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James William Wisler

Assistant Professor of Medicine
Medicine, Cardiology
3320 Wake Forest Rd, Suite 200, Raleigh, NC 27609
3320 Wake Forest Rd, Suite 200, Raleigh, NC 27609

Current Appointments & Affiliations


Assistant Professor of Medicine · 2021 - Present Medicine, Cardiology, Medicine

Recent Publications


The β-arrestin-biased β-adrenergic receptor blocker carvedilol enhances skeletal muscle contractility.

Journal Article Proc Natl Acad Sci U S A · June 2, 2020 A decrease in skeletal muscle strength and functional exercise capacity due to aging, frailty, and muscle wasting poses major unmet clinical needs. These conditions are associated with numerous adverse clinical outcomes including falls, fractures, and incr ... Full text Open Access Link to item Cite

β-arrestin 1 regulates β2-adrenergic receptor-mediated skeletal muscle hypertrophy and contractility.

Journal Article Skelet Muscle · December 27, 2018 BACKGROUND: β2-adrenergic receptors (β2ARs) are the target of catecholamines and play fundamental roles in cardiovascular, pulmonary, and skeletal muscle physiology. An important action of β2AR stimulation on skeletal muscle is anabolic growth, which has l ... Full text Open Access Link to item Cite
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Recent Grants


Mechanistic studies of Mas receptor activation and its role in aortic aneurysm formation

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2017 - 2021

Molecular mechanisms of aortic aneurysm development

ResearchPrincipal Investigator · Awarded by American College of Cardiology Foundation · 2016 - 2017

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Education, Training & Certifications


The Ohio State University, College of Medicine · 2009 M.D.