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Melissa DePaoli Johnson

Professor in Medicine
Medicine, Infectious Diseases
Duke Box 102359, Durham, NC 27710
Room 173 Hanes House, 315 Trent Drive, Durham, NC 27710

Overview


Prognostic indicators for patients with Candida spp. bloodstream infections
Antifungal pharmacokinetics/pharmacodynamics
Immunogenetics among patients with candidiasis
Management of the HIV infected patient and antiretroviral pharmacotherapy
Antibacterial drug utilization, resistance, and appropriate prescribing
Antimicrobial Stewardship

Current Appointments & Affiliations


Professor in Medicine · 2022 - Present Medicine, Infectious Diseases, Medicine

Recent Publications


Comprehensive Review of Candidozyma (Candida) auris Management: Insights From the Society of Infectious Diseases Pharmacists.

Journal Article Pharmacotherapy · April 2026 Candidozyma (Candida) auris has emerged over the past two decades as a formidable global health threat due to its multidrug resistance, persistence in healthcare environments, and rapid nosocomial spread. Recently reclassified into the genus Candidozyma ba ... Full text Link to item Cite

Concurrent Administration of Triazoles with Chemotherapeutic and/or Immunosuppressant Agents Known to Have Moderate-to-Severe Drug-Drug Interactions in Patients with Hematologic Malignancies Hospitalized for Invasive Aspergillosis.

Journal Article Mycopathologia · January 13, 2026 BACKGROUND: Triazoles are widely used for treatment and prevention of invasive aspergillosis (IA) but can cause serious drug-drug interactions (DDIs) with chemotherapeutic (CT) and immunosuppressant (IS) agents via CYP3A4 inhibition. The frequency of triaz ... Full text Link to item Cite

Co-administration of triazoles with calcineurin or mammalian target of rapamycin inhibitors in solid organ transplant patients hospitalized with invasive aspergillosis.

Journal Article J Antimicrob Chemother · January 6, 2026 BACKGROUND: All triazoles decrease the metabolism of calcineurin inhibitors (CNIs) and mammalian target of rapamycin (mTOR) inhibitors through CYP3A4 and P-glycoprotein inhibition leading to increased exposure and the potential for serious adverse events ( ... Full text Link to item Cite
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Recent Grants


Tri-Institutional Molecular Mycology and Pathogenesis Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2024 - 2029

Systems Biology for Infectious Diseases

ResearchPrincipal Investigator · Awarded by The Lundquist Institute · 2023 - 2028

Host directed medicine in invasive fungal infection - HDM-FUN

Clinical TrialCo Investigator · Awarded by European Union · 2020 - 2026

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Education


Duke University, School of Medicine · 2007 M.H.S.
Campbell University · 1997 Pharm.D.
Duke University, School of Medicine · 1992 B.S.