Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Advanced Inflammatory Bowel Disease Fellowship, Medicine, University of Pennsylvania 2014 - 2015
  • Gastroenterology Fellowship, Medicine, University of Pennsylvania 2011 - 2015
  • Internal Medicine Residency, Medicine, University of Pennsylvania 2009 - 2011
  • M.D., Washington University School of Medicine 2009
  • Ph.D., Washington University School of Medicine 2009
• 

  Duke Appointment History

  • Assistant Professor of Medicine, Medicine, Gastroenterology, Medicine 2015 - 2020
• Research
• 

  Selected Grants

  • Protocol CNTO1275CRD3007 awarded by Janssen Research & Development, LLC 2019 - 2024
  • A Study of the Efficacy and Safety of Guselkumab in Participants with Moderately to Severely Active Ulcerative Colitis awarded by Janssen Research & Development, LLC 2020 - 2022
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Papamichael, Konstantinos, Karen A. Chachu, Ravy K. Vajravelu, Byron P. Vaughn, Josephine Ni, Mark T. Osterman, and Adam S. Cheifetz. “Improved Long-term Outcomes of Patients With Inflammatory Bowel Disease Receiving Proactive Compared With Reactive Monitoring of Serum Concentrations of Infliximab.” Clinical Gastroenterology and Hepatology 15, no. 10 (October 2017): 1580-1588.e3. https://doi.org/10.1016/j.cgh.2017.03.031.
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    • Chachu, Karen A., Anna D. LoBue, David W. Strong, Ralph S. Baric, and Herbert W. Virgin. “Immune mechanisms responsible for vaccination against and clearance of mucosal and lymphatic norovirus infection.” Plos Pathog 4, no. 12 (December 2008): e1000236. https://doi.org/10.1371/journal.ppat.1000236.
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    • Purtha, Whitney E., Karen A. Chachu, Herbert W. Virgin, and Michael S. Diamond. “Early B-cell activation after West Nile virus infection requires alpha/beta interferon but not antigen receptor signaling.” J Virol 82, no. 22 (November 2008): 10964–74. https://doi.org/10.1128/JVI.01646-08.
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    • Chachu, Karen A., David W. Strong, Anna D. LoBue, Christiane E. Wobus, Ralph S. Baric, and Herbert W. Virgin. “Antibody is critical for the clearance of murine norovirus infection.” J Virol 82, no. 13 (July 2008): 6610–17. https://doi.org/10.1128/JVI.00141-08.
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    • Thackray, Larissa B., Christiane E. Wobus, Karen A. Chachu, Bo Liu, Eric R. Alegre, Kenneth S. Henderson, Scott T. Kelley, and Herbert W. Virgin. “Murine noroviruses comprising a single genogroup exhibit biological diversity despite limited sequence divergence.” J Virol 81, no. 19 (October 2007): 10460–73. https://doi.org/10.1128/JVI.00783-07.
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    • Au, Nora, Elke Kuester-Schoeck, Veena Mandava, Laura E. Bothwell, Susan P. Canny, Karen Chachu, Sierra A. Colavito, et al. “Genetic composition of the Bacillus subtilis SOS system.” J Bacteriol 187, no. 22 (November 2005): 7655–66. https://doi.org/10.1128/JB.187.22.7655-7666.2005.
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