Scholars@Duke
Keri Anne Seymour

Keri Anne Seymour

Associate Professor of Surgery
Surgery, Minimally Invasive Surgery
keri.seymour@duke.edu
DUMC 3807, Durham, NC 27710
407 Crutchfield St, Durham, NC 27704

Selected Publications

Short-term impact of bariatric surgery on systemic inflammation in patients with asthma.

Journal Article Respir Med · December 2025 BACKGROUND: The systemic inflammatory environment in obesity contributes to increased asthma symptoms and diminished asthma control. Asthma patients that have undergone bariatric surgery report significant improvements in asthma symptoms and medication use ... Full text Link to item Cite

Associations of Computerized Tomography-Based Body Composition and Food Insecurity in Bariatric Surgery Patients.

Journal Article Obes Surg · September 2025 INTRODUCTION: Food insecurity (FI) is associated with increased adiposity and obesity-related medical conditions, and body composition can affect metabolic risk. Bariatric surgery effectively treats obesity and metabolic diseases. The association of FI wit ... Full text Link to item Cite

Postoperative outcomes following revision or conversion surgery after primary sleeve gastrectomy: an analysis of the MBSAQIP database.

Journal Article Surg Obes Relat Dis · August 2025 BACKGROUND: A significant proportion of patients that undergo primary sleeve gastrectomy (SG) require revision or conversion metabolic and bariatric surgery (MBS). Despite various procedures performed in practice, comparative analyses of short-term outcome ... Full text Link to item Cite

Acute perioperative alterations in metabolism: A pilot study using mass spectrometry-based metabolomics.

Journal Article Surgery · April 2025 OBJECTIVE: To characterize early physiologic stresses imposed by surgery by applying metabolomic analyses to deeply phenotype pre- and postoperative plasma and urine of patients undergoing elective surgical procedures. BACKGROUND: Patients experience perio ... Full text Link to item Cite

Impact of metal vs non-absorbable, polymer clips during laparoscopic cholecystectomy.

Journal Article Surg Endosc · April 2025 BACKGROUND: Titanium metal clips have classically been used to occlude the cystic artery and duct during laparoscopic cholecystectomy (LC). Non-absorbable, polymer clips are an alternative with a locking feature. There is limited research evaluating the ad ... Full text Link to item Cite

Short-Term and Long-Term Fluvastatin Inhibit Effects of Thrombospondin-1 on Human Vascular Smooth Muscle Cells.

Journal Article Vasc Endovascular Surg · January 2025 INTRODUCTION: Vascular smooth muscle cells are important in intimal hyperplasia. Thrombospondin-1 is a matricellular protein involved in the vascular injury response. Statins are cholesterol lowering drugs that have beneficial cardiovascular effects. Stati ... Full text Link to item Cite

Venous Thromboembolic Events Following Revisional Gastric Bypass: An Analysis of the MBSAQIP Database from 2015 to 2019 Using Propensity Matching.

Journal Article Obes Surg · December 2024 BACKGROUND: Primary bariatric surgery is associated with moderate-to-high risk of venous thromboembolic events (VTE); however, the risk for revisional surgery lacks granularity. Our primary objective was to define the risk of VTE following revisional Roux- ... Full text Link to item Cite

Short-term cardiovascular events after bariatric surgery in patients with metabolic syndrome.

Journal Article Surg Obes Relat Dis · January 2024 BACKGROUND: Patients with metabolic syndrome (MetS) are at increased risk of developing cardiovascular disease along with other adverse events after bariatric surgery. OBJECTIVES: The incidence of short-term major adverse cardiovascular events (MACE) in pa ... Full text Open Access Link to item Cite

Development of a prospective biliary dashboard to compare performance and surgical cost.

Journal Article Surg Endosc · November 2023 BACKGROUND: Transparency around surgeon level data may align healthcare delivery with quality care for patients. Biliary surgery includes numerous procedures performed by both general surgeons and subspecialists alike. Cholecystectomy is a common surgical ... Full text Link to item Cite

Risk factors for metabolic syndrome in self-identified and questioning sexual minority women.

Journal Article Obesity (Silver Spring) · November 2023 OBJECTIVE: Studies have shown sexual minority women (SMW) have a higher incidence of obesity, but the risk of metabolic syndrome (MetS) in SMW is unclear. We examined the association between sexual orientation and MetS and its components. METHODS: Data wer ... Full text Link to item Cite

A Multidimensional Bioinformatic Platform for the Study of Human Response to Surgery.

Journal Article Ann Surg · June 1, 2022 OBJECTIVE: To design and establish a prospective biospecimen repository that integrates multi-omics assays with clinical data to study mechanisms of controlled injury and healing. BACKGROUND: Elective surgery is an opportunity to understand both the system ... Full text Link to item Cite

Trends in risk factors for readmission after bariatric surgery 2015-2018.

Journal Article Surg Obes Relat Dis · May 2022 BACKGROUND: Readmission after bariatric surgery is multifactorial. Understanding the trends in risk factors for readmission provides opportunity to optimize patients prior to surgery identify disparities in care, and improve outcomes. OBJECTIVES: This stud ... Full text Link to item Cite

Technical Feasibility, Outcomes, and Patient Satisfaction After Needlescopic and Laparoscopic Bariatric Surgery: a Randomized Study.

Journal Article Obes Surg · November 2021 BACKGROUND: Needlescopic instruments create a 3-mm incision and may result in less pain and superior cosmesis. There is limited understanding of the effectiveness of needlescopic instruments in patients with a body mass index (BMI) > 35 kg/m2. We report pe ... Full text Link to item Cite

Glycemic Control Predicts Severity of Hepatocyte Ballooning and Hepatic Fibrosis in Nonalcoholic Fatty Liver Disease.

Journal Article Hepatology · September 2021 BACKGROUND AND AIMS: Whether glycemic control, as opposed to diabetes status, is associated with the severity of NAFLD is open for study. We aimed to evaluate whether degree of glycemic control in the years preceding liver biopsy predicts the histological ... Full text Open Access Link to item Cite

Adolescent Bariatric Surgery: Racial Disparities in 30-Day Outcomes Using the MBSAQIP from 2015 to 2018.

Journal Article Obes Surg · August 2021 INTRODUCTION: Racial disparities exist in obesity prevalence and obesity-related comorbid conditions among youth. We hypothesized that non-White adolescents would have poorer 30-day outcomes after adolescent bariatric surgery. METHODS: Adolescent patients ... Full text Link to item Cite

The role of bariatric surgery in the management of nonalcoholic steatohepatitis.

Journal Article Curr Opin Gastroenterol · May 1, 2021 PURPOSE OF REVIEW: Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease in the United States and increasing globally. The progressive form of NAFLD, nonalcoholic steatohepatitis (NASH), can lead to cirrhosis and complicati ... Full text Open Access Link to item Cite

The Effectiveness of Single-Anastomosis Duodenoileal Bypass with Sleeve Gastrectomy/One Anastomosis Duodenal Switch (SADI-S/OADS): an Updated Systematic Review.

Journal Article Obes Surg · April 2021 Single-anastomosis duodenoileal bypass with sleeve gastrectomy/one anastomosis duodenal switch (SADI-S/OADS) was developed as a bariatric operation with reduced overall morbidity and lasting weight loss results. We performed a systematic review of the lite ... Full text Open Access Link to item Cite

Gastroesophageal Reflux Predicts Utilization of Dehydration Treatments After Bariatric Surgery.

Journal Article Obes Surg · February 2021 BACKGROUND: Dehydration treatments (DT) provide intravenous fluids to patients in the outpatient setting; however, the utilization of DT is not well-described. We characterize the cohort receiving DT, the first year it was recorded in a bariatric-specific ... Full text Open Access Link to item Cite

1839-P: Glycemic Control Impacts Severity of Hepatic Fibrosis in NAFLD/NASH

Conference Diabetes · June 1, 2020 T2DM increases risk for advanced fibrosis in NAFLD, however little is known about the impact of glycemic control on fibrosis severity.Objective: To assess whether glycemic control is associated with severity of fibr ... Full text Cite

Use of an intra-aortic balloon pump during laparoscopic sleeve gastrectomy

Journal Article Mini Invasive Surgery · January 1, 2020 Heart transplant is the primary treatment for end-stage heart failure; however, morbid obesity limits candidacy. Bariatric surgery performed in patients with advanced heart failure improves eligibility for heart transplantation. This is the first report of ... Full text Cite

Foramen of Winslow Hernia: a Review of the Literature Highlighting the Role of Laparoscopy.

Journal Article J Gastrointest Surg · October 2019 Foramen of Winslow hernia (FWH) is an extremely rare entity accounting for up to 8% of internal hernias and 0.08% of all hernias. Only 150 cases of FWH have been described in the literature to date with a peak incidence between the third and sixth decades ... Full text Open Access Link to item Cite

The INTUIT Study: Investigating Neuroinflammation Underlying Postoperative Cognitive Dysfunction.

Journal Article J Am Geriatr Soc · April 2019 BACKGROUND/OBJECTIVES: Every year, up to 40% of the more than 16 million older Americans who undergo anesthesia/surgery develop postoperative cognitive dysfunction (POCD) or delirium. Each of these distinct syndromes is associated with decreased quality of ... Full text Open Access Link to item Cite

Magnetic Liver Retraction: an Incision-Less Approach for Less Invasive Bariatric Surgery.

Journal Article Obes Surg · March 2019 BACKGROUND: In bariatric surgery, retraction of the liver is essential to ensure appropriate visualization of the surgical field. Many devices are currently employed for this purpose. Generally, these devices require constant use of a port, or an additiona ... Full text Link to item Cite

Laparoscopic Single-Site Inguinal Hernia Repair Using a Self-Fixating Mesh.

Journal Article JSLS · 2017 BACKGROUND AND OBJECTIVES: Every year ∼20 million inguinal hernia repairs are completed worldwide. Increased patient access to medical information and education has elicited interest in minimally invasive surgical techniques that obtain improved surgical o ... Full text Link to item Cite

The Impaired Surgeon.

Journal Article Surg Clin North Am · February 2016 Impaired physicians are unable to manage professional activities safely. Impairment can be the result of physical or mental disorders, but impaired physicians commonly refers to those suffering from substance use disorders. These disorders are at least as ... Full text Link to item Cite

Management of inguinal hernia recurrences (when pain is the primary symptom)

Chapter · December 9, 2015 Recurrence after inguinal hernia repair occurs in 5 % patients, while chronic pain affects 10 % of patients. Chronic pain can be debilitating, and a multidisciplinary approach to management is often necessary. Pain associated with recurrence requires an un ... Full text Cite

Statins and nitric oxide donors affect thrombospondin 1-induced chemotaxis.

Journal Article Vasc Endovascular Surg · 2014 BACKGROUND: Thrombospondin 1 (TSP-1) induces vascular smooth muscle cell (VSMC) migration and intimal hyperplasia. Statins and nitric oxide (NO) donors decrease intimal hyperplasia. We previously showed that statins (long-term exposure) and NO donors inhib ... Full text Link to item Cite

Lung hernia following robotic-assisted mitral valve repair.

Journal Article J Card Surg · July 2012 Lung hernia is an uncommon diagnosis characterized by lung tissue protruding through a chest wall defect. It may occur spontaneously, as a congenital defect, as a result of trauma, or as a postsurgical complication. We describe the occurrence of lung herni ... Full text Link to item Cite

The role of hyaluronic acid in atherosclerosis and intimal hyperplasia.

Journal Article J Surg Res · April 2012 Atherosclerosis is a chronic inflammatory condition of the blood vessel wall that can lead to arterial narrowing and subsequent vascular compromise. Although there are a variety of open and endovascular procedures used to alleviate the obstructions caused ... Full text Link to item Cite

Robotic-assisted or minithoracotomy incision for left ventricular lead placement: a single-surgeon, single-center experience.

Journal Article Innovations (Phila) · 2012 OBJECTIVE: Left ventricular (LV) resynchronization with epicardial lead placement after failed coronary sinus cannulation can be achieved with minimally invasive robotic-assisted (RA) or minithoracotomy (MT) incisions. We evaluated early outcomes and costs ... Full text Link to item Cite

Is body mass index a risk factor for isolated off-pump coronary revascularization?

Journal Article J Card Surg · November 2011 OBJECTIVE: The influence of body mass index (BMI) as a risk factor for isolated off-pump coronary artery bypass (OPCAB) surgery is unknown. We postulated that BMI ≥ 30 kg/m(2) would adversely affect outcomes following OPCAB at our institution. METHODS: Fro ... Full text Link to item Cite

The effects of nicotine on vascular smooth muscle cell chemotaxis induced by thrombospondin-1 and fibronectin.

Journal Article Am J Surg · November 2011 BACKGROUND: Vascular smooth muscle cell (VSMC) migration is an important process in many vascular disorders. Nicotine, thrombospondin-1 (TSP-1) and fibronectin (Fn) separately induce VSMC migration. The hypothesis of this study was that nicotine treatment ... Full text Link to item Cite

Vascular smooth muscle cell migration induced by domains of thrombospondin-1 is differentially regulated.

Journal Article Am J Surg · November 2011 BACKGROUND: Thrombospondin-1 (TSP-1) stimulates vascular smooth muscle cell (VSMC) migration via defined intracellular signaling pathways. The aim of this study was to examine the signaling pathways whereby TSP-1 folded domains (amino-terminal [NH(2)], pro ... Full text Link to item Cite

Outcome of lower extremity revascularization for peripheral artery occlusive disease: is there a difference between men and women?

Journal Article Vascular · April 2011 The incidence of peripheral arterial occlusive disease (PAD) increases with age. Women represent a growing percentage of the elderly population who present with PAD. While speculation exists that gender affects outcome after revascularization procedures, t ... Full text Link to item Cite

Ultrasound accelerated catheter directed thrombolysis for pulmonary embolus and right heart thrombus secondary to transvenous pacing wires.

Journal Article Vasc Endovascular Surg · April 2011 Acute pulmonary embolism is associated with a significant number of deaths each year, which are commonly attributed to deep venous thrombosis of the lower extremity. Pulmonary embolism due to right-sided cardiac thrombus associated with transvenous wires i ... Full text Link to item Cite

Differential effect of nitric oxide on thrombospondin-1-, PDGF- and fibronectin-induced migration of vascular smooth muscle cells.

Journal Article Am J Surg · November 2010 BACKGROUND: Neointimal hyperplasia involves the migration of medial vascular smooth muscle cells (VSMCs) in response to arterial injury. Thrombospondin-1 (TSP1), platelet-derived growth factor (PDGF), and fibronectin (Fn) induce VSMC migration. Nitric oxid ... Full text Link to item Cite

Statin therapy--Part II: Clinical considerations for cardiovascular disease.

Journal Article Vasc Endovascular Surg · August 2010 3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, commonly known as statins, are the medical treatment of choice for hypercholesterolemia. In addition to achieving a therapeutic decrease in serum cholesterol levels, statin therapy appea ... Full text Link to item Cite

Transabdominal duplex ultrasonography for bedside inferior vena cava filter placement: examples, technique, and review.

Journal Article Vasc Endovascular Surg · 2009 Pulmonary embolism remains an endemic challenge for public health care. The first line of treatment for venous thromboembolic disorder has been anticoagulation; however, in the absence of appropriate pharmacologic treatment, because of failure or contraind ... Full text Link to item Cite