Overview
My research focuses on injury, repair, metaplasia, and cancer development in the gastrointestinal tract. My laboratory performs clinical and translational research with the goal of improving health of the gastrointestinal tract. Our work is based in observations from human clinical research. We use clinical data combined with data from patient samples to learn more about clinical risk factors for disease. Currently, we are working in Barrett's esophagus, H. pylori infection, autoimmune gastritis, gastric intestinal metplasia, as well as cancer prevention. Our models include patient-derived organoids. We are particularly grateful to patients who partner with us in seeking new knowledge by enrolling in research protocols.
Current Appointments & Affiliations
Professor of Medicine
·
2025 - Present
Medicine, Gastroenterology,
Medicine
Member of the Duke Cancer Institute
·
2002 - Present
Duke Cancer Institute,
Institutes and Centers
Member of Duke Molecular Physiology Institute
·
2018 - Present
Duke Molecular Physiology Institute,
Institutes and Centers
Affiliate of the Duke Regeneration Center
·
2021 - Present
Duke Regeneration Center,
Basic Science Departments
Recent Publications
Adverse Childhood Experiences Are Associated With an Increased Risk of Dyspepsia in Patients Undergoing Upper Endoscopy.
Journal Article Gastro Hep Adv · 2025 BACKGROUND AND AIMS: Stress is a risk factor for dyspepsia; however, neither the type nor timing of stress exposures across the lifespan in this syndrome are well understood. We aimed to understand the association between both adverse childhood experiences ... Full text Link to item CitePrevalence of the cagA Virulence Factor Varies by Race Among Helicobacter pylori -Infected Patients Undergoing Upper Endoscopy.
Journal Article Clin Transl Gastroenterol · June 1, 2024 INTRODUCTION: We designed a race-conscious study to assess the presence of Helicobacter pylori v irulence factor cagA in a retrospective cohort of patients with active H. pylori infection. METHODS: We compared cagA status by race in gastric tissue samples ... Full text Link to item CiteComparison of the effects of normothermic machine perfusion and cold storage preservation on porcine intestinal allograft regenerative potential and viability.
Conference Am J Transplant · April 2024 Intestinal transplantation (IT) is the final treatment option for intestinal failure. Static cold storage (CS) is the standard preservation method used for intestinal allografts. However, CS and subsequent transplantation induce ischemia-reperfusion injury ... Full text Link to item CiteRecent Grants
Porcine Related apprOach to Multidisciplinary cOllaborative Translational ModEl Research (PROMOTER)
ResearchPrincipal Investigator · Awarded by University of North Carolina - Chapel Hill · 2025 - 2030Cooperative Human Tissue Network Support through Duke's BioRepository & Precision Pathology Center
ResearchCo Investigator · Awarded by National Cancer Institute · 2019 - 2029Project 2: Inflammation and Submucosal Glands During Esophageal Injury and Repair
ResearchPrincipal Investigator · Awarded by Case Western Reserve University · 2023 - 2028View All Grants
Education, Training & Certifications
Duke University ·
2002
M.D.