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Jenna Nicole McNeill

Assistant Professor of Medicine
Medicine, Pulmonary, Allergy, and Critical Care Medicine
Box 90978, Durham, NC 27708-0978
315 Trent Drive, Box 102352, Durham, NC 27710

Selected Publications

Uncovering Unrecognized Heart Failure With Preserved Ejection Fraction Among Individuals With Obesity and Dyspnea.

Journal Article Circ Heart Fail · May 2024 BACKGROUND: Although heart failure with preserved ejection fraction (HFpEF) has become the predominant heart failure subtype, it remains clinically under-recognized. HFpEF diagnosis is particularly challenging in the setting of obesity given the limitation ... Full text Link to item Cite

Obesity-Related Biomarkers Are Associated With Exercise Intolerance and HFpEF.

Journal Article Circ Heart Fail · November 2023 BACKGROUND: Obesity and adiposity are associated with an increased risk of heart failure with preserved ejection fraction (HFpEF); yet, specific underlying mechanisms remain unclear. We sought to examine the association of obesity-related biomarkers includ ... Full text Link to item Cite

The association of eicosanoids and eicosanoid-related metabolites with pulmonary hypertension.

Journal Article Eur Respir J · October 2023 BACKGROUND: Eicosanoids are bioactive lipids that regulate systemic inflammation and exert vasoactive effects. Specific eicosanoid metabolites have previously been associated with pulmonary hypertension (PH), yet their role remains incompletely understood. ... Full text Link to item Cite

Identifying high risk clinical phenogroups of pulmonary hypertension through a clustering analysis.

Journal Article PLoS One · 2023 INTRODUCTION: The classification and management of pulmonary hypertension (PH) is challenging due to clinical heterogeneity of patients. We sought to identify distinct multimorbid phenogroups of patients with PH that are at particularly high-risk for adver ... Full text Link to item Cite

The association of lung function and pulmonary vasculature volume with cardiorespiratory fitness in the community.

Journal Article Eur Respir J · August 2022 BACKGROUND: Cardiorespiratory fitness is not limited by pulmonary mechanical reasons in the majority of adults. However, the degree to which lung function contributes to exercise response patterns among ostensibly healthy individuals remains unclear. METHO ... Full text Link to item Cite

Plasma Proteomics of COVID-19–Associated Cardiovascular Complications: Implications for Pathophysiology and Therapeutics

Journal Article JACC: Basic to Translational Science · May 1, 2022 To gain insights into the mechanisms driving cardiovascular complications in COVID-19, we performed a case-control plasma proteomics study in COVID-19 patients. Our results identify the senescence-associated secretory phenotype, a marker of biological agin ... Full text Cite

Association of Pulmonary Artery Pulsatility Index With Adverse Cardiovascular Events Across a Hospital-Based Sample.

Journal Article Circ Heart Fail · February 2022 BACKGROUND: The pulmonary artery pulsatility index (PAPi), calculated from the ratio of the pulmonary artery pulse pressure to right atrial pressure, is a predictor of right ventricular failure after inferior myocardial infarction and left ventricular assi ... Full text Link to item Cite

Association of 71 cardiovascular disease-related plasma proteins with pulmonary function in the community.

Journal Article PLoS One · 2022 RATIONALE: It has been speculated that shared mechanisms underlie respiratory and cardiovascular diseases (CVD) including systemic inflammation or mutual risk factors. In this context, we sought to examine the associations of CVD-related plasma proteins wi ... Full text Link to item Cite

Association of obesity-related inflammatory pathways with lung function and exercise capacity.

Journal Article Respir Med · July 2021 BACKGROUND: Obesity has multifactorial effects on lung function and exercise capacity. The contributions of obesity-related inflammatory pathways to alterations in lung function remain unclear. RESEARCH QUESTION: To examine the association of obesity-relat ... Full text Link to item Cite

Monitoring and Management of Acute Pulmonary Embolism

Chapter · January 1, 2021 Acute pulmonary embolism (PE) is a commonly encountered medical condition that can lead to right ventricle compromise, systemic hypotension, and hemodynamic collapse. Early recognition of intermediate and high-risk PEs can help to reduce the likelihood of ... Full text Cite

Sex differences in inflammatory markers in patients hospitalized with COVID-19 infection: Insights from the MGH COVID-19 patient registry.

Journal Article PLoS One · 2021 BACKGROUND: Men are at higher risk for serious complications related to COVID-19 infection than women. More robust immune activation in women has been proposed to contribute to decreased disease severity, although systemic inflammation has been associated ... Full text Link to item Cite

The role of obesity in inflammatory markers in COVID-19 patients.

Journal Article Obes Res Clin Pract · 2021 Obesity has emerged as a significant risk factor for severe COVID-19 worldwide. Given both COVID-19 infection and obesity have been associated with increased systemic inflammation, we evaluated inflammatory markers in obese and non-obese individuals hospit ... Full text Link to item Cite

Advances in Interstitial Lung Disease Genetics.

Journal Article Am J Respir Crit Care Med · July 15, 2019 Full text Link to item Cite

Conditional Macrophage Depletion Increases Inflammation and Does Not Inhibit the Development of Osteoarthritis in Obese Macrophage Fas-Induced Apoptosis-Transgenic Mice.

Journal Article Arthritis Rheumatol · September 2017 OBJECTIVE: To investigate whether short-term, systemic depletion of macrophages can mitigate osteoarthritis (OA) following injury in the setting of obesity. METHODS: CSF-1R-GFP+ macrophage Fas-induced apoptosis (MaFIA)-transgenic mice that allow conditiona ... Full text Link to item Cite

Dietary fatty acid content regulates wound repair and the pathogenesis of osteoarthritis following joint injury.

Journal Article Ann Rheum Dis · November 2015 OBJECTIVE: The mechanisms linking obesity and osteoarthritis (OA) are not fully understood and have been generally attributed to increased weight, rather than metabolic or inflammatory factors. Here, we examined the influence of fatty acids, adipokines, an ... Full text Link to item Cite

Life-long caloric restriction does not alter the severity of age-related osteoarthritis.

Journal Article Age (Dordr) · 2014 Chronic adipose tissue inflammation and its associated adipokines have been linked to the development of osteoarthritis (OA). It has been shown that caloric restriction may decrease body mass index and adiposity. The objectives of this study were to invest ... Full text Link to item Cite