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Katy Liu

Assistant Professor of Ophthalmology
Ophthalmology, Glaucoma
2351 Erwin Road, Box 3802, Durham, NC 27705

Selected Publications


Glaucoma Tube Outcomes with and without Anti-VEGF in Patients with Age-related Macular Degeneration.

Journal Article Ophthalmol Glaucoma · 2024 PURPOSE: To compare glaucoma tube outcomes of wet age-related macular degeneration (AMD) eyes receiving anti-VEGF injections versus dry AMD eyes and no anti-VEGF. DESIGN: Retrospective clinical cohort study. PARTICIPANTS: Patients with wet AMD and a histor ... Full text Link to item Cite

Incident glaucoma and ocular hypertension after periocular and intravitreal steroid injections: a claims-based analysis.

Journal Article BMJ Open Ophthalmol · December 22, 2023 BACKGROUND/AIMS: This study aims to determine the incidence and risk of open-angle glaucoma or ocular hypertension (OHT) following ocular steroid injections using healthcare claims data. METHODS: We retrospectively reviewed deidentified insurance claims da ... Full text Link to item Cite

Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms.

Journal Article Invest Ophthalmol Vis Sci · February 1, 2022 Due to their similarities in anatomy, physiology, and pharmacology to humans, mice are a valuable model system to study the generation and mechanisms modulating conventional outflow resistance and thus intraocular pressure. In addition, mouse models are cr ... Full text Link to item Cite

Netarsudil Improves Trabecular Outflow Facility in Patients with Primary Open Angle Glaucoma or Ocular Hypertension: A Phase 2 Study.

Journal Article Am J Ophthalmol · June 2021 PURPOSE: Intraocular pressure (IOP) reduction is key to controlling primary open angle glaucoma (POAG). Pharmacotherapies for POAG or ocular hypertension (OHT) commonly lower IOP by increasing uveoscleral outflow or decreasing aqueous humor production. Net ... Full text Link to item Cite

Reticular Bullous Epithelial Edema in Corneas Treated with Netarsudil: A Case Series.

Journal Article Am J Ophthalmol · September 2020 PURPOSE: To describe the patient characteristics and the clinical course of an unusual reticular pattern of bullous epithelial corneal edema in a series of patients treated with netarsudil. DESIGN: Retrospective case series. METHODS: Case series at a singl ... Full text Link to item Cite

Presentation and Progression of Papilledema in Cerebral Venous Sinus Thrombosis.

Journal Article Am J Ophthalmol · May 2020 PURPOSE: To determine the natural history and visual outcomes of papilledema in cerebral venous sinus thrombosis (CVST). DESIGN: Retrospective observational case series. METHODS: This multicenter study included 7 tertiary care neuro-ophthalmology clinics. ... Full text Link to item Cite

Current concepts of cerebrospinal fluid dynamics and the translaminar cribrosa pressure gradient: a paradigm of optic disk disease.

Journal Article Surv Ophthalmol · 2020 Modern advances in measuring and studying cerebrospinal fluid dynamics have furthered our understanding of intracranial pressure and its pathophysiological effects on the eye. In particular, the cerebrospinal fluid pressure and composition within the optic ... Full text Link to item Cite

Recurrent Tube Erosions with Anti-Vascular Endothelial Growth Factor Therapy in Patients with Age-Related Macular Degeneration.

Journal Article Ophthalmol Glaucoma · 2020 PURPOSE: To determine the rates of primary and recurrent glaucoma tube shunt erosions in patients with age-related macular degeneration (AMD) receiving anti-vascular endothelial growth factor (VEGF) intravitreal injections. DESIGN: Retrospective case serie ... Full text Link to item Cite

Ocular involvement in neurolymphomatosis.

Journal Article Am J Ophthalmol Case Rep · June 2018 PURPOSE: To describe the ophthalmic symptoms and histopathological findings in a case of primary neurolymphomatosis (NL). OBSERVATIONS: A man in his 60s with a prior diagnosis of chronic inflammatory demyelinating polyneuropathy developed facial numbness, ... Full text Link to item Cite

Pediatric conjunctival melanoma arising from a compound nevus.

Journal Article J AAPOS · October 2017 We present a rare case of conjunctival melanoma in a 9-year-old girl who presented with a conjunctival lesion of the left eye, growth of which was documented by patient photographs. Examination showed a raised pigmented lesion at the temporal limbus, with  ... Full text Link to item Cite

Venous Loop Reveals an Occult Retinoblastoma Tumor.

Journal Article Ophthalmic Surg Lasers Imaging Retina · September 1, 2017 A 14-day-old girl presented with bilateral hereditary retinoblastoma. At 3 months, a slight bend in the superotemporal arcade was observed to have developed into a venous loop. With concern for an occult lesion along the arcade, handheld optical coherence ... Full text Link to item Cite

VEGF as a Paracrine Regulator of Conventional Outflow Facility.

Journal Article Invest Ophthalmol Vis Sci · March 1, 2017 PURPOSE: Vascular endothelial growth factor (VEGF) regulates microvascular endothelial permeability, and the permeability of Schlemm's canal (SC) endothelium influences conventional aqueous humor outflow. We hypothesize that VEGF signaling regulates outflo ... Full text Link to item Cite

Intravitreal Anti-VEGF Injections Reduce Aqueous Outflow Facility in Patients With Neovascular Age-Related Macular Degeneration.

Journal Article Invest Ophthalmol Vis Sci · March 1, 2017 PURPOSE: We assess the effect of intravitreal anti-VEGF injections on tonographic outflow facility. METHODS: Patients with age-related macular degeneration who had received unilateral intravitreal anti-VEGF injections were recruited into two groups, those ... Full text Link to item Cite

Autoimmunity in the Pathogenesis and Treatment of Keratoconjunctivitis Sicca

Journal Article Current Allergy and Asthma Reports · January 2014 Full text Cite

Perineural Optic Nerve Enhancement on Magnetic Resonance Imaging in Giant Cell Arteritis

Journal Article Journal of Neuro-Ophthalmology · September 2013 Full text Cite

Myosins in cell junctions

Journal Article BioArchitecture · September 2012 Full text Cite

Glaucoma Tube Outcomes with and without Anti-VEGF in Patients with Age-related Macular Degeneration.

Journal Article Ophthalmol Glaucoma · 2024 PURPOSE: To compare glaucoma tube outcomes of wet age-related macular degeneration (AMD) eyes receiving anti-VEGF injections versus dry AMD eyes and no anti-VEGF. DESIGN: Retrospective clinical cohort study. PARTICIPANTS: Patients with wet AMD and a histor ... Full text Link to item Cite

Incident glaucoma and ocular hypertension after periocular and intravitreal steroid injections: a claims-based analysis.

Journal Article BMJ Open Ophthalmol · December 22, 2023 BACKGROUND/AIMS: This study aims to determine the incidence and risk of open-angle glaucoma or ocular hypertension (OHT) following ocular steroid injections using healthcare claims data. METHODS: We retrospectively reviewed deidentified insurance claims da ... Full text Link to item Cite

Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms.

Journal Article Invest Ophthalmol Vis Sci · February 1, 2022 Due to their similarities in anatomy, physiology, and pharmacology to humans, mice are a valuable model system to study the generation and mechanisms modulating conventional outflow resistance and thus intraocular pressure. In addition, mouse models are cr ... Full text Link to item Cite

Netarsudil Improves Trabecular Outflow Facility in Patients with Primary Open Angle Glaucoma or Ocular Hypertension: A Phase 2 Study.

Journal Article Am J Ophthalmol · June 2021 PURPOSE: Intraocular pressure (IOP) reduction is key to controlling primary open angle glaucoma (POAG). Pharmacotherapies for POAG or ocular hypertension (OHT) commonly lower IOP by increasing uveoscleral outflow or decreasing aqueous humor production. Net ... Full text Link to item Cite

Reticular Bullous Epithelial Edema in Corneas Treated with Netarsudil: A Case Series.

Journal Article Am J Ophthalmol · September 2020 PURPOSE: To describe the patient characteristics and the clinical course of an unusual reticular pattern of bullous epithelial corneal edema in a series of patients treated with netarsudil. DESIGN: Retrospective case series. METHODS: Case series at a singl ... Full text Link to item Cite

Presentation and Progression of Papilledema in Cerebral Venous Sinus Thrombosis.

Journal Article Am J Ophthalmol · May 2020 PURPOSE: To determine the natural history and visual outcomes of papilledema in cerebral venous sinus thrombosis (CVST). DESIGN: Retrospective observational case series. METHODS: This multicenter study included 7 tertiary care neuro-ophthalmology clinics. ... Full text Link to item Cite

Current concepts of cerebrospinal fluid dynamics and the translaminar cribrosa pressure gradient: a paradigm of optic disk disease.

Journal Article Surv Ophthalmol · 2020 Modern advances in measuring and studying cerebrospinal fluid dynamics have furthered our understanding of intracranial pressure and its pathophysiological effects on the eye. In particular, the cerebrospinal fluid pressure and composition within the optic ... Full text Link to item Cite

Recurrent Tube Erosions with Anti-Vascular Endothelial Growth Factor Therapy in Patients with Age-Related Macular Degeneration.

Journal Article Ophthalmol Glaucoma · 2020 PURPOSE: To determine the rates of primary and recurrent glaucoma tube shunt erosions in patients with age-related macular degeneration (AMD) receiving anti-vascular endothelial growth factor (VEGF) intravitreal injections. DESIGN: Retrospective case serie ... Full text Link to item Cite

Ocular involvement in neurolymphomatosis.

Journal Article Am J Ophthalmol Case Rep · June 2018 PURPOSE: To describe the ophthalmic symptoms and histopathological findings in a case of primary neurolymphomatosis (NL). OBSERVATIONS: A man in his 60s with a prior diagnosis of chronic inflammatory demyelinating polyneuropathy developed facial numbness, ... Full text Link to item Cite

Pediatric conjunctival melanoma arising from a compound nevus.

Journal Article J AAPOS · October 2017 We present a rare case of conjunctival melanoma in a 9-year-old girl who presented with a conjunctival lesion of the left eye, growth of which was documented by patient photographs. Examination showed a raised pigmented lesion at the temporal limbus, with  ... Full text Link to item Cite

Venous Loop Reveals an Occult Retinoblastoma Tumor.

Journal Article Ophthalmic Surg Lasers Imaging Retina · September 1, 2017 A 14-day-old girl presented with bilateral hereditary retinoblastoma. At 3 months, a slight bend in the superotemporal arcade was observed to have developed into a venous loop. With concern for an occult lesion along the arcade, handheld optical coherence ... Full text Link to item Cite

VEGF as a Paracrine Regulator of Conventional Outflow Facility.

Journal Article Invest Ophthalmol Vis Sci · March 1, 2017 PURPOSE: Vascular endothelial growth factor (VEGF) regulates microvascular endothelial permeability, and the permeability of Schlemm's canal (SC) endothelium influences conventional aqueous humor outflow. We hypothesize that VEGF signaling regulates outflo ... Full text Link to item Cite

Intravitreal Anti-VEGF Injections Reduce Aqueous Outflow Facility in Patients With Neovascular Age-Related Macular Degeneration.

Journal Article Invest Ophthalmol Vis Sci · March 1, 2017 PURPOSE: We assess the effect of intravitreal anti-VEGF injections on tonographic outflow facility. METHODS: Patients with age-related macular degeneration who had received unilateral intravitreal anti-VEGF injections were recruited into two groups, those ... Full text Link to item Cite

Autoimmunity in the Pathogenesis and Treatment of Keratoconjunctivitis Sicca

Journal Article Current Allergy and Asthma Reports · January 2014 Full text Cite

Perineural Optic Nerve Enhancement on Magnetic Resonance Imaging in Giant Cell Arteritis

Journal Article Journal of Neuro-Ophthalmology · September 2013 Full text Cite

Myosins in cell junctions

Journal Article BioArchitecture · September 2012 Full text Cite

Myosin-X functions in polarized epithelial cells

Journal Article Molecular Biology of the Cell · May 2012 Myosin-X (Myo10) is an unconventional myosin that localizes to the tips of filopodia and has critical functions in filopodia. Although Myo10 has been studied primarily in nonpolarized, fibroblast-like cells, Myo10 is expressed in vivo in many epith ... Full text Cite