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Matt Scaglione

Assistant Professor of Molecular Genetics and Microbiology
Molecular Genetics and Microbiology
5128 MSRB III, Box 103853, Durham, NC 27710
5128 MSRB III, Durham, NC 27710

Selected Grants


Training Program in Developmental and Stem Cell Biology

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2001 - 2027

Investigation into protein quality control pathways in Dictyostelium discoideum

ResearchPrincipal Investigator · Awarded by National Institute of General Medical Sciences · 2022 - 2027

Cell and Molecular Biology Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2021 - 2026

Regulation of RIG-I signaling and viral immune evasion by ufmylation

ResearchCo Investigator · Awarded by National Institutes of Health · 2021 - 2026

Novel Insights into the Role of Prions in Polyglutamine Protein Homeostasis

FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2024 - 2026

Novel chaperones and neurodegeneration

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2019 - 2025

Elucidating the role of the E3 ligase CHIP in the cellular stress response and in neurodegeneration.

FellowshipPrincipal Investigator · Awarded by National Ataxia Foundation · 2022 - 2024

Mechanisms of Neurodegeneration in SCA48

ResearchPrincipal Investigator · Awarded by National Ataxia Foundation · 2022 - 2023

Medical Scientist Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1997 - 2022

Defining the Mechanism of ubiquitin transfer by Ube2k

ResearchPrincipal Investigator · Awarded by BERG · 2020 - 2022

Investigation into protein quality control pathways in Dictyostetlium discoideum

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2016 - 2022

Identification of novel mechanisms to suppress polyglutamine aggregation

FellowshipPrincipal Investigator · Awarded by National Ataxia Foundation · 2021 - 2021

Small molecule regulation of a protein quality control E3 to treat PSP

ResearchPrincipal Investigator · Awarded by CurePSP · 2020 - 2021

Analysis of a novel class of molecular chaperones that suppress polyglutamine aggregation

ResearchPrincipal Investigator · Awarded by Hereditary Disease Foundation · 2019 - 2020

External Relationships


  • National Institute of Health

This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.