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Jichun Xie

Associate Professor of Biostatistics & Bioinformatics
Biostatistics & Bioinformatics, Division of Integrative Genomics
Duke Box 103854, Durham, NC 27710
Hock Plaza 10048, 2424 Erwin Rd, Durham, NC 27705, Durham, NC 27705

Research Interests


My research is focused on the development of computational and statistical methods for extracting meaningful information from the high-throughput sequencing data in cancer and/or immunology. I am interested in understanding the complicated structure and the biological background of the data, and adaptively developing new methods to utilize the data structure and biological background to increase the analysis power. Thus, my research sits at the intersection of Statistics, Machine Learning,  Bioinformatics, and Genetics and Genomics/Cancer/Immunology. I enjoy collaborating with both biomedical and quantitative investigators, and involving students in those projects.

Aside from high-throughput sequencing data, I have also collaborated actively in analyzing EHR data and developing longitudinal models to compare health utilities and treatment outcomes.




Selected Grants


Duke Program of Training in Pulmonary ReSearch to Promote, Engage and Retain Academic Researchers (PROSPER)

Inst. Training Prgm or CMEPreceptor · Awarded by National Heart, Lung, and Blood Institute · 2022 - 2026

New computational methods to dynamically pinpointing the subregions carrying disease-associated rare variants

ResearchPrincipal Investigator · Awarded by National Human Genome Research Institute · 2022 - 2026

Training Program in Bioinformatics at the Intersection of Cancer Immunology and Microbiome

ResearchTraining Faculty · Awarded by National Cancer Institute · 2020 - 2025

Race-related differential RNA splicing: novel targets for precision oncology in non-small cell lung cancer

ResearchCo Investigator · Awarded by National Institutes of Health · 2020 - 2021

Bioinformatics and Computational Biology Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2005 - 2021

Identification and validation of plasma-based protein biomarkers for cediranib and olaparib

ResearchCo Investigator · Awarded by Leidos Biomedical Research, Inc. · 2019 - 2020

A hands-on, integrative next-generation sequencing course: design, experiment, and analysis

Inst. Training Prgm or CMETraining Faculty · Awarded by National Institutes of Health · 2016 - 2020

Statistical/Computational Methods for Pharmacogenomics and Individualized Therapy

ResearchCo Investigator · Awarded by University of North Carolina - Chapel Hill · 2015 - 2020

Identification and validation of plasma-based protein biomarkers for cediranib and olaparib

ResearchCo Investigator · Awarded by Leidos Biomedical Research, Inc. · 2019 - 2019

Duke CTSA (UL1)

ResearchBiostatistician Investigator · Awarded by National Institutes of Health · 2013 - 2018