Kelli Luginbuhl

Journal Article Sci Transl Med · April 7, 2021 Ebola virus (EBOV) hemorrhagic fever outbreaks have been challenging to deter due to the lack of health care infrastructure in disease-endemic countries and a corresponding inability to diagnose and contain the disease at an early stage. EBOV vaccines and ... Full text Open Access Link to item Cite

Genetically Encoded Cholesterol-Modified Polypeptides.

Journal Article Journal of the American Chemical Society · January 2019 Biological systems use post-translational modifications (PTMs) to control the structure, location, and function of proteins after expression. Despite the ubiquity of PTMs in biology, their use to create genetically encoded recombinant biomaterials is limit ... Full text Cite

Genetically encoded lipid-polypeptide hybrid biomaterials that exhibit temperature-triggered hierarchical self-assembly.

Journal Article Nature chemistry · May 2018 Post-translational modification of proteins is a strategy widely used in biological systems. It expands the diversity of the proteome and allows for tailoring of both the function and localization of proteins within cells as well as the material properties ... Full text Cite

Recombinant Synthesis of Hybrid Lipid-Peptide Polymer Fusions that Self-Assemble and Encapsulate Hydrophobic Drugs.

Journal Article Angewandte Chemie (International ed. in English) · November 2017 Inspired by biohybrid molecules that are synthesized in Nature through post-translational modification (PTM), we have exploited a eukaryotic PTM to recombinantly synthesize lipid-polypeptide hybrid materials. By co-expressing yeast N-myristoyltransferase w ... Full text Cite

One-week glucose control via zero-order release kinetics from an injectable depot of glucagon-like peptide-1 fused to a thermosensitive biopolymer.

Journal Article Nat Biomed Eng · 2017 Stimulation of the glucagon-like peptide-1 (GLP1) receptor is a useful treatment strategy for type 2 diabetes because of pleiotropic effects, including the regulation of islet hormones and the induction of satiety. However, the native ligand for the GLP1 r ... Full text Link to item Cite

Controlled release of biologics for the treatment of type 2 diabetes.

Journal Article Journal of controlled release : official journal of the Controlled Release Society · October 2016 Type 2 diabetes is a rapidly growing disease that poses a significant burden to the United States healthcare system. Despite the many available treatments for the disease, close to half of diagnosed type 2 diabetes cases are not properly managed, largely d ... Full text Cite

A brush-polymer conjugate of exendin-4 reduces blood glucose for up to five days and eliminates poly(ethylene glycol) antigenicity.

Journal Article Nat Biomed Eng · 2016 The delivery of therapeutic peptides and proteins is often challenged by a short half-life, and thus the need for frequent injections that limit efficacy, reduce patient compliance and increase treatment cost. Here, we demonstrate that a single subcutaneou ... Full text Link to item Cite

A depot-forming glucagon-like peptide-1 fusion protein reduces blood glucose for five days with a single injection.

Journal Article Journal of controlled release : official journal of the Controlled Release Society · November 2013 Peptide drugs are an exciting class of pharmaceuticals for the treatment of a variety of diseases; however, their short half-life dictates multiple and frequent injections causing undesirable side effects. Herein, we describe a novel peptide delivery syste ... Full text Cite

Injectable protease-operated depots of glucagon-like peptide-1 provide extended and tunable glucose control.

Journal Article Proceedings of the National Academy of Sciences of the United States of America · February 2013 Peptide drugs are an exciting class of pharmaceuticals increasingly used for the treatment of a variety of diseases; however, their main drawback is a short half-life, which dictates multiple and frequent injections and an undesirable "peak-and-valley" pha ... Full text Cite