Joe Chakkalakal
Associate Professor in Orthopaedic Surgery
The Chakkalakal laboratory studies the cellular and molecular mechanisms that contribute to the growth, regeneration, lifelong maintenance, and sarcopenia related deterioration of the neuromuscular system. We employ murine models, injury and transplant paradigms, cell isolation techniques, cell culture systems, gene expression analysis, high-resolution imaging methods, and assessment of neuromuscular function to determine how specific stem and progenitor cell populations, molecules of interest, and inflammatory related signals regulate neuromuscular development, regeneration, and aging.
Our studies have thus far established; interrelationships between age-related stem cell and neuromuscular decline, the involvement of stem cells in neuromuscular regeneration, cell specific roles for inflammation during neuromuscular regeneration, the cellular basis for juvenile neuromuscular growth, and contributors to lifelong neuromuscular decline in response to stressors such as DNA damaging paediatric cancer therapies. We hope insights gained from our studies can be exploited to identify therapeutic strategies that promote neuromuscular regenerative capacity and lifelong maintenance in a variety of contexts
Our studies have thus far established; interrelationships between age-related stem cell and neuromuscular decline, the involvement of stem cells in neuromuscular regeneration, cell specific roles for inflammation during neuromuscular regeneration, the cellular basis for juvenile neuromuscular growth, and contributors to lifelong neuromuscular decline in response to stressors such as DNA damaging paediatric cancer therapies. We hope insights gained from our studies can be exploited to identify therapeutic strategies that promote neuromuscular regenerative capacity and lifelong maintenance in a variety of contexts
Current Appointments & Affiliations
- Associate Professor in Orthopaedic Surgery, Orthopaedic Surgery, Clinical Science Departments 2022
- Associate Professor in Cell Biology, Cell Biology, Basic Science Departments 2022
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2022
Contact Information
- 308 Research Drive, LSRC B321b, Durham, NC 27710
-
joe.chakkalakal@duke.edu
-
Chakkalakal Lab
- Background
-
Education, Training, & Certifications
- Ph.D., University of Ottawa (Canada) 2006
-
Previous Appointments & Affiliations
- Instructor in the Department of Orthopaedic Surgery, Orthopaedic Surgery, Clinical Science Departments 2021 - 2022
- Research
-
Selected Grants
- Cellular Basis for Radiation induced acceleration of sarcopenia in juvenile cancer survivors awarded by National Institutes of Health 2022 - 2023
- Chondrocyte DNA Double-Strand Breaks in the Pathogenesis of Osteoarthritis awarded by University of Rochester 2022 - 2023
- Notch Signaling in non-myogenic mesenchymal cells regulates muscle development awarded by National Institutes of Health 2020 - 2023
-
Fellowships, Supported Research, & Other Grants
- Cellular Basis for Radiation induced acceleration of sarcopenia in juvenile cancer survivors awarded by National Cancer Institute (Rockville, US) 2017 - 2022
- Interrelationships between age-related skeletal muscle stem cell and NMJ decline awarded by National Institute on Aging (Bethesda, US) 2015 - 2020
- Cellular Basis for ADT-Induced Acceleration of Sarcopenia awarded by Congressionally Directed Medical Research Programs (Fort Detrick, US) 2014 - 2017
- The Establishment of Motor Unit Homogeneity during Development and after Axon Regeneration awarded by Canadian Institutes of Health Research (Ottawa, CA) 2006 - 2009
- Transcriptional and post-transcriptional regulation of utrophin expression in fast versus slow skeletal muscles awarded by Canadian Institutes of Health Research (Ottawa, CA) 2003 - 2006
- Publications & Artistic Works
-
Selected Publications
-
Academic Articles
-
Rambout, X., H. Cho, R. Blanc, Q. Lyu, J. M. Miano, J. V. Chakkalakal, G. M. Nelson, H. K. Yalamanchili, K. Adelman, and L. E. Maquat. “PGC-1α senses the CBC of pre-mRNA to dictate the fate of promoter-proximally paused RNAPII.” Molecular Cell 83, no. 2 (January 19, 2023): 186-202.e11. https://doi.org/10.1016/j.molcel.2022.12.022.Full Text
-
Leinroth, Abigail P., Anthony J. Mirando, Douglas Rouse, Yoshihiko Kobayahsi, Purushothama Rao Tata, Helen E. Rueckert, Yihan Liao, Jason T. Long, Joe V. Chakkalakal, and Matthew J. Hilton. “Identification of distinct non-myogenic skeletal-muscle-resident mesenchymal cell populations.” Cell Rep 39, no. 6 (May 10, 2022): 110785. https://doi.org/10.1016/j.celrep.2022.110785.Full Text Link to Item
-
Bachman, John F., and Joe V. Chakkalakal. “Insights into muscle stem cell dynamics during postnatal development.” Febs J 289, no. 10 (May 2022): 2710–22. https://doi.org/10.1111/febs.15856.Full Text Link to Item
-
O’Connor, Thomas N., Jacob G. Kallenbach, Haley M. Orciuoli, Nicole D. Paris, John F. Bachman, Carl J. Johnston, Eric Hernady, Jacqueline P. Williams, Robert T. Dirksen, and Joe V. Chakkalakal. “Endurance exercise attenuates juvenile irradiation-induced skeletal muscle functional decline and mitochondrial stress.” Skelet Muscle 12, no. 1 (April 12, 2022): 8. https://doi.org/10.1186/s13395-022-00291-y.Full Text Link to Item
-
Kallenbach, Jacob G., John F. Bachman, Nicole D. Paris, Roméo S. Blanc, Thomas O’Connor, Esraa Furati, Jacqueline P. Williams, and Joe V. Chakkalakal. “Muscle-specific functional deficits and lifelong fibrosis in response to paediatric radiotherapy and tumour elimination.” J Cachexia Sarcopenia Muscle 13, no. 1 (February 2022): 296–310. https://doi.org/10.1002/jcsm.12902.Full Text Link to Item
-
Larouche, Jacqueline A., Mahir Mohiuddin, Jeongmoon J. Choi, Peter J. Ulintz, Paula Fraczek, Kaitlyn Sabin, Sethuramasundaram Pitchiaya, et al. “Murine muscle stem cell response to perturbations of the neuromuscular junction are attenuated with aging.” Elife 10 (July 29, 2021). https://doi.org/10.7554/eLife.66749.Full Text Link to Item
-
Cole, Calvin L., John F. Bachman, Jian Ye, Joseph Murphy, Scott A. Gerber, Christopher A. Beck, Brendan F. Boyce, et al. “Increased myocellular lipid and IGFBP-3 expression in a pre-clinical model of pancreatic cancer-related skeletal muscle wasting.” J Cachexia Sarcopenia Muscle 12, no. 3 (June 2021): 731–45. https://doi.org/10.1002/jcsm.12699.Full Text Link to Item
-
Bachman, John F., Roméo S. Blanc, Nicole D. Paris, Jacob G. Kallenbach, Carl J. Johnston, Eric Hernady, Jacqueline P. Williams, and Joe V. Chakkalakal. “Radiation-Induced Damage to Prepubertal Pax7+ Skeletal Muscle Stem Cells Drives Lifelong Deficits in Myofiber Size and Nuclear Number.” Iscience 23, no. 11 (November 20, 2020): 101760. https://doi.org/10.1016/j.isci.2020.101760.Full Text Link to Item
-
Paris, Nicole D., Jacob G. Kallenbach, John F. Bachman, Roméo S. Blanc, Carl J. Johnston, Eric Hernady, Jacqueline P. Williams, and Joe V. Chakkalakal. “Chemoradiation impairs myofiber hypertrophic growth in a pediatric tumor model.” Sci Rep 10, no. 1 (November 11, 2020): 19501. https://doi.org/10.1038/s41598-020-75913-w.Full Text Link to Item
-
Blanc, Roméo S., Jacob G. Kallenbach, John F. Bachman, Amanda Mitchell, Nicole D. Paris, and Joe V. Chakkalakal. “Inhibition of inflammatory CCR2 signaling promotes aged muscle regeneration and strength recovery after injury.” Nat Commun 11, no. 1 (August 20, 2020): 4167. https://doi.org/10.1038/s41467-020-17620-8.Full Text Link to Item
-
Li, Jinbo, Xiangjiao Yi, Zhenqiang Yao, Joe V. Chakkalakal, Lianping Xing, and Brendan F. Boyce. “TNF Receptor-Associated Factor 6 Mediates TNFα-Induced Skeletal Muscle Atrophy in Mice During Aging.” J Bone Miner Res 35, no. 8 (August 2020): 1535–48. https://doi.org/10.1002/jbmr.4021.Full Text Link to Item
-
Pan, Chunliu, Neha Jaiswal Agrawal, Yanni Zulia, Shalini Singh, Kai Sha, James L. Mohler, Kevin H. Eng, Joe V. Chakkalakal, John J. Krolewski, and Kent L. Nastiuk. “Prostate tumor-derived GDF11 accelerates androgen deprivation therapy-induced sarcopenia.” Jci Insight 5, no. 6 (March 26, 2020). https://doi.org/10.1172/jci.insight.127018.Full Text Link to Item
-
Bell, Richard D., Emily K. Wu, Christopher A. Rudmann, Megan Forney, Claire R. W. Kaiser, Ronald W. Wood, Joe V. Chakkalakal, et al. “Selective Sexual Dimorphisms in Musculoskeletal and Cardiopulmonary Pathologic Manifestations and Mortality Incidence in the Tumor Necrosis Factor-Transgenic Mouse Model of Rheumatoid Arthritis.” Arthritis Rheumatol 71, no. 9 (September 2019): 1512–23. https://doi.org/10.1002/art.40903.Full Text Link to Item
-
Yue, Li, MA Hassan Talukder, Anagha Gurjar, Jung Il Lee, Mark Noble, Robert T. Dirksen, Joe Chakkalakal, and John C. Elfar. “4-Aminopyridine attenuates muscle atrophy after sciatic nerve crush injury in mice.” Muscle Nerve 60, no. 2 (August 2019): 192–201. https://doi.org/10.1002/mus.26516.Full Text Link to Item
-
Bachman, John F., Alanna Klose, Wenxuan Liu, Nicole D. Paris, Roméo S. Blanc, Melissa Schmalz, Emma Knapp, and Joe V. Chakkalakal. “Prepubertal skeletal muscle growth requires Pax7-expressing satellite cell-derived myonuclear contribution.” Development 145, no. 20 (October 25, 2018). https://doi.org/10.1242/dev.167197.Full Text Link to Item
-
Klose, Alanna, Wenxuan Liu, Nicole D. Paris, Sophie Forman, John J. Krolewski, Kent L. Nastiuk, and Joe V. Chakkalakal. “Castration induces satellite cell activation that contributes to skeletal muscle maintenance.” Jcsm Rapid Communications 1, no. 1 (January 2018): 1–16. https://doi.org/10.1002/j.2617-1619.2018.tb00004.x.Full Text
-
Dunne, Richard F., Karen M. Mustian, Jose M. Garcia, William Dale, Reid Hayward, Breton Roussel, Mary M. Buschmann, et al. “Research priorities in cancer cachexia: The University of Rochester Cancer Center NCI Community Oncology Research Program Research Base Symposium on Cancer Cachexia and Sarcopenia.” Curr Opin Support Palliat Care 11, no. 4 (December 2017): 278–86. https://doi.org/10.1097/SPC.0000000000000301.Full Text Link to Item
-
Liu, Wenxuan, Alanna Klose, Sophie Forman, Nicole D. Paris, Lan Wei-LaPierre, Mariela Cortés-Lopéz, Aidi Tan, et al. “Loss of adult skeletal muscle stem cells drives age-related neuromuscular junction degeneration.” Elife 6 (June 6, 2017). https://doi.org/10.7554/eLife.26464.Full Text Link to Item
-
Paris, Nicole D., Andrew Soroka, Alanna Klose, Wenxuan Liu, and Joe V. Chakkalakal. “Smad4 restricts differentiation to promote expansion of satellite cell derived progenitors during skeletal muscle regeneration.” Elife 5 (November 18, 2016). https://doi.org/10.7554/eLife.19484.Full Text Link to Item
-
Pan, Chunliu, Shalini Singh, Deepak M. Sahasrabudhe, Joe V. Chakkalakal, John J. Krolewski, and Kent L. Nastiuk. “TGFβ Superfamily Members Mediate Androgen Deprivation Therapy-Induced Obese Frailty in Male Mice.” Endocrinology 157, no. 11 (November 2016): 4461–72. https://doi.org/10.1210/en.2016-1580.Full Text Link to Item
-
Williams, Jacqueline P., Laura Calvi, Joe V. Chakkalakal, Jacob N. Finkelstein, M Kerry O’Banion, and Edward Puzas. “Addressing the Symptoms or Fixing the Problem? Developing Countermeasures against Normal Tissue Radiation Injury.” Radiat Res 186, no. 1 (July 2016): 1–16. https://doi.org/10.1667/RR14473.1.Full Text Link to Item
-
Liu, Wenxuan, Lan Wei-LaPierre, Alanna Klose, Robert T. Dirksen, and Joe V. Chakkalakal. “Inducible depletion of adult skeletal muscle stem cells impairs the regeneration of neuromuscular junctions.” Elife 4 (August 27, 2015). https://doi.org/10.7554/eLife.09221.Full Text Link to Item
-
Chakkalakal, Joe V., Josef Christensen, Wanyi Xiang, Mathew T. Tierney, Francesca S. Boscolo, Alessandra Sacco, and Andrew S. Brack. “Early forming label-retaining muscle stem cells require p27kip1 for maintenance of the primitive state.” Development 141, no. 8 (April 2014): 1649–59. https://doi.org/10.1242/dev.100842.Full Text Link to Item
-
Chakkalakal, Joe V., Kieran M. Jones, M Albert Basson, and Andrew S. Brack. “The aged niche disrupts muscle stem cell quiescence.” Nature 490, no. 7420 (October 18, 2012): 355–60. https://doi.org/10.1038/nature11438.Full Text Link to Item
-
Chakkalakal, Jv, and As Brack. “Extrinsic Regulation of Satellite Cell Function and Muscle Regeneration Capacity during Aging.” J Stem Cell Res Ther Suppl 11 (September 26, 2012): 001. https://doi.org/10.4172/2157-7633.S11-001.Full Text Link to Item
-
Chakkalakal, Joe V., Shihuan Kuang, Mario Buffelli, Jeff W. Lichtman, and Joshua R. Sanes. “Mouse transgenic lines that selectively label Type I, Type IIA, and Types IIX+B skeletal muscle fibers.” Genesis 50, no. 1 (January 2012): 50–58. https://doi.org/10.1002/dvg.20794.Full Text Link to Item
-
Chakkalakal, Joe V., Hiroshi Nishimune, Jorge L. Ruas, Bruce M. Spiegelman, and Joshua R. Sanes. “Retrograde influence of muscle fibers on their innervation revealed by a novel marker for slow motoneurons.” Development 137, no. 20 (October 2010): 3489–99. https://doi.org/10.1242/dev.053348.Full Text Link to Item
-
Miura, Pedro, Joe V. Chakkalakal, Louise Boudreault, Guy Bélanger, Richard L. Hébert, Jean-Marc Renaud, and Bernard J. Jasmin. “Pharmacological activation of PPARbeta/delta stimulates utrophin A expression in skeletal muscle fibers and restores sarcolemmal integrity in mature mdx mice.” Hum Mol Genet 18, no. 23 (December 1, 2009): 4640–49. https://doi.org/10.1093/hmg/ddp431.Full Text Link to Item
-
Chakkalakal, Joe V., Pedro Miura, Guy Bélanger, Robin N. Michel, and Bernard J. Jasmin. “Modulation of utrophin A mRNA stability in fast versus slow muscles via an AU-rich element and calcineurin signaling.” Nucleic Acids Res 36, no. 3 (February 2008): 826–38. https://doi.org/10.1093/nar/gkm1107.Full Text Link to Item
-
Michel, R. N., E. R. Chin, J. V. Chakkalakal, J. K. Eibl, and B. J. Jasmin. “Erratum: Ca2+/calmodulin-based signalling in the regulation of the muscle fibre phenotype and its therapeutic potential via modulation of utrophin A and myostatin expression (Applied Physiology, Nutrition and Metabolism (2007) 32, (921-929)).” Applied Physiology, Nutrition and Metabolism 32, no. 6 (December 1, 2007): 1274. https://doi.org/10.1139/H07-157.Full Text
-
Michel, Robin N., Eva R. Chin, Joe V. Chakkalakal, Joe K. Eibl, and Bernard J. Jasmin. “Ca2+/calmodulin-based signalling in the regulation of the muscle fibre phenotype and its therapeutic potential via modulation of utrophin A and myostatin expression.” Appl Physiol Nutr Metab 32, no. 5 (October 2007): 921–29. https://doi.org/10.1139/H07-093.Full Text Link to Item
-
Chakkalakal, Joe V., Stephanie A. Michel, Eva R. Chin, Robin N. Michel, and Bernard J. Jasmin. “Targeted inhibition of Ca2+ /calmodulin signaling exacerbates the dystrophic phenotype in mdx mouse muscle.” Hum Mol Genet 15, no. 9 (May 1, 2006): 1423–35. https://doi.org/10.1093/hmg/ddl065.Full Text Link to Item
-
Angus, Lindsay M., Joe V. Chakkalakal, Alexandre Méjat, Joe K. Eibl, Guy Bélanger, Lynn A. Megeney, Eva R. Chin, Laurent Schaeffer, Robin N. Michel, and Bernard J. Jasmin. “Calcineurin-NFAT signaling, together with GABP and peroxisome PGC-1{alpha}, drives utrophin gene expression at the neuromuscular junction.” Am J Physiol Cell Physiol 289, no. 4 (October 2005): C908–17. https://doi.org/10.1152/ajpcell.00196.2005.Full Text Link to Item
-
Davies, K. E. “Regulation of utrophin in transgenic mice.” Neuromuscul Disord 15, no. 9–10 (October 2005): 648. https://doi.org/10.1016/j.nmd.2005.06.013.Full Text Link to Item
-
Stocksley, Mark A., Joe V. Chakkalakal, Amanda Bradford, Pedro Miura, Yves De Repentigny, Rashmi Kothary, and Bernard J. Jasmin. “Reply to Davies.” Neuromuscular Disorders 15, no. 9–10 (October 2005): 648–49. https://doi.org/10.1016/j.nmd.2005.06.014.Full Text
-
Miura, Pedro, Jennifer Thompson, Joe V. Chakkalakal, Martin Holcik, and Bernard J. Jasmin. “The utrophin A 5'-untranslated region confers internal ribosome entry site-mediated translational control during regeneration of skeletal muscle fibers.” J Biol Chem 280, no. 38 (September 23, 2005): 32997–5. https://doi.org/10.1074/jbc.M503994200.Full Text Link to Item
-
Chakkalakal, Joe V., Jennifer Thompson, Robin J. Parks, and Bernard J. Jasmin. “Molecular, cellular, and pharmacological therapies for Duchenne/Becker muscular dystrophies.” Faseb J 19, no. 8 (June 2005): 880–91. https://doi.org/10.1096/fj.04-1956rev.Full Text Link to Item
-
Stocksley, Mark A., Joe V. Chakkalakal, Amanda Bradford, Pedro Miura, Yves De Repentigny, Rashmi Kothary, and Bernard J. Jasmin. “A 1.3 kb promoter fragment confers spatial and temporal expression of utrophin A mRNA in mouse skeletal muscle fibers.” Neuromuscul Disord 15, no. 6 (June 2005): 437–49. https://doi.org/10.1016/j.nmd.2005.03.008.Full Text Link to Item
-
St-Pierre, Simon J. G., Joe V. Chakkalakal, Steven M. Kolodziejczyk, Jennifer C. Knudson, Bernard J. Jasmin, and Lynn A. Megeney. “Glucocorticoid treatment alleviates dystrophic myofiber pathology by activation of the calcineurin/NF-AT pathway.” Faseb J 18, no. 15 (December 2004): 1937–39. https://doi.org/10.1096/fj.04-1859fje.Full Text Link to Item
-
Chakkalakal, Joe V., Mary-Ann Harrison, Salvatore Carbonetto, Eva Chin, Robin N. Michel, and Bernard J. Jasmin. “Stimulation of calcineurin signaling attenuates the dystrophic pathology in mdx mice.” Hum Mol Genet 13, no. 4 (February 15, 2004): 379–88. https://doi.org/10.1093/hmg/ddh037.Full Text Link to Item
-
Chakkalakal, Joe V., Mark A. Stocksley, Mary-Ann Harrison, Lindsay M. Angus, Julie Deschenes-Furry, Simon St-Pierre, Lynn A. Megeney, Eva R. Chin, Robin N. Michel, and Bernard J. Jasmin. “Expression of utrophin A mRNA correlates with the oxidative capacity of skeletal muscle fiber types and is regulated by calcineurin/NFAT signaling.” Proc Natl Acad Sci U S A 100, no. 13 (June 24, 2003): 7791–96. https://doi.org/10.1073/pnas.0932671100.Full Text Link to Item
-
Chakkalakal, Joe V., and Bernard J. Jasmin. “Localizing synaptic mRNAs at the neuromuscular junction: it takes more than transcription.” Bioessays 25, no. 1 (January 2003): 25–31. https://doi.org/10.1002/bies.10205.Full Text Link to Item
-
Jasmin, Bernard J., Lindsay M. Angus, Guy Bélanger, Joe V. Chakkalakal, Anthony O. Gramolini, John A. Lunde, Mark A. Stocksley, and Jennifer Thompson. “Multiple regulatory events controlling the expression and localization of utrophin in skeletal muscle fibers: insights into a therapeutic strategy for Duchenne muscular dystrophy.” J Physiol Paris 96, no. 1–2 (2002): 31–42. https://doi.org/10.1016/s0928-4257(01)00078-x.Full Text Link to Item
-
Gramolini, A. O., G. Bélanger, J. M. Thompson, J. V. Chakkalakal, and B. J. Jasmin. “Increased expression of utrophin in a slow vs. a fast muscle involves posttranscriptional events.” Am J Physiol Cell Physiol 281, no. 4 (October 2001): C1300–1309. https://doi.org/10.1152/ajpcell.2001.281.4.C1300.Full Text Link to Item
-
-
Book Sections
-
Liu, Wenxuan, and Joe V. Chakkalakal. “The Composition, Development, and Regeneration of Neuromuscular Junctions.,” 126:99–124, 2018. https://doi.org/10.1016/bs.ctdb.2017.08.005.Full Text Link to Item
-
-
Other Articles
-
O’Connor, T. N., J. G. Kallenbach, J. V. Chakkalakal, and R. T. Dirksen. “Exercise attenuates juvenile irradiation-induced skeletal muscle decline by improving calcium handling and decreasing mitochondrial stress (Accepted).” The Journal of General Physiology, September 5, 2022. https://doi.org/10.1085/jgp.2021ecc21.Full Text Open Access Copy
-
-
Conference Papers
-
Leinroth, Abigail, Anthony Mirando, Jason Long, Yihan Liao, Joe Chakkalakal, and Matthew Hilton. “Prx1Cre Expressing Cells and Their Descendants Form UniqueNon-Myogenic Mesenchymal Cell Populations Within Skeletal Muscle.” In Journal of Bone and Mineral Research, 37:54–55, 2022.Link to Item
-
Talukder, MA Hassan, Li Yue, Mark Noble, Robert Dirksen, Joe Chakkalakal, and John C. Elfar. “A Potassium Channel Blocker, 4-Aminopyridine, Attenuates Peripheral Nerve Injury-induced Muscle Atrophy, Improves Intrinsic Muscle Force, and Suppresses the Expression of Muscle Atrophy-related Transcription Factors in Mice.” In Faseb Journal, Vol. 33, 2019.Link to Item
-
Bell, Richard, Emily Wu, Ronald Wood, Joe Chakkalakal, Javier Rangel-Moreno, Maria de la Luz Garcia-Hernandez, Christopher T. Ritchlin, Edward Schwarz, and Homaira Rahimi. “Early Onset Morbidity and Mortality in Female Tumor Necrosis Factor Transgenic Mice with Inflammatory-Erosive Arthritis and Interstitial Lung Disease.” In Arthritis & Rheumatology, Vol. 68, 2016.Link to Item
-
Bell, Richard, Ronald Wood, Joe Chakkalakal, Christopher T. Ritchlin, Edward Schwarz, and Homaira Rahimi. “Increased Morbidity and Mortality in Female Versus Male Tumor Necrosis Factor-Transgenic Mice.” In Arthritis & Rheumatology, Vol. 67, 2015.Link to Item
-
Kryvalap, Yury, Ekaterina Manuylova, Raman Baldzizhar, Chi-Wen Lo, Joe Chakkalakal, and Jan Czyzyk. “The Role of Anti-serpin Immunity in Pancreatic Islet Regeneration.” In Diabetes, 64:A468–69, 2015.Link to Item
-
Miura, Pedro, Joe V. Chakkalakal, John Lunde, Amanda Shaver, Guy Belanger, and Bernard J. Jasmin. “Activation of PPAR delta stimulates utrophin A expression in skeletal muscle cells.” In Faseb Journal, 21:A1301–2, 2007.Link to Item
-
Chakkalakal, J. V., M. A. Stocksley, J. D. Furry, E. R. Chin, M. A. Harrison, R. N. Michel, and B. J. Jasmin. “Expression of utrophin a mRNA correlates with the metabolic efficiency of muscle and involves calcineurin.” In Faseb Journal, 17:A956–A956, 2003.Link to Item
-
-
Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.