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John Howard Sampson

Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine
Neurosurgery
Box 3810 Med Ctr, Durham, NC 27710
1293 Orange Zone, Duke South, 200 Trent Dr, Durham, NC 27710

Selected Grants


Clinical Neuroimmunology of CCL3 in Brain Tumors

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2024 - 2029

ATRXmutations,innate immune activation and therapeutic vunerabilityin malignant gliomas

ResearchCollaborator · Awarded by National Institutes of Health · 2022 - 2027

Medical Scientist Training Program

Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2022 - 2027

University Training Program in Biomolecular and Tissue Engineering

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1994 - 2027

Clinical Neuroimmunology of CCL3 in Brain Tumors

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2024 - 2029

ATRXmutations,innate immune activation and therapeutic vunerabilityin malignant gliomas

ResearchCollaborator · Awarded by National Institutes of Health · 2022 - 2027

Medical Scientist Training Program

Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2022 - 2027

University Training Program in Biomolecular and Tissue Engineering

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1994 - 2027

Basic Immunology Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2020 - 2025

Mechanisms and Clinical Impact of Myocardial Injury Following Traumatic Brain Injury

ResearchCo-Mentor · Awarded by National Institutes of Health · 2019 - 2025

Viral Oncology Training Grant

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1980 - 2024

Advanced Immunobiology Traning Program for Surgeons

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2019 - 2024

Experimental Therapy for Brain Tumors

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2018 - 2023

Metabolic reprogramming to improve EGFRvIII CAR T cell persistence

ResearchSignificant Contributor · Awarded by University of North Carolina - Chapel Hill · 2023 - 2023

Creating the next generation peptide vaccine directed at cytomegalovirus antigens in malignant brain

ResearchSignificant Contributor · Awarded by National Pediatric Cancer Foundation, Inc. · 2022 - 2023

Metabolic reprogramming to improve EGFRvIII CAR T cell persistence

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2021 - 2023

Human EGFRvIII-specific BiTE for the treatment of Glioblastoma

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2015 - 2023

Cabinet Radiation Therapy System for Small Animals

EquipmentMajor User · Awarded by North Carolina Biotechnology Center · 2022 - 2023

Clinical Neuroimmunology of Vaccines in Brain Tumors

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2021 - 2022

T32 UNC - Duke Immunotherapy Training Program

Inst. Training Prgm or CMEPreceptor · Awarded by University of North Carolina - Chapel Hill · 2021 - 2022

BATF3+ Dendritic Cells for the Treatment of Malignant Gliomas

ResearchCo-Mentor · Awarded by Department of Defense · 2020 - 2022

Translational Research in Surgical Oncology

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2002 - 2022

Image-Guided Radiation Therapy System for Small Animals

EquipmentMajor User · Awarded by National Institutes of Health · 2021 - 2022

Medical Scientist Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1997 - 2022

Is Low Tumor Mutational Burden Predictive of Response to Oncolytic Polio Virus Therapy in Recurrent Glioblastoma?

ResearchCollaborator · Awarded by National Institutes of Health · 2019 - 2022

PBTF Institute Grant

ResearchPrincipal Investigator · Awarded by Pediatric Brain Tumor Foundation · 2015 - 2021

CCL3 as a Developmental Therapeutic to Enhance Brain Tumor Therapy

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2016 - 2021

Improving CAR T cell immunotherapy for heterogeneous brain tumors

ResearchPrincipal Investigator · Awarded by University of Florida · 2019 - 2021

Efficacy of dendritic cell vaccines targeting CMV antigens in glioblastoma

ResearchPrincipal Investigator · Awarded by University of Florida · 2017 - 2021

Quantitative Staging and Therapeutic Response in IDH-1 Mutated Glioblastomas

ResearchCollaborator · Awarded by National Institutes of Health · 2017 - 2021

EGFRvIII-targeted Bispecific T cell Engagers for brain tumors

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2013 - 2019

Development of a Therapeutic for Brain Tumor Immunotherapy

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2018 - 2019

Systemically administrered EGRFvIII-targeted bispecific antibody as an immunotherapeutic for glioblastoma.

FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2015 - 2019

Brain tumors with regulatory T-cells treated with EGFRvIII-specific T-cells

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2013 - 2018

Loglio Project

ResearchPrincipal Investigator · Awarded by University of California - San Francisco · 2016 - 2018

Brain Tumor Targeting Using Tumor-Specific Neuroimmunology

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2014 - 2018

Targeting Translation Control in Malignant Glioma

ResearchCo Investigator · Awarded by National Institutes of Health · 2007 - 2018

A clinically-relevant anti-CD27 agonist antibody as a vaccine adjuvant for brain tumor immunotherapy

FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2016 - 2017

Enhancing dendritic cell migration to drive potent anti-tumor immune responses

FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2013 - 2017

Use of YH24931 in combination with antigen-specific DC vaccines for antitumor efficacy

ResearchSignificant Contributor · Awarded by Yuhan Corporation · 2016 - 2017

Pediatric Brain Tumor Consortium

Clinical TrialCollaborator · Awarded by St. Jude Children's Research Hospital · 2014 - 2017

Research Training In Neuro-Oncology

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1998 - 2016

HFTL event

Inst. Training Prgm or CMEPrincipal Investigator · Awarded by BrainLAB, Inc. · 2016 - 2016

Cancer Biology Training Grant

Inst. Training Prgm or CMEMentor · Awarded by National Cancer Institute · 1993 - 2016

Clinical Oncology Research Career Development Program

ResearchMentor · Awarded by National Institutes of Health · 2009 - 2015

Development of peptide vaccine for diffuse intrinsic pontine glioma

ResearchCo Investigator · Awarded by The Cure Starts Now · 2013 - 2014

Convection Enhanced Delivery of Chemokines can increase T-Cell Chemotaxis to Brain Tumors in an Adoptive T cell Model

ResearchPrincipal Investigator · Awarded by American Brain Tumor Association · 2014 - 2014

Targeting EGFRvIII in Brain Tumors with Bispecific Antibodies

FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2013 - 2014

Modulation of the blood-tumor barrier through targeted suppression of claudin 5

ResearchMentor · Awarded by National Institutes of Health · 2011 - 2013

RNA-based Immunotherapy Targeting Antigens Unique to Brain Tumor Stem Cells

Clinical TrialPrincipal Investigator · Awarded by National Institutes of Health · 2008 - 2013

Enterovirus Vectors with Respiratory Tropism for Cancer Immunotherapy

ResearchCo Investigator · Awarded by National Institutes of Health · 2009 - 2012

Pre-clinical Translation of Regulatory T-cell Inhibition in Brain Tumors

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2010 - 2012

Neuroimmunology of Vaccines in Adoptive T-cell Therapy for Brain Tumor

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2010 - 2012

Gene Targeted Therapy of Brain Tumors

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2009 - 2012

Research Training In Neuro-Oncology

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2005 - 2010

Effect on IL-2R Antibody on Regulatory T-cells in Patients with Malignant Gliomas

Clinical TrialPrincipal Investigator · Awarded by National Institutes of Health · 2008 - 2009

Dendritic Cell Immunotherapy of Malignant Gliomas

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2002 - 2008

Intracerebral Infusion of Radiolabeled Specific Antibody

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2002 - 2008

Regional AGT Depletion of CNS and Leptomeningeal Tumors

ResearchCollaborator · Awarded by National Institutes of Health · 2002 - 2006

GCRC CAP

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2000 - 2005

External Relationships


  • Annias Immunotherapeutics, Inc.
  • Celldex
  • Centuar Bio
  • Cognos Therapeutics
  • Immunomic Therapeutics
  • Annias Immunotherapeutics, Inc.
  • Celldex
  • Centuar Bio
  • Cognos Therapeutics
  • Immunomic Therapeutics
  • Insera health
  • Istari Oncology
  • Medicenna Therapeutics
  • Myeloid TX
  • Shorla

This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.