Overview
My research focuses on injury, repair, and cancer development in the gastrointestinal tract. My laboratory performs translational research with the goal of improving health of the gastrointestinal tract. Our work is based in observations from human clinical research. We use databases of esophageal and colon disease to learn more about clinical risk factors for disease. We also use pathology samples of tumors to study the gastrointestinal tract in different states: healthy, inflamed or damaged, and with cancer.
Current Appointments & Affiliations
Associate Professor of Medicine
·
2022 - Present
Medicine, Gastroenterology,
Medicine
Member of the Duke Cancer Institute
·
2002 - Present
Duke Cancer Institute,
Institutes and Centers
Member of Duke Molecular Physiology Institute
·
2018 - Present
Duke Molecular Physiology Institute,
Institutes and Centers
Affiliate of the Duke Regeneration Center
·
2021 - Present
Duke Regeneration Center,
Basic Science Departments
Recent Publications
Prevalence of the cagA Virulence Factor Varies by Race Among Helicobacter pylori -Infected Patients Undergoing Upper Endoscopy.
Journal Article Clin Transl Gastroenterol · June 1, 2024 INTRODUCTION: We designed a race-conscious study to assess the presence of Helicobacter pylori v irulence factor cagA in a retrospective cohort of patients with active H. pylori infection. METHODS: We compared cagA status by race in gastric tissue samples ... Full text Link to item CiteComparison of the effects of normothermic machine perfusion and cold storage preservation on porcine intestinal allograft regenerative potential and viability.
Conference Am J Transplant · April 2024 Intestinal transplantation (IT) is the final treatment option for intestinal failure. Static cold storage (CS) is the standard preservation method used for intestinal allografts. However, CS and subsequent transplantation induce ischemia-reperfusion injury ... Full text Link to item CiteType 2 Diabetes Mellitus and Helicobacter pylori Eradication in a Clinical Population.
Journal Article South Med J · April 2024 OBJECTIVES: Eradication of Helicobacter pylori reduces the risk of gastric cancer (GC). Individuals with type 2 diabetes mellitus (T2DM) are known to be at increased risk for GC. In a cohort of H. pylori-positive individuals, we assessed whether those with ... Full text Link to item CiteRecent Grants
Cooperative Human Tissue Network Support through Duke's BioRepository & Precision Pathology Center
ResearchCo Investigator · Awarded by National Cancer Institute · 2019 - 2029Project 3: EPHB2-Dependent Signaling: A New Molecular Paradigm in Barrett's Neoplasia
ResearchPrincipal Investigator · Awarded by Case Western Reserve University · 2023 - 2028Administrative Core: Pathways of Injury and Repair in Barrett's Carcinogenesis
ResearchPrincipal Investigator · Awarded by Case Western Reserve University · 2023 - 2028View All Grants
Education, Training & Certifications
Duke University ·
2002
M.D.