Overview
My research focuses on injury, repair, metaplasia, and cancer development in the gastrointestinal tract. My laboratory performs clinical and translational research with the goal of improving health of the gastrointestinal tract. Our work is based in observations from human clinical research. We use clinical data combined with data from patient samples to learn more about clinical risk factors for disease. Currently, we are working in Barrett's esophagus, H. pylori infection, autoimmune gastritis, gastric intestinal metplasia, as well as cancer prevention. Our models include patient-derived organoids. We are particularly grateful to patients who partner with us in seeking new knowledge by enrolling in research protocols.
Current Appointments & Affiliations
Professor of Medicine
·
2025 - Present
Medicine, Gastroenterology,
Medicine
Member of the Duke Cancer Institute
·
2002 - Present
Duke Cancer Institute,
Institutes and Centers
Member of Duke Molecular Physiology Institute
·
2018 - Present
Duke Molecular Physiology Institute,
Institutes and Centers
Affiliate of the Duke Regeneration Center
·
2021 - Present
Duke Regeneration Center,
Basic Science Departments
Recent Publications
Association between autoimmune thyroid disease and presence of CagA and gastric intestinal metaplasia among patients with H. pylori: a cross-sectional endoscopic study.
Journal Article BMC Endocr Disord · February 4, 2026 BACKGROUND: Autoimmune thyroid disease (AITD), specifically Graves’ disease and Hashimoto’s thyroiditis, has been seen to co-occur with Helicobacter pylori (H. pylori) infection. Some evidence suggests that the link is particularly strong with the H. pylor ... Full text Link to item CiteVSIG10L is a major determinant of esophageal homeostasis and inherited predisposition to Barrett's esophagus.
Journal Article Nat Commun · January 29, 2026 The molecular underpinnings contributing to the onset of Barrett's esophagus (BE) remain elusive. By studying familial clusters of the disease, here we identify a significant association between genetic variants in the V-set and Immunoglobulin Domain Conta ... Full text Link to item CitePathogenesis of Barrett's Esophagus: Evolving and Emerging Mechanisms.
Journal Article Gastrointest Endosc Clin N Am · January 2026 This article seeks to provide updated information on the pathogenesis of Barrett's esophagus (BE) including the possible cellular origins of esophageal columnar cells and the impact of chronic esophageal inflammation. Other considerations include clinical ... Full text Link to item CiteRecent Grants
Cooperative Human Tissue Network Support through Duke's BioRepository & Precision Pathology Center
ResearchCo Investigator · Awarded by National Cancer Institute · 2019 - 2029Project 3: EPHB2-Dependent Signaling: A New Molecular Paradigm in Barrett's Neoplasia
ResearchPrincipal Investigator · Awarded by Case Western Reserve University · 2023 - 2028Project 2: Inflammation and Submucosal Glands During Esophageal Injury and Repair
ResearchPrincipal Investigator · Awarded by Case Western Reserve University · 2023 - 2028View All Grants
Education
Duke University ·
2002
M.D.