Scholars@Duke
Jiaxing Wang

Jiaxing Wang

Provisional Faculty in the Department of Ophthalmology
Ophthalmology

Selected Publications

Surgical outcomes of intermittent and constant exotropia in an adult population between 18 and 60 years old.

Journal Article Br J Ophthalmol · January 5, 2026 BACKGROUND: Comitant exotropia in adults poses distinct surgical challenges and has been less extensively studied compared with paediatric cases. Evaluating surgical outcomes in this population can inform treatment approaches and help establish realistic e ... Full text Link to item Cite

Tauroursodeoxycholic Acid Protects Retinal Ganglion Cells and Reduces Inflammation in Mice Following Optic Nerve Crush.

Journal Article Pharmaceuticals (Basel) · April 14, 2025 Purpose: The aim of this study was to investigate the protective effects of systemically administered tauroursodeoxycholic acid (TUDCA) in an optic nerve crush (ONC) mouse model of retinal ganglion cell (RGC) death. Methods: C57BL/6J mice were injected int ... Full text Link to item Cite

Association of serum 25-hydroxyvitamin D levels with age-related macular degeneration and its clinical correlates: a cross-sectional study.

Journal Article Front Endocrinol (Lausanne) · 2025 INTRODUCTION: Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss in older adults, with significant inter-individual variability in clinical progression. Vitamin D, known for its role in calcium homeostasis and anti-inflam ... Full text Link to item Cite

An improved method of transducing retinal ganglion cells using AAV via transpupillary injection in adult mouse eyes.

Journal Article Mol Vis · 2025 PURPOSE: Intravitreal injection of adeno-associated virus (AAV) vectors is a good approach for transducing retinal ganglion cells (RGCs) in mice. It allows for high transduction efficiency and is relatively specific to RGCs. To deliver vectors, most studie ... Link to item Cite

POU6F2, a risk factor for glaucoma, myopia and dyslexia, labels specific populations of retinal ganglion cells.

Journal Article Sci Rep · May 2, 2024 Pou6f2 is a genetic connection between central corneal thickness (CCT) in the mouse and a risk factor for developing primary open-angle glaucoma. POU6F2 is also a risk factor for several conditions in humans, including glaucoma, myopia, and dyslexia. Recen ... Full text Link to item Cite

Optimizing retinal ganglion cell nuclear staining for automated cell counting.

Journal Article Exp Eye Res · May 2024 The retinal ganglion cells (RGCs) serve as the critical pathway for transmitting visual information from the retina to the brain, yet they can be dramatically impacted by diseases such as glaucoma. When investigating disease processes affecting RGCs in mou ... Full text Link to item Cite

Long-term outcomes of administration of intravitreal triamcinolone acetonide after posterior vitreous detachment during pars plana vitrectomy for proliferative diabetic retinopathy.

Journal Article Br J Ophthalmol · April 2023 AIM: To evaluate the long-term outcomes of intravitreal triamcinolone acetonide (TA) administration after posterior vitreous detachment (PVD) during pars plana vitrectomy (PPV) for patients with proliferative diabetic retinopathy (PDR). METHODS: A total of ... Full text Link to item Cite

Evaluation and Follow-up of Myopia Prevalence Among School-Aged Children Subsequent to the COVID-19 Home Confinement in Feicheng, China.

Journal Article JAMA Ophthalmol · April 1, 2023 IMPORTANCE: Progression of myopia in a school-aged population due to home confinement (January to May 2021) during the COVID-19 pandemic has been previously reported. A key remaining question was whether the myopia spike in children aged 6 to 8 years persi ... Full text Link to item Cite

Prevalence of primary open angle glaucoma in the last 20 years: a meta-analysis and systematic review.

Journal Article Sci Rep · July 2, 2021 Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness in the world and is influenced by various sociodemographic factors. This meta-analysis aims to determine the worldwide prevalence of POAG in the adult general population for th ... Full text Link to item Cite

Systemic Treatment with Nicotinamide Riboside Is Protective in Two Mouse Models of Retinal Ganglion Cell Damage.

Journal Article Pharmaceutics · June 16, 2021 Glaucoma etiology often includes retinal ganglion cell (RGC) death associated with elevated intraocular pressure (IOP). However, even when IOP is managed well, disease can progress. It is thus important to develop therapeutic approaches that directly prote ... Full text Link to item Cite

Commonalities of optic nerve injury and glaucoma-induced neurodegeneration: Insights from transcriptome-wide studies.

Journal Article Exp Eye Res · June 2021 Glaucoma is a collection of diseases that lead to an irreversible vision loss due to damage of retinal ganglion cells (RGCs). Although the underlying events leading to RGC death are not fully understood, recent research efforts are beginning to define the ... Full text Link to item Cite

Progression of Myopia in School-Aged Children After COVID-19 Home Confinement.

Journal Article JAMA Ophthalmol · March 1, 2021 IMPORTANCE: Time spent in outdoor activities has decreased owing to home confinement for the coronavirus disease 2019 (COVID-19) pandemic. Concerns have been raised about whether home confinement may have worsened the burden of myopia owing to substantiall ... Full text Link to item Cite

Epidemiology of Sports-Related Eye Injuries Among Athletes in Tianjin, China.

Journal Article Front Med (Lausanne) · 2021 Purpose: To investigate the incidence, characteristics, and risk factors of sports-related eye injuries among athletes in Tianjin, China. Methods: A cross-sectional study was carried out from March 2018 to October 2018. In this study, the athletes from Tia ... Full text Link to item Cite

Smarce1 and Tensin 4 Are Putative Modulators of Corneoscleral Stiffness.

Journal Article Front Bioeng Biotechnol · 2021 The biomechanical properties of the cornea and sclera are important in the onset and progression of multiple ocular pathologies and vary substantially between individuals, yet the source of this variation remains unknown. Here we identify genes putatively ... Full text Link to item Cite

Prevalence of Primary Angle Closure Glaucoma in the Last 20 Years: A Meta-Analysis and Systematic Review.

Journal Article Front Med (Lausanne) · 2020 Purpose: This meta-analysis aims to investigate the worldwide prevalence of primary angle-closure glaucoma (PACG) and its risk factors in the last 20 years. Methods: We conducted a systematic review and meta-analysis of 37 population-based studies and 144, ... Full text Link to item Cite

Genomic Locus Modulating IOP in the BXD RI Mouse Strains.

Journal Article G3 (Bethesda) · May 4, 2018 Intraocular pressure (IOP) is the primary risk factor for developing glaucoma, yet little is known about the contribution of genomic background to IOP regulation. The present study leverages an array of systems genetics tools to study genomic factors modul ... Full text Link to item Cite

Genomic locus modulating corneal thickness in the mouse identifies POU6F2 as a potential risk of developing glaucoma.

Journal Article PLoS Genet · January 2018 Central corneal thickness (CCT) is one of the most heritable ocular traits and it is also a phenotypic risk factor for primary open angle glaucoma (POAG). The present study uses the BXD Recombinant Inbred (RI) strains to identify novel quantitative trait l ... Full text Link to item Cite