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Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms.

Publication ,  Journal Article
McDowell, CM; Kizhatil, K; Elliott, MH; Overby, DR; van Batenburg-Sherwood, J; Millar, JC; Kuehn, MH; Zode, G; Acott, TS; Anderson, MG; Du, Y ...
Published in: Invest Ophthalmol Vis Sci
February 1, 2022

Due to their similarities in anatomy, physiology, and pharmacology to humans, mice are a valuable model system to study the generation and mechanisms modulating conventional outflow resistance and thus intraocular pressure. In addition, mouse models are critical for understanding the complex nature of conventional outflow homeostasis and dysfunction that results in ocular hypertension. In this review, we describe a set of minimum acceptable standards for developing, characterizing, and utilizing mouse models of open-angle ocular hypertension. We expect that this set of standard practices will increase scientific rigor when using mouse models and will better enable researchers to replicate and build upon previous findings.

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Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

February 1, 2022

Volume

63

Issue

2

Start / End Page

12

Location

United States

Related Subject Headings

  • Trabecular Meshwork
  • Tonometry, Ocular
  • Ophthalmology & Optometry
  • Ocular Hypertension
  • Mice
  • Intraocular Pressure
  • Glaucoma
  • Disease Models, Animal
  • Consensus
  • Aqueous Humor
 

Citation

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McDowell, C. M., Kizhatil, K., Elliott, M. H., Overby, D. R., van Batenburg-Sherwood, J., Millar, J. C., … Stamer, W. D. (2022). Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms. Invest Ophthalmol Vis Sci, 63(2), 12. https://doi.org/10.1167/iovs.63.2.12
McDowell, Colleen M., Krishnakumar Kizhatil, Michael H. Elliott, Darryl R. Overby, Joseph van Batenburg-Sherwood, J Cameron Millar, Markus H. Kuehn, et al. “Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms.Invest Ophthalmol Vis Sci 63, no. 2 (February 1, 2022): 12. https://doi.org/10.1167/iovs.63.2.12.
McDowell CM, Kizhatil K, Elliott MH, Overby DR, van Batenburg-Sherwood J, Millar JC, et al. Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms. Invest Ophthalmol Vis Sci. 2022 Feb 1;63(2):12.
McDowell, Colleen M., et al. “Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms.Invest Ophthalmol Vis Sci, vol. 63, no. 2, Feb. 2022, p. 12. Pubmed, doi:10.1167/iovs.63.2.12.
McDowell CM, Kizhatil K, Elliott MH, Overby DR, van Batenburg-Sherwood J, Millar JC, Kuehn MH, Zode G, Acott TS, Anderson MG, Bhattacharya SK, Bertrand JA, Borras T, Bovenkamp DE, Cheng L, Danias J, De Ieso ML, Du Y, Faralli JA, Fuchshofer R, Ganapathy PS, Gong H, Herberg S, Hernandez H, Humphries P, John SWM, Kaufman PL, Keller KE, Kelley MJ, Kelly RA, Krizaj D, Kumar A, Leonard BC, Lieberman RL, Liton P, Liu Y, Liu KC, Lopez NN, Mao W, Mavlyutov T, McDonnell F, McLellan GJ, Mzyk P, Nartey A, Pasquale LR, Patel GC, Pattabiraman PP, Peters DM, Raghunathan V, Rao PV, Rayana N, Raychaudhuri U, Reina-Torres E, Ren R, Rhee D, Chowdhury UR, Samples JR, Samples EG, Sharif N, Schuman JS, Sheffield VC, Stevenson CH, Soundararajan A, Subramanian P, Sugali CK, Sun Y, Toris CB, Torrejon KY, Vahabikashi A, Vranka JA, Wang T, Willoughby CE, Xin C, Yun H, Zhang HF, Fautsch MP, Tamm ER, Clark AF, Ethier CR, Stamer WD. Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms. Invest Ophthalmol Vis Sci. 2022 Feb 1;63(2):12.

Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

February 1, 2022

Volume

63

Issue

2

Start / End Page

12

Location

United States

Related Subject Headings

  • Trabecular Meshwork
  • Tonometry, Ocular
  • Ophthalmology & Optometry
  • Ocular Hypertension
  • Mice
  • Intraocular Pressure
  • Glaucoma
  • Disease Models, Animal
  • Consensus
  • Aqueous Humor