Scholars@Duke
Juliann Kosovec

Juliann Kosovec

House Staff
Surgery

Selected Publications

Sitravatinib combined with PD-1 blockade enhances cytotoxic T-cell infiltration by M2 to M1 tumor macrophage repolarization in esophageal adenocarcinoma.

Journal Article Carcinogenesis · April 2024 Esophageal adenocarcinoma (EAC) is a leading cause of cancer-related mortality. Sitravatinib is a novel multi-gene tyrosine kinase inhibitor (TKI) that targets tumor-associated macrophage (TAM) receptors, VEGF, PDGF and c-Kit. Currently, sitravatinib is ac ... Full text Cite

Comparing Survival After Resection, Ablation, and Radiation in Small Intrahepatic Cholangiocarcinoma.

Journal Article Ann Surg Oncol · October 2023 BACKGROUND: Hepatectomy is the cornerstone of curative-intent treatment for intrahepatic cholangiocarcinoma (ICC). However, in patients unable to be resected, data comparing efficacy of alternatives including thermal ablation and radiation therapy (RT) rem ... Full text Open Access Link to item Cite

Evolution in Management of Upfront Treatment For Desmoid Tumors

Conference ANNALS OF SURGICAL ONCOLOGY · 2023 Cite

Safety and efficacy of immunotherapy in combination with epigenetic therapy in an esophageal adenocarcinoma model.

Conference Journal of Clinical Oncology · February 1, 2022 335 Background: There is a critical need to develop effective therapeutic approaches for patients with esophageal cancer, a leading cause of cancer mortality. Recently, immune checkpoint blockade (ICB) has demonstrated modest sur ... Full text Cite

The effect of normal, metaplastic, and neoplastic esophageal extracellular matrix upon macrophage activation.

Conference Journal of immunology and regenerative medicine · August 2021 IntroductionMacrophages are capable of extreme plasticity and their activation state has been strongly associated with solid tumor growth progression and regression. Although the macrophage response to extracellular matrix (ECM) isolated from norm ... Full text Cite

Intratumoral immunotherapy with STING agonist, ADU-S100, induces CD8+ T-cell mediated anti-tumor immunity in an esophageal adenocarcinoma model.

Journal Article Oncotarget · February 2021 BackgroundEsophageal adenocarcinoma (EAC) is a deadly disease with limited treatment options. STING is a transmembrane protein that activates transcription of interferon genes, resulting in stimulation of APCs and enhanced CD8+ T-cell infiltration ... Full text Cite

Prognostic immune markers for recurrence and survival in locally advanced esophageal adenocarcinoma.

Journal Article Oncotarget · July 2019 Treatment options and risk stratification for esophageal adenocarcinomas (EAC) currently rely on pathological criteria such as tumor staging. However, with advancement in immune modulated treatments, there is a need for accurate predictive biomarkers that ... Full text Cite

Extracellular Matrix Degradation Products Downregulate Neoplastic Esophageal Cell Phenotype.

Journal Article Tissue engineering. Part A · March 2019 Impact statementExtracellular matrix (ECM) biomaterials were used to treat esophageal cancer patients after cancer resection and promoted regrowth of normal mucosa without recurrence of cancer. The present study investigates the mechanisms by whic ... Full text Cite

The Dynamic and Transient Immune Microenvironment in Locally Advanced Esophageal Adenocarcinoma Post Chemoradiation.

Journal Article Annals of surgery · December 2018 ObjectiveThe aim of this study was to assess the impact of chemoradiation on the immune microenvironment to influence and optimally design future neoadjuvant clinical trials.Summary background dataProgrammed death (PD)-1 inhibitors in met ... Full text Cite

Sep70/Pepsin expression in hypopharynx combined with hypopharyngeal multichannel intraluminal impedance increases diagnostic sensitivity of laryngopharyngeal reflux.

Journal Article Surgical endoscopy · May 2018 BackgroundImproved methods of diagnosis of laryngopharyngeal reflux (LPR) would enable surgeons to better identify patients who may benefit from antireflux surgery (ARS). The objective of the present study was to assess if hypopharyngeal Pepsin an ... Full text Cite

The Potential Clinical Utility of Circulating Tumor DNA in Esophageal Adenocarcinoma: From Early Detection to Therapy.

Journal Article Frontiers in oncology · January 2018 Esophageal adenocarcinoma (EAC) is a lethal cancer requiring improved screening strategies and treatment options due to poor detection methods, aggressive progression, and therapeutic resistance. Emerging circulating tumor DNA (ctDNA) technologies may offe ... Full text Cite

Serial Endoscopic Evaluation of Esophageal Disease in a Cancer Model: A Paradigm Shift for Esophageal Adenocarcinoma (EAC) Drug Discovery and Development.

Journal Article Cancer investigation · January 2018 A rat model of surgically induced reflux recapitulates the development and progression of human esophageal adenocarcinoma (EAC). In this study, reflux was induced in rats followed by postoperative endoscopy with biopsy, to diagnose and monitor disease prog ... Full text Cite

CDK4/6 dual inhibitor abemaciclib demonstrates compelling preclinical activity against esophageal adenocarcinoma: a novel therapeutic option for a deadly disease.

Journal Article Oncotarget · November 2017 Esophageal adenocarcinoma (EAC) is a deadly disease with limited therapeutic options. In the present study, we determined the preclinical efficacy of CDK4/6 inhibitor abemaciclib for treatment of EAC. In vitro, apoptosis, proliferation, and pathway ... Full text Cite

High yield reproducible rat model recapitulating human Barrett's carcinogenesis.

Journal Article World journal of gastroenterology · September 2017 AimTo efficiently replicate the biology and pathogenesis of human esophageal adenocarcinoma (EAC) using the modified Levrat model of end-to-side esophagojejunostomy.MethodsEnd-to-side esophagojejunostomy was performed on rats to induce ga ... Full text Cite

PI3K/mTOR Dual Inhibitor, LY3023414, Demonstrates Potent Antitumor Efficacy Against Esophageal Adenocarcinoma in a Rat Model.

Journal Article Annals of surgery · July 2017 ObjectiveThe purpose of the current study is to determine the efficacy of a PI3K/mTOR dual inhibitor, LY3023414, on established EAC in an in vivo model.BackgroundEsophageal adenocarcinoma (EAC) is a highly lethal cancer with limited treat ... Full text Cite

Magnitude and duration of immune checkpoint up-regulation and changes in the immune microenvironment post chemo-radiation (CRT) in esophageal cancer.

Conference Journal of Clinical Oncology · May 20, 2017 4060 Background: PD-1 inhibitors in metastatic gastroesophageal cancer have demonstrated response rates of approximately 25%. Unfortunately, the majority of patients do not respond. Therefore, a rationale strategy of combining im ... Full text Cite

Antitumor efficacy of CDK 4/6 dual inhibitor, abemaciclib, in an esophageal adenocarcinoma model.

Conference Journal of Clinical Oncology · May 20, 2017 e15598 Background: Esophageal adenocarcinoma (EAC) is a leading cause of cancer death, and current treatment options are extremely limited. Cell cycle regulators CDK6 and its homolog, CDK4, are known to be up-regulated in EAC and ... Full text Cite

Checkpoint expression pre and post chemoradiation in operable esophageal cancer.

Conference Journal of Clinical Oncology · February 1, 2017 139 Background: PD-L1 expression has been reported in 40% of gastroesophageal cancers, but little data exists with regards to expression of other immune checkpoints. Here, we examined baseline expression levels for multiple immun ... Full text Cite

Primary tumor microRNA signature predicts recurrence and survival in patients with locally advanced esophageal adenocarcinoma.

Journal Article Oncotarget · December 2016 Esophageal adenocarcinoma (EAC) is an aggressive cancer necessitating the development of improved risk stratification tools for personalized care. Previously, microRNAs have been shown to correlate with the progression and prognosis of various cancer types ... Full text Cite

Preclinical Study of AUY922, a Novel Hsp90 Inhibitor, in the Treatment of Esophageal Adenocarcinoma.

Journal Article Annals of surgery · August 2016 ObjectiveTo assess the efficacy of heat-shock protein 90 (Hsp90) inhibitor, NVP-AUY922-AG (AUY922), in the treatment of esophageal adenocarcinoma (EAC) in vitro and in vivo.BackgroundEAC is a leading cause of cancer death, and current tre ... Full text Cite

Hypopharyngeal pepsin and Sep70 as diagnostic markers of laryngopharyngeal reflux: preliminary study.

Journal Article Surgical endoscopy · May 2015 IntroductionThe management of laryngopharyngeal reflux (LPR) has been challenging. Hypopharyngeal multichannel intraluminal impedance (HMII) has shown to increase the sensitivity in diagnosing LPR. The objective of this study is to investigate the ... Full text Cite

Role of microbiota and Toll-like receptors in progression of esophageal adenocarcinoma (EAC) in a rat reflux model.

Conference Journal of Clinical Oncology · January 20, 2015 28 Background: The discovery of the link between H. pylori and gastric cancer may be the most direct proof that bacterial signaling and host response can result in carcinogenesis. Accumulating evidence supports that activation of ... Full text Cite

MicroRNA signature characterizes primary tumors that metastasize in an esophageal adenocarcinoma rat model.

Journal Article PloS one · January 2015 ObjectiveTo establish a miRNA signature for metastasis in an animal model of esophageal adenocarcinoma (EAC).BackgroundThe incidence of esophageal adenocarcinoma (EAC) has dramatically increased and esophageal cancer is now the sixth lead ... Full text Cite

Abstract B05: MRI provides a more reliable method of esophageal tumor detection than endoscopy in a rat model

Conference Molecular Cancer Research · November 1, 2014 AbstractBackground: The surgical rat model of end-to-side esophagojejunal anastomosis has proven utility in terms of its ability to replicate Barrett's carcinogenesis by inducing gastroduodenoesophageal refl ... Full text Cite

Establishing magnetic resonance imaging as an accurate and reliable tool to diagnose and monitor esophageal cancer in a rat model.

Journal Article PloS one · January 2014 ObjectiveTo assess the reliability of magnetic resonance imaging (MRI) for detection of esophageal cancer in the Levrat model of end-to-side esophagojejunostomy.BackgroundThe Levrat model has proven utility in terms of its ability to repl ... Full text Cite

Abstract A48: Enhanced efficacy of cisplatin and 5-fluorouracil combination with AUY-922 in esophageal adenocarcinoma cells

Conference Cancer Research · October 1, 2013 AbstractBackground: Esophageal Adenocarcinoma (EAC) continues to rise in incidence, with prognosis remaining poor despite advances in multimodality therapy. Several novel target agents are now being explored ... Full text Cite

Smoothened inhibition leads to decreased proliferation and induces apoptosis in esophageal adenocarcinoma cells.

Journal Article Cancer investigation · August 2013 The Hedgehog (Hh) pathway is known to be active in Barrett's carcinogenesis. Therefore, we evaluated the efficacy and underlying mechanisms of inhibition of cancer cell growth by the smoothened (Smo) antagonist BMS-833923 in esophageal adenocarcinoma (EAC) ... Full text Cite

Prevention of Barrett esophagus and esophageal adenocarcinoma by smoothened inhibitor in a rat model of gastroesophageal reflux disease.

Journal Article Annals of surgery · July 2013 BackgroundActivated hedgehog (Hh) pathway is associated with development of both Barrett esophagus (BE) and esophageal adenocarcinoma (EAC). We hypothesize that blockade of the Hh pathway with smoothened (Smo) inhibitor can prevent the development ... Full text Cite

Prognostic value and targeted inhibition of survivin expression in esophageal adenocarcinoma and cancer-adjacent squamous epithelium.

Journal Article PloS one · January 2013 BackgroundSurvivin is an inhibitor of apoptosis and its over expression is associated with poor prognosis in several malignancies. While several studies have analyzed survivin expression in esophageal squamous cell carcinoma, few have focused on e ... Full text Cite

In vitro circuit stability of 5-fluorouracil and oxaliplatin in support of hyperthermic isolated hepatic perfusion.

Journal Article The journal of extra-corporeal technology · March 2010 Over the years, a large number of drugs have been used in isolated perfusion of extremities or organs. To interpret the pharmacokinetics of these drugs correctly, the contributions of tissue or organ clearance and chemical degradation, respectively, to ove ... Cite

Quantitation of 5-fluorouracil (5-FU) in human plasma by liquid chromatography/electrospray ionization tandem mass spectrometry.

Journal Article Rapid communications in mass spectrometry : RCM · January 2008 5-Fluorouracil (5-FU) has long had a place in the treatment of many malignancies. 5-FU plasma concentrations have been correlated with toxicity and efficacy, and therapeutic drug monitoring has been reported to result in an improved response/toxicity balan ... Full text Cite