Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Pharm.D., Campbell University 1997
• 

  Duke Appointment History

  • Assistant Professor in Medicine, Medicine, Infectious Diseases, Medicine 2007 - 2013
  • Medical Instructor in the Department of Medicine, Medicine, Infectious Diseases, Medicine 2002 - 2007
• Research
• 

  Selected Grants

  • Improving antibiotic use through implementation and evaluation of Core Elements of Hospital Antibiotic Stewardship Programs (Domain 2) awarded by Centers for Disease Control and Prevention 2016 - 2019
  • Effectiveness of Posaconazole Prophylaxis in Patients with Hematological Malignancies awarded by Merck Sharp & Dohme 2017 - 2018
  • HIV Nurse Practitioner Training Program awarded by Health Resources and Service Administration 2013 - 2018
  • Accelerating hospital reporting to NHSN's Antibiotic Use Option awarded by Centers for Disease Control and Prevention 2015 - 2017
  • Phase I CTU Task Area A: Administrative and Overal Clinical Operations Support and Concept Development awarded by National Institutes of Health 2014 - 2015
  • Microfluidic PCR Platform to Detect Microbial DNA awarded by National Institutes of Health 2005 - 2010
  • Host-Response relationships in patients with candidemia awarded by National Institutes of Health 2002 - 2008
• Publications & Artistic Works
• 

  Selected Publications

  • Conference Papers

    • Davies, M, Johnson, M, Brown, J, and Townsend, M. "Predictors of glycemic control among HIV-positive veterans with diabetes." October 2013.  Link to Item
    • Depner, M, van de Veerdonk, F, Wanders, J, Stauss, H, Raabe, J, Atkinson, TP, Jr, SHW, Niehues, T, Dueckers, G, Puck, J, Stray-Pedersen, A, Baumann, U, Schmidt, R, Franco, JL, Orrego, J, Ben-Shoshan, M, McCusker, C, Jacob, CMA, Carneiro-Sampaio, M, Devlin, LA, Edgar, JD, Gkrania-Klotsas, E, Kumararatne, D, Doffinger, R, Henderson, P, Russell, RK, Dyrso, T, Seneviratne, SL, Matthijs, G, Abinun, M, Gennery, A, Johnson, M, van der Meer, JWM, Netea, MG, Lilic, D, and Grimbacher, B. "MUTATION SCREENING IN STAT1, CARD9 AND PKC-DELTA IN PATIENTS WITH CHRONIC MUCOCUTANEOUS CANDIDIASIS." September 2012.  Link to Item

  • Journal Articles

    • Matzaraki, V, Gresnigt, MS, Jaeger, M, Ricaño-Ponce, I, Johnson, MD, Oosting, M, Franke, L, Withoff, S, Perfect, JR, Joosten, LAB, Kullberg, BJ, van de Veerdonk, FL, Jonkers, I, Li, Y, Wijmenga, C, Netea, MG, and Kumar, V. "An integrative genomics approach identifies novel pathways that influence candidaemia susceptibility." PloS one 12, no. 7 (January 2017): e0180824-.  Full Text
    • Roth, S, Bergmann, H, Jaeger, M, Yeroslaviz, A, Neumann, K, Koenig, P-A, Prazeres da Costa, C, Vanes, L, Kumar, V, Johnson, M, Menacho-Márquez, M, Habermann, B, Tybulewicz, VL, Netea, M, Bustelo, XR, and Ruland, J. "Vav Proteins Are Key Regulators of Card9 Signaling for Innate Antifungal Immunity." Cell reports 17, no. 10 (December 2016): 2572-2583.  Full Text
    • Cournoyer, JM, Garms, AP, Thiessen, KN, Bowers, MT, Johnson, MD, and Relf, MV. "Cardiovascular Disease and HIV: Pathophysiology, Treatment Considerations, and Nursing Implications." Critical care nurse 36, no. 5 (October 2016): 37-46. (Review)  Full Text
    • Schneeweiss, S, Carver, PL, Datta, K, Galar, A, Johnson, MD, Johnson, MG, Marty, FM, Nagel, J, Najdzinowicz, M, Saul, M, Shoham, S, Silveira, FP, Varughese, CA, Wilck, M, Weatherby, L, Auton, T, and Walker, AM. "Short-term risk of liver and renal injury in hospitalized patients using micafungin: a multicentre cohort study." The Journal of antimicrobial chemotherapy 71, no. 10 (October 2016): 2938-2944.  Full Text
    • Maskarinec, SA, Johnson, MD, and Perfect, JR. "Genetic Susceptibility to Fungal Infections: What is in the Genes?." Current clinical microbiology reports 3, no. 2 (June 2016): 81-91.  Full Text
    • Swamydas, M, Gao, J-L, Break, TJ, Johnson, MD, Jaeger, M, Rodriguez, CA, Lim, JK, Green, NM, Collar, AL, Fischer, BG, Lee, C-CR, Perfect, JR, Alexander, BD, Kullberg, B-J, Netea, MG, Murphy, PM, and Lionakis, MS. "CXCR1-mediated neutrophil degranulation and fungal killing promote Candida clearance and host survival." Science translational medicine 8, no. 322 (January 2016): 322ra10-.  Full Text
    • Jaeger, M, van der Lee, R, Cheng, S-C, Johnson, MD, Kumar, V, Ng, A, Plantinga, TS, Smeekens, SP, Oosting, M, Wang, X, Barchet, W, Fitzgerald, K, Joosten, LAB, Perfect, JR, Wijmenga, C, van de Veerdonk, FL, Huynen, MA, Xavier, RJ, Kullberg, B-J, and Netea, MG. "The RIG-I-like helicase receptor MDA5 (IFIH1) is involved in the host defense against Candida infections." European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 34, no. 5 (May 2015): 963-974.  Full Text
    • American College of Clinical Pharmacy, , McBane, SE, Dopp, AL, Abe, A, Benavides, S, Chester, EA, Dixon, DL, Dunn, M, Johnson, MD, Nigro, SJ, Rothrock-Christian, T, Schwartz, AH, Thrasher, K, and Walker, S. "Collaborative drug therapy management and comprehensive medication management-2015." Pharmacotherapy 35, no. 4 (April 2015): e39-e50.  Full Text
    • Arnold, CJ, Johnson, M, Bayer, AS, Bradley, S, Giannitsioti, E, Miró, JM, Tornos, P, Tattevin, P, Strahilevitz, J, Spelman, D, Athan, E, Nacinovich, F, Fortes, CQ, Lamas, C, Barsic, B, Fernández-Hidalgo, N, Muñoz, P, and Chu, VH. "Candida infective endocarditis: an observational cohort study with a focus on therapy." Antimicrobial agents and chemotherapy 59, no. 4 (April 2015): 2365-2373.  Full Text
    • Davies, ML, Johnson, MD, Brown, JN, Bryan, WE, and Townsend, ML. "Predictors of glycaemic control among HIV-positive veterans with diabetes." INTERNATIONAL JOURNAL OF STD & AIDS 26, no. 4 (March 2015): 262-267.  Full Text  Link to Item
    • Ten Oever, J, Kox, M, van de Veerdonk, FL, Mothapo, KM, Slavcovici, A, Jansen, TL, Tweehuysen, L, Giamarellos-Bourboulis, EJ, Schneeberger, PM, Wever, PC, Stoffels, M, Simon, A, van der Meer, JWM, Johnson, MD, Kullberg, B-J, Pickkers, P, Pachot, A, Joosten, LAB, and Netea, MG. "The discriminative capacity of soluble Toll-like receptor (sTLR)2 and sTLR4 in inflammatory diseases." BMC immunology 15 (November 19, 2014): 55-.  Full Text
    • Kumar, V, Cheng, S-C, Johnson, MD, Smeekens, SP, Wojtowicz, A, Giamarellos-Bourboulis, E, Karjalainen, J, Franke, L, Withoff, S, Plantinga, TS, van de Veerdonk, FL, van der Meer, JWM, Joosten, LAB, Bochud, P-Y, Marchetti, O, Perfect, JR, Xavier, R, Kullberg, BJ, Wijmenga, C, and Netea, MG. "Immunochip SNP array identifies novel genetic variants conferring susceptibility to candidaemia." Nature communications 5 (September 8, 2014): 4675-.  Full Text
    • Paul DiMondi, V, Townsend, ML, Johnson, M, and Durkin, M. "Antifungal catheter lock therapy for the management of a persistent Candida albicans bloodstream infection in an adult receiving hemodialysis." Pharmacotherapy 34, no. 7 (July 2014): e120-e127.  Full Text
    • Kung, H-C, Johnson, MD, Drew, RH, Saha-Chaudhuri, P, and Perfect, JR. "Clinical effectiveness of posaconazole versus fluconazole as antifungal prophylaxis in hematology-oncology patients: a retrospective cohort study." Cancer medicine 3, no. 3 (June 2014): 667-673.  Full Text  Open Access Copy
    • Rosentul, DC, Plantinga, TS, Farcas, M, Oosting, M, Hamza, OJM, Scott, WK, Alexander, BD, Yang, JC, Laird, GM, Joosten, LAB, van der Meer, JWM, Perfect, JR, Kullberg, B-J, van der Ven, AJAM, Johnson, MD, and Netea, MG. "Role of autophagy genetic variants for the risk of Candida infections." Medical mycology 52, no. 4 (May 2014): 333-341.  Full Text
    • Smeekens, SP, Malireddi, RK, Plantinga, TS, Buffen, K, Oosting, M, Joosten, LAB, Kullberg, BJ, Perfect, JR, Scott, WK, van de Veerdonk, FL, Xavier, RJ, van de Vosse, E, Kanneganti, T-D, Johnson, MD, and Netea, MG. "Autophagy is redundant for the host defense against systemic Candida albicans infections." Eur J Clin Microbiol Infect Dis 33, no. 5 (May 2014): 711-722.  Full Text  Link to Item
    • "Alexander et al (Clin Infect Dis 2013; 56:1724-s32)." Clinical Infectious Diseases 58, no. 5 (March 1, 2014): 754-754.  Full Text
    • Smeekens, SP, Malireddi, RK, Plantinga, TS, Buffen, K, Oosting, M, Joosten, LAB, Kullberg, BJ, Perfect, JR, Scott, WK, Van De Veerdonk, FL, Xavier, RJ, Van De Vosse, E, Kanneganti, TD, Johnson, MD, and Netea, MG. "Autophagy is redundant for the host defense against systemic Candida albicans infections." European Journal of Clinical Microbiology and Infectious Diseases 33, no. 5 (January 1, 2014): 711-722.  Full Text
    • Lionakis, MS, Swamydas, M, Fischer, BG, Plantinga, TS, Johnson, MD, Jaeger, M, Green, NM, Masedunskas, A, Weigert, R, Mikelis, C, Wan, W, Lee, C-CR, Lim, JK, Rivollier, A, Yang, JC, Laird, GM, Wheeler, RT, Alexander, BD, Perfect, JR, Gao, J-L, Kullberg, B-J, Netea, MG, and Murphy, PM. "CX3CR1-dependent renal macrophage survival promotes Candida control and host survival." J Clin Invest 123, no. 12 (December 2013): 5035-5051.  Full Text  Link to Item
    • Alexander, BD, Johnson, MD, Pfeiffer, CD, Jiménez-Ortigosa, C, Catania, J, Booker, R, Castanheira, M, Messer, SA, Perlin, DS, and Pfaller, MA. "Increasing echinocandin resistance in Candida glabrata: clinical failure correlates with presence of FKS mutations and elevated minimum inhibitory concentrations." Clin Infect Dis 56, no. 12 (June 2013): 1724-1732.  Full Text  Link to Item
    • DeFreitas, AA, D'Souza, T-LM, Lazaro, GJ, Windes, EM, Johnson, MD, and Relf, MV. "Pharmacological considerations in human immunodeficiency virus-infected adults in the intensive care unit." Crit Care Nurse 33, no. 2 (April 2013): 46-56.  Full Text  Link to Item
    • Oever, JT, Giamarellos-Bourboulis, EJ, Veerdonk, FLVD, Stelma, FF, Simon, A, Janssen, M, Johnson, M, Pachot, A, Kullberg, B-J, Joosten, LAB, and al, E. "Circulating galectin-3 in infections and non-infectious inflammatory diseases." European Journal of Clinical Microbiology and Infectious Diseases 32, no. 12 (2013): 1605-1610.  Full Text
    • Oever, JT, Giamarellos-Bourboulis, EJ, Veerdonk, FLVD, Stelma, FF, Simon, A, Janssen, M, Johnson, M, Pachot, A, Kullberg, B-J, Joosten, LAB, and al, E. "Circulating galectin-3 in infections and non-infectious inflammatory diseases." European Journal of Clinical Microbiology and Infectious Diseases (2013): 1-6.  Full Text
    • Smeekens, SP, Ng, A, Kumar, V, Johnson, MD, Plantinga, TS, van Diemen, C, Arts, P, Verwiel, ETP, Gresnigt, MS, Fransen, K, van Sommeren, S, Oosting, M, Cheng, S-C, Joosten, LAB, Hoischen, A, Kullberg, B-J, Scott, WK, Perfect, JR, van der Meer, JWM, Wijmenga, C, Netea, MG, and Xavier, RJ. "Functional genomics identifies type I interferon pathway as central for host defense against Candida albicans." Nat Commun 4 (2013): 1342-.  Full Text  Link to Item
    • Plantinga, TS, Johnson, MD, Scott, WK, Joosten, LAB, van der Meer, JWM, Perfect, JR, Kullberg, BJ, and Netea, MG. "Human genetic susceptibility to Candida infections." Med Mycol 50, no. 8 (November 2012): 785-794. (Review)  Full Text  Link to Item
    • Dodds Ashley, E, Drew, R, Johnson, M, Danna, R, Dabrowski, D, Walker, V, Prasad, M, Alexander, B, Papadopoulos, G, and Perfect, J. "Cost of invasive fungal infections in the era of new diagnostics and expanded treatment options." Pharmacotherapy 32, no. 10 (October 2012): 890-901.  Full Text  Link to Item
    • Ashley, ED, Drew, R, Johnson, M, Danna, R, Dabrowski, D, Walker, V, Prasad, M, Alexander, B, Papadopoulos, G, and Perfect, J. "Cost of Invasive Fungal Infections in the Era of New Diagnostics and Expanded Treatment Options." Pharmacotherapy (September 18, 2012).  Full Text  Link to Item
    • Schell, WA, Benton, JL, Smith, PB, Poore, M, Rouse, JL, Boles, DJ, Johnson, MD, Alexander, BD, Pamula, VK, Eckhardt, AE, Pollack, MG, Benjamin, DK, Perfect, JR, and Mitchell, TG. "Evaluation of a digital microfluidic real-time PCR platform to detect DNA of Candida albicans in blood." Eur J Clin Microbiol Infect Dis 31, no. 9 (September 2012): 2237-2245.  Full Text  Open Access Copy  Link to Item
    • Plantinga, TS, Johnson, MD, Scott, WK, van de Vosse, E, Velez Edwards, DR, Smith, PB, Alexander, BD, Yang, JC, Kremer, D, Laird, GM, Oosting, M, Joosten, LAB, van der Meer, JWM, van Dissel, JT, Walsh, TJ, Perfect, JR, Kullberg, BJ, and Netea, MG. "Toll-like receptor 1 polymorphisms increase susceptibility to candidemia." J Infect Dis 205, no. 6 (March 15, 2012): 934-943.  Full Text  Link to Item
    • Rosentul, DC, Plantinga, TS, Scott, WK, Alexander, BD, van de Geer, NMD, Perfect, JR, Kullberg, BJ, Johnson, MD, and Netea, MG. "The impact of caspase-12 on susceptibility to candidemia." Eur J Clin Microbiol Infect Dis 31, no. 3 (March 2012): 277-280.  Full Text  Link to Item
    • Johnson, MD, Plantinga, TS, van de Vosse, E, Velez Edwards, DR, Smith, PB, Alexander, BD, Yang, JC, Kremer, D, Laird, GM, Oosting, M, Joosten, LAB, van der Meer, JWM, van Dissel, JT, Walsh, TJ, Perfect, JR, Kullberg, B-J, Scott, WK, and Netea, MG. "Cytokine gene polymorphisms and the outcome of invasive candidiasis: a prospective cohort study." Clin Infect Dis 54, no. 4 (February 15, 2012): 502-510.  Full Text  Link to Item
    • Goswami, ND, Johnson, MD, and Chu, VH. "Ertapenem for treatment of osteomyelitis: a case series. (Published online)" BMC Res Notes 4 (November 2, 2011): 478-.  Full Text  Link to Item
    • Rosentul, DC, Plantinga, TS, Oosting, M, Scott, WK, Velez Edwards, DR, Smith, PB, Alexander, BD, Yang, JC, Laird, GM, Joosten, LAB, van der Meer, JWM, Perfect, JR, Kullberg, B-J, Netea, MG, and Johnson, MD. "Genetic variation in the dectin-1/CARD9 recognition pathway and susceptibility to candidemia." J Infect Dis 204, no. 7 (October 1, 2011): 1138-1145.  Full Text  Link to Item
    • Ashley, ED, and Johnson, MD. "Combination antifungal therapy." (January 1, 2011): 153-163. (Chapter)  Full Text
    • Johnson, MD, and Perfect, JR. "Use of Antifungal Combination Therapy: Agents, Order, and Timing." Curr Fungal Infect Rep 4, no. 2 (May 1, 2010): 87-95.  Full Text  Link to Item
    • Heil, EL, Townsend, ML, Shipp, K, Clarke, A, and Johnson, MD. "Incidence of severe hepatotoxicity related to antiretroviral therapy in HIV/HCV coinfected patients." AIDS Research and Treatment 2010 (2010).  Full Text
    • Johnson, MD, and Netea, M. "Host Genomics and Bacterial Infections." Essentials of Genomic and Personalized Medicine (2010): 744-759.  Full Text
    • Ferwerda, B, Ferwerda, G, Plantinga, TS, Willment, JA, van Spriel, AB, Venselaar, H, Elbers, CC, Johnson, MD, Cambi, A, Huysamen, C, Jacobs, L, Jansen, T, Verheijen, K, Masthoff, L, Morré, SA, Vriend, G, Williams, DL, Perfect, JR, Joosten, LAB, Wijmenga, C, van der Meer, JWM, Adema, GJ, Kullberg, BJ, Brown, GD, and Netea, MG. "Human dectin-1 deficiency and mucocutaneous fungal infections." N Engl J Med 361, no. 18 (October 29, 2009): 1760-1767.  Full Text  Link to Item
    • Connelly, SM, Trinh, JV, Johnson, MD, Dodds-Ashley, ES, Stout, J, Engemann, JJ, Friedman, ND, Kaye, D, and Kaye, KS. "Mortality and time to extubation in severe hospital-acquired pneumonia." Am J Infect Control 37, no. 2 (March 2009): 143-149.  Full Text  Link to Item
    • Johnson, MD, and Netea, M. "Host Genomics and Bacterial Infections." Genomic and Personalized Medicine, Two-Vol Set (2009): 1347-1361.  Full Text
    • Johnson, MD. "Pharmacogenomics of systemic antifungal agents." Current Fungal Infection Reports 3, no. 2 (2009): 111-116.  Full Text
    • Bentley, D, and Johnson, M. "Safety in healthcare is not a new concept." International Surgery 93, no. 3 (2008): 139-140.
    • Lalani, T, Varkey, JB, Drew, R, Harrell, L, McGarry, S, Engemann, JG, Johnson, MD, and Kaye, KS. "Analysis of two- and three-year trends in antimicrobial resistance in intensive care units using unit-specific antibiograms." Scand J Infect Dis 40, no. 8 (2008): 672-674.  Link to Item
    • Mohr, J, Johnson, M, Cooper, T, II, JSL, and Ostrosky-Zeichner, L. "Current options in antifungal pharmacotherapy." Pharmacotherapy 28, no. 5 PART 1 (2008): 614-645.  Full Text
    • Townsend, ML, Hollowell, SB, Bhalodia, J, Wilson, KH, Kaye, KS, and Johnson, MD. "A comparison of the effectiveness of lipid-lowering therapy between HIV- and non-HIV-infected subjects with hyperlipidaemia." Int J STD AIDS 18, no. 12 (December 2007): 851-855.  Full Text  Link to Item
    • Johnson, MD, and Perfect, JR. "Combination antifungal therapy: what can and should we expect?." Bone Marrow Transplant 40, no. 4 (August 2007): 297-306. (Review)  Full Text  Link to Item
    • Smith, PB, Benjamin, DK, Alexander, BD, Johnson, MD, Finkelman, MA, and Steinbach, WJ. "Quantification of 1,3-beta-D-glucan levels in children: preliminary data for diagnostic use of the beta-glucan assay in a pediatric setting." Clin Vaccine Immunol 14, no. 7 (July 2007): 924-925.  Full Text  Link to Item
    • Zaas, AK, Dodds Ashley, ES, Alexander, BD, Johnson, MD, and Perfect, JR. "Caspofungin for invasive candidiasis at a tertiary care medical center." Am J Med 119, no. 11 (November 2006): 993.e1-993.e6.  Full Text  Link to Item
    • Anaissie, EJ, Segal, BH, Graybill, JR, Arndt, C, Perfect, JR, Kleinberg, M, Pappas, P, Benjamin, D, Rubin, R, Aberg, JA, Adderson, EE, Adler-Shohet, FC, Akan, H, Akova, M, Almyroudis, NG, Alexander, BD, Andes, D, Arrieta, A, Baddley, JW, Barron, MA, Belzberg, H, Boucher, HW, Boyce, TG, Casadevall, A, Chandrasekar, PH, Cleary, JD, Cordonnier, C, Cornely, OA, Cuenca-Estrella, M, Daly, JS, Daoura, N, Denning, DW, dePauw, B, de Repentigny, L, Dignani, MC, Dismukes, WE, Donnelly, JP, and Donowitz, GR et al. "Clinical research in the lay press: irresponsible journalism raises a huge dose of doubt." Clin Infect Dis 43, no. 8 (October 15, 2006): 1031-1039.  Full Text  Link to Item
    • Johnson, MD, Kleinberg, M, Danziger, L, and Ostrosky-Zeichner, L. "Pharmacoeconomics of antifungal pharmacotherapy--challenges and future directions." Expert Opin Pharmacother 6, no. 15 (December 2005): 2617-2632. (Review)  Full Text  Link to Item
    • Pope, SD, Johnson, MD, and May, DB. "Pharmacotherapy for human immunodeficiency virus-associated nephropathy." Pharmacotherapy 25, no. 12 (December 2005): 1761-1772. (Review)  Full Text  Link to Item
    • Johnson, MD, MacDougall, C, Ostrosky-Zeichner, L, Perfect, JR, and Rex, JH. "Combination antifungal therapy." Antimicrob Agents Chemother 48, no. 3 (March 2004): 693-715. (Review)  Link to Item
    • Johnson, MD, and Perfect, JR. "Caspofungin: first approved agent in a new class of antifungals." Expert Opin Pharmacother 4, no. 5 (May 2003): 807-823. (Review)  Full Text  Link to Item
    • Johnson, MD, Hamilton, CD, Drew, RH, Sanders, LL, Pennick, GJ, and Perfect, JR. "A randomized comparative study to determine the effect of omeprazole on the peak serum concentration of itraconazole oral solution." J Antimicrob Chemother 51, no. 2 (February 2003): 453-457.  Link to Item
    • Bohjanen, PR, Johnson, MD, Szczech, LA, Wray, DW, Petros, WP, Miller, CR, and Hicks, CB. "Steady-state pharmacokinetics of lamivudine in human immunodeficiency virus-infected patients with end-stage renal disease receiving chronic dialysis." Antimicrob Agents Chemother 46, no. 8 (August 2002): 2387-2392.  Link to Item
    • Johnson, MD, and Perfect, JR. "Fungal Infections of the Bones and Joints." Curr Infect Dis Rep 3, no. 5 (October 2001): 450-460.  Link to Item
    • Johnson, MD, Drew, RH, and Perfect, JR. "Chest discomfort associated with liposomal amphotericin B: report of three cases and review of the literature." Pharmacotherapy 18, no. 5 (September 1998): 1053-1061. (Review)  Link to Item
• Teaching & Mentoring
• 

  Recent Courses

  • NURSING 841: Pharmacologic Aspects of HIV/AIDS 2018

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