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Jichun Xie

Associate Professor of Biostatistics & Bioinformatics
Biostatistics & Bioinformatics, Division of Integrative Genomics
Duke Box 103854, Durham, NC 27710
Hock Plaza 10048, 2424 Erwin Rd, Durham, NC 27705, Durham, NC 27705

Current Appointments & Affiliations


Associate Professor of Biostatistics & Bioinformatics · 2025 - Present Biostatistics & Bioinformatics, Division of Integrative Genomics, Biostatistics & Bioinformatics
Associate Professor of Computer Science · 2025 - Present Computer Science, Trinity College of Arts & Sciences
Member of the Duke Cancer Institute · 2019 - Present Duke Cancer Institute, Institutes and Centers

Recent Publications


B-Lightning: using bait genes for marker gene hunting in single-cell data with complex heterogeneity.

Journal Article Brief Bioinform · November 22, 2024 In single-cell studies, cells can be characterized with multiple sources of heterogeneity (SOH) such as cell type, developmental stage, cell cycle phase, activation state, and so on. In some studies, many nuisance SOH are of no interest, but may confound t ... Full text Link to item Cite

SifiNet: a robust and accurate method to identify feature gene sets and annotate cells.

Journal Article Nucleic Acids Res · May 22, 2024 SifiNet is a robust and accurate computational pipeline for identifying distinct gene sets, extracting and annotating cellular subpopulations, and elucidating intrinsic relationships among these subpopulations. Uniquely, SifiNet bypasses the cell clusterin ... Full text Link to item Cite
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Recent Grants


Duke Program of Training in Pulmonary ReSearch to Promote, Engage and Retain Academic Researchers (PROSPER)

Inst. Training Prgm or CMEPreceptor · Awarded by National Heart, Lung, and Blood Institute · 2022 - 2026

New computational methods to dynamically pinpointing the subregions carrying disease-associated rare variants

ResearchPrincipal Investigator · Awarded by National Human Genome Research Institute · 2022 - 2026

Training Program in Bioinformatics at the Intersection of Cancer Immunology and Microbiome

ResearchTraining Faculty · Awarded by National Cancer Institute · 2020 - 2026

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Education, Training & Certifications


University of Pennsylvania · 2011 Ph.D.