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Joe Chakkalakal

Associate Professor in Orthopaedic Surgery
Orthopaedic Surgery

Selected Grants


Engineering Heterocellular Human Skeletal Muscle Tissues to Recreate and Study Native Stem Cell Niche Function

ResearchCo Investigator · Awarded by National Institutes of Health · 2024 - 2029

Engineering a Human Skeletal Muscle Tissue Model of LGMD2B

ResearchCo Investigator · Awarded by National Institutes of Health · 2023 - 2028

Training Program in Developmental and Stem Cell Biology

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2001 - 2027

Cell and Molecular Biology Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2021 - 2026

Genetic and Therapeutic Approaches to Alleviate the Pathology of Massive Rotator Cuff Tears

ResearchCo Investigator · Awarded by National Institutes of Health · 2024 - 2026

Understanding and engineering the relationship of muscle stem cells with the neuromuscular junction in aging

ResearchPrincipal Investigator · Awarded by University of Michigan · 2023 - 2026

Chondrocyte DNA Double-Strand Breaks in the Pathogenesis of Osteoarthritis

ResearchPrincipal Investigator · Awarded by University of Rochester · 2022 - 2025

Cellular Basis for Radiation induced acceleration of sarcopenia in juvenile cancer survivors

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2022 - 2023

Notch Signaling in non-myogenic mesenchymal cells regulates muscle development

FellowshipMentor · Awarded by National Institutes of Health · 2020 - 2023

Fellowships, Gifts, and Supported Research


Cellular Basis for Radiation induced acceleration of sarcopenia in juvenile cancer survivors · August 1, 2017 - July 31, 2022 Awarded by: National Cancer Institute (Rockville, US)
Interrelationships between age-related skeletal muscle stem cell and NMJ decline · September 30, 2015 - May 31, 2020 Awarded by: National Institute on Aging (Bethesda, US)
Cellular Basis for ADT-Induced Acceleration of Sarcopenia · September 1, 2014 - July 31, 2017 Awarded by: Congressionally Directed Medical Research Programs (Fort Detrick, US)
The Establishment of Motor Unit Homogeneity during Development and after Axon Regeneration · October 1, 2006 - September 30, 2009 Awarded by: Canadian Institutes of Health Research (Ottawa, CA)
Transcriptional and post-transcriptional regulation of utrophin expression in fast versus slow skeletal muscles · May 1, 2003 - April 30, 2006 Awarded by: Canadian Institutes of Health Research (Ottawa, CA)