Scholars@Duke
Kyle Todd Mitchell

Kyle Todd Mitchell

Associate Professor of Neurology
Neurology, Movement Disorders

Selected Publications

Sensing data and methodology from the Adaptive DBS Algorithm for Personalized Therapy in Parkinson’s Disease (ADAPT-PD) clinical trial

Journal Article npj Parkinson's Disease · December 1, 2024 Adaptive deep brain stimulation (aDBS) is an emerging advancement in DBS technology; however, local field potential (LFP) signal rate detection sufficient for aDBS algorithms and the methods to set-up aDBS have yet to be defined. Here we summarize sensing ... Full text Cite

At home adaptive dual target deep brain stimulation in Parkinson's disease with proportional control.

Journal Article Brain · March 1, 2024 Continuous deep brain stimulation (cDBS) of the subthalamic nucleus (STN) or globus pallidus is an effective treatment for the motor symptoms of Parkinson's disease. The relative benefit of one region over the other is of great interest but cannot usually ... Full text Link to item Cite

Automated deep brain stimulation programming with safety constraints for tremor suppression in patients with Parkinson's disease and essential tremor.

Journal Article J Neural Eng · August 18, 2022 Objective.Deep brain stimulation (DBS) programming for movement disorders requires systematic fine tuning of stimulation parameters to ameliorate tremor and other symptoms while avoiding side effects. DBS programming can be a time-consuming process and req ... Full text Link to item Cite

Benefits and Risks of a Staged-Bilateral VIM Versus Unilateral VIM DBS for Essential Tremor.

Journal Article Mov Disord Clin Pract · August 2022 BACKGROUND: Despite over 30 years of clinical experience, high-quality studies on the efficacy of bilateral versus unilateral deep brain stimulation (DBS) of the ventral intermediate (VIM) nucleus of the thalamus for medically refractory essential tremor ( ... Full text Link to item Cite

Initial Clinical Outcome With Bilateral, Dual-Target Deep Brain Stimulation Trial in Parkinson Disease Using Summit RC + S.

Journal Article Neurosurgery · July 1, 2022 BACKGROUND: Deep brain stimulation (DBS) is an effective therapy in advanced Parkinson disease (PD). Although both subthalamic nucleus (STN) and globus pallidus (GP) DBS show equivalent efficacy in PD, combined stimulation may demonstrate synergism. OBJECT ... Full text Open Access Link to item Cite

Comparative efficacy of surgical approaches to disease modification in Parkinson disease.

Journal Article NPJ Parkinsons Dis · March 25, 2022 Parkinson's disease (PD) may optimally be treated with a disease-modifying therapy to slow progression. We compare data underlying surgical approaches proposed to impart disease modification in PD: (1) cell transplantation therapy with stem cell-derived do ... Full text Link to item Cite

Evoked potentials generated by deep brain stimulation for Parkinson's disease.

Journal Article Brain Stimul · 2022 BACKGROUND AND OBJECTIVES: The goal of this review is to describe the general features, mechanisms, technical recording factors, and clinical applications of brain evoked potentials (EPs) generated by deep brain stimulation (DBS) for Parkinson's disease (P ... Full text Link to item Cite

Falling down the digital divide: A cautionary tale.

Journal Article Parkinsonism Relat Disord · December 2021 The disruptions of the coronavirus pandemic have enabled new opportunities for telehealth expansion within movement disorders. However, inadequate internet infrastructure has, unfortunately, led to fragmented implementation and may worsen disparities in so ... Full text Link to item Cite

Treatment of diaphragmatic dystonia with pallidal deep brain stimulation.

Journal Article BMJ Case Rep · March 25, 2021 We present the case of a 70-year-old woman with treatment-refractory diaphragmatic dystonia. Patient initially presented with blepharospasms followed by development of involuntary inspiratory spasms during speech. Her symptoms were drug-refractory, and she ... Full text Link to item Cite

The TOPAZ study: a home-based trial of zoledronic acid to prevent fractures in neurodegenerative parkinsonism.

Journal Article NPJ Parkinsons Dis · March 1, 2021 The Trial of Parkinson's And Zoledronic acid (TOPAZ, https://clinicaltrials.gov/ct2/show/NCT03924414 ) is a unique collaboration between experts in movement disorders and osteoporosis to test the efficacy of zoledronic acid, an FDA-approved parenteral trea ... Full text Link to item Cite

Bilateral Subthalamic Nucleus Deep Brain Stimulation in Elderly Patients With Parkinson Disease: A Case-Control Study.

Journal Article Oper Neurosurg (Hagerstown) · September 1, 2020 BACKGROUND: Subthalamic nucleus deep brain stimulation (STN DBS) is an effective adjunctive therapy for Parkinson disease. Studies have shown improvement of motor function but often exclude patients older than 75 yr. OBJECTIVE: To determine the safety and ... Full text Link to item Cite

Surgical Treatment of Parkinson Disease.

Journal Article Neurol Clin · May 2020 Surgery in Parkinson disease is effective for a select group of patients when optimal medical management is not sufficient. Functional neurosurgery can be used as either a salvage therapy in patients with disabling symptoms or to maintain quality of life a ... Full text Link to item Cite

Smart neuromodulation in movement disorders.

Chapter · 2020 Deep brain stimulation (DBS) is a technique for invasive subcortical neuromodulation using a totally implantable permanent device. DBS is an effective therapy for movement disorders and is under investigation for the treatment of many other conditions incl ... Full text Link to item Cite

Benefits and risks of unilateral and bilateral ventral intermediate nucleus deep brain stimulation for axial essential tremor symptoms.

Journal Article Parkinsonism Relat Disord · March 2019 INTRODUCTION: Many experts assume bilateral deep brain stimulation (DBS) is necessary to improve axial tremor in essential tremor (ET). In the largest clinical trial of DBS for ET to date evaluating a non-directional, constant current device, we studied th ... Full text Link to item Cite

Patient Experience with Rechargeable Implantable Pulse Generator Deep Brain Stimulation for Movement Disorders.

Journal Article Stereotact Funct Neurosurg · 2019 BACKGROUND/AIMS: Nonrechargeable deep brain stimulation implantable pulse generators (IPGs) for movement disorders require surgical replacement every few years due to battery depletion. Rechargeable IPGs reduce frequency of replacement surgeries and inhere ... Full text Link to item Cite

Automated Deep Brain Stimulation Programming for Tremor.

Journal Article IEEE Trans Neural Syst Rehabil Eng · August 2018 Deep brain stimulation (DBS) programming, the systematic selection of fixed electrical stimulation parameters that deliver maximal therapeutic benefit while limiting side effects, poses several challenges in the treatment of movement disorders. DBS program ... Full text Link to item Cite

Intractable Blepharospasm Treated with Bilateral Pallidal Deep Brain Stimulation.

Journal Article Tremor Other Hyperkinet Mov (N Y) · 2017 BACKGROUND: Blepharospasm can be present as an isolated dystonia or in conjunction with other forms of cranial dystonia, causing significant disability. CASE REPORT: We report a case of a 69-year-old male with craniocervical dystonia, manifesting primarily ... Full text Link to item Cite