Pathogenesis of Barrett's Esophagus: Evolving and Emerging Mechanisms.
Publication
, Journal Article
Martinez-Uribe, O; Becker, TC; Garman, KS
Published in: Gastrointest Endosc Clin N Am
January 2026
This article seeks to provide updated information on the pathogenesis of Barrett's esophagus (BE) including the possible cellular origins of esophageal columnar cells and the impact of chronic esophageal inflammation. Other considerations include clinical exposures and the importance of risk factor modifications such as weight loss and tobacco cessation. The article summarizes genetic risk factors in the pathogenesis of BE and discusses how familial risk and exposures are considered in current guidelines to identify those who may benefit from BE screening. Finally, insights gleaned from postablative therapy are integrated into this article for both clinical providers and researchers.
Duke Scholars
Published In
Gastrointest Endosc Clin N Am
DOI
EISSN
1558-1950
Publication Date
January 2026
Volume
36
Issue
1
Start / End Page
1 / 19
Location
United States
Related Subject Headings
- Risk Factors
- Humans
- Genetic Predisposition to Disease
- Gastroenterology & Hepatology
- Esophagus
- Esophageal Neoplasms
- Barrett Esophagus
Citation
APA
Chicago
ICMJE
MLA
NLM
Martinez-Uribe, O., Becker, T. C., & Garman, K. S. (2026). Pathogenesis of Barrett's Esophagus: Evolving and Emerging Mechanisms. Gastrointest Endosc Clin N Am, 36(1), 1–19. https://doi.org/10.1016/j.giec.2025.09.002
Martinez-Uribe, Omar, Thomas C. Becker, and Katherine S. Garman. “Pathogenesis of Barrett's Esophagus: Evolving and Emerging Mechanisms.” Gastrointest Endosc Clin N Am 36, no. 1 (January 2026): 1–19. https://doi.org/10.1016/j.giec.2025.09.002.
Martinez-Uribe O, Becker TC, Garman KS. Pathogenesis of Barrett's Esophagus: Evolving and Emerging Mechanisms. Gastrointest Endosc Clin N Am. 2026 Jan;36(1):1–19.
Martinez-Uribe, Omar, et al. “Pathogenesis of Barrett's Esophagus: Evolving and Emerging Mechanisms.” Gastrointest Endosc Clin N Am, vol. 36, no. 1, Jan. 2026, pp. 1–19. Pubmed, doi:10.1016/j.giec.2025.09.002.
Martinez-Uribe O, Becker TC, Garman KS. Pathogenesis of Barrett's Esophagus: Evolving and Emerging Mechanisms. Gastrointest Endosc Clin N Am. 2026 Jan;36(1):1–19.
Published In
Gastrointest Endosc Clin N Am
DOI
EISSN
1558-1950
Publication Date
January 2026
Volume
36
Issue
1
Start / End Page
1 / 19
Location
United States
Related Subject Headings
- Risk Factors
- Humans
- Genetic Predisposition to Disease
- Gastroenterology & Hepatology
- Esophagus
- Esophageal Neoplasms
- Barrett Esophagus