Overview
Jianbo earned his Ph.D. in Pharmacology from Pennsylvania State University, followed by postdoctoral training at Stanford University. He then started his independent academic career at the University of Hong Kong and City University of Hong Kong, prior to his appointment at DKU. His laboratory focuses on cell signaling and drug discovery, with research interests spanning autophagy, endosomal trafficking, metastasis, anticancer immunity, as well as the roles of calcium ions (Ca2+) and reactive oxygen species (ROS).
Current Appointments & Affiliations
Professor of Biology at Duke Kunshan University
·
2022 - Present
DKU Faculty
Professor of the Practice of Interdisciplinary Studies at DKU Unit at Duke University
·
2026 - Present
Interdisciplinary Studies at DKU Unit,
DKU Faculty
Recent Publications
Reactive Cysteines in Proteins are the Dominant Reductants for Platinum(IV) Prodrug Activation in Live Cells.
Journal Article Angewandte Chemie (International ed. in English) · June 2025 The intracellular reduction of Pt(IV) prodrugs is crucial for their anticancer efficacy. However, the major components responsible for the reduction of Pt(IV) complexes within live cells remain elusive. Herein, we developed an aminoluciferin-functionalized ... Full text CiteProtocol for monitoring the endosomal trafficking of membrane proteins in mammalian cells.
Journal Article STAR protocols · March 2025 Here, we present a protocol to study epidermal growth factor (EGF) receptor (EGFR) or transferrin trafficking in mammalian cells. We describe steps for using fluorescent ligands or antibodies, confocal imaging, and quantitative analysis to track their move ... Full text CiteFGR Src family kinase causes signaling and phenotypic shift mimicking retinoic acid-induced differentiation of leukemic cells.
Journal Article Oncotarget · March 2025 Retinoic acid (RA), an embryonic morphogen, is used in cancer differentiation therapy, causing extensive gene expression changes leading to cell differentiation. This study reveals that the expression of the Src-family kinase (SFK), FGR, alone can induce c ... Full text CiteEducation, Training & Certifications
Pennsylvania State University ·
2000
Ph.D.