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Melissa DePaoli Johnson

Professor in Medicine
Medicine, Infectious Diseases
Duke Box 102359, Durham, NC 27710
Room 173 Hanes House, 315 Trent Drive, Durham, NC 27710

Overview


Prognostic indicators for patients with Candida spp. bloodstream infections
Antifungal pharmacokinetics/pharmacodynamics
Immunogenetics among patients with candidiasis
Management of the HIV infected patient and antiretroviral pharmacotherapy
Antibacterial drug utilization, resistance, and appropriate prescribing
Antimicrobial Stewardship

Current Duke Appointments & Affiliations


Professor in Medicine · 2022 - Present Medicine, Infectious Diseases, Medicine

Recent Scholarly Works


Comprehensive Review of Candidozyma (Candida) auris Management: Insights From the Society of Infectious Diseases Pharmacists.

Journal article Pharmacotherapy · April 2026 Candidozyma (Candida) auris has emerged over the past two decades as a formidable global health threat due to its multidrug resistance, persistence in healthcare environments, and rapid nosocomial spread. Recently reclassified into the genus Candidozyma ba ... Full text Link to item Cite

MUC16-dependent Renal Vascular Adhesion of Candida Promotes Tissue Invasion and Predicts Clinical Outcome in Candidemia.

Journal article Res Sq · March 4, 2026 Bloodstream infection with Candida species is associated with high mortality, yet the molecular basis of vascular adhesion and invasion remains unclear. We identify the endothelial surface mucin MUC16 as a key host factor enabling fungal vascular adherence ... Full text Link to item Cite
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Recent Grants


Tri-Institutional Molecular Mycology and Pathogenesis Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institute of Allergy and Infectious Diseases · 2024 - 2029

Systems Biology for Infectious Diseases

ResearchPrincipal Investigator · Awarded by The Lundquist Institute · 2023 - 2028

Host directed medicine in invasive fungal infection - HDM-FUN

Clinical TrialCo Investigator · Awarded by European Union · 2020 - 2026

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Education


Duke University, School of Medicine · 2007 M.H.S.
Campbell University · 1997 Pharm.D.
Duke University, School of Medicine · 1992 B.S.