Jason Andrew Somarelli
Assistant Professor in Medicine
Current Appointments & Affiliations
- Assistant Professor in Medicine, Medicine, Medical Oncology, Medicine 2020
- Assistant Professor, Marine Science and Conservation, Nicholas School of the Environment 2018
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2017
Contact Information
- 3044 Gsrbi, Lasalle Street, Durham, NC 27710
- Box 3053, Durham, NC 27710
-
jason.somarelli@duke.edu
(919) 681-9604
- Background
-
Education, Training, & Certifications
- Ph.D., Florida International University 2009
-
Duke Appointment History
- Medical Instructor in the Department of Medicine, Medicine, Medical Oncology, Medicine 2017 - 2019
- Recognition
-
In the News
-
AUG 27, 2019 School of Medicine Magnify Magazine
-
- Research
-
Selected Grants
- Targeting convergent oncogenic signaling during AR inhibition to overcome metastasis and immune evasion in prostate cancer awarded by National Institutes of Health 2019 - 2024
- Targeting convergent mechanisms of castration resistant prostate cancer therapy resistance, metastasis, and immune evasion with AR-LDDs 2019 - 2022
- Targeting the p38/Snail/PD-L1 axis in hormone-therapy resistance and metastasis awarded by Department of Defense 2018 - 2021
- An integrated comparative physiology and genomics approach to understand dolphin adaptation to hypoxia 2020 - 2021
- An integrated comparative physiology and genomics approach to understand dolphin adaptation to hypoxia 2020 - 2021
- Bioengineering Plastic-Degrading Microbes To Eliminate Plastic Waste 2018 - 2020
- Targeting Convergent Mechanisms of Therapy Resistance, Metastasis, and Immune Evasion with CBP inhibitors 2018 - 2020
- Validation and interrogation of differentially expressed and alternatively spliced genes in African American prostate ca awarded by Department of Defense 2014 - 2020
- Development of Circulating Molecular Predictors of Chemotherapy and Novel Hormonal Therapy Benefit in Men with Metastatic Castration Resistant Prostate Cancer (mCRPC) 2014 - 2020
- Marine Mammals Point the Way Toward New Therapies to Prevent Hypoxia 2019 - 2020
- Scholars in Marine Medicine: Mentored Research at the Nexus of the Marine Environment and Human Health. 2019 - 2020
- Testing the efficacy of AR degrading compounds in enzalutamide-resistant prostate cancer 2017 - 2019
- Publications & Artistic Works
-
Selected Publications
-
Academic Articles
-
Gupta, Santosh, Daniel H. Hovelson, Gabor Kemeny, Susan Halabi, Wen-Chi Foo, Monika Anand, Jason A. Somarelli, et al. “Discordant and heterogeneous clinically relevant genomic alterations in circulating tumor cells vs plasma DNA from men with metastatic castration resistant prostate cancer.” Genes Chromosomes Cancer 59, no. 4 (April 2020): 225–39. https://doi.org/10.1002/gcc.22824.Full Text Link to Item
-
Tuohy, Joanne L., Jason A. Somarelli, Luke B. Borst, William C. Eward, B Duncan X. Lascelles, and Jonathan E. Fogle. “Immune dysregulation and osteosarcoma: Staphylococcus aureus downregulates TGF-β and heightens the inflammatory signature in human and canine macrophages suppressed by osteosarcoma.” Vet Comp Oncol 18, no. 1 (March 2020): 64–75. https://doi.org/10.1111/vco.12529.Full Text Link to Item
-
Yuan, Fuwen, William Hankey, Dayong Wu, Hongyan Wang, Jason Somarelli, Andrew J. Armstrong, Jiaoti Huang, Zhong Chen, and Qianben Wang. “Molecular determinants for enzalutamide-induced transcription in prostate cancer.” Nucleic Acids Res 47, no. 19 (November 4, 2019): 10104–14. https://doi.org/10.1093/nar/gkz790.Full Text Open Access Copy Link to Item
-
Sheth, M. U., S. K. Kwartler, E. R. Schmaltz, S. M. Hoskinson, E. J. Martz, M. M. Dunphy-Daly, T. F. Schultz, A. J. Read, W. C. Eward, and J. A. Somarelli. “Bioengineering a Future Free of Marine Plastic Waste.” Frontiers in Marine Science 6 (October 11, 2019). https://doi.org/10.3389/fmars.2019.00624.Full Text
-
Jolly, Mohit Kumar, Kathryn E. Ware, Shengnan Xu, Shivee Gilja, Samantha Shetler, Yanjun Yang, Xueyang Wang, et al. “E-Cadherin Represses Anchorage-Independent Growth in Sarcomas through Both Signaling and Mechanical Mechanisms.” Mol Cancer Res 17, no. 6 (June 2019): 1391–1402. https://doi.org/10.1158/1541-7786.MCR-18-0763.Full Text Link to Item
-
Armstrong, Andrew J., Susan Halabi, Jun Luo, David M. Nanus, Paraskevi Giannakakou, Russell Z. Szmulewitz, Daniel C. Danila, et al. “Prospective Multicenter Validation of Androgen Receptor Splice Variant 7 and Hormone Therapy Resistance in High-Risk Castration-Resistant Prostate Cancer: The PROPHECY Study.” J Clin Oncol 37, no. 13 (May 1, 2019): 1120–29. https://doi.org/10.1200/JCO.18.01731.Full Text Link to Item
-
Lazarides, Alexander L., David L. Kerr, Daniel P. Nussbaum, R Timothy Kreulen, Jason A. Somarelli, Dan G. Blazer, Brian E. Brigman, and William C. Eward. “Soft Tissue Sarcoma of the Extremities: What Is the Value of Treating at High-volume Centers?” Clin Orthop Relat Res 477, no. 4 (April 2019): 718–27. https://doi.org/10.1097/01.blo.0000533623.60399.1b.Full Text Link to Item
-
Xu, Shengnan, Kathryn E. Ware, Yuantong Ding, So Young Kim, Maya U. Sheth, Sneha Rao, Wesley Chan, et al. “An Integrative Systems Biology and Experimental Approach Identifies Convergence of Epithelial Plasticity, Metabolism, and Autophagy to Promote Chemoresistance.” J Clin Med 8, no. 2 (February 7, 2019). https://doi.org/10.3390/jcm8020205.Full Text Link to Item
-
Jolly, Mohit Kumar, Jason A. Somarelli, Maya Sheth, Adrian Biddle, Satyendra C. Tripathi, Andrew J. Armstrong, Samir M. Hanash, Sharmila A. Bapat, Annapoorni Rangarajan, and Herbert Levine. “Hybrid epithelial/mesenchymal phenotypes promote metastasis and therapy resistance across carcinomas.” Pharmacol Ther 194 (February 2019): 161–84. https://doi.org/10.1016/j.pharmthera.2018.09.007.Full Text Link to Item
-
Armstrong, Andrew J., Santosh Gupta, Patrick Healy, Gabor Kemeny, Beth Leith, Michael R. Zalutsky, Charles Spritzer, et al. “Pharmacodynamic study of radium-223 in men with bone metastatic castration resistant prostate cancer.” Plos One 14, no. 5 (2019): e0216934. https://doi.org/10.1371/journal.pone.0216934.Full Text Link to Item
-
George, Jason T., Mohit Kumar Jolly, Shengnan Xu, Jason A. Somarelli, and Herbert Levine. “Survival Outcomes in Cancer Patients Predicted by a Partial EMT Gene Expression Scoring Metric.” Cancer Res 77, no. 22 (November 15, 2017): 6415–28. https://doi.org/10.1158/0008-5472.CAN-16-3521.Full Text Link to Item
-
Jolly, Mohit Kumar, Kathryn E. Ware, Shivee Gilja, Jason A. Somarelli, and Herbert Levine. “EMT and MET: necessary or permissive for metastasis?” Molecular Oncology 11, no. 7 (July 2017): 755–69. https://doi.org/10.1002/1878-0261.12083.Full Text
-
Jolly, Mohit Kumar, Satyendra C. Tripathi, Jason A. Somarelli, Samir M. Hanash, and Herbert Levine. “Epithelial/mesenchymal plasticity: how have quantitative mathematical models helped improve our understanding?” Molecular Oncology 11, no. 7 (July 2017): 739–54. https://doi.org/10.1002/1878-0261.12084.Full Text
-
Ware, Kathryn E., Shivee Gilja, Shenghan Xu, Samantha Shetler, Mohit K. Jolly, Xueyang Wang, Suzanne Bartholf Dewitt, et al. “Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells.” Journal of Visualized Experiments : Jove, no. 122 (April 7, 2017). https://doi.org/10.3791/55520.Full Text
-
Somarelli, Jason A., Kathryn E. Ware, Rumen Kostadinov, Jeffrey M. Robinson, Hakima Amri, Mones Abu-Asab, Nicolaas Fourie, Rui Diogo, David Swofford, and Jeffrey P. Townsend. “PhyloOncology: Understanding cancer through phylogenetic analysis.” Biochim Biophys Acta Rev Cancer 1867, no. 2 (April 2017): 101–8. https://doi.org/10.1016/j.bbcan.2016.10.006.Full Text Link to Item
-
Gupta, Santosh, Jing Li, Gabor Kemeny, Rhonda L. Bitting, Joshua Beaver, Jason A. Somarelli, Kathryn E. Ware, Simon Gregory, and Andrew J. Armstrong. “Whole Genomic Copy Number Alterations in Circulating Tumor Cells from Men with Abiraterone or Enzalutamide-Resistant Metastatic Castration-Resistant Prostate Cancer.” Clin Cancer Res 23, no. 5 (March 1, 2017): 1346–57. https://doi.org/10.1158/1078-0432.CCR-16-1211.Full Text Link to Item
-
Somarelli, Jason A., Samantha Shetler, Mohit K. Jolly, Xueyang Wang, Suzanne Bartholf Dewitt, Alexander J. Hish, Shivee Gilja, et al. “Mesenchymal-Epithelial Transition in Sarcomas Is Controlled by the Combinatorial Expression of MicroRNA 200s and GRHL2.” Mol Cell Biol 36, no. 19 (October 1, 2016): 2503–13. https://doi.org/10.1128/MCB.00373-16.Full Text Open Access Copy Link to Item
-
Somarelli, J. A., D. Schaeffer, M. S. Marengo, T. Bepler, D. Rouse, K. E. Ware, A. J. Hish, et al. “Distinct routes to metastasis: plasticity-dependent and plasticity-independent pathways.” Oncogene 35, no. 33 (August 18, 2016): 4302–11. https://doi.org/10.1038/onc.2015.497.Full Text Open Access Copy Link to Item
-
Ware, Kathryn E., Jason A. Somarelli, Daneen Schaeffer, Jing Li, Tian Zhang, Sally Park, Steven R. Patierno, et al. “Snail promotes resistance to enzalutamide through regulation of androgen receptor activity in prostate cancer.” Oncotarget 7, no. 31 (August 2, 2016): 50507–21. https://doi.org/10.18632/oncotarget.10476.Full Text Open Access Copy Link to Item
-
Somarelli, Jason A., Mary-Keara Boss, Jonathan I. Epstein, Andrew J. Armstrong, and Mariano A. Garcia-Blanco. “Carcinosarcomas: tumors in transition?” Histol Histopathol 30, no. 6 (June 2015): 673–87. https://doi.org/10.14670/HH-30.673.Full Text Link to Item
-
Schaeffer, Daneen, Jason A. Somarelli, Gabi Hanna, Gregory M. Palmer, and Mariano A. Garcia-Blanco. “Cellular migration and invasion uncoupled: increased migration is not an inexorable consequence of epithelial-to-mesenchymal transition.” Mol Cell Biol 34, no. 18 (September 15, 2014): 3486–99. https://doi.org/10.1128/MCB.00694-14.Full Text Link to Item
-
Bitting, Rhonda L., Daneen Schaeffer, Jason A. Somarelli, Mariano A. Garcia-Blanco, and Andrew J. Armstrong. “The role of epithelial plasticity in prostate cancer dissemination and treatment resistance.” Cancer Metastasis Rev 33, no. 2–3 (September 2014): 441–68. https://doi.org/10.1007/s10555-013-9483-z.Full Text Link to Item
-
Somarelli, Jason A., Annia Mesa, Carol E. Rodriguez, Shalini Sharma, and Rene J. Herrera. “U1 small nuclear RNA variants differentially form ribonucleoprotein particles in vitro.” Gene 540, no. 1 (April 25, 2014): 11–15. https://doi.org/10.1016/j.gene.2014.02.054.Full Text Link to Item
-
Somarelli, Jason A., Daneen Schaeffer, Reggie Bosma, Vivian I. Bonano, Jang Wook Sohn, Gabor Kemeny, Abhinav Ettyreddy, and Mariano A. Garcia-Blanco. “Fluorescence-based alternative splicing reporters for the study of epithelial plasticity in vivo.” Rna 19, no. 1 (January 2013): 116–27. https://doi.org/10.1261/rna.035097.112.Full Text Link to Item
-
Evsyukova, Irina, Jason A. Somarelli, Simon G. Gregory, and Mariano A. Garcia-Blanco. “Alternative splicing in multiple sclerosis and other autoimmune diseases.” Rna Biol 7, no. 4 (July 2010): 462–73. https://doi.org/10.4161/rna.7.4.12301.Full Text Open Access Copy Link to Item
-
-
- Teaching & Mentoring
-
Recent Courses
- BIOLOGY 278LA: Comparative Physiology of Marine Animals 2020
- ENERGY 395: Connections in Energy: Interdisciplinary Team Projects 2020
- ENERGY 396: Connections in Energy: Interdisciplinary Team Projects 2020
- ENERGY 795: Connections in Energy: Interdisciplinary Team Projects 2020
- ENERGY 796: Connections in Energy: Interdisciplinary Team Projects 2020
- ENVIRON 278LA: Comparative Physiology of Marine Animals 2020
Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.
