Scholars@Duke
Kadiyala Venkata Ravindra

Kadiyala Venkata Ravindra

Professor of Surgery
Surgery, Abdominal Transplant Surgery
kadiyala.ravindra@duke.edu
330 Trent Dr Room 217, Box 3512, Durham, NC 27710

Selected Publications

Financial toxicity in living donor liver transplantation: A call to action for financial neutrality.

Journal Article Am J Transplant · October 2024 After 2 decades of limited growth, living donor liver transplant (LDLT) has been increasingly accepted as a promising solution to the growing organ shortage in the US. With experience, LDLT offers superior graft and patient survival with low rates of rejec ... Full text Link to item Cite

Banff 2022 Vascularized Composite Allotransplantation Meeting Report: Diagnostic criteria for vascular changes.

Journal Article Am J Transplant · May 2024 As more data become available, the Banff 2007 working classification of skin-containing vascularized composite allograft (VCA) pathology is expected to evolve and develop. This report represents the Banff VCA Working Group's consensus on the first revision ... Full text Link to item Cite

Contemporary trends in choledochal cyst excision: An analysis of the pediatric national surgical quality improvement program.

Journal Article World J Surg · April 2024 BACKGROUND: Choledochal cysts are rare congenital anomalies of the biliary tree that may lead to obstruction, chronic inflammation, infection, and malignancy. There is wide variation in the timing of resection, operative approach, and reconstructive techni ... Full text Link to item Cite

Improved survival and higher rates of surgical resection associated with hepatocellular carcinoma in children as compared to young adults.

Journal Article Int J Cancer · December 15, 2022 Hepatocellular adenocarcinoma (HCC) is the second most common primary hepatic malignancy in children with a 5-year overall survival of 30%. Few studies have examined the similarities and differences between pediatric and adult HCC. This article aims to exa ... Full text Link to item Cite

A Multidimensional Bioinformatic Platform for the Study of Human Response to Surgery.

Journal Article Ann Surg · June 1, 2022 OBJECTIVE: To design and establish a prospective biospecimen repository that integrates multi-omics assays with clinical data to study mechanisms of controlled injury and healing. BACKGROUND: Elective surgery is an opportunity to understand both the system ... Full text Link to item Cite

Left lateral segment liver volume is not correlated with anthropometric measures.

Journal Article HPB (Oxford) · December 2021 BACKGROUND: Liver transplantation is definitive therapy for end stage liver disease in pediatric patients. Living donor liver transplantation (LDLT) with the left lateral segment (LLS) is often a feasible option. However, the size of LLS is an important fa ... Full text Link to item Cite

Using Radiographic Domain for Evaluating Indications in Abdominal Wall Transplantation.

Journal Article Ann Plast Surg · September 1, 2021 BACKGROUND: There is currently no description of abdominal domain changes in small bowel transplantation population or consensus of criteria regarding which patients are at high risk for immediate postoperative abdominal wall complications or would benefit ... Full text Link to item Cite

Definition and Analysis of Textbook Outcome: A Novel Quality Measure in Kidney Transplantation.

Journal Article World J Surg · May 2021 BACKGROUND: "Textbook outcome" (TO) is a novel composite quality measure that encompasses multiple postoperative endpoints, representing the ideal "textbook" hospitalization for complex surgical procedures. We defined TO for kidney transplantation using a ... Full text Link to item Cite

CT and MR imaging evaluation of living liver donors.

Journal Article Abdom Radiol (NY) · January 2021 Preoperative cross-sectional imaging evaluation of potential living liver donors allows to exclude donors with an increased risk for morbidity and mortality, and to assure that a suitable graft for the recipient can be obtained, minimizing the risk of comp ... Full text Link to item Cite

Abdominal Wall Transplantation: Indications and Outcomes

Journal Article Current Transplantation Reports · December 1, 2020 Purpose of Review: This article aims to review published outcomes associated with full-thickness vascularized abdominal wall transplantation, with particular emphasis on advances in the field in the last 3 years. Recent Findings: Forty-six full-thickness v ... Full text Cite

Decreased graft loss following implementation of the kidney allocation score (KAS).

Journal Article Am J Surg · November 2020 BACKGROUND: The Kidney Allocation System (KAS) was developed to improve equity and utility in organ allocation. We examine the effect of this change on kidney graft distribution and survival. METHODS: UNOS data was used to identify first-time adult recipie ... Full text Link to item Cite

Surgical Techniques for Revascularization in Abdominal Wall Transplantation.

Journal Article J Reconstr Microsurg · September 2020 BACKGROUND:  Abdominal wall vascularized composite allotransplantation (AW-VCA) can be considered as a technically feasible option for abdominal wall reconstruction in patients whose abdomen cannot be closed using traditional methods. However, successful i ... Full text Open Access Link to item Cite

Synchronous Abdominal Wall and Small-bowel Transplantation: A 1-year Follow-up.

Journal Article Plast Reconstr Surg Glob Open · July 2020 Abdominal wall-vascularized composite allotransplantation (AW-VCA) has evolved as a technically feasible but challenging option in the rare event of abdominal wall reconstruction in patients whose abdomen cannot be closed by applying conventional methods. ... Full text Open Access Link to item Cite

Correlation of preoperative imaging characteristics with donor outcomes and operative difficulty in laparoscopic donor nephrectomy.

Journal Article Am J Transplant · March 2020 This study aimed to understand the relationship of preoperative measurements and risk factors on operative time and outcomes of laparoscopic donor nephrectomy. Two hundred forty-two kidney donors between 2010 and 2017 were identified. Patients' demographic ... Full text Open Access Link to item Cite

The Systemic Immune-Inflammation Index Predicts Clinical Outcomes in Kidney Transplant Recipients.

Journal Article In Vivo · 2020 BACKGROUND: Outcomes after kidney transplantation (KTx) remain limited by delayed graft function (DGF) and acute rejection. Non-invasive biomarkers may help identify patients at increased risk for these events. We examined the association between the syste ... Full text Link to item Cite

Small bowel and abdominal wall transplantation: A novel technique for synchronous revascularization.

Journal Article Am J Transplant · July 2019 Abdominal wall transplantation (AWT) was introduced in 1999 in the context of reconstruction of complex abdominal wall defects in conjunction with visceral organ transplantation. As of recently, 38 cases of total AWT have been performed worldwide, about ha ... Full text Link to item Cite

Lymphocyte depletion and risk of acute rejection in renal transplant recipients at increased risk for delayed graft function.

Journal Article Am J Transplant · March 2019 Delayed graft function (DGF) is a risk factor for acute rejection (AR) in renal transplant recipients, and KDIGO guidelines suggest use of lymphocyte-depletion induction when DGF is anticipated. We analyzed the United Network for Organ Sharing/Organ Procur ... Full text Link to item Cite

Pancreas Transplantation: Indications, Techniques, and Outcomes.

Journal Article Surg Clin North Am · February 2019 Pancreas transplantation treats insulin-dependent diabetes with or without concurrent end-stage renal disease. Pancreas transplantation increases survival versus no transplant, increases survival when performed as simultaneous pancreas-kidney versus deceas ... Full text Link to item Cite

Comparison between liver transplantation and resection for hilar cholangiocarcinoma: A systematic review and meta-analysis.

Journal Article PLoS One · 2019 BACKGROUND: Hilar cholangiocarcinoma (hCCA) is a rare and aggressive malignancy with R0 resection being currently the only option for long-term survival. With the improvement in the outcomes of liver transplantation (LT), the indications for LT have expand ... Full text Link to item Cite

A FIRST REPORT OF CHOLANGIOCARCINOMA IN GSD I

Conference MOLECULAR GENETICS AND METABOLISM · March 1, 2018 Link to item Cite

Report of Mesocaval Shunt in the Management of Variceal Hemorrhage Following Gastric Bypass Surgery.

Journal Article J Gastrointest Surg · October 2017 Gastrointestinal bleeding following Roux-en- Y gastric bypass (RYGB) is rare. We report an unusual cause of upper gastrointestinal bleeding following RYGB that was complicated by porto- splenic vein thrombosis. A 35- year- old woman was successfully treate ... Full text Link to item Cite

Application of a Novel CT-Based Iliac Artery Calcification Scoring System for Predicting Renal Transplant Outcomes.

Journal Article AJR Am J Roentgenol · February 2016 OBJECTIVE: The objective of our study was to assess whether the degree and distribution of iliac artery calcifications as determined by a CT-based calcium scoring system correlates with outcomes after renal transplant. MATERIALS AND METHODS: A retrospectiv ... Full text Link to item Cite

New frontiers and new technologies

Chapter · September 12, 2015 This chapter highlights the recent advancements in stem cell-based therapeutic applications in tissue repair/regeneration in experimental studies and, more recently, in the clinic. Translation of stem cell-based technology into clinical applications still ... Full text Cite

Abdominal Wall Transplantation

Journal Article Current Transplantation Reports · September 1, 2015 Abdominal wall vascularized composite allotransplantation (AW-VCA) is a relatively young field within transplantation with 21 reported cases to date in the last decade. All AW-VCAs have been performed on patients undergoing either simultaneous multiviscera ... Full text Cite

Selection of the brain-dead potential organ donor

Chapter · March 1, 2013 Over the past decade, the utilization of organs from older and other donors with compromised physiology has become commonplace. This has been achieved with satisfactory results. There has been significant progress in the assessment and resuscitation of exp ... Full text Cite

Surgical aspects of thoracic and abdominal organ procurement from brain-dead donors

Chapter · March 1, 2013 Over the past two decades, the procedure of synchronous multiple organ procurement has been standardized. This has enabled the utilization of organs from nearly 8,000 deceased donors each year in the USA. This chapter sheds light on the technical aspects o ... Full text Cite

Posterior reversible encephalopathy syndrome independently associated with tacrolimus and sirolimus after multivisceral transplantation.

Journal Article Am J Transplant · March 2013 Posterior reversible encephalopathy syndrome (PRES) is a small vessel microangiopathy of the cerebral vasculature that occurs in 0.5-5% of solid organ transplant recipients, most commonly associated with tacrolimus (Tac). Clinical manifestations include hy ... Full text Link to item Cite

Use of vascularized posterior rectus sheath allograft in pediatric multivisceral transplantation--report of two cases.

Journal Article Am J Transplant · August 2012 Restoring abdominal wall cover and contour in children undergoing bowel and multivisceral transplantation is often challenging due to discrepancy in size between donor and recipient, poor musculature related to birth defects and loss of abdominal wall inte ... Full text Link to item Cite

Immunology of vascularized composite allotransplantation: a primer for hand surgeons.

Journal Article J Hand Surg Am · April 2012 Vascularized composite allotransplantation is a recent innovation in the fields of transplantation surgery, plastic and reconstructive surgery, and orthopedic surgery. The success of hand and face transplantation has been based on extensive experience in s ... Full text Link to item Cite

Chimerism and tolerance without GVHD or engraftment syndrome in HLA-mismatched combined kidney and hematopoietic stem cell transplantation.

Journal Article Sci Transl Med · March 7, 2012 The toxicity of chronic immunosuppressive agents required for organ transplant maintenance has prompted investigators to pursue approaches to induce immune tolerance. We developed an approach using a bioengineered mobilized cellular product enriched for he ... Full text Link to item Cite

The need for inducing tolerance in vascularized composite allotransplantation.

Journal Article Clin Dev Immunol · 2012 Successful hand and face transplantation in the last decade has firmly established the field of vascularized composite allotransplantation (VCA). The experience in VCA has thus far been very similar to solid organ transplantation in terms of the morbidity ... Full text Link to item Cite

Laparoscopic liver surgery for the management of hepatocellular carcinoma: The American perspective

Journal Article · December 1, 2011 Despite better understanding and advances in oncology, the best available therapeutic option for the management of hepatocellular carcinoma (HCC) is surgical-either liver transplantation or resection. Liver transplantation appears most attractive since it ... Full text Cite

WITHDRAWN: The extended abdominal wall flap for transplantation.

Journal Article Transplant Proc · November 2011 INTRODUCTION: Patients with extensive loss of abdominal wall tissue have few options for restoring the abdominal cavity. Composite tissue allotransplantation has been used for limited abdominal wall reconstruction in the setting of visceral transplantation ... Full text Link to item Cite

Immunosuppressive protocols and immunological challenges related to hand transplantation.

Journal Article Hand Clin · November 2011 There are many immunological challenges related to hand transplantation. Curbing the immune system's ability to effectively mount an immune response against the graft is the goal. As the various components of the immune response are defined and their mecha ... Full text Link to item Cite

Vascularized composite allotransplantation at a crossroad.

Journal Article Transplant Proc · November 2011 Vascularized composite allotransplantation is a relatively young field that has shown significant growth in the past decade. The subspecialty offers opportunities that are not available with solid organ transplants. However, the field also faces significan ... Full text Link to item Cite

Development of an upper extremity transplant program.

Journal Article Hand Clin · November 2011 Starting a hand transplant program poses tremendous challenges. Solid organ transplantation and hand replantation are time-tested procedures and are now standard of care. Hand transplantation is the amalgamation of the scientific principles of reconstructi ... Full text Link to item Cite

The extended abdominal wall flap for transplantation.

Journal Article Transplant Proc · June 2011 INTRODUCTION AND AIMS: Patients with extensive loss of the abdominal wall tissue have few options for restoring the abdominal cavity. Composite tissue allotransplantation has been used for limited abdominal wall reconstruction in the setting of visceral tr ... Full text Link to item Cite

Graft hydroureteronephrosis secondary to inguinal hernia: A report of two unusual cases

Journal Article Nephro-Urology Monthly · January 1, 2011 Allograft hydroureteronephrosis caused by ipsilateral inguinal hernia occurs rarely. Its close proximity to the spermatic cord structures places the ureter at risk for herniation into the internal inguinal ring. Likewise, the ureter is also at risk for inj ... Cite

Perioperative anticoagulation and antiplatelet therapy in renal transplant: is there an increase in bleeding complication?

Journal Article Clin Transplant · 2011 BACKGROUND: Renal transplant recipients may have comorbidities requiring anticoagulation or antiplatelet therapy. While the effects of warfarin may be neutralized with plasma infusion, those of aspirin and clopidogrel are not easily reversible and may be a ... Full text Link to item Cite

Review of the use of hepatitis B core antibody-positive kidney donors.

Journal Article Transplant Rev (Orlando) · October 2010 This article reviews the risks of transplanting hepatitis B core antibody (anti-HBc)-positive (+) kidneys and strategies to minimize the risks to the recipient. In the United States, there is a shortage of kidneys available for transplantation. Presently, ... Full text Link to item Cite

Chylous ascites.

Other Am Surg · April 2010 Link to item Cite

Laparoscopic major hepatectomy: an evolution in standard of care.

Journal Article Ann Surg · November 2009 OBJECTIVE: To analyze the results of 6 international surgical centers performing laparoscopic major liver resections. SUMMARY BACKGROUND DATA: The safety and feasibility of laparoscopy for minor liver resections has been previously demonstrated. Major anat ... Full text Link to item Cite

Composite tissue allotransplantation: current challenges.

Journal Article Transplant Proc · November 2009 Composite tissue allotransplantation (CTA) in the clinic is taking firm root. Success at hand, face, knee, trachea, and laryngeal transplantation has led to widespread interest and increasing application. Despite this, skepticism is common, particularly in ... Full text Link to item Cite

Minimally invasive liver resection for metastatic colorectal cancer: a multi-institutional, international report of safety, feasibility, and early outcomes.

Journal Article Ann Surg · November 2009 OBJECTIVE: To evaluate a multicenter, international series on minimally invasive liver resection for colorectal carcinoma (CRC) metastasis. SUMMARY BACKGROUND DATA: Multiple single series have been reported on laparoscopic liver resection for CRC metastasi ... Full text Link to item Cite

Laparoscopic liver surgery: a synopsis.

Journal Article Minerva Chir · August 2009 The complex vascular and biliary anatomy of the liver poses great challenges even to experienced surgeons. However, with the experience accrued over the past two decades, surgery of the liver has become standardized. In the past few years innovative surgic ... Link to item Cite

Increasing utilization of human T-cell lymphotropic virus (+) donors in liver transplantation: is it safe?

Journal Article Transplantation · April 27, 2009 BACKGROUND: Liver transplantation is the best treatment option for endstage liver disease. The human T-cell lymphotrophic virus (HTLV) has been associated with leukemia/lymphoma and progressive neurologic disease. There has, however, been an increased util ... Full text Link to item Cite

The history of human composite tissue allotransplantation.

Journal Article Transplant Proc · March 2009 Restoration of amputations and disfigurement are represented in ancient mythology, but the modern history of composite tissue allotransplantation begins with World War II injuries that generated seminal immunologic experiments by Medawar and co-workers. Th ... Full text Link to item Cite

Is selective internal radioembolization safe and effective for patients with inoperable hepatocellular carcinoma and venous thrombosis?

Journal Article J Am Coll Surg · March 2009 BACKGROUND: The goal of this study was to examine the safety and efficacy of selective internal radioembolization (SIR) for hepatocellular carcinoma (HCC) with portal vein or caval thrombosis (VT), or both. Recent reports have demonstrated that SIR is safe ... Full text Link to item Cite

Composite tissue allotransplantation: past, present and future-the history and expanding applications of CTA as a new frontier in transplantation.

Journal Article Transplant Proc · March 2009 Composite tissue allotransplantation (CTA) transplantation is currently being performed with increasing frequency in the clinic. The feasibility of the procedure has been confirmed in over 40 successful hand transplants, 3 facial reconstructions, and vascu ... Full text Link to item Cite

Cecal volvulus following laparoscopic nephrectomy and renal transplantation.

Journal Article JSLS · 2009 Cecal volvulus is a rare cause of bowel obstruction that carries a high mortality. Recent surgery is known to be a risk factor for the development of cecal volvulus. We present a case of cecal volvulus following laparoscopic nephrectomy and renal transplan ... Full text Link to item Cite

The Effect of Hepatitis B Core Antibody Positive Kidneys on Graft and Patient Survival

Conference AMERICAN JOURNAL OF TRANSPLANTATION · January 1, 2009 Link to item Cite

Hand transplantation in the United States: experience with 3 patients.

Journal Article Surgery · October 2008 BACKGROUND: Composite tissue allotransplantation (CTA) is a newly emerging field of transplantation that involves the simultaneous transfer of multiple tissues with differing antigenicity. Hand transplantation, the most widely recognized form of CTA, aims ... Full text Link to item Cite

Science of composite tissue allotransplantation.

Journal Article Transplantation · September 15, 2008 The science of composite tissue allotransplantation (CTA) is rooted in progressive thinking by surgeons, fueled by innovative solutions, and aided by understanding the immunology of tolerance and rejection. These three factors have allowed CTA to progress ... Full text Link to item Cite

Experience with more than 500 minimally invasive hepatic procedures.

Journal Article Ann Surg · September 2008 OBJECTIVE: To evaluate our experience with more than 500 minimally invasive hepatic procedures. SUMMARY BACKGROUND DATA: Recent data have confirmed the safety and efficacy of minimally invasive liver surgery. Despite these reports, no programmatic approach ... Full text Link to item Cite

Composite tissue transplantation: a rapidly advancing field.

Journal Article Transplant Proc · June 2008 Composite tissue allotransplantation (CTA) is emerging as a potential treatment for complex tissue defects. It is currently being performed with increasing frequency in the clinic. The feasibility of the procedure has been confirmed through 30 hand transpl ... Full text Link to item Cite

Framingham risk assessment in composite tissue allograft (CTA) recipients

Conference AMERICAN JOURNAL OF TRANSPLANTATION · May 1, 2008 Link to item Cite

Optimal utilization of HTLV I/II positive organs - A nationwide survey.

Conference AMERICAN JOURNAL OF TRANSPLANTATION · May 1, 2008 Link to item Cite

Evaluation and screening of potential hand transplant recipients

Conference AMERICAN JOURNAL OF TRANSPLANTATION · May 1, 2008 Link to item Cite

Treatment of alcoholic liver disease.

Journal Article Ann Hepatol · 2008 Alcoholic Liver Disease (ALD) is a major cause of morbidity and mortality both in the United States and worldwide. In the United States, it is projected that over 2,000,000 persons have ALD, and the mortality for cirrhosis with superimposed alcoholic hepat ... Link to item Cite

Current management of sinusoidal portal hypertension.

Other Am Surg · January 2008 Portal hypertension resulting from cirrhosis was one of the biggest challenges faced by general surgeons up until the past two decades. The management of portal hypertensive variceal hemorrhage has undergone dramatic changes during this period. Endoscopic ... Link to item Cite

Hepatic imaging characteristics predict overall survival in hepatocellular carcinoma.

Journal Article Ann Surg Oncol · October 2007 BACKGROUND: Pathologic tumor-related factors, including vascular invasion, remain the only reliable predictor of recurrence and overall survival in hepatocellular cancer (HCC). Other preoperative factors, such as hepatitis status, degree of liver disease ( ... Full text Link to item Cite

Transplantation of the hand, face, and composite structures: evolution and current status.

Journal Article Clin Plast Surg · April 2007 This article reviews the world experience in the newly emerging field of composite tissue allotransplantation. These allografts contain multiple tissues that are usually musculoskeletal structures with a skin or epithelial surface, such as hand, facial str ... Full text Link to item Cite

Left hepatic trisectionectomy for hepatobiliary malignancy: results and an appraisal of its current role.

Journal Article Ann Surg · August 2005 OBJECTIVE: To analyze results of 70 patients undergoing left hepatic trisectionectomy and to clarify its current role. SUMMARY BACKGROUND DATA: Left hepatic trisectionectomy remains a complicated hepatectomy, and few reports have described the long-term re ... Full text Link to item Cite

Preoperative vascular imaging in pediatric liver transplantation.

Journal Article J Pediatr Surg · April 2005 BACKGROUND/PURPOSE: There is a considerable variation in the use of vascular imaging techniques in the preoperative assessment of children scheduled for liver transplantation. Duplex Doppler ultrasound scan (US), magnetic resonance angiography (MRA), and c ... Full text Link to item Cite

West Nile virus-associated encephalitis in recipients of renal and pancreas transplants: case series and literature review.

Journal Article Clin Infect Dis · May 1, 2004 Although West Nile fever is mild in the vast majority of infected persons, there is growing evidence that the disease may be more severe in the immunocompromised population. We describe 3 recipients of kidney or pancreas transplants who developed West Nile ... Full text Link to item Cite

West Nile encephalitis in recipients of organ transplants.

Conference AMERICAN JOURNAL OF TRANSPLANTATION · January 1, 2004 Link to item Cite

Major liver resection in the elderly

Conference BRITISH JOURNAL OF SURGERY · June 1, 2002 Link to item Cite

Asymptomatic T-tube remnant in common bile duct.

Journal Article Indian J Gastroenterol · 1999 A 46-year-old lady presented with itching, five years after a primary common bile duct repair following cholecystectomy. Prior to this she underwent an interno-external biliary drainage. At laparotomy the horizontal limb of a T-tube was found in the common ... Link to item Cite

Superior mesenteric artery syndrome following ileo-anal pouch procedure.

Journal Article Indian J Gastroenterol · 1999 A rare complication following ileo-anal pouch procedure is the occurrence of superior mesenteric artery syndrome. We report a patient with ulcerative colitis who developed vascular compression of the duodenum following J-pouch construction. ... Link to item Cite

Segment IV liver cyst with biliary communication following laparoscopic deroofing.

Journal Article Indian J Gastroenterol · 1999 Simple cysts of the liver rarely have a biliary communication. We record the development of a biliary communication following laparoscopic deroofing of a segment IV simple cyst of liver and document its successful sclerosis with tetracycline. ... Link to item Cite

Combined hepatocellular and cystadenocarcinoma presenting as a giant cyst of the liver--a case report.

Journal Article Trop Gastroenterol · 1999 Primary cystic lesions of the liver are very rare. Most of the solid tumours are hepatocellular carcinomas (HCC) with a smaller number being cholangiocarcinomas. The association of HCC with other primary liver malignancies is also extremely rare. This case ... Link to item Cite

Choledochoduodenostomy: influence of risk factors in post-operative morbidity.

Journal Article Indian J Gastroenterol · January 1996 BACKGROUND: Choledochoduodenostomy is performed for a variety of lower common bile duct lesions. AIMS: To analyse the influence of risk factors on the post-operative morbidity following choledochoduodenostomy. METHODS: Relation of risk factors including ag ... Link to item Cite

Transcholedochal cholecystolithotomy for a variant of Mirizzi's syndrome.

Journal Article Trop Gastroenterol · 1994 Obstruction of the common bile duct by impaction of a gallstone in the neck or the cystic duct of the gallbladder results into repeated attacks of cholangitis (Mirizzi's syndrome). In suspected cases preoperative diagnosis can be made by ultrasonography an ... Link to item Cite