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Jason Andrew Somarelli
Assistant Professor in Medicine
Medicine, Medical Oncology
jason.somarelli@duke.edu
Box 3053, Durham, NC 27710
3044 GSRBI, LaSalle Street, Durham, NC 27710
Research
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At a Glance
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Credentials
Education
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Academic Experience
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Expertise
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Research
Selected Grants
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Publications
Selected Publications
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Teaching
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Advising & Mentoring
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Selected Grants
GCR: The other plastic problem: quantifying and predicting impacts of plastic additives across levels of biological and social organization
Research
Principal Investigator ·
Awarded by National Science Foundation ·
2024 - 2029
Mitochondrial bioenergetics and colorectal cancer
Research
Principal Investigator ·
Awarded by Wake Forest University School Of Medicine ·
2024 - 2029
Inhibiting Rev1-mediated DNA translesion synthesis for cancer therapy
Research
Co Investigator ·
Awarded by National Cancer Institute ·
2024 - 2028
The Duke Preparing Research scholars In bioMEdical sciences (PRIME): Cancer Research Program
Research
Co-Principal Investigator ·
Awarded by National Cancer Institute ·
2023 - 2028
The other plastic problem: weathering and plastic additives synergize to impact organismal health
Research
Principal Investigator ·
Awarded by Underwriters Laboratories Inc. ·
2025 - 2028
XPO1 and proteasome inhibition as a novel therapeutic combination in osteosarcoma
Research
Co Investigator ·
Awarded by The Paula Takacs Foundation For Sarcoma Research ·
2026 - 2027
Amgen Scholars Program at Duke Year 3-4
Inst. Training Prgm or CME
Principal Investigator ·
Awarded by Amgen Foundation, Inc. ·
2025 - 2027
Duke Preparing Research Scholars in Biomedical Sciences- Post-Baccalaureate Research Education Program
Inst. Training Prgm or CME
Mentor ·
Awarded by National Institute of General Medical Sciences ·
2022 - 2027
Validation of the CREB binding protein inhibitor, Pocenbrodib, as a novel therapy for advanced, hormone therapy-resistant prostate cancer
Research
Principal Investigator ·
Awarded by Pathos AI, Inc. ·
2023 - 2026
Defining the molecular physiologic impacts of stress on beaked whale hypoxia tolerance: implications for behavioral response
Research
Principal Investigator ·
Awarded by Office of Naval Research ·
2022 - 2026
Multi-scale physiological and behavioral responses of bottlenose dolphin to novel anthropogenic sounds
Research
Principal Investigator ·
Awarded by Dolphin Quest ·
2024 - 2025
Therapeutic Targeting of The Long Noncoding RNA SCHLAP1 in Aggressive Prostate Cancer
Research
Co-Principal Investigator ·
Awarded by National Institutes of Health ·
2023 - 2025
Identifying novel CRM1 inhibitor combination therapies to treat sarcomas
Research
Principal Investigator ·
Awarded by Karyopharm Therapeutics ·
2021 - 2025
Amgen Scholars Program at Duke
Inst. Training Prgm or CME
Principal Investigator ·
Awarded by Amgen Foundation, Inc. ·
2023 - 2025
Targeting convergent oncogenic signaling during AR inhibition to overcome metastasis and immune evasion in prostate cancer
Research
Co-Principal Investigator ·
Awarded by National Institutes of Health ·
2019 - 2025
An integrated physiology and genomics analysis to define molecular adaptations to diving
Research
Principal Investigator ·
Awarded by Dolphin Quest ·
2024 - 2025
Modeling tumor heterogeneity and therapy resistance in osteosarcoma using patient-derived organoids
Research
Co Investigator ·
Awarded by Hyundai Hope on Wheels ·
2021 - 2024
Targeting convergent mechanisms of castration resistant prostate cancer therapy resistance, metastasis, and immune evasion with AR-LDDs
Research
Principal Investigator ·
Awarded by Celgene Corporation ·
2019 - 2024
DIRECT - Diversifying Research and Experiential Learning in Cancer Training
Inst. Training Prgm or CME
Co-Project Leader ·
Awarded by Emerson Collective ·
2021 - 2024
Mitochondrial bioenergetics and colorectal cancer
Research
Principal Investigator ·
Awarded by East Carolina University ·
2024 - 2024
Evaluating the preclinical efficacy of multi-tyrosine kinase inhibitor TT-00420 in hormone therapy-resistant prostate cancer
Research
Principal Investigator ·
Awarded by TransThera Biosciences Co. Ltd ·
2024 - 2024
Investigating the role of LCP1 in metastatic progression of chondrosarcoma
Research
Significant Contributor ·
Awarded by The Musculoskeletal Tumor Society ·
2022 - 2023
Dolphin Quest: An integrated comparative physiology and genomics approach to understand dolphin adaptation to hypoxia
Research
Principal Investigator ·
Awarded by Dolphin Quest ·
2020 - 2023
Dolphin Quest: Scholars - An integrated comparative physiology and genomics approach to understand dolphin adaptation to hypoxia
Research
Principal Investigator ·
Awarded by Dolphin Quest ·
2020 - 2023
Systems Analysis of Epigenomic Architecture in Cancer Progression (Outreach Core)
Research
Core Leader ·
Awarded by University of Texas Health Science Center at San Antonio ·
2019 - 2023
The Duke University Marine Laboratory Scholars Program: Enhancing mentored research experiences for undergraduates
Research
Principal Investigator ·
Awarded by Henry David Thoreau Foundation ·
2021 - 2022
Targeting Convergent Mechanisms of Therapy Resistance, Metastasis, and Immune Evasion with CBP inhibitors
Research
Principal Investigator ·
Awarded by FORMA Therapeutics, Inc. ·
2020 - 2022
Targeting the p38/Snail/PD-L1 axis in hormone-therapy resistance and metastasis
Research
Principal Investigator ·
Awarded by Department of Defense ·
2018 - 2022
Bioengineering Plastic-Degrading Microbes To Eliminate Plastic Waste
Research
Principal Investigator ·
Awarded by SeaWorld & Busch Gardens Conservation Fund ·
2018 - 2020
Validation and interrogation of differentially expressed and alternatively spliced genes in African American prostate cancer
Research
Postdoctoral Associate ·
Awarded by Department of Defense ·
2014 - 2020
Development of Circulating Molecular Predictors of Chemotherapy and Novel Hormonal Therapy Benefit in Men with Metastatic Castration Resistant Prostate Cancer (mCRPC)
Research
Post Doctoral Trainee ·
Awarded by Prostate Cancer Foundation ·
2014 - 2020
Scholars in Marine Medicine: Mentored Research at the Nexus of the Marine Environment and Human Health.
Research
Principal Investigator ·
Awarded by Dolphin Quest ·
2019 - 2020
Marine Mammals Point the Way Toward New Therapies to Prevent Hypoxia
Research
Principal Investigator ·
Awarded by Dolphin Quest ·
2019 - 2020
Testing the efficacy of AR degrading compounds in enzalutamide-resistant prostate cancer
Research
Principal Investigator ·
Awarded by Arvinas Inc. ·
2017 - 2019
