Matt Scaglione

The Scaglione lab is interested in the regulation of protein homeostasis (proteostasis) in neurodegenerative diseases.  We use a wide array of model systems including protein biochemistry, the social amoeba Dictyostelium discoideum, human cell culture, and mouse models to understand cellular pathways that deal with misfolded proteins. The goal of our research is to understand pathways that deal with misfolded proteins and develop strategies to enchance these pathways.  We hope this strategy will lead to the development of new therapies for neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, Amyotrophic Lateral Sclerosis (ALS), and the polyglutamine diseases.