Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • M.H.S., Duke University School of Medicine 2007
  • Fellow, Infectious Diseases, Duke University School of Medicine 1997 - 1998
  • Pharm.D., Campbell University 1997
  • B.S., Duke University School of Medicine 1992
• 

  Previous Appointments & Affiliations

  • Associate Professor in Medicine, Medicine, Infectious Diseases, Medicine 2021 - 2022
  • Associate Professor in Medicine, Medicine, Infectious Diseases, Medicine 2013 - 2020
  • Assistant Professor in Medicine, Medicine, Infectious Diseases, Medicine 2007 - 2013
  • Medical Instructor in the Department of Medicine, Medicine, Infectious Diseases, Medicine 2002 - 2007
• 

  Leadership & Clinical Positions at Duke

  • Liaison Clinical Pharmacist, Duke Antimicrobial Stewardship Outreach Network
    
    Faculty, Duke Center for Antimicrobial Stewardship & Infection Prevention
• Research
• 

  Selected Grants

  • Host directed medicine in invasive fungal infection - HDM-FUN awarded by European Union 2020 - 2024
  • Leveraging National Healthcare Safety Network Antimicrobial Use Option to Inform, Implement and Assess Antibiotic Stewardship Activities awarded by Centers for Disease Control and Prevention 2022 - 2023
  • Retrospective Observational Study to Evaluate the "Real World" Effectiveness of Posaconazole Prophylaxis in Patients with Hematological Malignancies at Duke University Hospital awarded by Merck Sharp & Dohme 2017 - 2020
  • Improving antibiotic use through implementation and evaluation of Core Elements of Hospital Antibiotic Stewardship Programs (Domain 2) awarded by Centers for Disease Control and Prevention 2016 - 2019
  • HIV Nurse Practitioner Training Program awarded by Health Resources and Service Administration 2013 - 2018
  • Accelerating hospital reporting to NHSN's Antibiotic Use Option awarded by Centers for Disease Control and Prevention 2015 - 2017
  • Phase I CTU Task Area A: Administrative and Overal Clinical Operations Support and Concept Development awarded by National Institutes of Health 2014 - 2015
  • Microfluidic PCR Platform to Detect Microbial DNA awarded by National Institutes of Health 2005 - 2010
  • Host-Response relationships in patients with candidemia awarded by National Institutes of Health 2002 - 2008
• 

  External Relationships

  • Cidara
  • Entasis
  • Merck & Co. USA (not assoc'd with Merck KGaA)
  • Pfizer Inc.
  • UpToDate, Inc.
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Strand, Andrew M., Barbara D. Alexander, Eric Sarpong, Jessica Retuerto Wong, Ashley Engemann, David Rizzieri, Yuan Wu, and Melissa D. Johnson. “Real-world effectiveness of antifungal prophylaxis with posaconazole as the primary agent in patients with haematological malignancies.” Mycoses 65, no. 11 (November 2022): 1050–60. https://doi.org/10.1111/myc.13495.
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    • Moehring, Rebekah W., Angelina Davis, Elizabeth Dodds Ashley, April P. Dyer, Richard H. Drew, Yuliya Loknyghina, Melissa D. Johnson, et al. “Harvesting the low-hanging fruit? Comparative assessment of intravenous to oral route antimicrobial conversion policy implementation.” Infect Control Hosp Epidemiol, July 15, 2022, 1–5. https://doi.org/10.1017/ice.2022.158.
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    • Johnson, Melissa D., Angelina P. Davis, April P. Dyer, Travis M. Jones, S Shaefer Spires, and Elizabeth Dodds Ashley. “Top Myths of Diagnosis and Management of Infectious Diseases in Hospital Medicine.” Am J Med 135, no. 7 (July 2022): 828–35. https://doi.org/10.1016/j.amjmed.2022.03.019.
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    • Cole, Kelli A., Anna Y. Zhou, Travis Jones, W Justin Moore, Elisabeth L. Chandler, Veronica B. Zafonte, Taylor Morrisette, et al. “How to Harness the Power of Social Media for Quality Drug Information in Infectious Diseases: Perspectives on Behalf of the Society of Infectious Diseases Pharmacists.” Clin Infect Dis 74, no. Suppl_3 (May 15, 2022): e23–33. https://doi.org/10.1093/cid/ciac081.
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    • Johnson, Alexandra A., Bobby G. Warren, Deverick J. Anderson, Melissa D. Johnson, Isabella Gamez, and Becky A. Smith. “Impact of alcohol-based hand-rub disinfection on bacterial bioburden on stethoscopes in a real-world clinical setting.” Infect Control Hosp Epidemiol, April 11, 2022, 1–3. https://doi.org/10.1017/ice.2022.54.
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    • Baddley, John W., George R. Thompson, Sharon C-A Chen, P Lewis White, Melissa D. Johnson, M Hong Nguyen, Ilan S. Schwartz, et al. “Coronavirus Disease 2019-Associated Invasive Fungal Infection.” Open Forum Infect Dis 8, no. 12 (December 2021): ofab510. https://doi.org/10.1093/ofid/ofab510.
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    • Johnson, Melissa D., Russell E. Lewis, Elizabeth S. Dodds Ashley, John R. Perfect, and Dimitrios P. Kontoyiannis. “Reply to Day et al.” J Infect Dis 224, no. 9 (November 16, 2021): 1627–28. https://doi.org/10.1093/infdis/jiab183.
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    • Moehring, Rebekah W., Michael E. Yarrington, Angelina E. Davis, April P. Dyer, Melissa D. Johnson, Travis M. Jones, S Shaefer Spires, Deverick J. Anderson, Daniel J. Sexton, and Elizabeth S. Dodds Ashley. “Effects of a Collaborative, Community Hospital Network for Antimicrobial Stewardship Program Implementation.” Clin Infect Dis 73, no. 9 (November 2, 2021): 1656–63. https://doi.org/10.1093/cid/ciab356.
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    • Steinbrink, Julie M., Rachel A. Myers, Kaiyuan Hua, Melissa D. Johnson, Jessica L. Seidelman, Ephraim L. Tsalik, Ricardo Henao, et al. “The host transcriptional response to Candidemia is dominated by neutrophil activation and heme biosynthesis and supports novel diagnostic approaches.” Genome Med 13, no. 1 (July 5, 2021): 108. https://doi.org/10.1186/s13073-021-00924-9.
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    • Johnson, Melissa D. “Antifungals in Clinical Use and the Pipeline.” Infect Dis Clin North Am 35, no. 2 (June 2021): 341–71. https://doi.org/10.1016/j.idc.2021.03.005.
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    • Matzaraki, Vasiliki, Kieu T. T. Le, Martin Jaeger, Raúl Aguirre-Gamboa, Melissa D. Johnson, Serena Sanna, Diletta Rosati, et al. “Inflammatory Protein Profiles in Plasma of Candidaemia Patients and the Contribution of Host Genetics to Their Variability.” Front Immunol 12 (2021): 662171. https://doi.org/10.3389/fimmu.2021.662171.
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    • Johnson, Melissa D., Russell E. Lewis, Elizabeth S. Dodds Ashley, Luis Ostrosky-Zeichner, Theoklis Zaoutis, George R. Thompson, David R. Andes, et al. “Core Recommendations for Antifungal Stewardship: A Statement of the Mycoses Study Group Education and Research Consortium.” J Infect Dis 222, no. Suppl 3 (August 5, 2020): S175–98. https://doi.org/10.1093/infdis/jiaa394.
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    • Schneeweiss, Sebastian, Peggy L. Carver, Kausik Datta, Alicia Galar, Melissa D. Johnson, Alyssa R. Letourneau, Francisco M. Marty, et al. “Long-term risk of hepatocellular carcinoma mortality in 23220 hospitalized patients treated with micafungin or other parenteral antifungals.” J Antimicrob Chemother 75, no. 1 (January 1, 2020): 221–28. https://doi.org/10.1093/jac/dkz396.
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    • Baker, Arthur W., Eileen K. Maziarz, Christopher J. Arnold, Melissa D. Johnson, Adrienne D. Workman, John M. Reynolds, John R. Perfect, and Barbara D. Alexander. “Invasive Fungal Infection After Lung Transplantation: Epidemiology in the Setting of Antifungal Prophylaxis.” Clin Infect Dis 70, no. 1 (January 1, 2020): 30–39. https://doi.org/10.1093/cid/ciz156.
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    • Yarrington, Michael E., Deverick J. Anderson, Elizabeth Dodds Ashley, Travis Jones, Angelina Davis, Melissa Johnson, Yuliya Lokhnygina, Daniel J. Sexton, and Rebekah W. Moehring. “Impact of FDA black box warning on fluoroquinolone and alternative antibiotic use in southeastern US hospitals.” Infect Control Hosp Epidemiol 40, no. 11 (November 2019): 1297–1300. https://doi.org/10.1017/ice.2019.247.
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    • Jaeger, Martin, Vasiliki Matzaraki, Raúl Aguirre-Gamboa, Mark S. Gresnigt, Xiaojing Chu, Melissa D. Johnson, Marije Oosting, et al. “A Genome-Wide Functional Genomics Approach Identifies Susceptibility Pathways to Fungal Bloodstream Infection in Humans.” J Infect Dis 220, no. 5 (July 31, 2019): 862–72. https://doi.org/10.1093/infdis/jiz206.
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    • Mourad, Ahmad, Jonathan A. Stiber, John R. Perfect, and Melissa D. Johnson. “Real-world implications of QT prolongation in patients receiving voriconazole and amiodarone.” J Antimicrob Chemother 74, no. 1 (January 1, 2019): 228–33. https://doi.org/10.1093/jac/dky392.
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    • Hostler, Christopher J., Rebekah W. Moehring, Elizabeth S Dodds Ashley, Melissa Johnson, Angelina Davis, Sarah S. Lewis, Daniel J. Sexton, Deverick J. Anderson, and Deverick J. CDC Prevention Epicenters Program. “Feasibility and Value of Developing a Regional Antibiogram for Community Hospitals.” Infect Control Hosp Epidemiol 39, no. 6 (June 2018): 718–22. https://doi.org/10.1017/ice.2018.71.
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    • Collar, Amanda L., Muthulekha Swamydas, Morgan O’Hayre, Md Sanaullah Sajib, Kevin W. Hoffman, Satya P. Singh, Ahmad Mourad, et al. “The homozygous CX3CR1-M280 mutation impairs human monocyte survival.” Jci Insight 3, no. 3 (February 8, 2018). https://doi.org/10.1172/jci.insight.95417.
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    • Matzaraki, Vasiliki, Mark S. Gresnigt, Martin Jaeger, Isis Ricaño-Ponce, Melissa D. Johnson, Marije Oosting, Lude Franke, et al. “An integrative genomics approach identifies novel pathways that influence candidaemia susceptibility.” Plos One 12, no. 7 (2017): e0180824. https://doi.org/10.1371/journal.pone.0180824.
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    • Roth, Susanne, Hanna Bergmann, Martin Jaeger, Assa Yeroslaviz, Konstantin Neumann, Paul-Albert Koenig, Clarissa Prazeres da Costa, et al. “Vav Proteins Are Key Regulators of Card9 Signaling for Innate Antifungal Immunity.” Cell Rep 17, no. 10 (December 6, 2016): 2572–83. https://doi.org/10.1016/j.celrep.2016.11.018.
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    • Cournoyer, Justin M., Aven P. Garms, Kimberly N. Thiessen, Margaret T. Bowers, Melissa D. Johnson, and Michael V. Relf. “Cardiovascular Disease and HIV: Pathophysiology, Treatment Considerations, and Nursing Implications.” Crit Care Nurse 36, no. 5 (October 2016): 37–46. https://doi.org/10.4037/ccn2016839.
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    • Schneeweiss, Sebastian, Peggy L. Carver, Kausik Datta, Alicia Galar, Melissa D. Johnson, Matthew G. Johnson, Francisco M. Marty, et al. “Short-term risk of liver and renal injury in hospitalized patients using micafungin: a multicentre cohort study.” J Antimicrob Chemother 71, no. 10 (October 2016): 2938–44. https://doi.org/10.1093/jac/dkw225.
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    • Maskarinec, Stacey A., Melissa D. Johnson, and John R. Perfect. “Genetic Susceptibility to Fungal Infections: What is in the Genes?” Curr Clin Microbiol Rep 3, no. 2 (June 2016): 81–91. https://doi.org/10.1007/s40588-016-0037-3.
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    • Swamydas, Muthulekha, Ji-Liang Gao, Timothy J. Break, Melissa D. Johnson, Martin Jaeger, Carlos A. Rodriguez, Jean K. Lim, et al. “CXCR1-mediated neutrophil degranulation and fungal killing promote Candida clearance and host survival.” Sci Transl Med 8, no. 322 (January 20, 2016): 322ra10. https://doi.org/10.1126/scitranslmed.aac7718.
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    • Jaeger, Martin, Robin van der Lee, Shih-Chin Cheng, Melissa D. Johnson, Vinod Kumar, Aylwin Ng, Theo S. Plantinga, et al. “The RIG-I-like helicase receptor MDA5 (IFIH1) is involved in the host defense against Candida infections.” Eur J Clin Microbiol Infect Dis 34, no. 5 (May 2015): 963–74. https://doi.org/10.1007/s10096-014-2309-2.
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    • American College of Clinical Pharmacy, Scot, Sarah E. McBane, Anna L. Dopp, Andrew Abe, Sandra Benavides, Elizabeth A. Chester, Dave L. Dixon, et al. “Collaborative drug therapy management and comprehensive medication management-2015.” Pharmacotherapy 35, no. 4 (April 2015): e39–50. https://doi.org/10.1002/phar.1563.
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    • Arnold, Christopher J., Melissa Johnson, Arnold S. Bayer, Suzanne Bradley, Efthymia Giannitsioti, José M. Miró, Pilar Tornos, et al. “Candida infective endocarditis: an observational cohort study with a focus on therapy.” Antimicrob Agents Chemother 59, no. 4 (April 2015): 2365–73. https://doi.org/10.1128/AAC.04867-14.
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    • Ten Oever, Jaap, Matthijs Kox, Frank L. van de Veerdonk, Khutso M. Mothapo, Adriana Slavcovici, Tim L. Jansen, Lieke Tweehuysen, et al. “The discriminative capacity of soluble Toll-like receptor (sTLR)2 and sTLR4 in inflammatory diseases.” Bmc Immunol 15 (November 19, 2014): 55. https://doi.org/10.1186/s12865-014-0055-y.
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    • Kumar, Vinod, Shih-Chin Cheng, Melissa D. Johnson, Sanne P. Smeekens, Agnieszka Wojtowicz, Evangelos Giamarellos-Bourboulis, Juha Karjalainen, et al. “Immunochip SNP array identifies novel genetic variants conferring susceptibility to candidaemia.” Nat Commun 5 (September 8, 2014): 4675. https://doi.org/10.1038/ncomms5675.
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    • Paul DiMondi, V., Mary L. Townsend, Melissa Johnson, and Michael Durkin. “Antifungal catheter lock therapy for the management of a persistent Candida albicans bloodstream infection in an adult receiving hemodialysis.” Pharmacotherapy 34, no. 7 (July 2014): e120–27. https://doi.org/10.1002/phar.1433.
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    • Kung, Hsiang-Chi, Melissa D. Johnson, Richard H. Drew, Paramita Saha-Chaudhuri, and John R. Perfect. “Clinical effectiveness of posaconazole versus fluconazole as antifungal prophylaxis in hematology-oncology patients: a retrospective cohort study.” Cancer Med 3, no. 3 (June 2014): 667–73. https://doi.org/10.1002/cam4.225.
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    • Rosentul, Diana C., Theo S. Plantinga, Marius Farcas, Marije Oosting, Omar J. M. Hamza, William K. Scott, Barbara D. Alexander, et al. “Role of autophagy genetic variants for the risk of Candida infections.” Med Mycol 52, no. 4 (May 2014): 333–41. https://doi.org/10.1093/mmy/myt035.
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    • Smeekens, S. P., R. K. Malireddi, T. S. Plantinga, K. Buffen, M. Oosting, L. A. B. Joosten, B. J. Kullberg, et al. “Autophagy is redundant for the host defense against systemic Candida albicans infections.” Eur J Clin Microbiol Infect Dis 33, no. 5 (May 2014): 711–22. https://doi.org/10.1007/s10096-013-2002-x.
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    • Alexander, B. D., M. D. Johnson, C. D. Pfeiffer, C. Jiménez-Ortigosa, J. Catania, and R. Booker. “Erratum: Increasing echinocandin resistance in Candida glabrata: Clinical failure correlates with presence of FKS mutations and elevated minimum inhibitory concentrations (Clinical Infectious Diseases (2013) 56 (1724-32)).” Clinical Infectious Diseases 58, no. 5 (March 1, 2014): 754. https://doi.org/10.1093/cid/cit956.
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    • Lionakis, Michail S., Muthulekha Swamydas, Brett G. Fischer, Theo S. Plantinga, Melissa D. Johnson, Martin Jaeger, Nathaniel M. Green, et al. “CX3CR1-dependent renal macrophage survival promotes Candida control and host survival.” J Clin Invest 123, no. 12 (December 2013): 5035–51. https://doi.org/10.1172/JCI71307.
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    • Oever, J. ten, E. J. Giamarellos-Bourboulis, F. L. van de Veerdonk, F. F. Stelma, A. Simon, M. Janssen, M. Johnson, et al. “Circulating galectin-3 in infections and non-infectious inflammatory diseases.” Eur J Clin Microbiol Infect Dis 32, no. 12 (December 2013): 1605–10. https://doi.org/10.1007/s10096-013-1919-4.
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    • Alexander, Barbara D., Melissa D. Johnson, Christopher D. Pfeiffer, Cristina Jiménez-Ortigosa, Jelena Catania, Rachel Booker, Mariana Castanheira, Shawn A. Messer, David S. Perlin, and Michael A. Pfaller. “Increasing echinocandin resistance in Candida glabrata: clinical failure correlates with presence of FKS mutations and elevated minimum inhibitory concentrations.” Clin Infect Dis 56, no. 12 (June 2013): 1724–32. https://doi.org/10.1093/cid/cit136.
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    • DeFreitas, Ashley A., Theresa-Lynda M. D’Souza, Ginille J. Lazaro, Emily M. Windes, Melissa D. Johnson, and Michael V. Relf. “Pharmacological considerations in human immunodeficiency virus-infected adults in the intensive care unit.” Crit Care Nurse 33, no. 2 (April 2013): 46–56. https://doi.org/10.4037/ccn2013854.
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    • Smeekens, Sanne P., Aylwin Ng, Vinod Kumar, Melissa D. Johnson, Theo S. Plantinga, Cleo van Diemen, Peer Arts, et al. “Functional genomics identifies type I interferon pathway as central for host defense against Candida albicans.” Nat Commun 4 (2013): 1342. https://doi.org/10.1038/ncomms2343.
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    • Plantinga, Theo S., Melissa D. Johnson, William K. Scott, Leo A. B. Joosten, Jos W. M. van der Meer, John R. Perfect, Bart Jan Kullberg, and Mihai G. Netea. “Human genetic susceptibility to Candida infections.” Med Mycol 50, no. 8 (November 2012): 785–94. https://doi.org/10.3109/13693786.2012.690902.
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    • Dodds Ashley, Elizabeth, Richard Drew, Melissa Johnson, Robert Danna, Dominika Dabrowski, Valery Walker, Manishi Prasad, Barbara Alexander, George Papadopoulos, and John Perfect. “Cost of invasive fungal infections in the era of new diagnostics and expanded treatment options.” Pharmacotherapy 32, no. 10 (October 2012): 890–901. https://doi.org/10.1002/j.1875-9114.2012.01124.
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    • Ashley, E. D., R. Drew, M. Johnson, R. Danna, D. Dabrowski, V. Walker, M. Prasad, B. Alexander, G. Papadopoulos, and J. Perfect. “Cost of Invasive Fungal Infections in the Era of New Diagnostics and Expanded Treatment Options.” Pharmacotherapy, September 18, 2012. https://doi.org/10.1002/phar.1124.
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    • Schell, W. A., J. L. Benton, P. B. Smith, M. Poore, J. L. Rouse, D. J. Boles, M. D. Johnson, et al. “Evaluation of a digital microfluidic real-time PCR platform to detect DNA of Candida albicans in blood.” Eur J Clin Microbiol Infect Dis 31, no. 9 (September 2012): 2237–45. https://doi.org/10.1007/s10096-012-1561-6.
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    • Plantinga, Theo S., Melissa D. Johnson, William K. Scott, Esther van de Vosse, Digna R. Velez Edwards, P Brian Smith, Barbara D. Alexander, et al. “Toll-like receptor 1 polymorphisms increase susceptibility to candidemia.” J Infect Dis 205, no. 6 (March 15, 2012): 934–43. https://doi.org/10.1093/infdis/jir867.
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    • Rosentul, D. C., T. S. Plantinga, W. K. Scott, B. D. Alexander, N. M. D. van de Geer, J. R. Perfect, B. J. Kullberg, M. D. Johnson, and M. G. Netea. “The impact of caspase-12 on susceptibility to candidemia.” Eur J Clin Microbiol Infect Dis 31, no. 3 (March 2012): 277–80. https://doi.org/10.1007/s10096-011-1307-x.
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    • Johnson, Melissa D., Theo S. Plantinga, Esther van de Vosse, Digna R. Velez Edwards, P Brian Smith, Barbara D. Alexander, John C. Yang, et al. “Cytokine gene polymorphisms and the outcome of invasive candidiasis: a prospective cohort study.” Clin Infect Dis 54, no. 4 (February 15, 2012): 502–10. https://doi.org/10.1093/cid/cir827.
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    • Goswami, Neela D., Melissa D. Johnson, and Vivian H. Chu. “Ertapenem for treatment of osteomyelitis: a case series.” Bmc Res Notes 4 (November 2, 2011): 478. https://doi.org/10.1186/1756-0500-4-478.
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    • Rosentul, Diana C., Theo S. Plantinga, Marije Oosting, William K. Scott, Digna R. Velez Edwards, P Brian Smith, Barbara D. Alexander, et al. “Genetic variation in the dectin-1/CARD9 recognition pathway and susceptibility to candidemia.” J Infect Dis 204, no. 7 (October 1, 2011): 1138–45. https://doi.org/10.1093/infdis/jir458.
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    • Ashley, E. D., and M. D. Johnson. “Combination antifungal therapy,” January 1, 2011, 153–63. https://doi.org/10.1007/978-1-4419-6640-7_10.
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    • Johnson, M. D., and M. Netea. “Host Genomics and Bacterial Infections,” December 1, 2010, 744–59. https://doi.org/10.1016/B978-0-12-374934-5.00058-1.
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    • Johnson, Melissa D., and John R. Perfect. “Use of Antifungal Combination Therapy: Agents, Order, and Timing.” Curr Fungal Infect Rep 4, no. 2 (May 1, 2010): 87–95. https://doi.org/10.1007/s12281-010-0018-6.
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    • Heil, Emily L., Mary L. Townsend, Kenneth Shipp, Amy Clarke, and Melissa D. Johnson. “Incidence of Severe Hepatotoxicity Related to Antiretroviral Therapy in HIV/HCV Coinfected Patients.” Aids Res Treat 2010 (2010): 856542. https://doi.org/10.1155/2010/856542.
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    • Johnson, M. D., and M. Netea. “Host Genomics and Bacterial Infections,” December 1, 2009, 1347–61. https://doi.org/10.1016/B978-0-12-369420-1.00110-4.
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    • Ferwerda, Bart, Gerben Ferwerda, Theo S. Plantinga, Janet A. Willment, Annemiek B. van Spriel, Hanka Venselaar, Clara C. Elbers, et al. “Human dectin-1 deficiency and mucocutaneous fungal infections.” N Engl J Med 361, no. 18 (October 29, 2009): 1760–67. https://doi.org/10.1056/NEJMoa0901053.
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    • Johnson, M. D. “Pharmacogenomics of systemic antifungal agents.” Current Fungal Infection Reports 3, no. 2 (June 1, 2009): 111–16. https://doi.org/10.1007/s12281-009-0015-9.
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    • Connelly, Sarah M., Jane V. Trinh, Melissa D. Johnson, Elizabeth S. Dodds-Ashley, Jason Stout, John J. Engemann, N Deborah Friedman, Donald Kaye, and Keith S. Kaye. “Mortality and time to extubation in severe hospital-acquired pneumonia.” Am J Infect Control 37, no. 2 (March 2009): 143–49. https://doi.org/10.1016/j.ajic.2008.03.011.
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    • Plantinga, T., M. Johnsson, B. Scott, E van de Vosse, D. Velez, JWM van der Meer, J. van Dissel, J. Perfect, B. -. J. Kullberg, and M. G. Netea. “Toll like receptor 1 polymorphisms and susceptibility to invasive candidiasis.” Critical Care (London, England) 13, no. Suppl 4 (January 2009): P28–P28. https://doi.org/10.1186/cc8084.
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    • Mohr, John, Melissa Johnson, Travis Cooper, James S. Lewis, and Luis Ostrosky-Zeichner. “Current options in antifungal pharmacotherapy.” Pharmacotherapy 28, no. 5 (May 2008): 614–45. https://doi.org/10.1592/phco.28.5.614.
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    • Bentley, D., and M. Johnson. “Safety in healthcare is not a new concept.” International Surgery 93, no. 3 (2008): 139–40.
    • Lalani, Tahaniyat, Jay B. Varkey, Richard Drew, Lizzie Harrell, Sarah McGarry, John G. Engemann, Melissa D. Johnson, and Keith S. Kaye. “Analysis of two- and three-year trends in antimicrobial resistance in intensive care units using unit-specific antibiograms.” Scand J Infect Dis 40, no. 8 (2008): 672–74. https://doi.org/10.1080/00365540801971403.
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    • Townsend, Mary L., Stephanie B. Hollowell, Jasmin Bhalodia, Kenneth H. Wilson, Keith S. Kaye, and Melissa D. Johnson. “A comparison of the effectiveness of lipid-lowering therapy between HIV- and non-HIV-infected subjects with hyperlipidaemia.” Int J Std Aids 18, no. 12 (December 2007): 851–55. https://doi.org/10.1258/095646207782716974.
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    • Johnson, Melissa D., and John R. Perfect. “Fungal infections of the bones and joints.” Curr Infect Dis Rep 3, no. 5 (October 2007): 450–60. https://doi.org/10.1007/s11908-007-1002-3.
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    • Johnson, M. D., and J. R. Perfect. “Combination antifungal therapy: what can and should we expect?” Bone Marrow Transplant 40, no. 4 (August 2007): 297–306. https://doi.org/10.1038/sj.bmt.1705687.
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    • Smith, P Brian, Daniel K. Benjamin, Barbara D. Alexander, Melissa D. Johnson, Malcolm A. Finkelman, and William J. Steinbach. “Quantification of 1,3-beta-D-glucan levels in children: preliminary data for diagnostic use of the beta-glucan assay in a pediatric setting.” Clin Vaccine Immunol 14, no. 7 (July 2007): 924–25. https://doi.org/10.1128/CVI.00025-07.
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    • Zaas, Aimee K., Elizabeth S. Dodds Ashley, Barbara D. Alexander, Melissa D. Johnson, and John R. Perfect. “Caspofungin for invasive candidiasis at a tertiary care medical center.” Am J Med 119, no. 11 (November 2006): 993.e1-993.e6. https://doi.org/10.1016/j.amjmed.2006.02.029.
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    • Anaissie, Elias J., Brahm H. Segal, John R. Graybill, Carola Arndt, John R. Perfect, Michael Kleinberg, Peter Pappas, et al. “Clinical research in the lay press: irresponsible journalism raises a huge dose of doubt.” Clin Infect Dis 43, no. 8 (October 15, 2006): 1031–39. https://doi.org/10.1086/509116.
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    • Johnson, Melissa D., Michael Kleinberg, Larry Danziger, and Luis Ostrosky-Zeichner. “Pharmacoeconomics of antifungal pharmacotherapy--challenges and future directions.” Expert Opin Pharmacother 6, no. 15 (December 2005): 2617–32. https://doi.org/10.1517/14656566.6.15.2617.
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    • Pope, Scott D., Melissa D. Johnson, and D Byron May. “Pharmacotherapy for human immunodeficiency virus-associated nephropathy.” Pharmacotherapy 25, no. 12 (December 2005): 1761–72. https://doi.org/10.1592/phco.2005.25.12.1761.
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    • Johnson, Melissa D., Conan MacDougall, Luis Ostrosky-Zeichner, John R. Perfect, and John H. Rex. “Combination antifungal therapy.” Antimicrob Agents Chemother 48, no. 3 (March 2004): 693–715. https://doi.org/10.1128/AAC.48.3.693-715.2004.
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    • Johnson, Melissa D. “Book Review: Management of the HIV-Infected Patient. 2nd Edition.” Annals of Pharmacotherapy 37, no. 6 (June 2003): 921–921. https://doi.org/10.1345/aph.1c341.
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    • Johnson, Melissa D., and John R. Perfect. “Caspofungin: first approved agent in a new class of antifungals.” Expert Opin Pharmacother 4, no. 5 (May 2003): 807–23. https://doi.org/10.1517/14656566.4.5.807.
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    • Johnson, Melissa D., Carol D. Hamilton, Richard H. Drew, Linda L. Sanders, Gennethel J. Pennick, and John R. Perfect. “A randomized comparative study to determine the effect of omeprazole on the peak serum concentration of itraconazole oral solution.” J Antimicrob Chemother 51, no. 2 (February 2003): 453–57. https://doi.org/10.1093/jac/dkg089.
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    • Bohjanen, Paul R., Melissa D. Johnson, Lynda A. Szczech, Dannah W. Wray, William P. Petros, Cameron R. Miller, and Charles B. Hicks. “Steady-state pharmacokinetics of lamivudine in human immunodeficiency virus-infected patients with end-stage renal disease receiving chronic dialysis.” Antimicrob Agents Chemother 46, no. 8 (August 2002): 2387–92. https://doi.org/10.1128/AAC.46.8.2387-2392.2002.
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    • Johnson, M. D., R. H. Drew, and J. R. Perfect. “Chest discomfort associated with liposomal amphotericin B: report of three cases and review of the literature.” Pharmacotherapy 18, no. 5 (1998): 1053–61.
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  • Book Sections

    • Johnson, Melissa, John Mohr, and Ahmad Mourad. “Echinocandins for Prevention and Treatment of Invasive Fungal Infections.” In Antifungal Therapy. CRC Press, 2019.
    • Johnson, M. D., and M. Netea. “Host Genomics and Bacterial Infections.” In Genomic and Personalized Medicine: V1-2, 1347–61, 2008. https://doi.org/10.1016/B978-0-12-369420-1.00110-4.
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    • Drew, R. H., M. D. Johnson, E. D. Ashley, and J. R. Perfect. “Rational use of antifungals for invasive fungal infections in the institutional setting.” In Antibiotic Optimization: Concepts and Strategies in Clinical Practice, 577–644, 2004.

  • Conference Papers

    • Johnson, Alexandra, Bobby Warren, Deverick John Anderson, Melissa Johnson, Isabella Gamez, and Becky Smith. “Alcohol Hand Rub Significantly Reduces Overall Bacterial Bioburden on Stethoscopes in a Real-World Clinical Setting.” In Infection Control &Amp; Hospital Epidemiology, 41:s114–15. Cambridge University Press (CUP), 2020. https://doi.org/10.1017/ice.2020.620.
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    • Steinbrink, Julie Marie, Rachel Myers, Melissa D. Johnson, Barbara D. Alexander, and Micah T. McClain. “Transcriptomic approaches elucidate novel aspects of the host immune response to candidemia.” In Journal of Immunology, Vol. 204, 2020.
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    • Mourad, A., melissa Johnson, and john Perfect. “Predictors of Mortality in Patients Receiving Voriconazole.” Atlanta, GA: American Society of Microbiology - Microbe, 2018.
    • Kumar, Vinod, Vasiliki Matzaraki, Martin Jaeger, R. Aguirre-Gamboa, Melissa D. Johnson, Mihai G. Netea, and Cisca Wijmenga. “A genetic and genomics approach identifies novel pathways of human antifungal immune responses.” In Medical Mycology, 56:S61–S61. OXFORD UNIV PRESS, 2018.
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    • Mourad, A., Melissa Johnson, and John Perfect. “A Decade of Voriconazole Use at Duke University Medical Center: What are the Challenges with Dosing?” New Orleans, LA: American Society of Microbiology - Microbe, 2017.
    • Davies, Marie L., Melissa D. Johnson, Jamie N. Brown, William E. Bryan, and Mary L. Townsend. “Predictors of glycaemic control among HIV-positive veterans with diabetes.” In Int J Std Aids, 26:262–67, 2015. https://doi.org/10.1177/0956462414535207.
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    • Mantovani, Emily, Rebecca Webb, Elizabeth Price, Michael Jiroutek, and Melissa Johnson. “The prevalence of HIV testing in pregnant women.” In Pharmacotherapy, 34:E276–E276, 2014.
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    • Depner, M., F. van de Veerdonk, J. Wanders, H. Stauss, J. Raabe, T. P. Atkinson, H. W. Schroeder, et al. “MUTATION SCREENING IN STAT1, CARD9 AND PKC-DELTA IN PATIENTS WITH CHRONIC MUCOCUTANEOUS CANDIDIASIS.” In Journal of Clinical Immunology, 32:334–35. SPRINGER/PLENUM PUBLISHERS, 2012.
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    • Peters, Katherine, Patrick Healy, James Herndon, Eric Lipp, Sujata Panta, Dina Randazzo, Gordana Vlahovic, Henry Friedman, and Annick Desjardins. “Perceived cognitive dysfunction at diagnosis and beyond disease progression in newly diagnosed glioblastoma patients.” In Supportive Care in Cancer, 25:S60–S60. Springer (part of Springer Nature), n.d.
• Teaching & Mentoring
• 

  Recent Courses

  • NURSING 846: Advanced Practice Nursing: HIV Specialty I 2022
  • NURSING 841: Pharmacologic Aspects of HIV/AIDS 2021
• Scholarly, Clinical, & Service Activities
• 

  Service to the Profession

  • President. Society of Infectious Diseases Pharmacists. November 1, 2022 - October 31, 2023  2022 - 2023
  • President-Elect. Society of Infectious Diseases Pharmacists. November 2021 - November 2022  2021 - 2022

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