralph Garcia-Bertrand, and Rene J. Herrera. “The Marquesans at the fringes of the Austronesian expansion.” Eur J Hum Genet 27, no. 5 (May 2019): 801–10. https://doi.org/10.1038/s41431-019-0336-2.
       Full Text  Link to Item
    • Armstrong, Andrew J., Susan Halabi, Jun Luo, David M. Nanus, Paraskevi Giannakakou, Russell Z. Szmulewitz, Daniel C. Danila, et al. “Prospective Multicenter Validation of Androgen Receptor Splice Variant 7 and Hormone Therapy Resistance in High-Risk Castration-Resistant Prostate Cancer: The PROPHECY Study.” J Clin Oncol 37, no. 13 (May 1, 2019): 1120–29. https://doi.org/10.1200/JCO.18.01731.
       Full Text  Link to Item
    • Lazarides, Alexander L., David L. Kerr, Daniel P. Nussbaum, R Timothy Kreulen, Jason A. Somarelli, Dan G. Blazer, Brian E. Brigman, and William C. Eward. “Soft Tissue Sarcoma of the Extremities: What Is the Value of Treating at High-volume Centers?” Clin Orthop Relat Res 477, no. 4 (April 2019): 718–27. https://doi.org/10.1097/01.blo.0000533623.60399.1b.
       Full Text  Link to Item
    • Xu, Shengnan, Kathryn E. Ware, Yuantong Ding, So Young Kim, Maya U. Sheth, Sneha Rao, Wesley Chan, et al. “An Integrative Systems Biology and Experimental Approach Identifies Convergence of Epithelial Plasticity, Metabolism, and Autophagy to Promote Chemoresistance.” J Clin Med 8, no. 2 (February 7, 2019). https://doi.org/10.3390/jcm8020205.
       Full Text  Link to Item
    • Jolly, Mohit Kumar, Jason A. Somarelli, Maya Sheth, Adrian Biddle, Satyendra C. Tripathi, Andrew J. Armstrong, Samir M. Hanash, Sharmila A. Bapat, Annapoorni Rangarajan, and Herbert Levine. “Hybrid epithelial/mesenchymal phenotypes promote metastasis and therapy resistance across carcinomas.” Pharmacol Ther 194 (February 2019): 161–84. https://doi.org/10.1016/j.pharmthera.2018.09.007.
       Full Text  Link to Item
    • Armstrong, Andrew J., Santosh Gupta, Patrick Healy, Gabor Kemeny, Beth Leith, Michael R. Zalutsky, Charles Spritzer, et al. “Pharmacodynamic study of radium-223 in men with bone metastatic castration resistant prostate cancer.” Plos One 14, no. 5 (2019): e0216934. https://doi.org/10.1371/journal.pone.0216934.
       Full Text  Link to Item
    • George, Jason T., Mohit Kumar Jolly, Shengnan Xu, Jason A. Somarelli, and Herbert Levine. “Survival Outcomes in Cancer Patients Predicted by a Partial EMT Gene Expression Scoring Metric.” Cancer Res 77, no. 22 (November 15, 2017): 6415–28. https://doi.org/10.1158/0008-5472.CAN-16-3521.
       Full Text  Link to Item
    • Jolly, Mohit Kumar, Satyendra C. Tripathi, Jason A. Somarelli, Samir M. Hanash, and Herbert Levine. “Epithelial/mesenchymal plasticity: how have quantitative mathematical models helped improve our understanding?” Mol Oncol 11, no. 7 (July 2017): 739–54. https://doi.org/10.1002/1878-0261.12084.
       Full Text  Link to Item
    • Jolly, Mohit Kumar, Kathryn E. Ware, Shivee Gilja, Jason A. Somarelli, and Herbert Levine. “EMT and MET: necessary or permissive for metastasis?” Mol Oncol 11, no. 7 (July 2017): 755–69. https://doi.org/10.1002/1878-0261.12083.
       Full Text  Link to Item
    • Ware, Kathryn E., Shivee Gilja, Shenghan Xu, Samantha Shetler, Mohit K. Jolly, Xueyang Wang, Suzanne Bartholf Dewitt, et al. “Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells.” J Vis Exp, no. 122 (April 7, 2017). https://doi.org/10.3791/55520.
       Full Text  Link to Item
    • Somarelli, Jason A., Kathryn E. Ware, Rumen Kostadinov, Jeffrey M. Robinson, Hakima Amri, Mones Abu-Asab, Nicolaas Fourie, Rui Diogo, David Swofford, and Jeffrey P. Townsend. “PhyloOncology: Understanding cancer through phylogenetic analysis.” Biochim Biophys Acta Rev Cancer 1867, no. 2 (April 2017): 101–8. https://doi.org/10.1016/j.bbcan.2016.10.006.
       Full Text  Link to Item
    • Gupta, Santosh, Jing Li, Gabor Kemeny, Rhonda L. Bitting, Joshua Beaver, Jason A. Somarelli, Kathryn E. Ware, Simon Gregory, and Andrew J. Armstrong. “Whole Genomic Copy Number Alterations in Circulating Tumor Cells from Men with Abiraterone or Enzalutamide-Resistant Metastatic Castration-Resistant Prostate Cancer.” Clin Cancer Res 23, no. 5 (March 1, 2017): 1346–57. https://doi.org/10.1158/1078-0432.CCR-16-1211.
       Full Text  Link to Item
    • Somarelli, Jason A., Samantha Shetler, Mohit K. Jolly, Xueyang Wang, Suzanne Bartholf Dewitt, Alexander J. Hish, Shivee Gilja, et al. “Mesenchymal-Epithelial Transition in Sarcomas Is Controlled by the Combinatorial Expression of MicroRNA 200s and GRHL2.” Mol Cell Biol 36, no. 19 (October 1, 2016): 2503–13. https://doi.org/10.1128/MCB.00373-16.
       Full Text  Open Access Copy  Link to Item
    • Somarelli, J. A., D. Schaeffer, M. S. Marengo, T. Bepler, D. Rouse, K. E. Ware, A. J. Hish, et al. “Distinct routes to metastasis: plasticity-dependent and plasticity-independent pathways.” Oncogene 35, no. 33 (August 18, 2016): 4302–11. https://doi.org/10.1038/onc.2015.497.
       Full Text  Open Access Copy  Link to Item
    • Ware, Kathryn E., Jason A. Somarelli, Daneen Schaeffer, Jing Li, Tian Zhang, Sally Park, Steven R. Patierno, et al. “Snail promotes resistance to enzalutamide through regulation of androgen receptor activity in prostate cancer.” Oncotarget 7, no. 31 (August 2, 2016): 50507–21. https://doi.org/10.18632/oncotarget.10476.
       Full Text  Open Access Copy  Link to Item
    • Somarelli, Jason A., Mary-Keara Boss, Jonathan I. Epstein, Andrew J. Armstrong, and Mariano A. Garcia-Blanco. “Carcinosarcomas: tumors in transition?” Histol Histopathol 30, no. 6 (June 2015): 673–87. https://doi.org/10.14670/HH-30.673.
       Full Text  Link to Item
    • Schaeffer, Daneen, Jason A. Somarelli, Gabi Hanna, Gregory M. Palmer, and Mariano A. Garcia-Blanco. “Cellular migration and invasion uncoupled: increased migration is not an inexorable consequence of epithelial-to-mesenchymal transition.” Mol Cell Biol 34, no. 18 (September 15, 2014): 3486–99. https://doi.org/10.1128/MCB.00694-14.
       Full Text  Link to Item
    • Bitting, Rhonda L., Daneen Schaeffer, Jason A. Somarelli, Mariano A. Garcia-Blanco, and Andrew J. Armstrong. “The role of epithelial plasticity in prostate cancer dissemination and treatment resistance.” Cancer Metastasis Rev 33, no. 2–3 (September 2014): 441–68. https://doi.org/10.1007/s10555-013-9483-z.
       Full Text  Link to Item
    • Somarelli, Jason A., Annia Mesa, Carol E. Rodriguez, Shalini Sharma, and Rene J. Herrera. “U1 small nuclear RNA variants differentially form ribonucleoprotein particles in vitro.” Gene 540, no. 1 (April 25, 2014): 11–15. https://doi.org/10.1016/j.gene.2014.02.054.
       Full Text  Link to Item
    • Mesa, A., J. A. Somarelli, W. Wu, L. Martinez, M. B. Blom, E. L. Greidinger, and R. J. Herrera. “Differential immunoglobulin class-mediated responses to components of the U1 small nuclear ribonucleoprotein particle in systemic lupus erythematosus and mixed connective tissue disease.” Lupus 22, no. 13 (November 2013): 1371–81. https://doi.org/10.1177/0961203313508444.
       Full Text  Link to Item
    • Somarelli, Jason A., Daneen Schaeffer, Reggie Bosma, Vivian I. Bonano, Jang Wook Sohn, Gabor Kemeny, Abhinav Ettyreddy, and Mariano A. Garcia-Blanco. “Fluorescence-based alternative splicing reporters for the study of epithelial plasticity in vivo.” Rna 19, no. 1 (January 2013): 116–27. https://doi.org/10.1261/rna.035097.112.
       Full Text  Link to Item
    • Somarelli, J. A., A. Mesa, R. Rodriguez, R. Avellan, L. Martinez, Y. J. Zang, E. L. Greidinger, and R. J. Herrera. “Epitope mapping of the U1 small nuclear ribonucleoprotein particle in patients with systemic lupus erythematosus and mixed connective tissue disease.” Lupus 20, no. 3 (March 2011): 274–89. https://doi.org/10.1177/0961203310387180.
       Full Text  Link to Item
    • Somarelli, Jason A., Annia Mesa, Myron E. Fuller, Jacqueline O. Torres, Carol E. Rodriguez, Christina M. Ferrer, and Rene J. Herrera. “Genome-based identification of spliceosomal proteins in the silk moth Bombyx mori.” Arch Insect Biochem Physiol 75, no. 4 (December 2010): 231–63. https://doi.org/10.1002/arch.20390.
       Full Text  Link to Item
    • Evsyukova, Irina, Jason A. Somarelli, Simon G. Gregory, and Mariano A. Garcia-Blanco. “Alternative splicing in multiple sclerosis and other autoimmune diseases.” Rna Biol 7, no. 4 (July 2010): 462–73. https://doi.org/10.4161/rna.7.4.12301.
       Full Text  Open Access Copy  Link to Item
    • Herrera, Kristian J., Jason A. Somarelli, Robert K. Lowery, and Rene J. Herrera. “To what extent did Neanderthals and modern humans interact?” Biol Rev Camb Philos Soc 84, no. 2 (May 2009): 245–57. https://doi.org/10.1111/j.1469-185x.2008.00071.x.
       Full Text  Link to Item
    • Somarelli, J. A., A. Mesa, S. S. Smail, A. L. Ares, and R. J. Herrera. “U2 snRNA variants are differentially incorporated into spliceosomes.” Entomological Research 39, no. 2 (March 1, 2009): 135–45. https://doi.org/10.1111/j.1748-5967.2009.00211.x.
       Full Text
    • Mesa, Annia, Jason A. Somarelli, and Rene J. Herrera. “Spliceosomal immunophilins.” Febs Lett 582, no. 16 (July 9, 2008): 2345–51. https://doi.org/10.1016/j.febslet.2008.06.006.
       Full Text  Link to Item
    • Somarelli, J. A., S. Y. Lee, J. Skolnick, and R. J. Herrera. “Structure-based classification of 45 FK506-binding proteins.” Proteins 72, no. 1 (July 2008): 197–208. https://doi.org/10.1002/prot.21908.
       Full Text  Link to Item
    • Mesa, A., J. A. Somarelli, and R. J. Herrera. “Small nuclear RNA variants of three Bombyx mori strains.” Entomological Research 38, no. 1 (March 1, 2008): 61–68. https://doi.org/10.1111/j.1748-5967.2008.00131.x.
       Full Text
    • Somarelli, J. A., J. L. Coll, A. Velandia, L. Martinez, and R. J. Herrera. “Characterization of immunophilins in the silkmoth Bombyx mori.” Arch Insect Biochem Physiol 65, no. 4 (August 2007): 195–209. https://doi.org/10.1002/arch.20177.
       Full Text  Link to Item
    • Somarelli, Jason A., and Rene J. Herrera. “Evolution of the 12 kDa FK506-binding protein gene.” Biol Cell 99, no. 6 (June 2007): 311–21. https://doi.org/10.1042/BC20060125.
       Full Text  Link to Item
    • Somarelli, J. A., J. C. Makarewicz, R. Sia, and R. Simon. “Wildlife identified as major source of Escherichia coli in agriculturally dominated watersheds by BOX A1R-derived genetic fingerprints.” J Environ Manage 82, no. 1 (January 2007): 60–65. https://doi.org/10.1016/j.jenvman.2005.12.013.
       Full Text  Link to Item
    • Blawas, Ashley M., Kathryn E. Ware, Emma Schmaltz, Larry Zheng, Jake Spruance, Austin S. Allen, Nicole West, et al. “An integrated comparative physiology and molecular approach pinpoints mediators of breath-hold capacity in dolphins,” n.d. https://doi.org/10.1101/2021.01.20.425775.
       Full Text

  • Book Sections

    • Somarelli, J. A., A. J. Armstrong, M. U. Sheth, K. E. Ware, and M. K. Jolly. “Phenotypic plasticity and lineage switching in prostate cancer.” In Phenotypic Switching: Implications in Biology and Medicine, 591–615, 2020. https://doi.org/10.1016/B978-0-12-817996-3.00021-9.
       Full Text

  • Conference Papers

    • Patierno, Brendon M., Wen-Chi Foo, Tyler Allen, Jason A. Somarelli, Kathryn E. Ware, Santosh Gupta, Sandra Wise, et al. “Characterization of a castrate-resistant prostate cancer xenograft derived from a patient of West African ancestry.” In Prostate Cancer Prostatic Dis, 2021. https://doi.org/10.1038/s41391-021-00460-y.
       Full Text  Open Access Copy  Link to Item
• Teaching & Mentoring
• 

  Recent Courses

  • BIOLOGY 293: Research Independent Study 2022
  • BIOLOGY 493: Research Independent Study 2022
  • ENERGY 395: Connections in Energy: Interdisciplinary Team Projects 2022
  • ENERGY 396: Connections in Energy: Interdisciplinary Team Projects 2022
  • ENERGY 795: Connections in Energy: Interdisciplinary Team Projects 2022
  • ENERGY 796: Connections in Energy: Interdisciplinary Team Projects 2022
  • K_INDSTU 391: Independent Study 2022
  • BIOLOGY 278LA: Comparative Physiology of Marine Animals 2021
  • BIOLOGY 293: Research Independent Study 2021
  • BIOLOGY 293A: Research Independent Study 2021
  • BIOLOGY 493: Research Independent Study 2021
  • BIOLOGY 778LA: Comparative Physiology of Marine Animals 2021
  • ENERGY 395: Connections in Energy: Interdisciplinary Team Projects 2021
  • ENERGY 396: Connections in Energy: Interdisciplinary Team Projects 2021
  • ENERGY 795: Connections in Energy: Interdisciplinary Team Projects 2021
  • ENERGY 796: Connections in Energy: Interdisciplinary Team Projects 2021
  • ENVIRON 278LA: Comparative Physiology of Marine Animals 2021
  • ENVIRON 778LA: Comparative Physiology of Marine Animals 2021
  • K_RINDST 393: Research Independent Study 2021
  • BIOLOGY 278L: Comparative Physiology of Marine Animals 2020
  • BIOLOGY 293A: Research Independent Study 2020
  • ENERGY 395: Connections in Energy: Interdisciplinary Team Projects 2020
  • ENERGY 396: Connections in Energy: Interdisciplinary Team Projects 2020
  • ENERGY 795: Connections in Energy: Interdisciplinary Team Projects 2020
  • ENERGY 796: Connections in Energy: Interdisciplinary Team Projects 2020
  • ENVIRON 278L: Comparative Physiology of Marine Animals 2020
• Scholarly, Clinical, & Service Activities
• 

  Outreach & Engaged Scholarship

  • Bass Connections Team Leader. Bioremediating Plastic Pollution to Conserve Marine Biodiversity. 2021 - 2022  2021 - 2022
  • Bass Connections Team Leader. Learning from Whales: Oxygen, Ecosystems and Human Health. 2020 - 2021  2020 - 2021
  • Bass Connections Team Leader. Bioremediation of Plastic Pollution to Conserve Marine Biodiversity. 2019 - 2020  2019 - 2020

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.