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Racial Differences in Helicobacter pylori Prevalence in the US: A Systematic Review.

Publication ,  Journal Article
Brown, H; Cantrell, S; Tang, H; Epplein, M; Garman, KS
Published in: Gastro Hep Adv
2022

BACKGROUND AND AIMS: Helicobacter pylori remains an important risk factor for noncardia gastric cancer and a spectrum of disease from H. pylori infection to gastric cancer. As a step toward improved clinical strategies for gastric cancer prevention, we assessed racial differences in prevalence of H. pylori from studies across the United States. This systematic review provides a comprehensive evaluation of the literature regarding racial differences in H. pylori in the United States. METHODS: MEDLINE, Embase, and Web of Science database searches were performed through May 26, 2021. Ultimately, 25 studies that reported H. pylori infection prevalence by race were included. RESULTS: All studies included in the review documented higher H. pylori prevalence in Blacks and Hispanics than in whites. The ratio of H. pylori prevalence for Blacks compared to non-Hispanic whites ranged from 1.3 to 5.4, and the ratio for Hispanics compared to non-Hispanic whites ranged from 1.8 to 4.4. Of the 5 studies that examined H. pylori CagA prevalence by race, 4 found higher prevalence among Blacks and Hispanics compared to whites, with CagA prevalence ranging from 19% to 77% in whites, 62% to 90% in Blacks, and 64% to 74% in Hispanics. CONCLUSION: In this review, across 25 studies, varying in underlying population, time period, and geographic location, Blacks and Hispanics appeared to have a higher prevalence of H. pylori infection than whites. This increased prevalence of H. pylori among populations also at a higher risk of gastric cancer is relevant in the clinical setting for decision-making related to H. pylori testing and gastric cancer prevention.

Duke Scholars

Published In

Gastro Hep Adv

DOI

EISSN

2772-5723

Publication Date

2022

Volume

1

Issue

5

Start / End Page

857 / 868

Location

Netherlands
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Brown, H., Cantrell, S., Tang, H., Epplein, M., & Garman, K. S. (2022). Racial Differences in Helicobacter pylori Prevalence in the US: A Systematic Review. Gastro Hep Adv, 1(5), 857–868. https://doi.org/10.1016/j.gastha.2022.06.001
Brown, HannahSofia, Sarah Cantrell, Helen Tang, Meira Epplein, and Katherine S. Garman. “Racial Differences in Helicobacter pylori Prevalence in the US: A Systematic Review.Gastro Hep Adv 1, no. 5 (2022): 857–68. https://doi.org/10.1016/j.gastha.2022.06.001.
Brown H, Cantrell S, Tang H, Epplein M, Garman KS. Racial Differences in Helicobacter pylori Prevalence in the US: A Systematic Review. Gastro Hep Adv. 2022;1(5):857–68.
Brown, HannahSofia, et al. “Racial Differences in Helicobacter pylori Prevalence in the US: A Systematic Review.Gastro Hep Adv, vol. 1, no. 5, 2022, pp. 857–68. Pubmed, doi:10.1016/j.gastha.2022.06.001.
Brown H, Cantrell S, Tang H, Epplein M, Garman KS. Racial Differences in Helicobacter pylori Prevalence in the US: A Systematic Review. Gastro Hep Adv. 2022;1(5):857–868.

Published In

Gastro Hep Adv

DOI

EISSN

2772-5723

Publication Date

2022

Volume

1

Issue

5

Start / End Page

857 / 868

Location

Netherlands