https://orcid.org/0000-0001-5905-6728
Current Duke Appointments & Affiliations
Associate Professor of Biostatistics & Bioinformatics
·
2025 - Present
Biostatistics & Bioinformatics, Division of Integrative Genomics,
Biostatistics & Bioinformatics
Associate Professor of Mathematics
·
2020 - Present
Mathematics,
Trinity College of Arts & Sciences
Associate Professor of Computer Science
·
2025 - Present
Computer Science,
Trinity College of Arts & Sciences
Member of the Duke Cancer Institute
·
2019 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Scholarly Works
HaploPerturb: Low-rank copula construction of haplotype perturbations improves sequence-to-function analysis of Alzheimer's disease loci
Preprint · August 5, 2026 Sequence-to-function models predict molecular phenotypes from complete sequence windows. At genome-wide association study loci, however, the prevailing design perturbs only the lead variant on the reference genome, even though the lead is often correlated ... Link to item CiteA transcriptomics-native foundation model for universal cell representation and virtual cell synthesis.
Journal article bioRxiv · April 14, 2026 Current single-cell foundation models rely on language-model architectures that ignore transcriptomic data distributions, often underperforming specialized methods. We introduce xVERSE, a transcriptomics-native foundation model coupling batch-invariant rep ... Full text Link to item CiteSingle-cell and spatial detection of senescent cells using DeepScence.
Journal article Cell Genom · December 10, 2025 Accurately identifying senescent cells is essential for studying their spatial and molecular features. We developed DeepScence, a method based on deep neural networks, to identify senescent cells in single-cell and spatial transcriptomics data. DeepScence ... Full text Link to item CiteRecent Grants
Computational Biology and Bioinformatics Training Grant
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2026 - 2031Pathway-Centric AI for Dissecting Colorectal Cancer Heterogeneity Using Single-Cell and Spatial Omics
ResearchMentor · Awarded by National Institutes of Health · 2026 - 2028New computational methods to dynamically pinpointing the subregions carrying disease-associated rare variants
ResearchPrincipal Investigator · Awarded by National Human Genome Research Institute · 2022 - 2027View All Grants
Education
University of Pennsylvania ·
2011
Ph.D.