Katherine Schuver Garman

Katherine Schuver Garman
Associate Professor of Medicine

My research focuses on injury, repair, and cancer development in the gastrointestinal tract. My laboratory performs translational research with the goal of improving health of the gastrointestinal tract. Our work is based in observations from human clinical research. We use databases of esophageal and colon disease to learn more about clinical risk factors for disease. We also use pathology samples of tumors to study the gastrointestinal tract in different states: healthy, inflamed or damaged, and with cancer.

Current Appointments & Affiliations

Associate Professor of Medicine, Medicine, Gastroenterology, Medicine 2022
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2002
Member of Duke Molecular Physiology Institute, Duke Molecular Physiology Institute, Duke Molecular Physiology Institute 2018
Affiliate of the Duke Regeneration Center, Regeneration Next Initiative, Basic Science Departments 2021

Contact Information

Dept of Medicine, Durham, NC 27710
Duke Box 3913, Durham, NC 27710
(919) 684-1205

Background
Education, Training, & Certifications
- Fellow in Gastroenterology, Medicine, Duke University 2007 - 2009
- Chief Resident, Medicine, Duke University School of Medicine 2006 - 2007
- Fellow in Gastroenterology, Medicine, Duke University 2005 - 2006
- Medical Resident, Medicine, Duke University 2002 - 2005
- M.D., Duke University 2002
Previous Appointments & Affiliations
- Associate Professor of Medicine, Medicine, Gastroenterology, Medicine 2019 - 2022
- Assistant Professor of Medicine, Medicine, Gastroenterology, Medicine 2009 - 2019
- Medical Instructor in the Department of Medicine, Medicine, General Internal Medicine, Medicine 2006 - 2007
- Instructor, Temporary in the Department of Medicine, Medicine, General Internal Medicine, Medicine 2006
Recognition
In the News
- SEP 6, 2022 School of Medicine Magnify
  
  Stopping Cancer Before It Starts
Expertise
Subject Headings
Research
Selected Grants
- Delineating the underlying reasons for the racial disparity in gastric cancer incidence in the United States awarded by National Institutes of Health 2022 - 2027
- Duke Training Grant in Digestive Diseases and Nutrition awarded by National Institutes of Health 1988 - 2027
- Cooperative Human Tissue Network Support through Duke's BioRepository & Precision Pathology Center awarded by National Institutes of Health 2019 - 2024
- Effects of storage method on intestinal allograft immune profile and viability awarded by Department of Defense 2019 - 2023
- Developing bacteria-derived therapies to cure inflammatory bowel diseases awarded by Hartwell Foundation 2020 - 2023
- The role of gastrin in esophageal submucosal gland acinar ductal metaplasia awarded by National Institutes of Health 2018 - 2023
- Postdoctoral Training in Genomic Medicine Research awarded by National Institutes of Health 2017 - 2023
- Genetic and Epigenetic Regulation of Intestinal Inflammation awarded by National Institutes of Health 2018 - 2022
- Medical Student Research Training Supplement awarded by National Institutes of Health 2020 - 2021
- Role of CAV3 Mutation in the Pathogenesis of Barrett's Esophagus awarded by Case Western Reserve University 2019 - 2021
- Nanoplasmonics-based molecular analysis tool for molecular biomarkers of cancer awarded by National Institutes of Health 2015 - 2018
- Submucosal esophageal structures as a progenitor niche for esophageal repair awarded by National Institutes of Health 2013 - 2018
- Epigenetic Control of Intestinal Inflammation awarded by Kenneth Rainin Foundation 2016 - 2017
- Epigenetic control of intestinal inflammation awarded by Kenneth Rainin Foundation 2015 - 2016
- Development of a Porcine Model of Esophageal Injury and Repair awarded by University of North Carolina - Chapel Hill 2012 - 2014
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Venkitachalam, Srividya, Deepak Babu, Durgadevi Ravillah, Ramachandra M. Katabathula, Peronne Joseph, Salendra Singh, Bhavatharini Udhayakumar, et al. “The Ephrin B2 Receptor Tyrosine Kinase Is a Regulator of Proto-oncogene MYC and Molecular Programs Central to Barrett's Neoplasia.” Gastroenterology 163, no. 5 (November 2022): 1228–41. https://doi.org/10.1053/j.gastro.2022.07.045.
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  - Markwell, Stacy A., Katherine S. Garman, Iris L. Vance, Ami Patel, and Melissa Teitelman. “Individualized ergonomic wellness approach for the practicing gastroenterologist (with video).” Gastrointest Endosc 94, no. 2 (August 2021): 248-259.e2. https://doi.org/10.1016/j.gie.2021.01.045.
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  - Garman, Katherine S. “Drivers of Esophageal Adenocarcinoma and Opportunities for Cancer Interception.” Cell Mol Gastroenterol Hepatol 12, no. 2 (2021): 787–88. https://doi.org/10.1016/j.jcmgh.2021.04.018.
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  - Crawford, Bridget M., Hsin-Neng Wang, Christina Stolarchuk, Richard J. von Furstenberg, Pietro Strobbia, Dadong Zhang, Xiaodi Qin, Kouros Owzar, Katherine S. Garman, and Tuan Vo-Dinh. “Plasmonic nanobiosensors for detection of microRNA cancer biomarkers in clinical samples.” The Analyst 145, no. 13 (July 2020): 4587–94. https://doi.org/10.1039/d0an00193g.
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  - Krüger, Leandi, Tiffany A. Pridgen, Ellie R. Taylor, Katherine S. Garman, and Anthony T. Blikslager. “Lubiprostone protects esophageal mucosa from acid injury in porcine esophagus.” Am J Physiol Gastrointest Liver Physiol 318, no. 4 (April 1, 2020): G613–23. https://doi.org/10.1152/ajpgi.00086.2019.
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  - Garman, Katherine S., Teminioluwa A. Ajayi, Harold J. Boutte, Shih-Ting Chiu, Richard J. von Furstenberg, Benjamin R. Lloyd, Cecelia Zhang, Mark W. Onaitis, Shein-Chung Chow, and Shannon J. McCall. “Prior tonsillectomy is associated with an increased risk of esophageal adenocarcinoma.” Plos One 15, no. 7 (2020): e0235906. https://doi.org/10.1371/journal.pone.0235906.
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  - LaRiviere, Ben, N Lynn Ferguson, Katherine S. Garman, Deborah A. Fisher, and Nan M. Jokerst. “Methods of extraction of optical properties from diffuse reflectance measurements of ex-vivo human colon tissue using thin film silicon photodetector arrays.” Biomed Opt Express 10, no. 11 (November 1, 2019): 5703–15. https://doi.org/10.1364/BOE.10.005703.
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  - Que, Jianwen, Katherine S. Garman, Rhonda F. Souza, and Stuart Jon Spechler. “Pathogenesis and Cells of Origin of Barrett's Esophagus.” Gastroenterology 157, no. 2 (August 2019): 349-364.e1. https://doi.org/10.1053/j.gastro.2019.03.072.
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  - Spaete, Joshua P., Jiayin Zheng, Shein-Chung Chow, Rebecca A. Burbridge, and Katherine S. Garman. “Inconsistencies in Colonic Tattooing Practice: Differences in Reported and Actual Practices at a Tertiary Medical Center.” South Med J 112, no. 4 (April 2019): 222–27. https://doi.org/10.14423/SMJ.0000000000000964.
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  - Ajayi, Teminioluwa A., Sarah Cantrell, Ashley Spann, and Katherine S. Garman. “Barrett's esophagus and esophageal cancer: Links to microbes and the microbiome.” Plos Pathog 14, no. 12 (December 2018): e1007384. https://doi.org/10.1371/journal.ppat.1007384.
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  - Feder, Rachel, Shai Posner, Yi Qin, Jiayin Zheng, Shein-Chung Chow, and Katherine S. Garman. “Helicobacter pylori-associated peptic ulcer disease: A retrospective analysis of post-treatment testing practices.” Helicobacter 23, no. 6 (December 2018): e12540. https://doi.org/10.1111/hel.12540.
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  - Garman, Katherine S., and Shannon J. McCall. “Esophageal submucosal glands as a potential source of subsquamous intestinal metaplasia in Barrett's esophagus.” Gastrointest Endosc 88, no. 1 (July 2018): 200–201. https://doi.org/10.1016/j.gie.2018.01.027.
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  - Lariviere, Ben, Katherine S. Garman, N Lynn Ferguson, Deborah A. Fisher, and Nan M. Jokerst. “Spatially resolved diffuse reflectance spectroscopy endoscopic sensing with custom Si photodetectors.” Biomed Opt Express 9, no. 3 (March 1, 2018): 1164–76. https://doi.org/10.1364/BOE.9.001164.
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  - Xiong, Zhaohui, Shuang Ren, Hao Chen, Yao Liu, Caizhi Huang, Yawan Lyvia Zhang, Joab Otieno Odera, et al. “PAX9 regulates squamous cell differentiation and carcinogenesis in the oro-oesophageal epithelium.” J Pathol 244, no. 2 (February 2018): 164–75. https://doi.org/10.1002/path.4998.
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  - Furstenberg, Richard J. von, Joy Li, Christina Stolarchuk, Rachel Feder, Alexa Campbell, Leandi Kruger, Liara M. Gonzalez, et al. “Porcine Esophageal Submucosal Gland Culture Model Shows Capacity for Proliferation and Differentiation.” Cell Mol Gastroenterol Hepatol 4, no. 3 (November 2017): 385–404. https://doi.org/10.1016/j.jcmgh.2017.07.005.
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  - Krüger, Leandi, Liara M. Gonzalez, Tiffany A. Pridgen, Shannon J. McCall, Richard J. von Furstenberg, Ivan Harnden, Gwendolyn E. Carnighan, Abigail M. Cox, Anthony T. Blikslager, and Katherine S. Garman. “Ductular and proliferative response of esophageal submucosal glands in a porcine model of esophageal injury and repair.” Am J Physiol Gastrointest Liver Physiol 313, no. 3 (September 1, 2017): G180–91. https://doi.org/10.1152/ajpgi.00036.2017.
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  - Garman, Katherine S. “Origin of Barrett's Epithelium: Esophageal Submucosal Glands.” Cell Mol Gastroenterol Hepatol 4, no. 1 (July 2017): 153–56. https://doi.org/10.1016/j.jcmgh.2017.01.016.
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  - Cancer Genome Atlas Research Network, Sudha K., Sudha K. Analysis Working Group: Asan University, Sudha K. BC Cancer Agency, Sudha K. Brigham and Women’s Hospital, Sudha K. Broad Institute, Sudha K. Brown University, Sudha K. Case Western Reserve University, et al. “Integrated genomic characterization of oesophageal carcinoma.” Nature 541, no. 7636 (January 2017): 169–75. https://doi.org/10.1038/nature20805.
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  - Michelotti, Gregory A., Anikia Tucker, Marzena Swiderska-Syn, Mariana Verdelho Machado, Steve S. Choi, Leandi Kruger, Erik Soderblom, et al. “Pleiotrophin regulates the ductular reaction by controlling the migration of cells in liver progenitor niches.” Gut 65, no. 4 (2016): 683–92. https://doi.org/10.1136/gutjnl-2014-308176.
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  - Garman, Katherine S., Leandi Kruger, Samantha Thomas, Marzena Swiderska-Syn, Barry K. Moser, Anna Mae Diehl, and Shannon J. McCall. “Ductal metaplasia in oesophageal submucosal glands is associated with inflammation and oesophageal adenocarcinoma.” Histopathology 67, no. 6 (December 2015): 771–82. https://doi.org/10.1111/his.12707.
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  - Cancer Genome Atlas Research Network, Renato D. “Comprehensive molecular characterization of gastric adenocarcinoma.” Nature 513, no. 7517 (September 11, 2014): 202–9. https://doi.org/10.1038/nature13480.
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  - Karaca, Gamze, Marzena Swiderska-Syn, Guanhua Xie, Wing-Kin Syn, Leandi Krüger, Mariana Verdelho Machado, Katherine Garman, et al. “TWEAK/Fn14 signaling is required for liver regeneration after partial hepatectomy in mice.” Plos One 9, no. 1 (2014): e83987. https://doi.org/10.1371/journal.pone.0083987.
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  - Garman, Katherine S., Kouros Owzar, Elizabeth R. Hauser, Kristen Westfall, Blair R. Anderson, Rhonda F. Souza, Anna Mae Diehl, Dawn Provenzale, and Nicholas J. Shaheen. “MicroRNA expression differentiates squamous epithelium from Barrett's esophagus and esophageal cancer.” Dig Dis Sci 58, no. 11 (November 2013): 3178–88. https://doi.org/10.1007/s10620-013-2806-7.
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  - Fang, Yu, Xiaoxin Chen, Manisha Bajpai, Amit Verma, Kiron M. Das, Rhonda F. Souza, Katherine S. Garman, et al. “Cellular origins and molecular mechanisms of Barrett's esophagus and esophageal adenocarcinoma.” Ann N Y Acad Sci 1300 (October 2013): 187–99. https://doi.org/10.1111/nyas.12249.
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  - Peery, Anne F., Toshitaka Hoppo, Katherine S. Garman, Evan S. Dellon, Norma Daugherty, Susan Bream, Alejandro F. Sanz, et al. “Feasibility, safety, acceptability, and yield of office-based, screening transnasal esophagoscopy (with video).” Gastrointest Endosc 75, no. 5 (May 2012): 945-953.e2. https://doi.org/10.1016/j.gie.2012.01.021.
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  - Garman, Katherine S., and Nicholas J. Shaheen. “Ablative therapies for Barrett's esophagus.” Curr Gastroenterol Rep 13, no. 3 (June 2011): 226–39. https://doi.org/10.1007/s11894-011-0182-z.
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  - Garman, K. S., and D. Provenzale. “Colorectal cancer screening,” August 31, 2010, 212–18.
  - Garman, Katie, Behrooz Tavakoly, and Anna Gilmore. “UK: price-based promotions target poor.” Tob Control 19, no. 4 (August 2010): 264–65.
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  - Tempelhof, Michael W., Katherine S. Garman, Matthew K. Langman, and Martha B. Adams. “Leveraging time and learning style, iPod vs. realtime attendance at a series of medicine residents conferences: a randomised controlled trial.” Inform Prim Care 17, no. 2 (2009): 87–94. https://doi.org/10.14236/jhi.v17i2.720.
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  - Ferrara, Joseph, Deepak Gupta, Emily Foster, Katherine Garman, and Mark Stacy. “Extraocular muscle dystonia due to acquired (non-Wilsonian) hepatocerebral degeneration.” Mov Disord 23, no. 6 (April 30, 2008): 875–78. https://doi.org/10.1002/mds.21841.
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  - Echols, Melvin R., Katherine S. Garman, and Kenneth W. Lyles. “Clinical diagnostic reasoning.” N Engl J Med 356, no. 12 (March 22, 2007): 1272.
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  - Garman, Katherine S., Amy Jeffreys, Cynthia Coffman, and Deborah A. Fisher. “Colorectal cancer screening, comorbidity, and follow-up in elderly patients.” Am J Med Sci 332, no. 4 (October 2006): 159–63. https://doi.org/10.1097/00000441-200610000-00001.
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  - Garman, Katherine Schuver, Eleanor S. McConnell, and Harvey Jay Cohen. “Inpatient care for elderly cancer patients: the role for Geriatric Evaluation and Management Units in fulfilling goals for care.” Crit Rev Oncol Hematol 51, no. 3 (September 2004): 241–47. https://doi.org/10.1016/j.critrevonc.2004.03.002.
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  - Garman, Katherine S., Carl F. Pieper, Pearl Seo, and Harvey Jay Cohen. “Function in elderly cancer survivors depends on comorbidities.” J Gerontol a Biol Sci Med Sci 58, no. 12 (December 2003): M1119–24. https://doi.org/10.1093/gerona/58.12.m1119.
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  - Garman, Katherine S., and Harvey Jay Cohen. “Functional status and the elderly cancer patient.” Crit Rev Oncol Hematol 43, no. 3 (September 2002): 191–208. https://doi.org/10.1016/s1040-8428(02)00062-8.
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- Conference Papers
  - LaRiviere, B., K. S. Garman, N. L. Ferguson, D. A. Fisher, and N. M. Jokerst. “Spatially resolved diffuse reflectance spectroscopy of tumor and normal excised human colon with thin film Si sensors.” In Optics Infobase Conference Papers, Vol. Part F166-Sensors 2019, 2019. https://doi.org/10.1364/SENSORS.2019.STu2D.5.
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  - Feder, Rachel, Shai Posner, Yi Qin, Jiayin Zheng, Shein-Chung Chow, and Katherine S. Garman. “Effect of Outpatient Status on Practice Management of H. pylori-associated Peptic Ulcer Disease.” In American Journal of Gastroenterology, 112:S598–S598. Ovid Technologies (Wolters Kluwer Health), 2017. https://doi.org/10.14309/00000434-201710001-01094.
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  - Spaete, Joshua P., Shein-Chung Chow, Rebecca A. Burbridge, and Katherine S. Garman. “Sa1758 Colonic Tattooing: Differences in Reported and Actual Practices at a Tertiary Medical Center.” In Gastrointestinal Endoscopy, 83:AB289–AB289. Elsevier BV, 2016. https://doi.org/10.1016/j.gie.2016.03.453.
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  - Zhang, X., L. Zhao, C. D. Guy, S. J. McCall, D. M. Cardona, R. A. Burbridge, K. S. Garman, et al. “Delayed Specimen Collection May Artifactually Damage the Mucosal Surface in Barrett's EMR Specimens.” In Laboratory Investigation, 94:211A-211A. NATURE PUBLISHING GROUP, 2014.
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  - Tucker, Anikia, Gregory A. Michelotti, Steve S. Choi, Guanhua Xie, Gamze Karaca, Marzena Swiderska-Syn, Leandi Kruger, Mariana V. Machado, Katherine S. Garman, and Anna Mae Diehl. “The Role of Pleiotrophin Signaling in the Hepatic Stem Cell Niche.” In Hepatology, 58:1007A-1007A. WILEY-BLACKWELL, 2013.
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  - Garman, Katherine S., Amy Jeffreys MStat, and Deborah Fisher. “COLORECTAL CANCER SCREENING AND FOLLOW-UP IN THE ELDERLY.” In American Journal of Gastroenterology, 99:S325–S325. Ovid Technologies (Wolters Kluwer Health), 2004. https://doi.org/10.14309/00000434-200410001-00984.
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Education, Training, & Certifications

Previous Appointments & Affiliations

In the News

Subject Headings

Selected Grants

Selected Publications

Academic Articles

Conference Papers