Scholars@Duke
Jianbo Yue

Jianbo Yue

Professor of Biology at Duke Kunshan University
DKU Faculty

Selected Publications

Bis-benzylisoquinoline alkaloids inhibit flavivirus entry and replication by compromising endolysosomal trafficking and autophagy.

Journal Article Virologica Sinica · September 2024 Flaviviruses, such as dengue virus (DENV), Zika virus (ZIKV), and Japanese encephalitis virus (JEV), represent a substantial public health challenge as there are currently no approved treatments available. Here, we investigated the antiviral effects of bis ... Full text Cite

The temporal association of CapZ with early endosomes regulates endosomal trafficking and viral entry into host cells.

Journal Article BMC biology · January 2024 BackgroundMany viruses enter host cells by hijacking endosomal trafficking. CapZ, a canonical actin capping protein, participates in endosomal trafficking, yet its precise role in endocytosis and virus infection remains elusive.ResultsHer ... Full text Cite

Identification of a small chemical as a lysosomal calcium mobilizer and characterization of its ability to inhibit autophagy and viral infection.

Journal Article The FEBS journal · November 2023 We previously identified glyceraldehyde 3-phosphate dehydrogenase (GAPDH) as one of the cyclic adenosine diphosphoribose (cADPR)'s binding proteins and found that GAPDH participates in cADPR-mediated Ca2+ release from endoplasmic reticulum via r ... Full text Cite

An ultrasound-activatable platinum prodrug for sono-sensitized chemotherapy.

Journal Article Science advances · June 2023 Despite the great success achieved by photoactivated chemotherapy, eradicating deep tumors using external sources with high tissue penetration depth remains a challenge. Here, we present cyaninplatin, a paradigm of Pt(IV) anticancer prodrug that can be act ... Full text Cite

Manipulation of PD-L1 Endosomal Trafficking Promotes Anticancer Immunity.

Journal Article Advanced science (Weinheim, Baden-Wurttemberg, Germany) · February 2023 The aberrant regulation of PD-L1 in tumor cells remains poorly understood. Here, the authors systematically investigate the endosomal trafficking of plasma membrane PD-L1 in tumor cells. They show that plasma membrane PD-L1 is continuously internalized, an ... Full text Open Access Cite

Vacuolin-1 enhances RA-induced differentiation of human myeloblastic leukemia cells: evidence for involvement of a CD11b/FAK/LYN/SLP-76 axis subject to endosomal regulation that drives late differentiation steps.

Journal Article Cell & bioscience · November 2022 BackgroundRetinoic acid(RA), an embryonic morphogen, regulates cell differentiation. Endocytosis regulates receptor signaling that governs such RA-directed cellular processes. Vacuolin-1 is a small molecule that disrupts endocytosis, motivating in ... Full text Cite

The phosphorylation and dephosphorylation switch of VCP/p97 regulates the architecture of centrosome and spindle.

Journal Article Cell death and differentiation · October 2022 The proper orientation of centrosome and spindle is essential for genome stability; however, the mechanism that governs these processes remains elusive. Here, we demonstrated that polo-like kinase 1 (Plk1), a key mitotic kinase, phosphorylates residue Thr7 ... Full text Cite

Capping protein regulates endosomal trafficking by controlling F-actin density around endocytic vesicles and recruiting RAB5 effectors.

Journal Article eLife · November 2021 Actin filaments (F-actin) have been implicated in various steps of endosomal trafficking, and the length of F-actin is controlled by actin capping proteins, such as CapZ, which is a stable heterodimeric protein complex consisting of α and β subunits. Howev ... Full text Cite

The ERK1/2-ATG13-FIP200 signaling cascade is required for autophagy induction to protect renal cells from hypoglycemia-induced cell death.

Journal Article Journal of cellular physiology · October 2021 Autophagy, an evolutionarily conserved lysosomal degradation pathway, is known to regulate a variety of physiological and pathological processes. At present, the function and the precise mechanism of autophagy regulation in kidney and renal cells remain el ... Full text Cite

High-content screening of diterpenoids from Isodon species as autophagy modulators and the functional study of their antiviral activities.

Journal Article Cell biology and toxicology · October 2021 Autophagy is a conserved lysosomal degradation process, and abnormal autophagy has been associated with various pathological processes, e.g., neurodegeneration, cancer, and pathogen infection. Small chemical modulators of autophagy show the potential to tr ... Full text Cite

Metformin accelerates zebrafish heart regeneration by inducing autophagy.

Journal Article NPJ Regenerative medicine · October 2021 Metformin is one of the most widely used drugs for type 2 diabetes and it also exhibits cardiovascular protective activity. However, the underlying mechanism of its action is not well understood. Here, we used an adult zebrafish model of heart cryoinjury, ... Full text Cite

Japanese encephalitis virus manipulates lysosomes membrane for RNA replication and utilizes autophagy components for intracellular growth.

Journal Article Veterinary microbiology · April 2021 Japanese encephalitis virus is absolutely dependent on their host cells and has evolved various strategies to manipulate the cellular secretory pathways for viral replication. However, how cellular secretory pathways are hijacked, and the origin of the vir ... Full text Cite

Vacuolin-1 inhibits endosomal trafficking and metastasis via CapZβ.

Journal Article Oncogene · March 2021 Metastasis is the fundamental cause of cancer mortality, but there are still very few anti-metastatic drugs available. Endosomal trafficking has been implicated in tumor metastasis, and we have previously found that small chemical vacuolin-1 (V1) potently ... Full text Cite

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.

Journal Article Autophagy · January 2021 In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been ... Full text Link to item Cite

Dissecting the novel partners of nuclear c-Raf and its role in all-trans retinoic acid (ATRA)-induced myeloblastic leukemia cells differentiation.

Journal Article Experimental cell research · September 2020 All-trans retinoic acid (ATRA) is an anti-cancer differentiation therapy agent effective for acute promyelocytic leukemia (APL) but not acute myeloid leukemia (AML) in general. Using the HL-60 human non-APL AML model where ATRA causes nuclear enrichment of ... Full text Cite

Depleting interferon regulatory factor-1(IRF-1) with CRISPR/Cas9 attenuates inducible oxidative metabolism without affecting RA-induced differentiation in HL-60 human AML cells.

Journal Article FASEB bioAdvances · June 2020 The known collaboration between all-transretinoic acid and interferon motivates this study of the dependence of RA-induced leukemic cell differentiation on interferon regulatory factor-1 (IRF-1), a transcription factor that is the main mediator of interfer ... Full text Cite

Autophagy in host-microbe interactions.

Journal Article Seminars in cell & developmental biology · May 2020 Full text Cite

The interplay of autophagy and enterovirus.

Journal Article Seminars in cell & developmental biology · May 2020 Autophagy, an evolutional conserved lysosomal degradation process, has been implicated to play an important role in cellular defense against a variety of microbial infection. Interestingly, numerous studies found that some pathogens, especially positive-si ... Full text Cite

VCP/p97 targets the nuclear export and degradation of p27Kip1 during G1 to S phase transition.

Journal Article FASEB journal : official publication of the Federation of American Societies for Experimental Biology · April 2020 One of the critical regulatory mechanisms for cell cycle progression is the timely degradation of CDK inhibitors, including p21Cip1 and p27Kip1 . VCP/p97, an AAA-ATPase, is reported to be overexpressed in many types of cancers. Here, ... Full text Cite

Isoscoparins R and S, two new ent-clerodane diterpenoids from Isodon scoparius.

Journal Article Journal of Asian natural products research · October 2019 Two new ent-clerodane diterpenoids, named isoscoparins R and S (1 and 2), were isolated from the aerial parts of Isodon scoparius. Their structures were characterized mainly by analyzing the NMR and HRESIMS data, and the relativ ... Full text Cite

Autophagy inhibitor Vacuolin-1 interferes with lipid-based small interference RNA delivery.

Journal Article Biochemical and biophysical research communications · March 2019 Autophagy and endocytosis are important pathways regulating macromolecule recycling and regeneration. Small molecule inhibitors are utilized to modulate these pathways and to treat autophagy-related diseases. Vacuolin-1 is a small molecule that can potentl ... Full text Cite

Mir223 restrains autophagy and promotes CNS inflammation by targeting ATG16L1.

Journal Article Autophagy · March 2019 Microglia are innate immune cells in the central nervous system (CNS), that supplies neurons with key factors for executing autophagosomal/lysosomal functions. Macroautophagy/autophagy is a cellular catabolic process that maintains cell balance in response ... Full text Cite

Saikosaponin D suppresses enterovirus A71 infection by inhibiting autophagy.

Journal Article Signal transduction and targeted therapy · January 2019 The dysregulation of autophagy, an evolutionarily conserved lysosomal degradation process, has been implicated in a wide variety of human diseases, and thus, small chemicals that modulate autophagy have therapeutic potential. Here, we assessed the ability ... Full text Cite

TPC2 mediates autophagy progression and extracellular vesicle secretion in cancer cells.

Journal Article Experimental cell research · September 2018 Autophagy is an evolutionarily conserved lysosomal degradation process, and is involved in various cellular processes. Here we studied the role of two pore channel 2 (TPC2), a lysosomal non-selective Na+/Ca2+ channel, in autophagy pro ... Full text Cite

Development of a magnetic microrobot for carrying and delivering targeted cells.

Journal Article Science robotics · June 2018 The precise delivery of targeted cells through magnetic field-driven microrobots/carriers is a promising technique for targeted therapy and tissue regeneration. This paper presents a microrobot designed with a burr-like porous spherical structure for carry ... Full text Cite

TRPC3 is required for the survival, pluripotency and neural differentiation of mouse embryonic stem cells (mESCs).

Journal Article Science China. Life sciences · March 2018 Transient receptor potential canonical subfamily member 3 (TRPC3) is known to be important for neural development and the formation of neuronal networks. Here, we investigated the role of TRPC3 in undifferentiated mouse embryonic stem cells (mESCs) and dur ... Full text Cite

The effect of pyrazole 3 treatment on the generation of intracellular ca 2+ transients and mitochondrial membrane potential, as well as the survival and neural differentiation of mouse embryonic stem cells

Journal Article Journal of Stem Cells · January 1, 2018 The identification and use of pharmacological agents to regulate the fate of embryonic stem cells (ESCs) and promote their differentiation into neurons has great potential in the development of novel clinical therapies. Here, we investigated the effect of ... Cite

Direct detection of two different tumor-derived extracellular vesicles by SAM-AuNIs LSPR biosensor.

Journal Article Biosensors & bioelectronics · August 2017 Extracellular vesicles (EVs) are abundant in various biological fluids including blood, saliva, urine, as well as extracellular milieu. Accumulating evidence has indicated that EVs, which contain functional proteins and small RNAs, facilitate intercellular ... Full text Cite

Oxidative stress activates the TRPM2-Ca2+-CaMKII-ROS signaling loop to induce cell death in cancer cells.

Journal Article Biochimica et biophysica acta. Molecular cell research · June 2017 High intracellular levels of reactive oxygen species (ROS) cause oxidative stress that results in numerous pathologies, including cell death. Transient potential receptor melastatin-2 (TRPM2), a Ca2+-permeable cation channel, is mainly activated ... Full text Cite

Identification of Novel Vacuolin-1 Analogues as Autophagy Inhibitors by Virtual Drug Screening and Chemical Synthesis.

Journal Article Molecules (Basel, Switzerland) · May 2017 Autophagy is a fundamental cellular degradation process which is essential for cell homeostasis, and dysfunctional autophagy has been associated with a variety of human diseases, such as cancer. Several autophagy chemical modulators have been applied in a ... Full text Cite

ROS and Oxidative Stress in Stem Cells.

Journal Article Oxidative medicine and cellular longevity · January 2017 Full text Cite

Identifying Glyceraldehyde 3-Phosphate Dehydrogenase as a Cyclic Adenosine Diphosphoribose Binding Protein by Photoaffinity Protein-Ligand Labeling Approach.

Journal Article Journal of the American Chemical Society · January 2017 Cyclic adenosine diphosphoribose (cADPR), an endogenous nucleotide derived from nicotinamide adenine dinucleotide (NAD+), mobilizes Ca2+ release from endoplasmic reticulum (ER) via ryanodine receptors (RyRs), yet the bridging protein( ... Full text Cite

Halofuginone and artemisinin synergistically arrest cancer cells at the G1/G0 phase by upregulating p21Cip1 and p27Kip1.

Journal Article Oncotarget · August 2016 Combinational drug therapy is one of the most promising strategies in modern anticancer research. Traditional Chinese medicine (TCM) formulas represent a wealth of complex combinations proven successful over centuries of clinical application. One such form ... Full text Cite

Requirement of IP3 receptor 3 (IP3R3) in nitric oxide induced cardiomyocyte differentiation of mouse embryonic stem cells.

Journal Article Experimental cell research · August 2016 Nitric oxide (NO) markedly induces cardiomyocyte (CM) differentiation of embryonic stem (ES) cells. Here we examined the role of the Ca(2+) signaling in the NO-induced CM differentiation of mouse ES cells. We found that NO induced intracellular Ca(2+) incr ... Full text Cite

Mechanistic study of TRPM2-Ca(2+)-CAMK2-BECN1 signaling in oxidative stress-induced autophagy inhibition.

Journal Article Autophagy · August 2016 Reactive oxygen species (ROS) have been commonly accepted as inducers of autophagy, and autophagy in turn is activated to relieve oxidative stress. Yet, whether and how oxidative stress, generated in various human pathologies, regulates autophagy remains u ... Full text Cite

Monitoring the intracellular calcium response to a dynamic hypertonic environment.

Journal Article Scientific reports · March 2016 The profiling of physiological response of cells to external stimuli at the single cell level is of importance. Traditional approaches to study cell responses are often limited by ensemble measurement, which is challenging to reveal the complex single cell ... Full text Cite

The role of Ca(2+) signaling on the self-renewal and neural differentiation of embryonic stem cells (ESCs).

Journal Article Cell calcium · March 2016 Embryonic stem cells (ESCs) are promising resources for both scientific research and clinical regenerative medicine. With regards to the latter, ESCs are especially useful for treating several neurodegenerative disorders. Two significant characteristics of ... Full text Cite

CD38 Is Required for Neural Differentiation of Mouse Embryonic Stem Cells by Modulating Reactive Oxygen Species.

Journal Article Stem cells (Dayton, Ohio) · September 2015 CD38 is a multifunctional membrane enzyme and the main mammalian ADP-ribosyl cyclase, which catalyzes the synthesis and hydrolysis of cADPR, a potent endogenous Ca(2+) mobilizing messenger. Here, we explored the role of CD38 in the neural differentiation o ... Full text Cite

Cyclic adenosine 5'-diphosphoribose (cADPR) mimics used as molecular probes in cell signaling.

Journal Article Chemical record (New York, N.Y.) · April 2015 Cyclic adenosine 5'-diphosphate ribose (cADPR) is a second messenger in the Ca(2+) signaling pathway. To elucidate its molecular mechanism in calcium release, a series of cADPR analogues with modification on ribose, nucleobase, and pyrophosphate have been ... Full text Cite

Ca(2+) handling in mouse embryonic stem cell-derived cardiomyocytes.

Journal Article Methods in molecular biology (Clifton, N.J.) · January 2015 Embryonic stem (ES) cells are alternative cell source for cell replacement therapy for cardiac diseases, thus it is important to verify if the cardiomyocytes derived from ES cells have comparable functional parameters similar to the mature cardiomyocytes. ... Full text Cite

Functional TRPV and TRPM channels in human preadipocytes.

Journal Article Pflugers Archiv : European journal of physiology · May 2014 Preadipocytes are widely used as an in vitro model to investigate proliferation, adipogenic differentiation, and lipodystrophy; however, cellular physiology and biology are not fully understood in human preadipocytes. The present study was to investigate t ... Full text Cite

Role of STIM1 in survival and neural differentiation of mouse embryonic stem cells independent of Orai1-mediated Ca2+ entry.

Journal Article Stem cell research · March 2014 Store-operated Ca(2+) entry (SOCE) is an important Ca(2+) influx pathway in non-excitable cells. STIM1, an ER Ca(2+) sensor, and Orai1, a plasma membrane Ca(2+) selective channel, are the two essential components of the Ca(2+) release activated channel (CR ... Full text Cite

Roles and mechanisms of the CD38/cyclic adenosine diphosphate ribose/Ca(2+) signaling pathway.

Journal Article World journal of biological chemistry · February 2014 Mobilization of intracellular Ca(2+) stores is involved in many diverse cell functions, including: cell proliferation; differentiation; fertilization; muscle contraction; secretion of neurotransmitters, hormones and enzymes; and lymphocyte activation and p ... Full text Cite

BKCa and hEag1 channels regulate cell proliferation and differentiation in human bone marrow-derived mesenchymal stem cells.

Journal Article Journal of cellular physiology · February 2014 Human bone marrow-derived mesenchymal stem cells (MSCs) serve as a reservoir for the continuous renewal of various mesenchymal tissues; however, cellular physiology of ion channels is not fully understood. The present study investigated potential roles of ... Full text Cite

Vacuolin-1 potently and reversibly inhibits autophagosome-lysosome fusion by activating RAB5A.

Journal Article Autophagy · January 2014 Autophagy is a catabolic lysosomal degradation process essential for cellular homeostasis and cell survival. Dysfunctional autophagy has been associated with a wide range of human diseases, e.g., cancer and neurodegenerative diseases. A large number of sma ... Full text Cite

NAADP/TPC2/Ca(2+) Signaling Inhibits Autophagy.

Journal Article Communicative & integrative biology · November 2013 Nicotinic adenine acid dinucleotide phosphate (NAADP) is one of the most potent endogenous Ca(2+) mobilizing messengers. NAADP mobilizes Ca(2+) from an acidic lysosome-related store, which can be subsequently amplified into global Ca(2+) waves by calcium-i ... Full text Cite

Requirement of B-Raf, C-Raf, and A-Raf for the growth and survival of mouse embryonic stem cells.

Journal Article Experimental cell research · November 2013 Extracellular signal-regulated kinases (ERKs) have been implicated to be dispensable for self-renewal of mouse embryonic stem (ES) cells, and simultaneous inhibition of both ERK signaling and glycogen synthase kinase 3 (GSK3) not only allows mouse ES cells ... Full text Cite

Two pore channel 2 (TPC2) inhibits autophagosomal-lysosomal fusion by alkalinizing lysosomal pH.

Journal Article The Journal of biological chemistry · August 2013 Autophagy is an evolutionarily conserved lysosomal degradation pathway, yet the underlying mechanisms remain poorly understood. Nicotinic acid adenine dinucleotide phosphate (NAADP), one of the most potent Ca(2+) mobilizing messengers, elicits Ca(2+) relea ... Full text Cite

Two pore channel 2 differentially modulates neural differentiation of mouse embryonic stem cells.

Journal Article PloS one · January 2013 Nicotinic acid adenine dinucleotide phosphate (NAADP) is an endogenous Ca(2+) mobilizing nucleotide presented in various species. NAADP mobilizes Ca(2+) from acidic organelles through two pore channel 2 (TPC2) in many cell types and it has been previously ... Full text Cite

Inhibition of cardiomyocytes differentiation of mouse embryonic stem cells by CD38/cADPR/Ca2+ signaling pathway.

Journal Article The Journal of biological chemistry · October 2012 Cyclic adenosine diphosphoribose (cADPR) is an endogenous Ca(2+) mobilizing messenger that is formed by ADP-ribosyl cyclases from nicotinamide adenine dinucleotide (NAD). The main ADP-ribosyl cyclase in mammals is CD38, a multi-functional enzyme and a type ... Full text Cite

A novel fluorescent cell membrane-permeable caged cyclic ADP-ribose analogue.

Journal Article The Journal of biological chemistry · July 2012 Cyclic adenosine diphosphate ribose is an endogenous Ca(2+) mobilizer involved in diverse cellular processes. A cell membrane-permeable cyclic adenosine diphosphate ribose analogue, cyclic inosine diphosphoribose ether (cIDPRE), can induce Ca(2+) increase ... Full text Cite

Synthesis and calcium mobilization activity of cADPR analogues which integrate nucleobase, northern and southern ribose modifications.

Journal Article Molecules (Basel, Switzerland) · April 2012 Novel cADPR mimics, which integrate nucleobase, northern and southern ribose modifications were synthesized. The key steps of the synthesis were a Cu(I)-catalyzed Hüisgen [3+2] cycloaddition and a microwave-assisted intramolecular pyrophosphorylation. Prel ... Full text Cite

A cell permeable NPE caged ADP-ribose for studying TRPM2.

Journal Article PloS one · January 2012 Transient potential receptor melastatin-2 (TRPM2) is a non-selective Ca(2+)-permeable cation channel of the TRPM channel subfamily and is mainly activated by intracellular adenosine diphosphate ribose (ADPR). Here we synthesized a 1-(2-nitrophenyl)ethyl ca ... Full text Cite

Intracellular alkalinization induces cytosolic Ca2+ increases by inhibiting sarco/endoplasmic reticulum Ca2+-ATPase (SERCA).

Journal Article PloS one · January 2012 Intracellular pH (pHi) and Ca(2+) regulate essentially all aspects of cellular activities. Their inter-relationship has not been mechanistically explored. In this study, we used bases and acetic acid to manipulate the pHi. We found that transient pHi rise ... Full text Cite

Design, synthesis and biological characterization of novel inhibitors of CD38.

Journal Article Organic & biomolecular chemistry · May 2011 Human CD38 is a novel multi-functional protein that acts not only as an antigen for B-lymphocyte activation, but also as an enzyme catalyzing the synthesis of a Ca(2+) messenger molecule, cyclic ADP-ribose, from NAD(+). It is well established that this nov ... Full text Cite

CD38/cADPR/Ca2+ pathway promotes cell proliferation and delays nerve growth factor-induced differentiation in PC12 cells.

Journal Article The Journal of biological chemistry · October 2009 Intracellular Ca(2+) mobilization plays an important role in a wide variety of cellular processes, and multiple second messengers are responsible for mediating intracellular Ca(2+) changes. Here we explored the role of one endogenous Ca(2+)-mobilizing nucl ... Full text Cite

Mechanistic studies of the mitotic activation of Mos.

Journal Article Molecular and cellular biology · July 2006 The protein kinase Mos is responsible for the activation of MEK1 and p42 mitogen-activated protein kinase during Xenopus oocyte maturation and during mitosis in Xenopus egg extracts. Here we show that the activation of Mos depends upon the phosphorylation ... Full text Cite

B-Raf and C-Raf are required for Ras-stimulated p42 MAP kinase activation in Xenopus egg extracts.

Journal Article Oncogene · June 2006 During mitosis, a select pool of MEK1 and p42/p44 MAPK becomes activated at the kinetochores and spindle poles, without substantial activation of the bulk of the cytoplasmic p42/p44 MAPK. Recently, we set out to identify the MAP kinase kinase kinase (MAPKK ... Full text Cite

Mos mediates the mitotic activation of p42 MAPK in Xenopus egg extracts.

Journal Article Current biology : CB · September 2004 The ERK1/ERK2 MAP kinases (MAPKs) are transiently activated during mitosis, and MAPK activation has been implicated in the spindle assembly checkpoint and in establishing the timing of an unperturbed mitosis. The MAPK activator MEK1 is required for mitotic ... Full text Cite

Requirement of TGF-beta receptor-dependent activation of c-Jun N-terminal kinases (JNKs)/stress-activated protein kinases (Sapks) for TGF-beta up-regulation of the urokinase-type plasminogen activator receptor.

Journal Article Journal of cellular physiology · May 2004 We have previously demonstrated that activation of the Ras/Mapk pathways is required for transforming growth factor beta (TGF-beta) induction of TGF-beta(1) expression. Here we examined the role of the Ras/Mapk pathways in TGF-beta induction of urokinase-t ... Full text Cite

Transforming growth factor-beta signal transduction in epithelial cells.

Journal Article Pharmacology & therapeutics · July 2001 Transforming growth factor (TGF)-beta is a natural and potent growth inhibitor of a variety of cell types, including epithelial, endothelial, and hematopoietic cells. The ability of TGF-beta to potently inhibit the growth of many solid tumors of epithelial ... Full text Cite

Requirement of Ras/MAPK pathway activation by transforming growth factor beta for transforming growth factor beta 1 production in a Smad-dependent pathway.

Journal Article The Journal of biological chemistry · October 2000 Our previous results have shown that transforming growth factor beta (TGFbeta) rapidly activates Ras, as well as both ERKs and SAPKs. In order to address the biological significance of the activation of these pathways by TGFbeta, here we examined the role ... Full text Cite

Activation of the mitogen-activated protein kinase pathway by transforming growth factor-beta.

Journal Article Methods in molecular biology (Clifton, N.J.) · January 2000 Full text Cite

Cloning and expression of a rat Smad1: regulation by TGFbeta and modulation by the Ras/MEK pathway.

Journal Article Journal of cellular physiology · March 1999 A new family of signaling intermediates for TGFbeta superfamily members and other growth factors has recently been identified and termed Smads. It has been suggested that the Smad1 subfamily is regulated primarily by the TGFbeta superfamily member bone mor ... Full text Cite

Cross-talk between the Smad1 and Ras/MEK signaling pathways for TGFbeta.

Journal Article Oncogene · March 1999 Our previous data demonstrated that Ras activation was necessary and sufficient for transforming growth factor-beta (TGFbeta)-mediated Erk1 activation, and was required for TGFbeta up-regulation of the Cdk inhibitors (CKI's) p27(Kip1) and p21(Cip1) (KM Mul ... Full text Cite

Transforming growth factor beta signaling through Smad1 in human breast cancer cells.

Journal Article Cancer research · October 1998 Previous results have suggested that Smad1 transduces signals in response to bone morphogenetic proteins (BMPs), but not in response to transforming growth factor beta (TGF-beta). Here we investigated the ability of TGF-beta to regulate Smad1 phosphorylati ... Cite

Blockade of TGFbeta3 up-regulation of p27Kip1 and p21Cip1 by expression of RasN17 in epithelial cells.

Journal Article Oncogene · July 1998 Our previous data demonstrated that Ras activation is necessary and sufficient for transforming growth factor beta (TGFbeta)-mediated Erk1 activation, and is partially required for the inhibition of cyclin-dependent kinase 2 (Cdk2) activity, cyclin A expre ... Full text Cite