Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Cardiovascular Diseases Fellowship, Medicine, Duke University School of Medicine 2011 - 2016
  • Internal Medicine Residency, Medicine, Duke University School of Medicine 2009 - 2011
  • M.D., The Ohio State University College of Medicine 2009
• 

  Previous Appointments & Affiliations

  • Assistant Professor of Medicine, Medicine, Cardiology, Medicine 2019 - 2020
  • Medical Instructor in the Department of Medicine, Medicine, Cardiology, Medicine 2016 - 2019
• Research
• 

  Selected Grants

  • Mechanistic studies of Mas receptor activation and its role in aortic aneurysm formation awarded by National Institutes of Health 2017 - 2021
  • Molecular mechanisms of aortic aneurysm development awarded by American College of Cardiology Foundation 2016 - 2017
• 

  External Relationships

  • ConsumerMedical
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Kim, Jihee, Chad A. Grotegut, James W. Wisler, Lan Mao, Paul B. Rosenberg, Howard A. Rockman, and Robert J. Lefkowitz. “The β-arrestin-biased β-adrenergic receptor blocker carvedilol enhances skeletal muscle contractility.” Proc Natl Acad Sci U S A 117, no. 22 (June 2, 2020): 12435–43. https://doi.org/10.1073/pnas.1920310117.
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    • Kim, Jihee, Chad A. Grotegut, James W. Wisler, Tianyu Li, Lan Mao, Minyong Chen, Wei Chen, Paul B. Rosenberg, Howard A. Rockman, and Robert J. Lefkowitz. “β-arrestin 1 regulates β2-adrenergic receptor-mediated skeletal muscle hypertrophy and contractility.” Skelet Muscle 8, no. 1 (December 27, 2018): 39. https://doi.org/10.1186/s13395-018-0184-8.
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    • Kochar, Ajar, Jennifer Rymer, Zainab Samad, and Zainab Duke Cardiovascular Education Group. “Disrupting Fellow Education Through Group Texting: WhatsApp in Fellow Education?” J Am Coll Cardiol 72, no. 25 (December 25, 2018): 3366–69. https://doi.org/10.1016/j.jacc.2018.11.007.
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    • Wisler, James W., Howard A. Rockman, and Robert J. Lefkowitz. “Biased G Protein-Coupled Receptor Signaling: Changing the Paradigm of Drug Discovery.” Circulation 137, no. 22 (May 29, 2018): 2315–17. https://doi.org/10.1161/CIRCULATIONAHA.117.028194.
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    • Rein, Lindsay Am, James W. Wisler, Jihee Kim, Barbara Theriot, LiYin Huang, Trevor Price, Haeyoon Yang, et al. “β-Arrestin2 mediates progression of murine primary myelofibrosis.” Jci Insight 2, no. 24 (December 21, 2017). https://doi.org/10.1172/jci.insight.98094.
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    • Kahsai, Alem W., James W. Wisler, Jungmin Lee, Seungkirl Ahn, Thomas J. Cahill Iii, S Moses Dennison, Dean P. Staus, et al. “Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor.” Nat Chem Biol 12, no. 9 (September 2016): 709–16. https://doi.org/10.1038/nchembio.2126.
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    • Wisler, James W., Emily M. Harris, Michael Raisch, Lan Mao, Jihee Kim, Howard A. Rockman, and Robert J. Lefkowitz. “The role of β-arrestin2-dependent signaling in thoracic aortic aneurysm formation in a murine model of Marfan syndrome.” Am J Physiol Heart Circ Physiol 309, no. 9 (November 2015): H1516–27. https://doi.org/10.1152/ajpheart.00291.2015.
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    • Wisler, James W., and Richard C. Becker. “Antithrombotic therapy: new areas to understand efficacy and bleeding.” Expert Opin Ther Targets 18, no. 12 (December 2014): 1427–34. https://doi.org/10.1517/14728222.2014.953929.
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    • Wisler, James W., Kunhong Xiao, Alex R. B. Thomsen, and Robert J. Lefkowitz. “Recent developments in biased agonism.” Curr Opin Cell Biol 27 (April 2014): 18–24. https://doi.org/10.1016/j.ceb.2013.10.008.
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    • Wisler, James W., and Richard C. Becker. “Emerging paradigms in arterial thrombosis.” J Thromb Thrombolysis 37, no. 1 (January 2014): 4–11. https://doi.org/10.1007/s11239-013-0965-1.
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    • Han, Sang-oh, Kunhong Xiao, Jihee Kim, Jiao-Hui Wu, James W. Wisler, Nobuhiro Nakamura, Neil J. Freedman, and Sudha K. Shenoy. “MARCH2 promotes endocytosis and lysosomal sorting of carvedilol-bound β(2)-adrenergic receptors.” J Cell Biol 199, no. 5 (November 26, 2012): 817–30. https://doi.org/10.1083/jcb.201208192.
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    • Wisler, Jon R., James W. Wisler, Shelly Bansal, and Clay B. Marsh. “Challenges and opportunities in implementing pharmacogenomics testing in the clinics.” Per Med 9, no. 6 (August 2012): 609–19. https://doi.org/10.2217/pme.12.64.
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    • Wisler, James W., and Richard C. Becker. “A guidance pathway for the selection of novel anticoagulants in the treatment of atrial fibrillation.” Crit Pathw Cardiol 11, no. 2 (June 2012): 55–61. https://doi.org/10.1097/HPC.0b013e31825298ef.
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    • Wisler, James W., Jeffrey B. Washam, and Richard C. Becker. “Evaluation of dose requirements for prolonged bivalirudin administration in patients with renal insufficiency and suspected heparin-induced thrombocytopenia.” J Thromb Thrombolysis 33, no. 3 (April 2012): 287–95. https://doi.org/10.1007/s11239-011-0677-3.
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    • Wisler, James W., and Richard C. Becker. “Oral factor Xa inhibitors for the long-term management of ACS.” Nat Rev Cardiol 9, no. 7 (February 21, 2012): 392–401. https://doi.org/10.1038/nrcardio.2012.18.
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    • Wisler, J. W. “Clinical trials update: Recent and ongoing studies in anticoagulation for atrial fibrillation.” Open Access Journal of Clinical Trials 5, no. 1 (January 1, 2012): 101–10. https://doi.org/10.2147/OAJCT.S49106.
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    • Wisler, James W., Jonathan R. Wisler, Rebecca Coffey, and Sidney F. Miller. “The diversity of wound presentation associated with freon contact frostbite injury.” J Burn Care Res 31, no. 5 (2010): 809–12. https://doi.org/10.1097/BCR.0b013e3181eed452.
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    • Drake, Matthew T., Jonathan D. Violin, Erin J. Whalen, James W. Wisler, Sudha K. Shenoy, and Robert J. Lefkowitz. “beta-arrestin-biased agonism at the beta2-adrenergic receptor.” J Biol Chem 283, no. 9 (February 29, 2008): 5669–76. https://doi.org/10.1074/jbc.M708118200.
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    • Wisler, James W., Scott M. DeWire, Erin J. Whalen, Jonathan D. Violin, Matthew T. Drake, Seungkirl Ahn, Sudha K. Shenoy, and Robert J. Lefkowitz. “A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling.” Proc Natl Acad Sci U S A 104, no. 42 (October 16, 2007): 16657–62. https://doi.org/10.1073/pnas.0707936104.
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    • Wu, Zengru, Xu Xing, Casey E. Bohl, James W. Wisler, James T. Dalton, and Charles E. Bell. “Domain structure and DNA binding regions of beta protein from bacteriophage lambda.” J Biol Chem 281, no. 35 (September 1, 2006): 25205–14. https://doi.org/10.1074/jbc.M512450200.
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    • Rajan, Rakhi, James W. Wisler, and Charles E. Bell. “Probing the DNA sequence specificity of Escherichia coli RECA protein.” Nucleic Acids Res 34, no. 8 (2006): 2463–71. https://doi.org/10.1093/nar/gkl302.
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  • Conference Papers

    • Rein, Lindsay A. M., James W. Wisler, Barbara S. Theriot, Li-Yin Huang, Richard T. Premont, and Robert J. Lefkowitz. “beta-arrestin2 Is Necessary for Development of MPLW515L Mutant Primary Myelofibrosis.” In Blood, Vol. 126. AMER SOC HEMATOLOGY, 2015.
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    • Wisler, James, Emily Harris, Michael Raisch, Lan Mao, Jihee Kim, Howard Rockman, and Robert Lefkowitz. “NON-CANONICAL ANGIOTENSIN II TYPE 1A RECEPTOR-MEDIATED, BETA-ARRESTIN2-DEPENDENT SIGNALING CONTRIBUTES TO THORACIC AORTIC ANEURYSM FORMATION IN A MURINE MODEL OF MARFAN SYNDROME.” In Journal of the American College of Cardiology, 63:A2148–A2148. Elsevier BV, 2014. https://doi.org/10.1016/s0735-1097(14)62151-3.
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    • Rein, Lindsay A. M., Minyong Chen, Barbara S. Theriot, James W. Wisler, Laura M. Wingler, Richard T. Premont, Wei Chen, Julia K. L. Walker, and Robert J. Lefkowitz. “Targeting β-arrestin2 Enhances Survival in a Murine Model of Chronic Myeloid Leukemia.” In Blood, 122:857–857. American Society of Hematology, 2013. https://doi.org/10.1182/blood.v122.21.857.857.
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    • Wisler, James W., Jeffrey B. Washam, and Richard C. Becker. “Evaluation of Dose Requirements for Prolonged Bivalirudin Administration in Patients with Renal Insufficiency and Suspected Heparin-Induced Thrombocytopenia.” In Journal of the American College of Cardiology, 58:B46–47. ELSEVIER SCIENCE INC, 2011.
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