Jianbo Yue
Professor of Biology at Duke Kunshan University

Jianbo graduated from Pennsylvania State University with a Ph.D. degree in Pharmacology. After a postdoc training at Stanford University, he moved to the University of Hong Kong to start his independent academic career as an assistant professor in the Department of Physiology. He later joined the City University of Hong Kong as an associate professor in the Department of Biomedical Sciences before joining DKU. His cell signaling and drug discovery laboratory studies autophagy, endosomal trafficking, metastasis, anticancer immunity, Ca2+, and reactive oxygen species (ROS).

Current Research Interests

Research interests: cell signaling and drug discovery related to autophagy, endosomal trafficking, and Ca2+, in the context of metastasis, anticancer immunity, and virus-host interaction.

Currently, several research themes are going on in Yue laboratory: (1) Endosomal trafficking in metastasis and anticancer immune response; (2) virus-host interaction; (3) regulation of autophagy and cell death by Ca2+ signaling and ROS.

REPRESENTIVE PUBLICATIONS:  

  1. Ye Z, Xiong X, Peng W, Wei W, Huang L, Yue J, Zhang C, Lin G, Huang F, Zhang L, Zheng S, Yue J* (2022) Manipulation of PD-L1 endosomal trafficking promotes anticancer immunity. Advanced Science (Online ahead of print).
  2. Zhu K, Cai Y, Shi X, Ye Z, Gao Y, Liu C, Wang R, Ma Z, Zhu H, Zhang L, Li S*, Zhang H*, Yue J* (2022) The phosphorylation and dephosphorylation switch of VCP/p97 regulates centrosome and spindle orientation. Cell Death and Differentiation 29:2070-2088.
  3. Wang D, Ye Z, Wei W, Yu J, Huang L, Zhang H, Yue J* (2021) Capping protein regulates endocytosis by controlling F-actin density and recruiting RAB5 effectors to early endosomes. eLife 10: e65910.
  4. Xie F, Xu S, Lu Y, Manno S, Won KF, Sun L, Yue J*, Cheng SH* (2021) Metformin accelerates zebrafish heart regeneration by inducing autophagy. npj Regernative Medicine 6: 62.
  5. Huang L, Li H, Ye Z, Xu Q, Fu Q, Sun W, Qi W*, Yue J* (2021) Berbamine inhibits Japanese Encephalitis virus (JEV) infection by compromising TPRMLs-mediated endolysosomal trafficking of Low-density lipoprotein receptor (LDLR). Emerging Microbes & Infections 10, 1257-1271
  6. Huang L, Yuen T, Ye Z, Liu S, Zhang G, Chu H*, Yue J* (2021) Berbamine inhibits SARS-CoV-2 infection by compromising TPRMLs-mediated endolysosomal trafficking of ACE2. Signal Transduct Target Ther. 6: 168.
  7. Ye Z, Wang D, He Y, Yu J, Wei W, Chen C, Wang R, Zhang L, Zhang LH, Zhang LR, Le M, Cho W, M Yang, Zhang H, Yue J* (2021) Vacuolin-1 inhibits endosomal trafficking and metastasis via CapZbeta. Oncogene 40, 1775-1791.
  8. Guo W, Wang Q, Pan S, Li J, Shu Y, Chen J, Wang Q, Zhang S, Zhang X, Yue J*  (2021) The ERK1/2-ATG13-FIP200 signaling cascade is required for autophagy induction to protect renal cells from hypoglycemia-induced cell death. J. Cell. Physiol. 236: 6932-6947.
  9. Shi X, Zhu K, Ye Z, Yue J* (2020) VCP/p97 targets the nuclear export and degradation of p27Kip1 during G1 to S phase transition. FASEB J. 34(4):5193-5207
  10. Li C, Huang L, Sun W, Chen Y, He M*, Yue J*, Ballard H* (2019) Saikosaponin D potently Inhibits Autophagy to Suppress EV71 infection. Signal Transduct Target Ther. 4:4
  11. Zhang K, Sun W, Huang L, Zhu K, Zhu L, Wang Q, Lu Y, Zhang HM, Jin H, Zhang LH*, Zhang LR*, Yue J* (2017) Identifying GAPDH as a Novel Cyclic Adenosine Diphosphoribose (cADPR) Binding Protein by Photoaffinity Protein-Ligand Labeling Approach. J Am Chem. Soc. 139:156-170.
  12. Wang Q, Guo W, Hao B, Shi X, Wong C, Hao Q, Cheung HK, Wu WT, Li GR, Lu Y, Yue J* (2016) Mechanistic Study of the Role of TRPM2-Ca2+ Signaling in Oxidative Stress Induced Autophagy Inhibition. Autophagy 12: 1340-1354.
  13. Wei W, Lu Y, Hai B, Zhang K, Wang Q, Miller AL, Zhang LR, Zhang LH, Yue J* (2015) CD38 is Required for Neural Differentiation of Mouse Embryonic Stem Cells by Modulating Reactive Oxygen Species (ROS). Stem Cells 33, 2664-2673
  14. Lu Y, Dong S, Hao B, Wang Q, Guo W,Cheung KH, Wong C, Wu WT, Markus H, Yue J* (2014) Vacuolin-1 Potently and Reversibly Inhibits Autophagy by Activating Rab5. Autophagy 10, 1895-1905.
  15. Wei W, Sun H, Ting K, Zhang LH, Lee HC, Li G, Yue J* (2012) Inhibition of Cardiomyocyte Differentiation of Mouse Embryonic Stem Cells by CD38/cADPR/Ca2+ Signaling Pathway. J. Biol. Chem. 287, 35599–35611.
  16. Yu P, Zhang Z, Hao B, Zhao Y, Lee HC, Zhang LH, Zhang LR, Yue J* (2012) A Novel Fluorescent Cell Membrane Permeable Caged-cADPR Analogue. J. Biol. Chem. 287, 24774-24783
  17. Yue J*, Wei W, Lam CM, Zhao YJ, Dong M, Zhang LR, Zhang LH, Lee HC*. (2009) Inhibition of cardiomyocytes differentiation of mouse embryonic stem cells by CD38/cADPR/Ca2+ signaling pathway. J. Biol. Chem. 284, 29335-29342
  18. Yue J*, Ferrell JE Jr. (2006) Mechanistic Studies of the Mitotic Activation of Mos. Mol Cell Biol. 26, 5300-5309
  19. Yue J*, Xiong W, Ferrell JE Jr. (2006) B-Raf and C-Raf are required for Ras-stimulated p42 MAP kinase activation in Xenopus egg extracts. Oncogene, 25, 3307-3315.
  20. Yue J*, Ferrell JE Jr. (2004) Mos Mediates the Mitotic Activation of p42 MAPK in Xenopus Egg Extracts. Curr. Biol. 14, 1581-1586.

            *Corresponding author

PATENTS (from Yue lab)

  1. A METHOD OF PROMOTING ANTITUMOR OR ANTICANCER IMMUNITY. Provisional application for patent (PCT63/163,221).
  2. USE OF BERBAMINE OR ITS ANALOGUE FOR PREVENTING OR TREATING RNA VIRUS INFECTION. Provisional application for patent (PCT/CN2020/113378).
  3. METHOD OF TREATING METASTATIC CANCER IN A SUBJECT WITH A PROTEIN INHIBITOR. US patent application (US16/937,995).
  4. METHODS OF PREVENTING OR TREATING FLAVIVIRUS INFECTIONS AND METHODS OF INHIBITING THE ENTRY OF FLAVIVIRUS, ENTEROVIRUS OR LENTIVIRUS INTO HOST CELLS. US patent No: 11,357.771 B2.
  5. METHOD OF TREATING METASTATIC CANCER IN A SUBJECT,US patent No:US1089405182, and China patent (pending).
  6. VACUOLIN-1 AS AN INHIBITOR OF AUTOPHAGY AND ENDOSOMAL TRAFFICKING AND THE USE THEREOF FOR INHIBITING TUMOR PROGRESSION. US patent No: US 9,717,737 B2;  European patent No: 15751298.9-1109, and China patents (CPCH1661599P).


GRANT SUPPORTS:

Grants as the Principal Investigator of external grants (total of 26): 2 NSFC grants, 1 NSFC-HRC-NZ joint grant, 1 NSFC-RGC joint grant, 9 RGC grants, 4 ITF grants, and 1 Croucher-CAS grant, etc.

RESEARCH TRAINEES SUPERVISED:

Current-          3 postdoctoral fellows, 2 Ph.D. students, and 5 Research assistants

Past-               5 postdoctoral fellows, 12 Ph.D. students (6 from HKU and 6 from CityU),
2 Joint Ph.D. students (HKU and Peking University), and 4 MPhil students (HKU)

Current Appointments & Affiliations

Contact Information

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