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Jianpeng Yu

Jianpeng Yu

Visiting Scholar in the Department of Pathology
Pathology

Selected Publications

Monoacylglycerol lipase blockades the senescence-associated secretory phenotype by interfering with NF-κB activation and promotes docetaxel efficacy in prostate cancer.

Journal Article Oncogene · September 2024 Metabolic reprogramming and cellular senescence greatly contribute to cancer relapse and recurrence. In aging and treated prostate, persistent accumulating senescence-associated secretory phenotype (SASP) of cancer cells often limits the overall survival o ... Full text Link to item Cite

HOXB3 drives WNT-activation associated progression in castration-resistant prostate cancer.

Journal Article Cell Death Dis · March 27, 2023 Enabled resistance or innate insensitiveness to antiandrogen are lethal for castration-resistant prostate cancer (CRPC). Unfortunately, there seems to be little can be done to overcome the antiandrogen resistance because of the largely unknown mechanisms. ... Full text Link to item Cite

Circular RNAs in Prostate Cancer: Is it Time to Further Explore Liquid Biopsies?

Journal Article Mini Rev Med Chem · 2023 BACKGROUND: Although diagnosis and treatment of prostate cancer (PCa) have evolved rapidly in recent years, clinically significant molecular biomarkers are still needed to lower the mortality. Circular RNAs (circRNAs) are a poorly characterized component o ... Full text Link to item Cite

Identification of LAT/ZAP70 characterized immune subtypes of prostate cancer.

Journal Article World J Urol · November 2022 BACKGROUND: While immunotherapy has shown potent efficacy in clinical practices, patient selection to receive checkpoint blockade is still challenging in prostate cancer (PCa). LAT and ZAP70 functions in lymphocyte activation and plays a critical role in T ... Full text Link to item Cite

hsa_circ_0092339 acts as a molecular sponge in castration-resistant prostate cancer via the hsa-mir-940/C-MYC axis.

Journal Article Epigenomics · July 19, 2022 Aims: We aimed to determine whether intronic circRNA acts as a molecular sponge in castration-resistant prostate cancer (CRPC). Materials & methods: A gene chip technique was used to conduct sequencing. A qPCR experiment was performed to verify the result. ... Full text Link to item Cite

YAP1 plays a key role of the conversion of normal fibroblasts into cancer-associated fibroblasts that contribute to prostate cancer progression.

Journal Article J Exp Clin Cancer Res · February 17, 2020 BACKGROUND: Cancer-associated fibroblasts (CAFs) are an important part of the tumour microenvironment, and their functions are of great concern. This series of experiments aimed to explore how Yes-associated protein 1 (YAP1) regulates the function of strom ... Full text Link to item Cite

A retrospective analysis of the correlation between AXL expression and clinical outcomes of patients with urothelial bladder carcinoma

Journal Article Translational Cancer Research · June 1, 2019 Background: Immunohistochemistry (IHC) analysis of primary tumors revealed that AXL expression is associated with survival in patients with different cancers. The objective of our study is to investigate the relationship between the expression of AXL and c ... Full text Cite

LncRNA PCAT1 activates AKT and NF-κB signaling in castration-resistant prostate cancer by regulating the PHLPP/FKBP51/IKKα complex.

Journal Article Nucleic Acids Res · May 7, 2019 In PTEN-deficient prostate cancers, AKT signaling may be activated upon suppression of androgen receptor signaling. Activation of AKT as well as NF-κB signaling involves a key regulatory protein complex containing PHLPP, FKBP51 and IKKα. Here, we report a ... Full text Link to item Cite

KIF20A Affects the Prognosis of Bladder Cancer by Promoting the Proliferation and Metastasis of Bladder Cancer Cells.

Journal Article Dis Markers · 2019 OBJECTIVE: To investigate the expression of kinesin family member 20A (KIF20A) in bladder cancer, the effect of KIF20A on the proliferation and metastasis of bladder cancer cells, and the effect of KIF20A expression on the prognosis of bladder cancer patie ... Full text Link to item Cite

High Expression of KIF22/Kinesin-Like DNA Binding Protein (Kid) as a Poor Prognostic Factor in Prostate Cancer Patients.

Journal Article Med Sci Monit · November 14, 2018 BACKGROUND Kid (kinesin-like DNA binding protein), a member of microtubule-dependent molecular motor proteins, also known as KIF22, is reported to be associated with carcinogenesis and cancer progression in different types of malignant tumor, but the biolo ... Full text Link to item Cite

Sox5 contributes to prostate cancer metastasis and is a master regulator of TGF-β-induced epithelial mesenchymal transition through controlling Twist1 expression.

Journal Article Br J Cancer · January 2018 BACKGROUND: Metastatic castration-resistant prostate cancer (mCRPC) is one of the main contributors to the death of prostate cancer patients. To date, the detailed molecular mechanisms underlying mCRPC are unclear. Given the crucial role of epithelial-mese ... Full text Link to item Cite

Squamous differentiation in patients with superficial bladder urothelial carcinoma is associated with high risk of recurrence and poor survival.

Journal Article BMC Cancer · August 8, 2017 BACKGROUND: The independent prognostic role of squamous differentiation in pT1 bladder urothelial carcinoma has not been reported in previous studies. This article describes the impact of squamous differentiation on tumor recurrence and survival, and wheth ... Full text Link to item Cite

Clinicopathological study on thyroid follicular carcinoma-like renal tumor related to serious hypertension: Case report and review of the literature.

Journal Article Medicine (Baltimore) · March 2017 RATIONALE: Thyroid carcinoma-like tumor of the kidney (TLFCK) is an extremely rare variant of renal cell carcinoma. Most cases were incidentally found, while we report the first case of TLFCK presented with hypertension. PATIENT CONCERNS: A 25-year-old wom ... Full text Link to item Cite

An extramedullary plasmacytoma in the kidney of a 14-year-old girl: Case report and review of the literature.

Journal Article Medicine (Baltimore) · February 2017 RATIONALE: Extramedullary plasmacytoma (EMP) a rare plasma cell disorder and is frequently associated with plasma cell bone marrow infiltration. Most EMPs involve mucosal lymphoid tissue, especially in the nasopharyngeal area, respiratory tract, and head a ... Full text Link to item Cite