Overview
Jianbo earned his Ph.D. in Pharmacology from Pennsylvania State University, followed by postdoctoral training at Stanford University. He then started his independent academic career at the University of Hong Kong and City University of Hong Kong, prior to his appointment at DKU. His laboratory focuses on cell signaling and drug discovery, with research interests spanning autophagy, endosomal trafficking, metastasis, anticancer immunity, as well as the roles of calcium ions (Ca2+) and reactive oxygen species (ROS).
Current Appointments & Affiliations
Professor of Biology at Duke Kunshan University
·
2022 - Present
DKU Faculty
Professor of the Practice of DKU Studies at Duke University
·
2023 - Present
DKU Studies
Recent Publications
Protocol for monitoring the endosomal trafficking of membrane proteins in mammalian cells.
Journal Article STAR protocols · March 2025 Here, we present a protocol to study epidermal growth factor (EGF) receptor (EGFR) or transferrin trafficking in mammalian cells. We describe steps for using fluorescent ligands or antibodies, confocal imaging, and quantitative analysis to track their move ... Full text CiteEndosomal trafficking participates in lipid droplet catabolism to maintain lipid homeostasis.
Journal Article Nature communications · February 2025 The interplay between lipid droplets (LDs) and endosomes remains unknown. Here, we screen and synthesize AP1-coumarin, an LD-specific probe, by conjugating a fluorescent dye coumarin to a triazine compound AP1. AP1-coumarin labels all stages of LDs in live ... Full text CiteBis-benzylisoquinoline alkaloids inhibit flavivirus entry and replication by compromising endolysosomal trafficking and autophagy.
Journal Article Virologica Sinica · December 2024 Flaviviruses, such as dengue virus (DENV), Zika virus (ZIKV), and Japanese encephalitis virus (JEV), represent a substantial public health challenge as there are currently no approved treatments available. Here, we investigated the antiviral effects of bis ... Full text CiteEducation, Training & Certifications
Pennsylvania State University ·
2000
Ph.D.