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Symptomatic versus asymptomatic COVID-19: does it impact placental vasculopathy?

Publication ,  Journal Article
Ramey-Collier, K; Craig, AM; Hall, A; Weaver, KE; Wheeler, SM; Gilner, JB; Swamy, GK; Hughes, BL; Dotters-Katz, SK
Published in: J Matern Fetal Neonatal Med
December 2022

This study sought to assess the impact of COVID-19 on placental vasculature in the context of maternal symptomatology - comparing asymptomatic to symptomatic pregnant patients - and disease severity - comparing pregnant patients with mild, moderate, severe, and critical COVID-19 infection. PCR-confirmed COVID-19 positive pregnant patients in a single health system who delivered between 3/2020-5/2021 included. All patients had positive COVID test and delivered during the study period. Primary outcome was incidence of any vascular malperfusion on placental pathology. Secondary outcomes were FVM and MVM on placental pathology. Placental pathology compared between symptomatic (sCOVID) and asymptomatic (aCOVID) patients. Secondary analysis of symptomatic patients, comparing placental pathology between mild disease(mCOVID) and worse disease(moderate, severe, or critical-defined by 2020 NIH guidelines) (dCOVID), also performed. Of 112 patients, 53 (47%) had symptoms. Twenty-seven (24.1%) patients had evidence of vascular malperfusion; 26 (23.2%) had MVM. When comparing aCOVID and sCOVID patients, no difference in rate of vascular malperfusion identified, nor any differences in rates of FVM or MVM. Among sCOVID patients (n = 53), 39 (74%) had mCOVID and 14 (26%) had dCOVID (moderate n = 4, severe n = 9, critical n = 1). Patients with dCOVID had earlier median delivery GA (37.4wks vs 39.2wks, p = .03). No difference in latency from diagnosis to delivery seen between mCOVID and dCOVID groups (4.4 vs 3.0wks, p = .96). Twelve (30.8%) patients had vascular malperfusion on pathology, all had mCOVID (p = .02). Eleven (28.2%) mCOVID patients had MVM; no dCOVID patients had evidence of vascular malperfusion (p = .03). No difference in FVM was found between cohorts. Symptomatic COVID-19 infection did not impact placental vasculature differently than asymptomatic infection, even when stratifying by trimester of infection. Among pregnant patients with symptomatic COVID-19, mild disease was associated with placental vascular changes on the maternal side while severe disease was not. Further studies are needed to understand the implications of these findings.

Duke Scholars

Published In

J Matern Fetal Neonatal Med

DOI

EISSN

1476-4954

Publication Date

December 2022

Volume

35

Issue

25

Start / End Page

9460 / 9462

Location

England

Related Subject Headings

  • Vascular Diseases
  • Pregnancy
  • Placenta Diseases
  • Placenta
  • Obstetrics & Reproductive Medicine
  • Humans
  • Female
  • COVID-19
  • 4204 Midwifery
  • 3215 Reproductive medicine
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ramey-Collier, K., Craig, A. M., Hall, A., Weaver, K. E., Wheeler, S. M., Gilner, J. B., … Dotters-Katz, S. K. (2022). Symptomatic versus asymptomatic COVID-19: does it impact placental vasculopathy? J Matern Fetal Neonatal Med, 35(25), 9460–9462. https://doi.org/10.1080/14767058.2022.2041597
Ramey-Collier, Khaila, Amanda M. Craig, Allison Hall, Kristin E. Weaver, Sarahn M. Wheeler, Jennifer B. Gilner, Geeta K. Swamy, Brenna L. Hughes, and Sarah K. Dotters-Katz. “Symptomatic versus asymptomatic COVID-19: does it impact placental vasculopathy?J Matern Fetal Neonatal Med 35, no. 25 (December 2022): 9460–62. https://doi.org/10.1080/14767058.2022.2041597.
Ramey-Collier K, Craig AM, Hall A, Weaver KE, Wheeler SM, Gilner JB, et al. Symptomatic versus asymptomatic COVID-19: does it impact placental vasculopathy? J Matern Fetal Neonatal Med. 2022 Dec;35(25):9460–2.
Ramey-Collier, Khaila, et al. “Symptomatic versus asymptomatic COVID-19: does it impact placental vasculopathy?J Matern Fetal Neonatal Med, vol. 35, no. 25, Dec. 2022, pp. 9460–62. Pubmed, doi:10.1080/14767058.2022.2041597.
Ramey-Collier K, Craig AM, Hall A, Weaver KE, Wheeler SM, Gilner JB, Swamy GK, Hughes BL, Dotters-Katz SK. Symptomatic versus asymptomatic COVID-19: does it impact placental vasculopathy? J Matern Fetal Neonatal Med. 2022 Dec;35(25):9460–9462.

Published In

J Matern Fetal Neonatal Med

DOI

EISSN

1476-4954

Publication Date

December 2022

Volume

35

Issue

25

Start / End Page

9460 / 9462

Location

England

Related Subject Headings

  • Vascular Diseases
  • Pregnancy
  • Placenta Diseases
  • Placenta
  • Obstetrics & Reproductive Medicine
  • Humans
  • Female
  • COVID-19
  • 4204 Midwifery
  • 3215 Reproductive medicine