Scholars@Duke
K.K. Lam

K.K. Lam

Clinical Trials Project Leader III
Duke Clinical & Translational Science Institute
kk.lam@duke.edu
Chesterfield Bldg, Suite 500, 701 W. Main St., Durham, NC 27701

Selected Publications

A case study of inclusion of rural populations in research: Implications for science and health equity.

Journal Article Clin Transl Sci · August 2024 Prior research highlights that rural populations have been historically underrepresented/excluded from clinical research. The primary objective of this study was to describe the inclusion of rural populations within our research enterprise using Clinical R ... Full text Open Access Link to item Cite

Health and economic outcomes of newborn screening for infantile-onset Pompe disease.

Journal Article Genetics in medicine : official journal of the American College of Medical Genetics · April 2021 PurposeTo estimate health and economic outcomes associated with newborn screening (NBS) for infantile-onset Pompe disease in the United States.MethodsA decision analytic microsimulation model simulated health and economic outcomes of a bi ... Full text Cite

Cognitive outcomes and age of detection of severe mucopolysaccharidosis type 1.

Journal Article Genetics in medicine : official journal of the American College of Medical Genetics · September 2017 The US Secretary of Health and Human Services recommended in February 2016 that mucopolysaccharidosis type 1 (MPS I) be added to the recommended uniform screening panel for state newborn screening programs. One of the key factors in this decision was the e ... Full text Cite

Newborn screening for X-linked adrenoleukodystrophy: evidence summary and advisory committee recommendation.

Journal Article Genetics in medicine : official journal of the American College of Medical Genetics · January 2017 The secretary of the US Department of Health and Human Services in February 2016 recommended that X-linked adrenoleukodystrophy (X-ALD) be added to the recommended uniform screening panel for state newborn screening programs. This decision was informed by ... Full text Cite

Characteristics of pediatric cardiovascular clinical trials registered on ClinicalTrials.gov.

Journal Article Am Heart J · June 2014 BACKGROUND: ClinicalTrials.gov is an National Institutes of Health-sponsored registry of federally and privately funded trials. We sought to determine fundamental characteristics of registered pediatric cardiovascular trials (PCVTs). METHODS: A data set in ... Full text Link to item Cite

Decision-making process for conditions nominated to the recommended uniform screening panel: statement of the US Department of Health and Human Services Secretary's Advisory Committee on Heritable Disorders in Newborns and Children.

Journal Article Genetics in medicine : official journal of the American College of Medical Genetics · February 2014 PurposeThe US Secretary of Health and Human Services provides guidance to state newborn screening programs about which conditions should be included in screening (i.e., the "Recommended Uniform Screening Panel"). This guidance is informed by evide ... Full text Cite

Status of the pediatric clinical trials enterprise: an analysis of the US ClinicalTrials.gov registry.

Journal Article Pediatrics · November 2012 BACKGROUND AND OBJECTIVES: Clinical trials are the gold standard for generating evidence-based knowledge in medicine. Recent legislation requiring trials to be registered at ClinicalTrials.gov has enabled evaluation of the clinical trial enterprise as a wh ... Full text Link to item Cite

Parent training with behavioral couples therapy for fathers' alcohol abuse: effects on substance use, parental relationship, parenting, and CPS involvement.

Journal Article Child maltreatment · August 2009 This pilot study examined effects of Parent Skills with Behavioral Couples Therapy (PSBCT) on substance use, parenting, and relationship conflict among fathers with alcohol use disorders. Male participants (N = 30) entering outpatient alcohol treatment, th ... Full text Cite

Gender differences in the impact of social support on crack use among African Americans.

Journal Article Substance use & misuse · January 2008 This article examines the influence of social support on crack use in a sample of 435 African American out-of-treatment crack users recruited through street outreach in Raleigh, North Carolina, between 2000 and 2002. Multivariate regression models indicate ... Full text Cite

Perceived neighborhood safety and depressive symptoms among African American crack users.

Journal Article Substance use & misuse · January 2008 This study examined the association between perceived neighborhood safety and depressive symptoms among 443 out-of-treatment African American crack cocaine users interviewed between 2000 and 2002 in North Carolina and tested the regression of depression on ... Full text Cite

African-American crack abusers and drug treatment initiation: barriers and effects of a pretreatment intervention.

Journal Article Substance abuse treatment, prevention, and policy · March 2007 BackgroundIndividual and sociocultural factors may pose significant barriers for drug abusers seeking treatment, particularly for African-American crack cocaine abusers. However, there is evidence that pretreatment interventions may reduce treatme ... Full text Cite

Substance use, sexual risk, and violence: HIV prevention intervention with sex workers in Pretoria.

Journal Article AIDS and behavior · March 2006 This paper describes an HIV prevention intervention designed in the US that was adapted and implemented in South Africa. Using an experimental design, 93 women who reported recent substance use and sex trading were randomly assigned to a modified Standard ... Full text Cite

Violence against substance-abusing South African sex workers: intersection with culture and HIV risk.

Journal Article AIDS care · June 2005 The Republic of South Africa has become an epicentre of heterosexual HIV transmission among Black women, and the interface between violence against women, substance abuse, and HIV risk is becoming evident. This paper describes the characteristics of Black ... Full text Cite

Efficacy of a woman-focused intervention to reduce HIV risk and increase self-sufficiency among African American crack abusers.

Journal Article American journal of public health · July 2004 ObjectivesThis study compares 3- and 6-month outcomes of a woman-focused HIV intervention for crack abusers, a revised National Institute on Drug Abuse standard intervention, and a control group.MethodsOut-of-drug-treatment African Americ ... Full text Cite

Treatment readiness among out-of-treatment African-American crack users.

Journal Article Journal of psychoactive drugs · October 2003 Crack cocaine use is linked to high rates of HIV and other sexually transmitted infections, as well as violence and criminal activity. Substance abuse treatment can play an important role in reducing drug use and related problems. However, many crack users ... Full text Cite

Violence, homelessness, and HIV risk among crack-using African-American women.

Journal Article Substance use & misuse · February 2003 This study compares the characteristics of out-of-treatment, homeless, crack-using African-American women with those who are not homeless to determine what risks and protective factors differentiate the two groups. From 1999 to 2001, 683 out-of-treatment, ... Full text Cite

Alcohol use among out-of-treatment crack using African-American women.

Journal Article The American journal of drug and alcohol abuse · January 2002 ObjectiveThe purpose of this study was to categorize the quantity and frequency of alcohol use among African-American women who were abusing crack cocaine and to explore relationships between categories of alcohol use and demographic variables, co ... Full text Cite