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Matt Scaglione

Associate Professor of Molecular Genetics and Microbiology
Molecular Genetics and Microbiology
5128 MSRB III, Box 103853, Durham, NC 27710
5128 MSRB III, Durham, NC 27710

Overview


The Scaglione lab is interested in the regulation of protein homeostasis (proteostasis) in neurodegenerative diseases.  We use a wide array of model systems including protein biochemistry, the social amoeba Dictyostelium discoideum, human cell culture, and mouse models to understand cellular pathways that deal with misfolded proteins. The goal of our research is to understand pathways that deal with misfolded proteins and develop strategies to enchance these pathways.  We hope this strategy …

Current Appointments & Affiliations


Associate Professor of Molecular Genetics and Microbiology · 2025 - Present Molecular Genetics and Microbiology, Basic Science Departments
Associate Professor in Cell Biology · 2025 - Present Cell Biology, Basic Science Departments

Recent Publications


Acute stress and multicellular development alter the solubility of the Dictyostelium Sup35 ortholog ERF3.

Journal Article Microbiol Spectr · November 5, 2024 Among sequenced organisms, the genome of Dictyostelium discoideum is unique in that it encodes for a massive amount of repeat-rich sequences in the coding region of genes. This results in the Dictyostelium proteome encoding for thousands of repeat-rich pro ... Full text Link to item Cite

Viral vector gene delivery of the novel chaperone protein SRCP1 to modify insoluble protein in in vitro and in vivo models of ALS.

Journal Article Gene therapy · June 2023 Protein misfolding and aggregation are shared features of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), and protein quality control disruption contributes to neuronal toxicity. Therefore, reducing protein aggregation could hold ... Full text Cite
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Recent Grants


Training Program in Developmental and Stem Cell Biology

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2001 - 2027

Investigation into protein quality control pathways in Dictyostelium discoideum

ResearchPrincipal Investigator · Awarded by National Institute of General Medical Sciences · 2022 - 2027

Cell and Molecular Biology Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2021 - 2026

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Education, Training & Certifications


Saint Louis University, School of Medicine · 2001 Ph.D.