Kimberly Carpenter | Scholars@Duke

Kimberly Carpenter
Assistant Professor in Psychiatry and Behavioral Sciences

Dr. Kimberly Carpenter is a clinical neuroscientist specializing in understanding complex brain-behavior relationships in young children with autism and associated disorders. Her program of research includes four interrelated research themes: (1) Understanding the impact of comorbid disorders on clinical and behavioral outcomes of young autistic children; (2) Identification of early risk factors for the development of psychiatric and neurodevelopmental disorders; (3) Identification of brain-based biomarkers for group stratification and treatment response tracking in young children; and (4) Improving methods for screening, early identification, and treatment monitoring in autism and associated disorders. She currently leads an innovative research program exploring the shared and unique impacts that co-occurring anxiety and ADHD have on brain and behavioral biomarkers in young autistic children. She was the first to demonstrate that sensory over-responsivity, a symptom that has been described as part of a number of disorders including autism, anxiety, and ADHD, is a specific and unidirectional risk factor for the development of anxiety disorders in young children. She was also the first to demonstrate that, when accounting for comorbidity among individual anxiety disorders, specific anxiety disorders are associated with phenotypically meaningful differences in brain connectivity using MRI. Dr. Carpenter has also collaborated with experts in early childhood mental health, computer science, and engineering to develop novel technologies that utilize multi-modal methods via computer vision and machine learning to develop, refine, and test novel screening tools for early identification and treatment monitoring in young children with autism and related disorders.

Current Appointments & Affiliations

Assistant Professor in Psychiatry and Behavioral Sciences, Psychiatry, Child & Family Mental Health & Community Psychiatry, Psychiatry & Behavioral Sciences 2021

Contact Information

2424 Erwin Road, Suite 501, Durham, NC 27705
DUMC 2737, Durham, NC 27710
kimberly.carpenter@duke.edu (919) 668-2904

Background
Education, Training, & Certifications
- Ph.D., University of North Carolina - Chapel Hill 2011
Previous Appointments & Affiliations
- Assistant Research Professor in the Social Science Research Institute, Social Science Research Institute, University Institutes and Centers 2016 - 2021
- Assistant Professor in Psychiatry and Behavioral Sciences, Psychiatry, Child & Family Mental Health & Community Psychiatry, Psychiatry & Behavioral Sciences 2018 - 2020
- Medical Instructor in the Department of Psychiatry and Behavioral Sciences, Psychiatry, Child & Family Mental Health & Community Psychiatry, Psychiatry & Behavioral Sciences 2016 - 2017
Recognition
In the News
- JUL 16, 2018
  
  Kim Carpenter on Autism, Anxiety and the Importance of Collaboration
Research
Selected Grants
- Stratifying the Heterogeneity of Autism Spectrum Disorder: Impact of Co-Occurring Anxiety and ADHD awarded by National Institutes of Health 2021 - 2026
- Neural pathways linking early adversity and preschool psychopathology to adolescent mental health awarded by University of North Carolina - Chapel Hill 2020 - 2023
- Marcus Foundation Phase II MSC ASD awarded by The Marcus Foundation 2019 - 2022
- Psychological and Behavioral Impacts of the COVID-19 pandemic on children with Autism and/or Attention Deficit Hyperactivity Disorder awarded by Autism Science Foundation 2021 - 2022
- The Role of Sensory Over-Responsivity in the Development of Anxiety in Children With and Without Autism awarded by Brain and Behavior Research Foundation 2016 - 2018
- Precursors to the development of anxiety disorders in young children with autism spectrum disorder awarded by Department of Defense 2014 - 2017
- Longitudinal Functional Imaging of Early Childhood Anxiety Disorders awarded by National Institutes of Health 2008 - 2013
External Relationships
- Apple Inc.
- National Institutes of Health
- US Department of Defense
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Krishnappa Babu, Pradeep Raj, J Matias Di Martino, Zhuoqing Chang, Sam Perochon, Rachel Aiello, Kimberly L. H. Carpenter, Scott Compton, et al. “Complexity analysis of head movements in autistic toddlers.” J Child Psychol Psychiatry 64, no. 1 (January 2023): 156–66. https://doi.org/10.1111/jcpp.13681.
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  - Carpenter, Kimberly L. H., Naomi O. Davis, Marina Spanos, Maura Sabatos-DeVito, Rachel Aiello, Grace T. Baranek, Scott N. Compton, et al. “Adaptive Behavior in Young Autistic Children: Associations with Irritability and ADHD Symptoms.” J Autism Dev Disord, October 12, 2022. https://doi.org/10.1007/s10803-022-05753-2.
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  - Major, Samantha, Dmitry Isaev, Jordan Grapel, Todd Calnan, Elena Tenenbaum, Kimberly Carpenter, Lauren Franz, et al. “Shorter average look durations to dynamic social stimuli are associated with higher levels of autism symptoms in young autistic children.” Autism 26, no. 6 (August 2022): 1451–59. https://doi.org/10.1177/13623613211056427.
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  - Stein, Cheryl R., Margaret A. Sheridan, William E. Copeland, Laura S. Machlin, Kimberly L. H. Carpenter, and Helen L. Egger. “Association of adversity with psychopathology in early childhood: Dimensional and cumulative approaches.” Depress Anxiety 39, no. 6 (June 2022): 524–35. https://doi.org/10.1002/da.23269.
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  - Simhal, Anish K., Kimberly L. H. Carpenter, Joanne Kurtzberg, Allen Song, Allen Tannenbaum, Lijia Zhang, Guillermo Sapiro, and Geraldine Dawson. “Changes in the geometry and robustness of diffusion tensor imaging networks: Secondary analysis from a randomized controlled trial of young autistic children receiving an umbilical cord blood infusion.” Front Psychiatry 13 (2022): 1026279. https://doi.org/10.3389/fpsyt.2022.1026279.
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  - Tenenbaum, Elena J., Samantha Major, Kimberly L. H. Carpenter, Jill Howard, Michael Murias, and Geraldine Dawson. “Distance from Typical Scan Path When Viewing Complex Stimuli in Children with Autism Spectrum Disorder and its Association with Behavior.” J Autism Dev Disord 51, no. 10 (October 2021): 3492–3505. https://doi.org/10.1007/s10803-020-04812-w.
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  - Perochon, Sam, Matias Di Martino, Rachel Aiello, Jeffrey Baker, Kimberly Carpenter, Zhuoqing Chang, Scott Compton, et al. “A scalable computational approach to assessing response to name in toddlers with autism.” J Child Psychol Psychiatry 62, no. 9 (September 2021): 1120–31. https://doi.org/10.1111/jcpp.13381.
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  - Chang, Zhuoqing, J Matias Di Martino, Rachel Aiello, Jeffrey Baker, Kimberly Carpenter, Scott Compton, Naomi Davis, et al. “Computational Methods to Measure Patterns of Gaze in Toddlers With Autism Spectrum Disorder.” Jama Pediatr 175, no. 8 (August 1, 2021): 827–36. https://doi.org/10.1001/jamapediatrics.2021.0530.
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  - Harrop, Clare, Vanessa Bal, Kimberly Carpenter, and Alycia Halladay. “A lost generation? The impact of the COVID-19 pandemic on early career ASD researchers.” Autism Res 14, no. 6 (June 2021): 1078–87. https://doi.org/10.1002/aur.2503.
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  - Harikumar, Amritha, David W. Evans, Chase C. Dougherty, Kimberly L. H. Carpenter, and Andrew M. Michael. “A Review of the Default Mode Network in Autism Spectrum Disorders and Attention Deficit Hyperactivity Disorder.” Brain Connect 11, no. 4 (May 2021): 253–63. https://doi.org/10.1089/brain.2020.0865.
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  - Carpenter, Kimberly L. H., Jordan Hahemi, Kathleen Campbell, Steven J. Lippmann, Jeffrey P. Baker, Helen L. Egger, Steven Espinosa, Saritha Vermeer, Guillermo Sapiro, and Geraldine Dawson. “Digital Behavioral Phenotyping Detects Atypical Pattern of Facial Expression in Toddlers with Autism.” Autism Res 14, no. 3 (March 2021): 488–99. https://doi.org/10.1002/aur.2391.
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  - Chakraborty, Payal, Kimberly L. H. Carpenter, Samantha Major, Megan Deaver, Saritha Vermeer, Brianna Herold, Lauren Franz, Jill Howard, and Geraldine Dawson. “Gastrointestinal problems are associated with increased repetitive behaviors but not social communication difficulties in young children with autism spectrum disorders.” Autism 25, no. 2 (February 2021): 405–15. https://doi.org/10.1177/1362361320959503.
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  - Hashemi, Jordan, Geraldine Dawson, Kimberly L. H. Carpenter, Kathleen Campbell, Qiang Qiu, Steven Espinosa, Samuel Marsan, Jeffrey P. Baker, Helen L. Egger, and Guillermo Sapiro. “Computer Vision Analysis for Quantification of Autism Risk Behaviors.” Ieee Trans Affect Comput 12, no. 1 (2021): 215–26. https://doi.org/10.1109/taffc.2018.2868196.
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  - Krishnappababu, P. R., M. Di Martino, Z. Chang, S. P. Perochon, K. L. H. Carpenter, S. Compton, S. Espinosa, G. Dawson, and G. Sapiro. “Exploring Complexity of Facial Dynamics in Autism Spectrum Disorder.” Ieee Transactions on Affective Computing, January 1, 2021. https://doi.org/10.1109/TAFFC.2021.3113876.
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  - Major, Samantha, Kathleen Campbell, Steven Espinosa, Jeffrey P. Baker, Kimberly Lh Carpenter, Guillermo Sapiro, Saritha Vermeer, and Geraldine Dawson. “Impact of a digital Modified Checklist for Autism in Toddlers-Revised on likelihood and age of autism diagnosis and referral for developmental evaluation.” Autism 24, no. 7 (October 2020): 1629–38. https://doi.org/10.1177/1362361320916656.
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  - Tenenbaum, Elena J., Kimberly L. H. Carpenter, Maura Sabatos-DeVito, Jordan Hashemi, Saritha Vermeer, Guillermo Sapiro, and Geraldine Dawson. “A Six-Minute Measure of Vocalizations in Toddlers with Autism Spectrum Disorder.” Autism Res 13, no. 8 (August 2020): 1373–82. https://doi.org/10.1002/aur.2293.
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  - Simhal, Anish K., Kimberly L. H. Carpenter, Saad Nadeem, Joanne Kurtzberg, Allen Song, Allen Tannenbaum, Guillermo Sapiro, and Geraldine Dawson. “Measuring robustness of brain networks in autism spectrum disorder with Ricci curvature.” Sci Rep 10, no. 1 (July 2, 2020): 10819. https://doi.org/10.1038/s41598-020-67474-9.
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  - Major, S., K. Carpenter, L. Beyer, H. Kwak, G. Dawson, and M. Murias. “The influence of background auditory noise on P50 and N100 suppression elicited by the paired-click paradigm.” Journal of Psychophysiology 34, no. 3 (July 1, 2020): 171–78. https://doi.org/10.1027/0269-8803/a000245.
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  - Dawson, Geraldine, Jessica M. Sun, Jennifer Baker, Kimberly Carpenter, Scott Compton, Megan Deaver, Lauren Franz, et al. “A Phase II Randomized Clinical Trial of the Safety and Efficacy of Intravenous Umbilical Cord Blood Infusion for Treatment of Children with Autism Spectrum Disorder.” J Pediatr 222 (July 2020): 164-173.e5. https://doi.org/10.1016/j.jpeds.2020.03.011.
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  - Isaev, Dmitry Yu, Samantha Major, Michael Murias, Kimberly L. H. Carpenter, David Carlson, Guillermo Sapiro, and Geraldine Dawson. “Relative Average Look Duration and its Association with Neurophysiological Activity in Young Children with Autism Spectrum Disorder.” Sci Rep 10, no. 1 (February 5, 2020): 1912. https://doi.org/10.1038/s41598-020-57902-1.
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  - Dawson, Geraldine, Kathleen Campbell, Jordan Hashemi, Steven J. Lippmann, Valerie Smith, Kimberly Carpenter, Helen Egger, et al. “Author Correction: Atypical postural control can be detected via computer vision analysis in toddlers with autism spectrum disorder.” Sci Rep 10, no. 1 (January 14, 2020): 616. https://doi.org/10.1038/s41598-020-57570-1.
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  - Carpenter, Kimberly L. H., Grace T. Baranek, William E. Copeland, Scott Compton, Nancy Zucker, Geraldine Dawson, and Helen L. Egger. “Sensory Over-Responsivity: An Early Risk Factor for Anxiety and Behavioral Challenges in Young Children.” J Abnorm Child Psychol 47, no. 6 (June 2019): 1075–88. https://doi.org/10.1007/s10802-018-0502-y.
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  - Campbell, Kathleen, Kimberly Lh Carpenter, Jordan Hashemi, Steven Espinosa, Samuel Marsan, Jana Schaich Borg, Zhuoqing Chang, et al. “Computer vision analysis captures atypical attention in toddlers with autism.” Autism 23, no. 3 (April 2019): 619–28. https://doi.org/10.1177/1362361318766247.
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  - Carpenter, Kimberly L. H., Samantha Major, Catherine Tallman, Lyon W. Chen, Lauren Franz, Jessica Sun, Joanne Kurtzberg, Allen Song, and Geraldine Dawson. “White Matter Tract Changes Associated with Clinical Improvement in an Open-Label Trial Assessing Autologous Umbilical Cord Blood for Treatment of Young Children with Autism.” Stem Cells Transl Med 8, no. 2 (February 2019): 138–47. https://doi.org/10.1002/sctm.18-0251.
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  - Dawson, Geraldine, Kathleen Campbell, Jordan Hashemi, Steven J. Lippmann, Valerie Smith, Kimberly Carpenter, Helen Egger, et al. “Atypical postural control can be detected via computer vision analysis in toddlers with autism spectrum disorder.” Sci Rep 8, no. 1 (November 19, 2018): 17008. https://doi.org/10.1038/s41598-018-35215-8.
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  - Egger, Helen L., Geraldine Dawson, Jordan Hashemi, Kimberly L. H. Carpenter, Steven Espinosa, Kathleen Campbell, Samuel Brotkin, et al. “Automatic emotion and attention analysis of young children at home: a ResearchKit autism feasibility study.” Npj Digit Med 1 (2018): 20. https://doi.org/10.1038/s41746-018-0024-6.
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  - Campbell, Kathleen, Kimberly L. H. Carpenter, Steven Espinosa, Jordan Hashemi, Qiang Qiu, Mariano Tepper, Robert Calderbank, et al. “Use of a Digital Modified Checklist for Autism in Toddlers - Revised with Follow-up to Improve Quality of Screening for Autism.” J Pediatr 183 (April 2017): 133-139.e1. https://doi.org/10.1016/j.jpeds.2017.01.021.
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  - Carpenter, Kimberly L. H., Wei Li, Hongjiang Wei, Bing Wu, Xue Xiao, Chunlei Liu, Gordon Worley, and Helen Link Egger. “Magnetic susceptibility of brain iron is associated with childhood spatial IQ.” Neuroimage 132 (May 15, 2016): 167–74. https://doi.org/10.1016/j.neuroimage.2016.02.028.
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  - Carpenter, Kimberly L. H., Pablo Sprechmann, Robert Calderbank, Guillermo Sapiro, and Helen L. Egger. “Quantifying Risk for Anxiety Disorders in Preschool Children: A Machine Learning Approach.” Plos One 11, no. 11 (2016): e0165524. https://doi.org/10.1371/journal.pone.0165524.
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  - Hashemi, Jordan, Kathleen Campbell, Kimberly L. H. Carpenter, Adrianne Harris, Qiang Qiu, Mariano Tepper, Steven Espinosa, et al. “A scalable app for measuring autism risk behaviors in young children: A technical validity and feasibility study.” Eai Endorsed Trans. Scalable Inf. Syst. 3 (2016): e1–e1. https://doi.org/10.4108/eai.14-10-2015.2261939.
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  - Zucker, Nancy, William Copeland, Lauren Franz, Kimberly Carpenter, Lori Keeling, Adrian Angold, and Helen Egger. “Psychological and Psychosocial Impairment in Preschoolers With Selective Eating.” Pediatrics 136, no. 3 (September 2015): e582–90. https://doi.org/10.1542/peds.2014-2386.
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  - Carpenter, Kimberly L. H., Adrian Angold, Nan-Kuei Chen, William E. Copeland, Pooja Gaur, Kevin Pelphrey, Allen W. Song, and Helen L. Egger. “Preschool anxiety disorders predict different patterns of amygdala-prefrontal connectivity at school-age.” Plos One 10, no. 1 (2015): e0116854. https://doi.org/10.1371/journal.pone.0116854.
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  - Hashemi, J., K. Campbell, K. Carpenter, A. Harris, Q. Qiu, M. Tepper, S. Espinosa, et al. “A scalable app for measuring autism risk behaviors in young children: A technical validity and feasibility study.” Proceedings of the 5th Eai International Conference on Wireless Mobile Communication and Healthcare, 2015, 23–27.
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  - Carpenter, K., P. Sprechmann, M. Fiori, R. Calderbank, H. Egger, and G. Sapiro. “Questionnaire simplification for fast risk analysis of children's mental health.” Icassp, Ieee International Conference on Acoustics, Speech and Signal Processing Proceedings, January 1, 2014, 6009–13. https://doi.org/10.1109/ICASSP.2014.6854757.
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  - Belger, Aysenil, Kimberly L. H. Carpenter, Gunes H. Yucel, Katherine M. Cleary, and Franc C. L. Donkers. “The neural circuitry of autism.” Neurotox Res 20, no. 3 (October 2011): 201–14. https://doi.org/10.1007/s12640-010-9234-7.
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  - Sasson, Noah J., Amy E. Pinkham, Kimberly L. H. Carpenter, and Aysenil Belger. “The benefit of directly comparing autism and schizophrenia for revealing mechanisms of social cognitive impairment.” J Neurodev Disord 3, no. 2 (June 2011): 87–100. https://doi.org/10.1007/s11689-010-9068-x.
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  - Carter, James D., Josh Bizzell, Cy Kim, Carolyn Bellion, Kimberly L. H. Carpenter, Gabriel Dichter, and Aysenil Belger. “Attention deficits in schizophrenia--preliminary evidence of dissociable transient and sustained deficits.” Schizophr Res 122, no. 1–3 (September 2010): 104–12. https://doi.org/10.1016/j.schres.2010.03.019.
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- Conference Papers
  - Leahy, Caroline, Samantha T. Major, Jill Howard, Kimberly Carpenter, Elena Tenenbaum, Lauren Franz, Saritha Vermeer, et al. “3.43 More Severe Executive Function Impairments Are Associated With Increases in Frontal Theta and Decreases in Beta and Gamma EEG Power in Young Children With ASD.” In Journal of the American Academy of Child &Amp; Adolescent Psychiatry, 61:S241–42. Elsevier BV, 2022. https://doi.org/10.1016/j.jaac.2022.09.322.
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  - Carpenter, Kimberly L. H., Jill Lorenzi, Brianna Herold, Megan McVea, Saritha Vermeer, Lauren Franz, and Geraldine Dawson. “RELATIONSHIP BETWEEN SENSORY PROCESSING DIFFERENCES AND CLINICAL FEATURES OF CHILDREN WITH ASD.” In Journal of the American Academy of Child and Adolescent Psychiatry, 58:S151–S151. ELSEVIER SCIENCE INC, 2019. https://doi.org/10.1016/jaac.2019.08.037.
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  - Carpenter, Kimberly L. H., Anish K. Simhal, Saad Nadeem, Jessica Sun, Joanne Kurtzberg, Allen Song, Allen Tannenbaum, Guillermo Sapiro, and Geraldine Dawson. “1.14 GRAPH CURVATURE AS A METHOD FOR DISCERNING ROBUSTNESS IN BRAIN NETWORKS IN ASD.” In Journal of the American Academy of Child &Amp; Adolescent Psychiatry, 58:S151–S151. Elsevier BV, 2019. https://doi.org/10.1016/j.jaac.2019.08.036.
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  - Bovery, Matthieu D. M. J., Kimberly L. H. Carpenter, Jordan Hashemi, Zhuoqing Chang, Geraldine Dawson, and Guillermo Sapiro. “5.18 A Scalable Off-the-Shelf Framework for Measuring Children’s Direction of Attention in ASD.” In Journal of the American Academy of Child &Amp; Adolescent Psychiatry, 57:S233–S233. Elsevier BV, 2018. https://doi.org/10.1016/j.jaac.2018.09.313.
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  - Egger, Helen L., Geraldine Dawson, Jordan Hashemi, Kimberly L. H. Carpenter, and Guillermo Sapiro. “23.1 Autism and Beyond: Lessons From an Iphone Study of Young Children.” In Journal of the American Academy of Child &Amp; Adolescent Psychiatry, 57:S33–34. Elsevier BV, 2018. https://doi.org/10.1016/j.jaac.2018.07.145.
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  - Carpenter, Kimberly, Samantha Major, Catherine Tallman, Lyon Chen, Lauren Franz, Jessica Sun, Joanne Kurtzberg, Allen Song, and Geraldine Dawson. “Phase I Open Label Trial of Autologous Cord Blood for Treatment of Autism: Correlations Between Behavioral Improvement and Increased White Matter Connectivity in Children With Autism.” In Neuropsychopharmacology, 42:S495–96. NATURE PUBLISHING GROUP, 2017.
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  - Carpenter, Kimberly L. H., Gabriel Dichter, and Aysenil Belger. “Functional neuroimaging of social and executive processes in individuals with autism.” In Biological Psychiatry, 63:194S-195S. ELSEVIER SCIENCE INC, 2008.
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Teaching & Mentoring
Recent Courses
Scholarly, Clinical, & Service Activities
Outreach & Engaged Scholarship
- Summer Neuroscience Program Mentor. Summer Neuroscience Program. 2020 2020

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Education, Training, & Certifications

Previous Appointments & Affiliations

In the News

Selected Grants

External Relationships

Selected Publications

Academic Articles

Conference Papers

Recent Courses

Outreach & Engaged Scholarship