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Melissa DePaoli Johnson

Professor in Medicine
Medicine, Infectious Diseases
Duke Box 102359, Durham, NC 27710
Room 173 Hanes House, 315 Trent Drive, Durham, NC 27710

Overview


Prognostic indicators for patients with Candida spp. bloodstream infections
Antifungal pharmacokinetics/pharmacodynamics
Immunogenetics among patients with candidiasis
Management of the HIV infected patient and antiretroviral pharmacotherapy
Antibacterial drug utilization, resistance, and appropriate prescribing
Antimicrobial Stewardship

Current Appointments & Affiliations


Professor in Medicine · 2022 - Present Medicine, Infectious Diseases, Medicine

Recent Publications


Co-administration of triazoles with calcineurin or mammalian target of rapamycin inhibitors in solid organ transplant patients hospitalized with invasive aspergillosis.

Journal Article J Antimicrob Chemother · December 19, 2025 BACKGROUND: All triazoles decrease the metabolism of calcineurin inhibitors (CNIs) and mammalian target of rapamycin (mTOR) inhibitors through CYP3A4 and P-glycoprotein inhibition leading to increased exposure and the potential for serious adverse events ( ... Full text Link to item Cite

Healthcare Resource Utilization, Treatment Costs, and Mortality in Patients with Malignancies or Transplantation Who Develop Invasive Aspergillosis.

Journal Article J Fungi (Basel) · September 6, 2025 Objectives: Invasive aspergillosis (IA) poses significant risks to patients with malignancies or transplantation; however, estimates of burden-of-illness in patients with IA are sparse. We sought to assess in-hospital and outpatient healthcare resource uti ... Full text Link to item Cite

Building upon the core elements of antifungal stewardship: practical recommendations for effective antifungal stewardship in resource-limited settings.

Journal Article Expert Rev Anti Infect Ther · August 2025 INTRODUCTION: Despite the crucial importance of effective AFS in resource-limited settings, such settings remain comparatively underserved and underrepresented in terms of resource-setting-specific guidance and research. Further practical contextualization ... Full text Link to item Cite
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Recent Grants


Tri-Institutional Molecular Mycology and Pathogenesis Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2024 - 2029

Systems Biology for Infectious Diseases

ResearchPrincipal Investigator · Awarded by The Lundquist Institute · 2023 - 2028

Host directed medicine in invasive fungal infection - HDM-FUN

Clinical TrialCo Investigator · Awarded by European Union · 2020 - 2026

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Education, Training & Certifications


Duke University, School of Medicine · 2007 M.H.S.
Campbell University · 1997 Pharm.D.
Duke University, School of Medicine · 1992 B.S.