Scholars@Duke
Katherine Schuver Garman

Katherine Schuver Garman

Associate Professor of Medicine
Medicine, Gastroenterology
Duke Box 3913, Durham, NC 27710
Dept of Medicine, Durham, NC 27710

Selected Publications

Prevalence of the cagA Virulence Factor Varies by Race Among Helicobacter pylori -Infected Patients Undergoing Upper Endoscopy.

Journal Article Clin Transl Gastroenterol · June 1, 2024 INTRODUCTION: We designed a race-conscious study to assess the presence of Helicobacter pylori v irulence factor cagA in a retrospective cohort of patients with active H. pylori infection. METHODS: We compared cagA status by race in gastric tissue samples ... Full text Link to item Cite

Comparison of the effects of normothermic machine perfusion and cold storage preservation on porcine intestinal allograft regenerative potential and viability.

Conference Am J Transplant · April 2024 Intestinal transplantation (IT) is the final treatment option for intestinal failure. Static cold storage (CS) is the standard preservation method used for intestinal allografts. However, CS and subsequent transplantation induce ischemia-reperfusion injury ... Full text Link to item Cite

Type 2 Diabetes Mellitus and Helicobacter pylori Eradication in a Clinical Population.

Journal Article South Med J · April 2024 OBJECTIVES: Eradication of Helicobacter pylori reduces the risk of gastric cancer (GC). Individuals with type 2 diabetes mellitus (T2DM) are known to be at increased risk for GC. In a cohort of H. pylori-positive individuals, we assessed whether those with ... Full text Link to item Cite

Surface-Enhanced Raman Spectroscopy-Based Detection of Micro-RNA Biomarkers for Biomedical Diagnosis Using a Comparative Study of Interpretable Machine Learning Algorithms.

Journal Article Appl Spectrosc · January 2024 Surface-enhanced Raman spectroscopy (SERS) has wide diagnostic applications due to narrow spectral features that allow multiplex analysis. We have previously developed a multiplexed, SERS-based nanosensor for micro-RNA (miRNA) detection called the inverse ... Full text Link to item Cite

Helicobacter pylori testing prior to or at gastric cancer diagnosis and survival in a diverse US patient population.

Journal Article Gastric Cancer · January 2024 BACKGROUND: Gastric cancer (GC) accounts for the greatest disparity in cancer mortality between Black and White Americans. Although clinical trials have shown that Helicobacter pylori (Hp) treatment reduces risk of GC, Hp testing and treatment is not consi ... Full text Link to item Cite

Promises and Limitations of Current Models for Understanding Barrett's Esophagus and Esophageal Adenocarcinoma.

Journal Article Cell Mol Gastroenterol Hepatol · 2024 BACKGROUND & AIMS: This review was developed to provide a thorough and effective update on models relevant to esophageal metaplasia, dysplasia, and carcinogenesis, focusing on the advantages and limitations of different models of Barrett's esophagus (BE) a ... Full text Link to item Cite

TNF Promoter Hypomethylation Is Associated With Mucosal Inflammation in IBD and Anti-TNF Response.

Journal Article Gastro Hep Adv · 2024 BACKGROUND AND AIMS: Inflammatory bowel diseases (IBDs) are chronic inflammatory conditions influenced heavily by environmental factors. DNA methylation is a form of epigenetic regulation linking environmental stimuli to gene expression changes and inflamm ... Full text Link to item Cite

Cancer Progress and Priorities: Gastric Cancer-Reply.

Journal Article Cancer Epidemiol Biomarkers Prev · September 1, 2023 Full text Link to item Cite

Cancer Progress and Priorities: Gastric Cancer.

Journal Article Cancer Epidemiol Biomarkers Prev · April 3, 2023 Gastric cancer, the fifth leading cause of cancer worldwide, is estimated to be responsible for approximately 1.4% of all new cancers and 1.8% of all cancer-related deaths in the United States. Despite declining incidence rates and improved survival rates, ... Full text Link to item Cite

The Ephrin B2 Receptor Tyrosine Kinase Is a Regulator of Proto-oncogene MYC and Molecular Programs Central to Barrett's Neoplasia.

Journal Article Gastroenterology · November 2022 BACKGROUND & AIMS: Mechanisms contributing to the onset and progression of Barrett's (BE)-associated esophageal adenocarcinoma (EAC) remain elusive. Here, we interrogated the major signaling pathways deregulated early in the development of Barrett's neopla ... Full text Link to item Cite

Orthotopic Transplantation of the Full-length Porcine Intestine After Normothermic Machine Perfusion.

Journal Article Transplant Direct · November 2022 UNLABELLED: Successful intestinal transplantation is currently hindered by graft injury that occurs during procurement and storage, which contributes to postoperative sepsis and allograft rejection. Improved graft preservation may expand transplantable gra ... Full text Open Access Link to item Cite

Shared Decision-Making for Juvenile Scoliosis.

Journal Article Pediatrics · April 1, 2022 Full text Link to item Cite

Racial Differences in Helicobacter pylori Prevalence in the US: A Systematic Review.

Journal Article Gastro Hep Adv · 2022 BACKGROUND AND AIMS: Helicobacter pylori remains an important risk factor for noncardia gastric cancer and a spectrum of disease from H. pylori infection to gastric cancer. As a step toward improved clinical strategies for gastric cancer prevention, we ass ... Full text Link to item Cite

Individualized ergonomic wellness approach for the practicing gastroenterologist (with video).

Journal Article Gastrointest Endosc · August 2021 BACKGROUND AND AIMS: The prevalence and burden of ergonomic-related musculoskeletal injury are well established in the literature, but data are scarce on techniques that can be used to avoid injury. This pilot study aimed to develop a new method of endosco ... Full text Link to item Cite

Plasmonic nanobiosensors for detection of microRNA cancer biomarkers in clinical samples.

Journal Article Analyst · July 7, 2020 MicroRNAs (miRNAs) play an important role in the regulation of biological processes and have demonstrated great potential as biomarkers for the early detection of various diseases, including esophageal adenocarcinoma (EAC) and Barrett's esophagus (BE), the ... Full text Link to item Cite

Lubiprostone protects esophageal mucosa from acid injury in porcine esophagus.

Journal Article Am J Physiol Gastrointest Liver Physiol · April 1, 2020 Esophageal injury from acid exposure related to gastroesophageal reflux disease is a common problem and a risk factor for development of Barrett's esophagus and esophageal adenocarcinoma. Our previous work highlights the benefits of using porcine esophagus ... Full text Link to item Cite

Prior tonsillectomy is associated with an increased risk of esophageal adenocarcinoma.

Journal Article PLoS One · 2020 BACKGROUND: Esophageal cancer is a deadly cancer with 5-year survival <20%. Although multiple risk factors for esophageal adenocarcinoma (EAC) including obesity, GERD and smoking have been identified, these risk factors do not fully explain the rising inci ... Full text Link to item Cite

Methods of extraction of optical properties from diffuse reflectance measurements of ex-vivo human colon tissue using thin film silicon photodetector arrays.

Journal Article Biomed Opt Express · November 1, 2019 Spatially resolved diffuse reflectance spectroscopy (SRDRS) is a promising technique for characterization of colon tissue. Herein, two methods for extracting the reduced scattering and absorption coefficients ( μ s ' ( λ ) and μ a ( λ ) ) from SRDRS dat ... Full text Link to item Cite

Pathogenesis and Cells of Origin of Barrett's Esophagus.

Journal Article Gastroenterology · August 2019 In patients with Barrett's esophagus (BE), metaplastic columnar mucosa containing epithelial cells with gastric and intestinal features replaces esophageal squamous mucosa damaged by gastroesophageal reflux disease. This condition is estimated to affect 5. ... Full text Link to item Cite

Inconsistencies in Colonic Tattooing Practice: Differences in Reported and Actual Practices at a Tertiary Medical Center.

Journal Article South Med J · April 2019 OBJECTIVES: Accurate localization of a colonic lesion is crucial to successful resection. Although colonic tattooing is a widely accepted technique to mark lesions for future identification surgery or repeat colonoscopy, no consensus guidelines exist. The ... Full text Open Access Link to item Cite

Spatially resolved diffuse reflectance spectroscopy of tumor and normal excised human colon with thin film Si sensors

Conference Optics InfoBase Conference Papers · January 1, 2019 Spatially resolved diffuse reflectance spectroscopy of normal and cancerous ex-vivo human colon tissue using a thin film Si photodiode array sensor is presented as a step toward the realization of in-vivo endoscopic spectral tissue characterization. ... Full text Cite

Helicobacter pylori-associated peptic ulcer disease: A retrospective analysis of post-treatment testing practices.

Journal Article Helicobacter · December 2018 BACKGROUND & AIMS: Guidelines recommend that patients with Helicobacter pylori (H. pylori)-associated peptic ulcer disease (PUD) receive H. pylori eradication therapy followed by post-treatment testing to prove eradication; however, post-treatment testing ... Full text Link to item Cite

Spatially resolved diffuse reflectance spectroscopy endoscopic sensing with custom Si photodetectors.

Journal Article Biomed Opt Express · March 1, 2018 Early detection and surveillance of disease progression in epithelial tissue is key to improving long term patient outcomes for colon and esophageal cancers, which account for nearly a quarter of cancer related mortalities worldwide. Spatially resolved dif ... Full text Link to item Cite

PAX9 regulates squamous cell differentiation and carcinogenesis in the oro-oesophageal epithelium.

Journal Article J Pathol · February 2018 PAX9 is a transcription factor of the PAX family characterized by a DNA-binding paired domain. Previous studies have suggested a potential role of PAX9 in squamous cell differentiation and carcinogenesis of the oro-oesophageal epithelium. However, its func ... Full text Link to item Cite

Porcine Esophageal Submucosal Gland Culture Model Shows Capacity for Proliferation and Differentiation.

Journal Article Cell Mol Gastroenterol Hepatol · November 2017 BACKGROUND & AIMS: Although cells comprising esophageal submucosal glands (ESMGs) represent a potential progenitor cell niche, new models are needed to understand their capacity to proliferate and differentiate. By histologic appearance, ESMGs have been as ... Full text Link to item Cite

Ductular and proliferative response of esophageal submucosal glands in a porcine model of esophageal injury and repair.

Journal Article Am J Physiol Gastrointest Liver Physiol · September 1, 2017 Esophageal injury is a risk factor for diseases such as Barrett's esophagus (BE) and esophageal adenocarcinoma. To improve understanding of signaling pathways associated with both normal and abnormal repair, animal models are needed. Traditional rodent mod ... Full text Link to item Cite

Origin of Barrett's Epithelium: Esophageal Submucosal Glands.

Journal Article Cell Mol Gastroenterol Hepatol · July 2017 The origin of the progenitor cell for Barrett's esophagus remains a major unsolved mystery. Understanding the source of this progenitor may improve strategies to prevent the development of esophageal adenocarcinoma. Esophageal submucosal glands (ESMGs) and ... Full text Link to item Cite

Integrated genomic characterization of oesophageal carcinoma.

Journal Article Nature · January 12, 2017 Oesophageal cancers are prominent worldwide; however, there are few targeted therapies and survival rates for these cancers remain dismal. Here we performed a comprehensive molecular analysis of 164 carcinomas of the oesophagus derived from Western and Eas ... Full text Link to item Cite

Ductal metaplasia in oesophageal submucosal glands is associated with inflammation and oesophageal adenocarcinoma.

Journal Article Histopathology · December 2015 AIMS: Recent studies have suggested that oesophageal submucosal gland (ESMG) ducts harbour progenitor cells that may contribute to oesophageal metaplasia. Our objective was to determine whether histological differences exist between the ESMGs of individual ... Full text Link to item Cite

Comprehensive molecular characterization of gastric adenocarcinoma.

Journal Article Nature · September 11, 2014 Featured Publication Gastric cancer is a leading cause of cancer deaths, but analysis of its molecular and clinical characteristics has been complicated by histological and aetiological heterogeneity. Here we describe a comprehensive molecular evaluation of 295 primary gastric ... Full text Link to item Cite

TWEAK/Fn14 signaling is required for liver regeneration after partial hepatectomy in mice.

Journal Article PLoS One · 2014 Featured Publication BACKGROUND & AIMS: Pro-inflammatory cytokines are important for liver regeneration after partial hepatectomy (PH). Expression of Fibroblast growth factor-inducible 14 (Fn14), the receptor for TNF-like weak inducer of apoptosis (TWEAK), is induced rapidly a ... Full text Open Access Link to item Cite

MicroRNA expression differentiates squamous epithelium from Barrett's esophagus and esophageal cancer.

Journal Article Dig Dis Sci · November 2013 Featured Publication BACKGROUND: Current strategies fail to identify most patients with esophageal adenocarcinoma (EAC) before the disease becomes advanced and incurable. Given the dismal prognosis associated with EAC, improvements in detection of early-stage esophageal neopla ... Full text Link to item Cite

Cellular origins and molecular mechanisms of Barrett's esophagus and esophageal adenocarcinoma.

Journal Article Ann N Y Acad Sci · October 2013 Featured Publication This paper presents commentaries on animal models used for Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) research; acid- and bile-induced chromosomal instability and clonal selection during the progression of BE to EAC; how the components of ... Full text Link to item Cite

Feasibility, safety, acceptability, and yield of office-based, screening transnasal esophagoscopy (with video).

Journal Article Gastrointest Endosc · May 2012 Featured Publication BACKGROUND: Endoscopic screening for esophageal neoplasia can identify patients eligible for early intervention for precancerous lesions. Unsedated transnasal esophagoscopy may provide an efficient and accurate endoscopic assessment with fewer risks and le ... Full text Link to item Cite

Ablative therapies for Barrett's esophagus.

Journal Article Curr Gastroenterol Rep · June 2011 Featured Publication Barrett's esophagus has gained increased clinical attention because of its association with esophageal adenocarcinoma, a cancer with increasing incidence and poor survival rates. The goals of ablating Barrett's esophagus are to decrease esophageal cancer r ... Full text Link to item Cite

Colorectal cancer screening

Journal Article · August 31, 2010 Featured Publication Colorectal cancer screening is an important mission for a practicing gastroenterologist. Several different screening modalities are available: Fecal occult blood test, fl exible sigmoidoscopy, colonoscopy, barium enema, and, more recently, CT - colonograph ... Cite

UK: price-based promotions target poor.

Journal Article Tob Control · August 2010 Link to item Cite

Leveraging time and learning style, iPod vs. realtime attendance at a series of medicine residents conferences: a randomised controlled trial.

Journal Article Inform Prim Care · 2009 Featured Publication OBJECTIVE: To determine whether participation in educational conferences utilising iPod technology enhances both medical knowledge and accessibility to educational content among medical residents in training. DESIGN/MEASUREMENTS: In May 2007, the authors l ... Full text Link to item Cite

Extraocular muscle dystonia due to acquired (non-Wilsonian) hepatocerebral degeneration.

Journal Article Mov Disord · April 30, 2008 We present a video report of a patient with advanced non-Wilsonian cirrhotic liver disease who developed extraocular muscle dystonia (oculogyric crisis) and severe orofaciolingual dyskinesias. Acquired hepatocerebral degeneration causes choreic movements, ... Full text Link to item Cite

Clinical diagnostic reasoning.

Journal Article N Engl J Med · March 22, 2007 Link to item Cite

Colorectal cancer screening, comorbidity, and follow-up in elderly patients.

Journal Article Am J Med Sci · October 2006 OBJECTIVE: We examined the relationship between comorbid disease and performance of complete colon examination by colonoscopy or double contrast barium enema (DCBE) after positive screening fecal occult blood test (FOBT) in patients 70 years of age or olde ... Full text Link to item Cite

COLORECTAL CANCER SCREENING AND FOLLOW-UP IN THE ELDERLY

Conference American Journal of Gastroenterology · October 2004 Full text Cite

Inpatient care for elderly cancer patients: the role for Geriatric Evaluation and Management Units in fulfilling goals for care.

Journal Article Crit Rev Oncol Hematol · September 2004 PURPOSE: To describe patterns of functional status, symptoms, therapeutic goals and outcomes among older adults with cancer diagnoses hospitalized on a Geriatric Evaluation and Management Unit (GEMU). DESIGN AND METHODS: Retrospective chart review of veter ... Full text Link to item Cite

Function in elderly cancer survivors depends on comorbidities.

Journal Article J Gerontol A Biol Sci Med Sci · December 2003 BACKGROUND: Factors associated with functional status in elderly cancer survivors, in particular, comorbidity, have been inadequately studied. METHODS: Of 4162 participants aged 65 and older enrolled in the Duke Established Populations for Epidemiologic St ... Full text Link to item Cite

Functional status and the elderly cancer patient.

Journal Article Crit Rev Oncol Hematol · September 2002 Evaluation of functional status plays a unique role in the assessment of older cancer patients. While performance status has been the traditional method for oncologists to assess the impact of a cancer patient's disease, older cancer patients may require a ... Full text Link to item Cite