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Jennifer B Gilner

Assistant Professor of Obstetrics and Gynecology
Obstetrics and Gynecology, Maternal Fetal Medicine
DUMC 3967, Durham, NC 27710
2608 Erwin Rd., Suite 200, Durham, NC 27710

Selected Publications


Predictors of Breastfeeding among Patients Admitted with Preterm Prelabor Rupture of Membranes.

Conference Am J Perinatol · May 2024 OBJECTIVE: We sought to describe rates of breastmilk feeding (BF) at hospital discharge and 6 weeks postpartum and to identify risk factors for noninitiation or cessation among pregnancies complicated by preterm prelabor rupture of membranes (PPROM). STUDY ... Full text Link to item Cite

Delivery outcomes in the subsequent pregnancy following the conservative management of placenta accreta spectrum disorder: a systematic review and meta-analysis.

Journal Article Am J Obstet Gynecol · May 2024 OBJECTIVE: Cesarean hysterectomy is generally presumed to decrease maternal morbidity and mortality secondary to placenta accreta spectrum disorder. Recently, uterine-sparing techniques have been introduced in conservative management of placenta accreta sp ... Full text Link to item Cite

CT-001, a novel fast-clearing factor VIIa, enhanced the hemostatic activity in postpartum samples.

Journal Article Blood Adv · January 23, 2024 The hemostatic system is upregulated to protect pregnant mothers from hemorrhage during childbirth. Studies of the details just before and after delivery, however, are lacking. Recombinant factor VIIa (rFVIIa) has recently been granted approval by the Euro ... Full text Link to item Cite

The association of placental pathology and neurodevelopmental outcomes in patients with neonatal encephalopathy.

Journal Article Pediatr Res · November 2023 BACKGROUND: Studies conflict on how acute versus chronic placental pathology impacts outcomes after neonatal encephalopathy from presumed hypoxic-ischemic encephalopathy (HIE). We examine how outcomes after presumed HIE vary by placental pathology categori ... Full text Link to item Cite

Validation of a sonographic checklist for the detection of histologic placenta accreta spectrum.

Journal Article Am J Obstet Gynecol MFM · August 2023 Featured Publication BACKGROUND: To standardize research terminology and to reduce unanticipated placenta accreta spectrum, the European Working Group for Abnormally Invasive Placenta developed a consensus checklist for reporting suspected placenta accreta spectrum observed du ... Full text Link to item Cite

Knowledge Gaps in Placenta Accreta Spectrum.

Journal Article Am J Perinatol · July 2023 Since its first description early in the 20th Century, placenta accreta and its variants have changed substantially in incidence, risk factor profile, clinical presentation, diagnosis and management. While systematic use of diagnostic tools and a multidisc ... Full text Link to item Cite

Graduate and Continuing Medical Education of Placenta Accreta Spectrum.

Journal Article Am J Perinatol · July 2023 Surgical training experience in obstetrics-gynecology (OB-GYN) residency and fellowship training, particularly in open abdominal surgeries has declined over the last 2 decades. This is due, in part, due to a universal trend toward non-invasive treatments f ... Full text Link to item Cite

Placenta Accreta Spectrum.

Journal Article Obstet Gynecol · July 1, 2023 Featured Publication Placenta accreta spectrum (PAS) is one of the most dangerous conditions in pregnancy and is increasing in frequency. The risk of life-threatening bleeding is present throughout pregnancy but is particularly high at the time of delivery. Although the exact ... Full text Link to item Cite

Bivalent Prefusion F Vaccine in Pregnancy to Prevent RSV Illness in Infants.

Journal Article N Engl J Med · April 20, 2023 Featured Publication BACKGROUND: Whether vaccination during pregnancy could reduce the burden of respiratory syncytial virus (RSV)-associated lower respiratory tract illness in newborns and infants is uncertain. METHODS: In this phase 3, double-blind trial conducted in 18 coun ... Full text Link to item Cite

Maternal Cardiovascular Morbidity Events Following Preeclampsia: A Retrospective Cohort Study.

Journal Article Anesth Analg · April 1, 2023 BACKGROUND: Patients with preeclampsia are at high risk for long-term cardiovascular events, yet the short-term, acute cardiovascular complications that follow preeclampsia are understudied. The objective of this study was to compare the short-term, acute ... Full text Link to item Cite

Symptomatic versus asymptomatic COVID-19: does it impact placental vasculopathy?

Journal Article J Matern Fetal Neonatal Med · December 2022 This study sought to assess the impact of COVID-19 on placental vasculature in the context of maternal symptomatology - comparing asymptomatic to symptomatic pregnant patients - and disease severity - comparing pregnant patients with mild, moderate, severe ... Full text Link to item Cite

Transfusion Requirements with Hybrid Management of Placenta Accreta Spectrum Incorporating Targeted Embolization and a Selective Use of Delayed Hysterectomy.

Journal Article Am J Perinatol · October 2022 OBJECTIVE: This study compares the number of units of red blood cells (RBCs) transfused in patients with placenta accreta spectrum (PAS) treated with or without a multidisciplinary algorithm that includes placental uterine arterial embolization (P-UAE) and ... Full text Link to item Cite

Clinical Correlates of Placenta Accreta Spectrum Disorder Depending on the Presence or Absence of Placenta Previa: A Systematic Review and Meta-analysis.

Journal Article Obstet Gynecol · October 1, 2022 OBJECTIVE: To evaluate whether there are differences in risk factors and maternal outcomes of pregnancies complicated by placenta accreta spectrum depending on the presence or absence of placenta previa. DATA SOURCES: We performed a systematic search in Me ... Full text Link to item Cite

Universal Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Testing for Obstetric Inpatient Units Across the United States.

Journal Article Clin Infect Dis · August 24, 2022 Featured Publication BACKGROUND: The purpose of this study was to estimate prevalence of asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among patients admitted to obstetric inpatient units throughout the United States as detected by univers ... Full text Link to item Cite

Innate immune signaling in trophoblast and decidua organoids defines differential antiviral defenses at the maternal-fetal interface.

Journal Article Elife · August 17, 2022 Infections at the maternal-fetal interface can directly harm the fetus and induce complications that adversely impact pregnancy outcomes. Innate immune signaling by both fetal-derived placental trophoblasts and the maternal decidua must provide antimicrobi ... Full text Link to item Cite

A Multidimensional Bioinformatic Platform for the Study of Human Response to Surgery.

Journal Article Ann Surg · June 1, 2022 OBJECTIVE: To design and establish a prospective biospecimen repository that integrates multi-omics assays with clinical data to study mechanisms of controlled injury and healing. BACKGROUND: Elective surgery is an opportunity to understand both the system ... Full text Link to item Cite

Predictors of Breastfeeding among Patients Admitted with Preterm Prelabor Rupture of Membranes.

Conference Am J Perinatol · May 2024 OBJECTIVE: We sought to describe rates of breastmilk feeding (BF) at hospital discharge and 6 weeks postpartum and to identify risk factors for noninitiation or cessation among pregnancies complicated by preterm prelabor rupture of membranes (PPROM). STUDY ... Full text Link to item Cite

Delivery outcomes in the subsequent pregnancy following the conservative management of placenta accreta spectrum disorder: a systematic review and meta-analysis.

Journal Article Am J Obstet Gynecol · May 2024 OBJECTIVE: Cesarean hysterectomy is generally presumed to decrease maternal morbidity and mortality secondary to placenta accreta spectrum disorder. Recently, uterine-sparing techniques have been introduced in conservative management of placenta accreta sp ... Full text Link to item Cite

CT-001, a novel fast-clearing factor VIIa, enhanced the hemostatic activity in postpartum samples.

Journal Article Blood Adv · January 23, 2024 The hemostatic system is upregulated to protect pregnant mothers from hemorrhage during childbirth. Studies of the details just before and after delivery, however, are lacking. Recombinant factor VIIa (rFVIIa) has recently been granted approval by the Euro ... Full text Link to item Cite

The association of placental pathology and neurodevelopmental outcomes in patients with neonatal encephalopathy.

Journal Article Pediatr Res · November 2023 BACKGROUND: Studies conflict on how acute versus chronic placental pathology impacts outcomes after neonatal encephalopathy from presumed hypoxic-ischemic encephalopathy (HIE). We examine how outcomes after presumed HIE vary by placental pathology categori ... Full text Link to item Cite

Validation of a sonographic checklist for the detection of histologic placenta accreta spectrum.

Journal Article Am J Obstet Gynecol MFM · August 2023 Featured Publication BACKGROUND: To standardize research terminology and to reduce unanticipated placenta accreta spectrum, the European Working Group for Abnormally Invasive Placenta developed a consensus checklist for reporting suspected placenta accreta spectrum observed du ... Full text Link to item Cite

Knowledge Gaps in Placenta Accreta Spectrum.

Journal Article Am J Perinatol · July 2023 Since its first description early in the 20th Century, placenta accreta and its variants have changed substantially in incidence, risk factor profile, clinical presentation, diagnosis and management. While systematic use of diagnostic tools and a multidisc ... Full text Link to item Cite

Graduate and Continuing Medical Education of Placenta Accreta Spectrum.

Journal Article Am J Perinatol · July 2023 Surgical training experience in obstetrics-gynecology (OB-GYN) residency and fellowship training, particularly in open abdominal surgeries has declined over the last 2 decades. This is due, in part, due to a universal trend toward non-invasive treatments f ... Full text Link to item Cite

Placenta Accreta Spectrum.

Journal Article Obstet Gynecol · July 1, 2023 Featured Publication Placenta accreta spectrum (PAS) is one of the most dangerous conditions in pregnancy and is increasing in frequency. The risk of life-threatening bleeding is present throughout pregnancy but is particularly high at the time of delivery. Although the exact ... Full text Link to item Cite

Bivalent Prefusion F Vaccine in Pregnancy to Prevent RSV Illness in Infants.

Journal Article N Engl J Med · April 20, 2023 Featured Publication BACKGROUND: Whether vaccination during pregnancy could reduce the burden of respiratory syncytial virus (RSV)-associated lower respiratory tract illness in newborns and infants is uncertain. METHODS: In this phase 3, double-blind trial conducted in 18 coun ... Full text Link to item Cite

Maternal Cardiovascular Morbidity Events Following Preeclampsia: A Retrospective Cohort Study.

Journal Article Anesth Analg · April 1, 2023 BACKGROUND: Patients with preeclampsia are at high risk for long-term cardiovascular events, yet the short-term, acute cardiovascular complications that follow preeclampsia are understudied. The objective of this study was to compare the short-term, acute ... Full text Link to item Cite

Symptomatic versus asymptomatic COVID-19: does it impact placental vasculopathy?

Journal Article J Matern Fetal Neonatal Med · December 2022 This study sought to assess the impact of COVID-19 on placental vasculature in the context of maternal symptomatology - comparing asymptomatic to symptomatic pregnant patients - and disease severity - comparing pregnant patients with mild, moderate, severe ... Full text Link to item Cite

Transfusion Requirements with Hybrid Management of Placenta Accreta Spectrum Incorporating Targeted Embolization and a Selective Use of Delayed Hysterectomy.

Journal Article Am J Perinatol · October 2022 OBJECTIVE: This study compares the number of units of red blood cells (RBCs) transfused in patients with placenta accreta spectrum (PAS) treated with or without a multidisciplinary algorithm that includes placental uterine arterial embolization (P-UAE) and ... Full text Link to item Cite

Clinical Correlates of Placenta Accreta Spectrum Disorder Depending on the Presence or Absence of Placenta Previa: A Systematic Review and Meta-analysis.

Journal Article Obstet Gynecol · October 1, 2022 OBJECTIVE: To evaluate whether there are differences in risk factors and maternal outcomes of pregnancies complicated by placenta accreta spectrum depending on the presence or absence of placenta previa. DATA SOURCES: We performed a systematic search in Me ... Full text Link to item Cite

Universal Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Testing for Obstetric Inpatient Units Across the United States.

Journal Article Clin Infect Dis · August 24, 2022 Featured Publication BACKGROUND: The purpose of this study was to estimate prevalence of asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among patients admitted to obstetric inpatient units throughout the United States as detected by univers ... Full text Link to item Cite

Innate immune signaling in trophoblast and decidua organoids defines differential antiviral defenses at the maternal-fetal interface.

Journal Article Elife · August 17, 2022 Infections at the maternal-fetal interface can directly harm the fetus and induce complications that adversely impact pregnancy outcomes. Innate immune signaling by both fetal-derived placental trophoblasts and the maternal decidua must provide antimicrobi ... Full text Link to item Cite

A Multidimensional Bioinformatic Platform for the Study of Human Response to Surgery.

Journal Article Ann Surg · June 1, 2022 OBJECTIVE: To design and establish a prospective biospecimen repository that integrates multi-omics assays with clinical data to study mechanisms of controlled injury and healing. BACKGROUND: Elective surgery is an opportunity to understand both the system ... Full text Link to item Cite

Anesthetic management of placenta accreta spectrum at an academic center and a comparison of the combined spinal epidural with the double catheter technique: A retrospective study.

Journal Article J Clin Anesth · May 2022 Featured Publication STUDY OBJECTIVES: To describe the anesthetic management and outcomes of placenta accreta spectrum (PAS) cases at our institution over a 19 year period and to compare outcomes associated with the lumbar combined spinal epidural (CSE) technique versus the do ... Full text Link to item Cite

Preterm birth rates and race disparities pre and post COVID vaccination

Conference AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY · 2022 Cite

Serum sFlt-1/PIGF Ratio as a Biological Marker of Preeclampsia in Women with Rheumatic Disease

Conference AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY · 2022 Cite

Factors associated with cesarean section in patients with COVID

Conference AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY · 2022 Cite

COVID-19 and the Placenta: Impact of Maternal Disease Severity

Conference AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY · 2022 Cite

COVID-19 and the Placenta: Impact of Maternal Disease Severity

Conference AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY · 2022 Cite

Placental uterine artery embolization followed by delayed hysterectomy for placenta percreta: A case series.

Journal Article Gynecol Oncol Rep · August 2021 We describe outcomes of patients with suspected placenta percreta treated with placental uterine artery embolization (P-UAE) followed by delayed hysterectomy. This is a prospective case series of subjects from 2005 to 2018 with suspected placenta percreta ... Full text Link to item Cite

High-risk third trimester pregnancy with decompensated cirrhosis safely delivered following emergent preoperative interventional radiology for mitigation of variceal bleeding.

Journal Article Clin Imaging · December 2020 Coagulopathy coupled with severe portal hypertension in the setting of cirrhosis increases the risk of mortality from variceal bleeding in pregnant women. Studies suggest transjugular intrahepatic portosystemic shunt (TIPS) creation to be a safe procedure ... Full text Link to item Cite

Making the Case for Reproductive Counseling in Liver Transplant Care.

Journal Article Liver Transpl · October 2020 Featured Publication Full text Link to item Cite

Uterine Vascular Embolization Followed by Hysterectomy After Cesarean for MAP Without Extrauterine Involvement [32T]

Conference Obstetrics & Gynecology · May 2019 INTRODUCTION:To review outcomes in women with morbidly adherent placenta (MAP) managed with selective uterine vasculature embolization (SUVE) at the time of cesarean hysterectomy (CHYS).< ... Full text Cite

Polyreactive IgM initiates complement activation by PF4/heparin complexes through the classical pathway.

Journal Article Blood · December 6, 2018 The mechanisms by which exposure to heparin initiates antibody responses in many, if not most, recipients are poorly understood. We recently demonstrated that antigenic platelet factor 4 (PF4)/heparin complexes activate complement in plasma and bind to B c ... Full text Link to item Cite

Identification and Management of Abdominal Wall Varices in Pregnancy.

Journal Article Obstet Gynecol · October 2018 Featured Publication BACKGROUND: Portal hypertension in pregnancy is associated with elevated risk of variceal hemorrhage. Ectopic varices, those located outside the esophagus or stomach, are rare but have a high risk of associated maternal morbidity or mortality. CASE: A 31-y ... Full text Link to item Cite

Molecular Genetic Technology

Chapter · 2018 Featured Publication Cite

Closed-Incision Negative-Pressure Therapy in Obese Patients Undergoing Cesarean Delivery: A Randomized Controlled Trial.

Journal Article AJP Rep · July 2017 Background  Postcesarean wound morbidity is a costly complication of cesarean delivery for which preventative strategies remain understudied. Objective  We compared surgical site occurrences (SSOs) in cesarean patients receiving closed-incision negative-pr ... Full text Open Access Link to item Cite

Novel pathogenic variants in FOXP3 in fetuses with echogenic bowel and skin desquamation identified by ultrasound.

Journal Article Am J Med Genet A · May 2017 Immunodysregulation, Polyendocrinopathy, Enteropathy, X-linked (IPEX) syndrome is a rare, X-linked recessive disease that affects regulatory T cells (Tregs) resulting in diarrhea, enteropathy, eczema, and insulin-dependent diabetes mellitus. IPEX syndrome ... Full text Link to item Cite

Reproductive genetics

Chapter · 2017 Cite

Chagas Disease Screening in Maternal Donors of Publicly Banked Umbilical Cord Blood, United States.

Journal Article Emerg Infect Dis · August 2016 To assess patterns of Chagas disease, we reviewed results of screening umbilical cord blood from a US public cord blood bank during 2007-2014. Nineteen maternal donors tested positive for Trypanosoma cruzi parasites (0.04%). Because perinatal transmission ... Full text Open Access Link to item Cite

Blood-Conservation Strategies in a Blood-Refusal Parturient with Placenta Previa and Placenta Percreta.

Journal Article A A Case Rep · March 1, 2016 Abnormal placentation can be associated with significant blood loss and massive blood transfusions. Caring for parturients with abnormal placentation who refuse blood transfusion is very challenging. We present a 35-year-old, gravida 3, para 1, Jehovah's W ... Full text Link to item Cite

Management of Short Cervix during Pregnancy: A Review.

Journal Article Am J Perinatol · February 2016 Sonographic evaluation of the uterine cervix has evolved as one of the best clinical tools available for the prediction of subsequent spontaneous preterm birth (PTB), particularly when combined with prior poor obstetric history. There is a growing body of ... Full text Link to item Cite

530: Preterm umbilical cord blood is enriched for progenitor cells

Conference American Journal of Obstetrics and Gynecology · January 2016 Full text Cite

27: Chagas disease screening in umbilical cord blood: an opportunity for prevention

Conference American Journal of Obstetrics and Gynecology · December 2015 Full text Cite

140: The maximal oxytocin infusion rate in labor is associated with uterine atony

Conference American Journal of Obstetrics and Gynecology · January 2015 Full text Cite

523: The effect of progesterone on TNF-α induced MMP 9 activity in human fetal membranes

Conference American Journal of Obstetrics and Gynecology · January 2012 Full text Cite

Antibodies to stem cell marker antigens reduce engraftment of hematopoietic stem cells.

Journal Article Stem Cells · February 2007 Hematopoietic stem cells (HSCs) have enormous potential for use in transplantation and gene therapy. However, the frequency of repopulating HSCs is often very low; thus, highly effective techniques for cell enrichment and maintenance are required to obtain ... Full text Link to item Cite

Wnt2 coordinates the commitment of mesoderm to hematopoietic, endothelial, and cardiac lineages in embryoid bodies.

Journal Article J Biol Chem · January 5, 2007 Our recent gene expression profiling analyses demonstrated that Wnt2 is highly expressed in Flk1(+) cells, which serve as common progenitors of endothelial cells, blood cells, and mural cells. In this report, we characterize the role of Wnt2 in mesoderm de ... Full text Link to item Cite

Insight into the mechanism of asparaginase-induced depletion of antithrombin III in treatment of childhood acute lymphoblastic leukemia.

Journal Article Leuk Res · July 2000 Asparaginase (ASNase) is a widely used and successful agent against childhood acute lymphoblastic leukemia (ALL). Asparaginase cleaves asparagine (Asn) to give aspartic acid and ammonia, thereby depleting free Asn in the blood. However, treatment with ASNa ... Full text Link to item Cite