Research Interests
- Antibody responses to HIV-1
- HIV-1 Vaccinology
- Complement-mediated antigen trafficking
- Glycobiology of HIV-1 protein
- Antibody recognition of glycans
- Antibody engineering
- Gene transfer as active and passive vaccination modalities
- Coronavirus antibody development
- Pan-coronavirus vaccine development
- Antibody affinity maturation
Selected Grants
Advanced Immunobiology Traning Program for Surgeons
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2019 - 2029SOSIP-NP/mRNA combination for novel preventive and therapeutic HIV-1 vaccine regimens
ResearchInvestigator · Awarded by National Institute of Allergy and Infectious Diseases · 2022 - 2027Conjugate nanoparticle platform development for HIV-1 envelope immunogens
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2021 - 2026Neutralizing antibody vaccine for pandemic and pre-emergent coronaviruses - Base
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2022 - 2026Protein Production Facility
ResearchInvestigator · Awarded by Bill and Melinda Gates Foundation · 2022 - 2026Neutralizing antibody vaccine for pandemic and pre-emergent coronaviruses - Option 2
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2023 - 2026Collaboratory of AIDS Researchers for Eradication (CARE)
ResearchInvestigator · Awarded by University of North Carolina - Chapel Hill · 2021 - 2026SHIV/HIV Env-antibody coevolution as a molecular guide to V3 glycan targeted vaccine design
ResearchCo Investigator · Awarded by University of Pennsylvania · 2022 - 2026PTVDS Task Area C - Feasibility of a Liposome/LNP Base
ResearchInvestigator · Awarded by National Institutes of Health · 2024 - 2026Interdisciplinary Research Training Program in AIDS
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2010 - 2025HIV-1 vaccine-elicited antibodies target envelope glycans
ResearchPrincipal Investigator · Awarded by National Institute of Allergy and Infectious Diseases · 2015 - 2025Basic Immunology Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2020 - 2025Neutralizing antibody vaccine for pandemic and pre-emergent coronaviruses - Option 1
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2022 - 2025Viral Oncology Training Grant
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1980 - 2025A novel vaccine against multidrug-resistant gonorrhea
ResearchPrincipal Investigator · Awarded by University of Massachusetts Medical School · 2024 - 2024Neutralizing antibody vaccine for pandemic and pre-emergent coronaviruses - Option 5
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2023 - 2024CIVICs B - Opt 27B
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2023 - 2024Duke DARPA Pandemic Prevention Platform (P3)
ResearchInvestigator · Awarded by Defense Advanced Research Projects Agency · 2017 - 2024Neutralizing antibody vaccine for pandemic and pre-emergent coronaviruses - Option 4
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2023 - 2024CIVICs B Option 23
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2022 - 2024CIVICs B Option 39 Cost to Complete
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2022 - 2024CIVICs B Option 39
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2022 - 2024Assessment of Clinical Grade Near-Native Cleavage-Independent Trimer Protein Compared to Membrane-Bound mRNA Expression Coupled with Glycan Deletion, Restoration and Heterologous Boosting
ResearchPrincipal Investigator · Awarded by Tulane University · 2022 - 2023Targeting the HIV-1 reservoir with a combination of an IDLV-SIVGag therapeutic vaccine and Fc-engineered bnAbs (R01)
ResearchCo Investigator · Awarded by National Institutes of Health · 2020 - 2023Immunogen Design of HIV Sequential Envelopes Derived from SHIV-infected Macaques
ResearchInvestigator · Awarded by University of Pennsylvania · 2017 - 2023Dissection of polyreactivity and neutralization activity of HIV-1 Abs (R01)
ResearchInvestigator · Awarded by National Institutes of Health · 2016 - 2023Protein Production Facility
ResearchInvestigator · Awarded by Bill and Melinda Gates Foundation · 2016 - 2022Neutralizing and non-neutralizing antibody effector functions in HIV infected children
ResearchInvestigator · Awarded by National Institutes of Health · 2019 - 2022CARE Focus 2: Clearance of HIV Antigen-Positive Cells
ResearchInvestigator · Awarded by University of North Carolina - Chapel Hill · 2016 - 2022Coronavirus Vaccine Design
ResearchInvestigator · Awarded by State of North Carolina · 2020 - 2021Novel vaccine strategies to induce V2 apex-directed broad neutralizing antibodies
ResearchCo Investigator · Awarded by San Diego Biomedical Research Institute · 2019 - 2021Defining parameters to induce breadth in knockin mice expressing HIV bnAb precursors
ResearchPrincipal Investigator · Awarded by San Diego Biomedical Research Institute · 2019 - 2020Defining parameters to induce breadth in knockin mice expressing HIV bnAb precursors
ResearchCo Investigator · Awarded by National Institutes of Health · 2010 - 2018Elucidation of the Mechanisms of CD8+ T Cell Noncytolytic Antiviral Response
FellowshipPredoctoral Trainee · Awarded by National Institutes of Health · 2009 - 2010External Relationships
- Pennsylvania Department of Health
- University of Texas MD Anderson Cancer Center
This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.