Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., University of Pennsylvania 2011
• 

  Duke Appointment History

  • Associate Professor of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2018 - 2019
  • Assistant Professor of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2014 - 2018
• Research
• 

  Selected Grants

  • Race-Related Alternative Splicing: Novel Targets in Prostate Cancer awarded by National Institutes of Health 2017 - 2022
  • Mechanisms that Direct Airway Remodeling in Obese Asthma awarded by National Institutes of Health 2017 - 2021
  • A hands-on, integrative next-generation sequencing course: design, experiment, and analysis awarded by National Institutes of Health 2016 - 2020
  • Bioinformatics and Computational Biology Training Program awarded by National Institutes of Health 2005 - 2020
  • Statistical/Computational Methods for Pharmacogenomics and Individualized Therapy awarded by University of North Carolina - Chapel Hill 2015 - 2020
  • Identification and validation of plasma-based protein biomarkers for cediranib and olaparib 2019
  • Duke CTSA (UL1) awarded by National Institutes of Health 2013 - 2018
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Wang, Xiaomeng, Hongliang Liu, Yinghui Xu, Jichun Xie, Dakai Zhu, Christopher I. Amos, Shenying Fang, et al. “Genetic variants in the calcium signaling pathway genes are associated with cutaneous melanoma-specific survival..” Carcinogenesis 40, no. 2 (April 29, 2019): 279–88. https://doi.org/10.1093/carcin/bgy188.
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    • Elsamadicy, Aladine A., Xinru Ren, Hanna Kemeny, Lefko Charalambous, Amanda R. Sergesketter, Shervin Rahimpour, Theresa Williamson, et al. “Independent Associations With 30- and 90-Day Unplanned Readmissions After Elective Lumbar Spine Surgery: A National Trend Analysis of 144 123 Patients..” Neurosurgery 84, no. 3 (March 1, 2019): 758–67. https://doi.org/10.1093/neuros/nyy215.
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    • Xu, Yinghui, Hongliang Liu, Shun Liu, Yanru Wang, Jichun Xie, Thomas E. Stinchcombe, Li Su, et al. “Genetic variant of IRAK2 in the toll-like receptor signaling pathway and survival of non-small cell lung cancer..” Int J Cancer 143, no. 10 (November 15, 2018): 2400–2408. https://doi.org/10.1002/ijc.31660.
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    • Xie, Jichun, and Ruosha Li. “False discovery rate control for high dimensional networks of quantile associations conditioning on covariates..” J R Stat Soc Series B Stat Methodol 80, no. 5 (November 2018): 1015–34. https://doi.org/10.1111/rssb.12288.
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    • Elsamadicy, Aladine A., Bilal Ashraf, Xinru Ren, Amanda R. Sergesketter, Lefko Charalambous, Hanna Kemeny, Tiffany Ejikeme, et al. “Prevalence and Cost Analysis of Chronic Pain After Hernia Repair: A Potential Alternative Approach With Neurostimulation..” Neuromodulation, October 15, 2018. https://doi.org/10.1111/ner.12871.
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    • Lin, Jiaxing, Jeremy Gresham, Tongrong Wang, So Young Kim, James Alvarez, Jeffrey S. Damrauer, Scott Floyd, et al. “bcSeq: an R package for fast sequence mapping in high-throughput shRNA and CRISPR screens..” Bioinformatics 34, no. 20 (October 15, 2018): 3581–83. https://doi.org/10.1093/bioinformatics/bty402.
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    • Zeng, Yi, Chao Nie, Junxia Min, Huashuai Chen, Xiaomin Liu, Rui Ye, Zhihua Chen, et al. “Sex Differences in Genetic Associations With Longevity..” Jama Netw Open 1, no. 4 (August 2018). https://doi.org/10.1001/jamanetworkopen.2018.1670.
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    • Elsamadicy, Aladine A., Siyun Yang, Amanda R. Sergesketter, Bilal Ashraf, Lefko Charalambous, Hanna Kemeny, Tiffany Ejikeme, et al. “Prevalence and Cost Analysis of Complex Regional Pain Syndrome (CRPS): A Role for Neuromodulation..” Neuromodulation 21, no. 5 (July 2018): 423–30. https://doi.org/10.1111/ner.12691.
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    • Lad, Shivanand P., Siyun Yang, Jichun Xie, Alfredo Farjat, Promila Pagadala, and Beth Parente. “Down the Rabbit Hole: Specialty Influence on SCS Outcomes..” Neuromodulation 21, no. 4 (June 2018): 417–20. https://doi.org/10.1111/ner.12789.
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    • Duan, Bensong, Jiangfeng Hu, Hongliang Liu, Yanru Wang, Hongyu Li, Shun Liu, Jichun Xie, et al. “Genetic variants in the platelet-derived growth factor subunit B gene associated with pancreatic cancer risk..” Int J Cancer 142, no. 7 (April 1, 2018): 1322–31. https://doi.org/10.1002/ijc.31171.
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    • Charalambous, Lefko T., Alykhan Premji, Caroline Tybout, Anastasia Hunt, Drew Cutshaw, Aladine A. Elsamadicy, Siyun Yang, et al. “Prevalence, healthcare resource utilization and overall burden of fungal meningitis in the United States..” J Med Microbiol 67, no. 2 (February 2018): 215–27. https://doi.org/10.1099/jmm.0.000656.
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    • Feng, Yun, Yanru Wang, Hongliang Liu, Zhensheng Liu, Coleman Mills, Kouros Owzar, Jichun Xie, et al. “Novel genetic variants in the P38MAPK pathway gene ZAK and susceptibility to lung cancer..” Mol Carcinog 57, no. 2 (February 2018): 216–24. https://doi.org/10.1002/mc.22748.
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    • Elsamadicy, Aladine A., Amanda Sergesketter, Xinru Ren, Syed Mohammed Qasim Hussaini, Avra Laarakker, Shervin Rahimpour, Tiffany Ejikeme, et al. “Drivers and Risk Factors of Unplanned 30-Day Readmission Following Spinal Cord Stimulator Implantation..” Neuromodulation 21, no. 1 (January 2018): 87–92. https://doi.org/10.1111/ner.12689.
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    • Farber, S Harrison, Jing L. Han, Aladine A. Elsamadicy, Qasim Hussaini, Siyun Yang, Promila Pagadala, Beth Parente, Jichun Xie, and Shivanand P. Lad. “Long-term Cost Utility of Spinal Cord Stimulation in Patients with Failed Back Surgery Syndrome..” Pain Physician 20, no. 6 (September 2017): E797–805.
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    • Farber, S Harrison, Jing L. Han, Aladine A. Elsamadicy, Qasim Hussaini, Siyun Yang, Promila Pagadala, Beth Parente, Jichun Xie, and Shivanand P. Lad. “Long-term Cost Utility of Spinal Cord Stimulation in Patients with Failed Back Surgery Syndrome.” Pain Physician 20, no. 6 (September 1, 2017): E796–804.
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    • Farber, S Harrison, Jing L. Han, Frank W. Petraglia Iii, Robert Gramer, Siyun Yang, Promila Pagadala, Beth Parente, Jichun Xie, Jeffrey R. Petrella, and Shivanand P. Lad. “Increasing Rates of Imaging in Failed Back Surgery Syndrome Patients: Implications for Spinal Cord Stimulation..” Pain Physician 20, no. 6 (September 2017): E969–77.
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    • Farber, S Harrison, Jing L. Han, Frank W. Petraglia, Robert Gramer, Siyun Yang, Promila Pagadala, Beth Parente, Jichun Xie, Jeffrey R. Petrella, and Shivanand P. Lad. “Increasing Rates of Imaging in Failed Back Surgery Syndrome Patients: Implications for Spinal Cord Stimulation.” Pain Physician 20, no. 6 (September 1, 2017): E968–76.
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    • Elsamadicy, Aladine A., Samuel Harrison Farber, Siyun Yang, Syed Mohammed Qasim Hussaini, Kelly R. Murphy, Amanda Sergesketter, Carter M. Suryadevara, et al. “Impact of Insurance Provider on Overall Costs in Failed Back Surgery Syndrome: A Cost Study of 122,827 Patients..” Neuromodulation 20, no. 4 (June 2017): 354–60. https://doi.org/10.1111/ner.12584.
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    • Han, Jing L., Kelly R. Murphy, Syed Mohammed Qasim Hussaini, Siyun Yang, Beth Parente, Jichun Xie, Promila Pagadala, and Shivanand P. Lad. “Explantation Rates and Healthcare Resource Utilization in Spinal Cord Stimulation..” Neuromodulation 20, no. 4 (June 2017): 331–39. https://doi.org/10.1111/ner.12567.
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    • Hussaini, Syed Mohammed Qasim, Kelly Ryan Murphy, Jing L. Han, Aladine A. Elsamadicy, Siyun Yang, Alykhan Premji, Beth Parente, Jichun Xie, Promila Pagadala, and Shivanand P. Lad. “Specialty-Based Variations in Spinal Cord Stimulation Success Rates for Treatment of Chronic Pain..” Neuromodulation 20, no. 4 (June 2017): 340–47. https://doi.org/10.1111/ner.12582.
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    • Murphy, Kelly Ryan, Jing L. Han, Syed Mohammed Qasim Hussaini, Siyun Yang, Beth Parente, Jichun Xie, and Shivanand P. Lad. “The Volume-Outcome Effect: Impact on Trial-to-Permanent Conversion Rates in Spinal Cord Stimulation..” Neuromodulation 20, no. 3 (April 2017): 256–62. https://doi.org/10.1111/ner.12526.
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    • Xie, Jichun, and Jian Kang. “High-dimensional tests for functional networks of brain anatomic regions..” J Multivar Anal 156 (April 2017): 70–88. https://doi.org/10.1016/j.jmva.2017.01.011.
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    • Farber, S Harrison, Kelly R. Murphy, Carter M. Suryadevara, Ranjith Babu, Siyun Yang, Liqi Feng, Jichun Xie, John R. Perfect, and Shivanand P. Lad. “Comparing outcomes of early, late, and non-surgical management of intraspinal abscess..” J Clin Neurosci 36 (February 2017): 64–71. https://doi.org/10.1016/j.jocn.2016.10.035.
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    • Murphy, Kelly Ryan, Jing L. Han, Siyun Yang, Syed Mohammed Qasim Hussaini, Aladine A. Elsamadicy, Beth Parente, Jichun Xie, Promila Pagadala, and Shivanand P. Lad. “Prevalence of Specific Types of Pain Diagnoses in a Sample of United States Adults..” Pain Physician 20, no. 2 (February 2017): E257–68.
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    • Krucoff, Max O., Steven Cook, Owoicho Adogwa, Jessica Moreno, Siyun Yang, Jichun Xie, Alexander O. Firempong, Nandan Lad, and Carlos A. Bagley. “Racial, Socioeconomic, and Gender Disparities in the Presentation, Treatment, and Outcomes of Adult Chiari I Malformations..” World Neurosurg 97 (January 2017): 431–37. https://doi.org/10.1016/j.wneu.2016.10.026.
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    • Cai, T Tony, Hongzhe Li, Weidong Liu, and Jichun Xie. “Joint Estimation of Multiple High-dimensional Precision Matrices..” Stat Sin 26, no. 2 (April 2016): 445–64. https://doi.org/10.5705/ss.2014.256.
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    • Farber, S Harrison, Jeffrey Hatef, Jing L. Han, Andrew H. Marky, Jichun Xie, Kevin Huang, Terence Verla, Yuliya Lokhnygina, Timothy A. Collins, and Shivanand P. Lad. “Implantable Neurostimulation for Headache Disorders: Effect on Healthcare Utilization and Expenditures..” Neuromodulation 19, no. 3 (April 2016): 319–28. https://doi.org/10.1111/ner.12393.
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    • Ha, Min Jin, Wei Sun, and Jichun Xie. “PenPC: A two-step approach to estimate the skeletons of high-dimensional directed acyclic graphs..” Biometrics 72, no. 1 (March 2016): 146–55. https://doi.org/10.1111/biom.12415.
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    • Xie, J., T. T. Cai, and H. Li. “Correction to the paper "Optimal false discovery rate control for dependent data" [Statistics and Its Interface, 4 (2011) 417-430].” Statistics and Its Interface 9, no. 1 (January 1, 2016): 33–35. https://doi.org/10.4310/SII.2016.v9.n1.e1.
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    • Napoli, Alessandro, Jichun Xie, and Iyad Obeid. “Understanding the temporal evolution of neuronal connectivity in cultured networks using statistical analysis..” Bmc Neurosci 15 (January 21, 2014). https://doi.org/10.1186/1471-2202-15-17.
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    • Cai, T Tony, Hongzhe Li, Weidong Liu, and Jichun Xie. “Covariate-Adjusted Precision Matrix Estimation with an Application in Genetical Genomics..” Biometrika 100, no. 1 (March 2013): 139–56. https://doi.org/10.1093/biomet/ass058.
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    • John Daye, Z., J. Xie, and H. Li. “A sparse structured shrinkage estimator for nonparametric varying-coefficient model with an application in genomics.” Journal of Computational and Graphical Statistics 21, no. 1 (April 23, 2012): 110–33. https://doi.org/10.1198/jcgs.2011.10102.
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    • Xie, Jichun, T Tony Cai, and Hongzhe Li. “Sample size and power analysis for sparse signal recovery in genome-wide association studies..” Biometrika 98, no. 2 (June 2011): 273–90. https://doi.org/10.1093/biomet/asr003.
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    • Chen, Jun, Jichun Xie, and Hongzhe Li. “A penalized likelihood approach for bivariate conditional normal models for dynamic co-expression analysis..” Biometrics 67, no. 1 (March 2011): 299–308. https://doi.org/10.1111/j.1541-0420.2010.01413.x.
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    • Xie, Jichun, T Tony Cai, John Maris, and Hongzhe Li. “Optimal False Discovery Rate Control for Dependent Data..” Stat Interface 4, no. 4 (2011): 417–30.
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    • Cotch, Mary Frances, Jon Peet, Justine Shults, Dwight Stambolian, and Jichun Xie. “Quasi-least squares with mixed linear correlation structures.” Statistics and Its Interface 3, no. 2 (2010): 223–33. https://doi.org/10.4310/sii.2010.v3.n2.a9.
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    • Pura, John, Cliburn Chan, and Jichun Xie. “Multiple Testing Embedded in an Aggregation Tree to Identify where Two Distributions Differ,” n.d.
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• Teaching & Mentoring
• 

  Recent Courses

  • BIOSTAT 906: Statistical Inference 2019

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