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Methods of extraction of optical properties from diffuse reflectance measurements of ex-vivo human colon tissue using thin film silicon photodetector arrays.

Publication ,  Journal Article
LaRiviere, B; Ferguson, NL; Garman, KS; Fisher, DA; Jokerst, NM
Published in: Biomed Opt Express
November 1, 2019

Spatially resolved diffuse reflectance spectroscopy (SRDRS) is a promising technique for characterization of colon tissue. Herein, two methods for extracting the reduced scattering and absorption coefficients ( μ s ' ( λ ) and μ a ( λ ) ) from SRDRS data using lookup tables of simulated diffuse reflectance are reported. Experimental measurements of liquid tissue phantoms performed with a custom multi-pixel silicon SRDRS sensor spanning the 450 - 750 nm wavelength range were used to evaluate the extraction methods, demonstrating that the combined use of spatial and spectral data reduces extraction error compared to use of spectral data alone. Additionally, SRDRS measurements of normal and tumor ex-vivo human colon tissue are presented along with μ s ' ( λ ) and μ a ( λ ) extracted from these measurements.

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Published In

Biomed Opt Express

DOI

ISSN

2156-7085

Publication Date

November 1, 2019

Volume

10

Issue

11

Start / End Page

5703 / 5715

Location

United States

Related Subject Headings

  • 5102 Atomic, molecular and optical physics
  • 4003 Biomedical engineering
  • 3212 Ophthalmology and optometry
  • 0912 Materials Engineering
  • 0205 Optical Physics
 

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LaRiviere, B., Ferguson, N. L., Garman, K. S., Fisher, D. A., & Jokerst, N. M. (2019). Methods of extraction of optical properties from diffuse reflectance measurements of ex-vivo human colon tissue using thin film silicon photodetector arrays. Biomed Opt Express, 10(11), 5703–5715. https://doi.org/10.1364/BOE.10.005703
LaRiviere, Ben, N Lynn Ferguson, Katherine S. Garman, Deborah A. Fisher, and Nan M. Jokerst. “Methods of extraction of optical properties from diffuse reflectance measurements of ex-vivo human colon tissue using thin film silicon photodetector arrays.Biomed Opt Express 10, no. 11 (November 1, 2019): 5703–15. https://doi.org/10.1364/BOE.10.005703.
LaRiviere B, Ferguson NL, Garman KS, Fisher DA, Jokerst NM. Methods of extraction of optical properties from diffuse reflectance measurements of ex-vivo human colon tissue using thin film silicon photodetector arrays. Biomed Opt Express. 2019 Nov 1;10(11):5703–15.
LaRiviere, Ben, et al. “Methods of extraction of optical properties from diffuse reflectance measurements of ex-vivo human colon tissue using thin film silicon photodetector arrays.Biomed Opt Express, vol. 10, no. 11, Nov. 2019, pp. 5703–15. Pubmed, doi:10.1364/BOE.10.005703.
LaRiviere B, Ferguson NL, Garman KS, Fisher DA, Jokerst NM. Methods of extraction of optical properties from diffuse reflectance measurements of ex-vivo human colon tissue using thin film silicon photodetector arrays. Biomed Opt Express. 2019 Nov 1;10(11):5703–5715.
Journal cover image

Published In

Biomed Opt Express

DOI

ISSN

2156-7085

Publication Date

November 1, 2019

Volume

10

Issue

11

Start / End Page

5703 / 5715

Location

United States

Related Subject Headings

  • 5102 Atomic, molecular and optical physics
  • 4003 Biomedical engineering
  • 3212 Ophthalmology and optometry
  • 0912 Materials Engineering
  • 0205 Optical Physics