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Lawrence Simeon Barak
Associate Research Professor of Cell Biology
Cell Biology
l.barak@cellbio.duke.edu
Duke Box 3287, Durham, NC 27710
483 Clin & Res Labs, Durham, NC 27710
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AT A GLANCE
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Credentials
Education
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Academic Experience
Current Appointments & Affiliations
Previous Appointments & Affiliations
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Expertise
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Research
Selected Grants
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Publications
Selected Publications
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Artistic Works / Events
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Teaching
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Advising & Mentoring
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Recognition
In the News
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Professional Activities
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Selected Grants
Developing non-opiate GPCR signaling biased agents for pain management
Research
Co Investigator ·
Awarded by Department of Defense ·
2022 - 2026
Development of SBI-553, an allosteric modulator of NTR1, for the treatment of substance use disorders
Research
Principal Investigator ·
Awarded by Sanford Burnham Prebys Medical Discovery Institute ·
2023 - 2025
Development of arrestin-biased dopamine D1 receptor (D1R) ligand for the treatment of Parkinson's disease with minimal L-DOPA induced dyskinesia
Research
Principal Investigator ·
Awarded by Michael J. Fox Foundation for Parkinson's Research ·
2023 - 2024
Exploiting Biased Agonism at the Ghrelin Receptor (GHSR 1a) for Opioid Addiction
Fellowship
Co-Sponsor ·
Awarded by National Institutes of Health ·
2022 - 2023
Development of SBI-553, an allosteric modulator of NTR1, for the treatment of substance use disorders
Research
Co-Principal Investigator ·
Awarded by Sanford Burnham Prebys Medical Discovery Institute ·
2019 - 2022
More
Developing non-opiate GPCR signaling biased agents for pain management
Research
Co Investigator ·
Awarded by Department of Defense ·
2022 - 2026
Development of SBI-553, an allosteric modulator of NTR1, for the treatment of substance use disorders
Research
Principal Investigator ·
Awarded by Sanford Burnham Prebys Medical Discovery Institute ·
2023 - 2025
Development of arrestin-biased dopamine D1 receptor (D1R) ligand for the treatment of Parkinson's disease with minimal L-DOPA induced dyskinesia
Research
Principal Investigator ·
Awarded by Michael J. Fox Foundation for Parkinson's Research ·
2023 - 2024
Exploiting Biased Agonism at the Ghrelin Receptor (GHSR 1a) for Opioid Addiction
Fellowship
Co-Sponsor ·
Awarded by National Institutes of Health ·
2022 - 2023
Development of SBI-553, an allosteric modulator of NTR1, for the treatment of substance use disorders
Research
Co-Principal Investigator ·
Awarded by Sanford Burnham Prebys Medical Discovery Institute ·
2019 - 2022
A novel functionally selective drug for the treatment of cocaine abuse by antagonism of the beta-arrestin signaling arm of the Ghrelin Receptor
Research
Principal Investigator ·
Awarded by National Institutes of Health ·
2020 - 2022
Managing L-DOPA Induced Dyskinesias by Targeting Dopamine D1 Receptor Biased Signaling
Research
Co Investigator ·
Awarded by Michael J. Fox Foundation for Parkinson's Research ·
2019 - 2022
Leveraging Functional Selectivity in the Neurotensin Receptor 1-Mediated Treatment of Addiction
Research
Co-Mentor ·
Awarded by National Institutes of Health ·
2019 - 2021
Establishing the molecular and cellular mechanisms of Lgr5 signaling for controlling cancer stem cell behavior
Research
Collaborator ·
Awarded by National Institutes of Health ·
2017 - 2021
Akt/GSK-3 Signaling Cascade and the Actions of Dopamine
Research
Co Investigator ·
Awarded by National Institutes of Health ·
2005 - 2020
Inhibition of Wnt/B-Catenin Signaling in Colorectal Cancer Therapy
Research
Co Investigator ·
Awarded by National Institutes of Health ·
2013 - 2019
Biased Agonism at Neurotensin Receptor 1 for the Treatment of Methamphetamine Addiction
Fellowship
Co-Sponsor ·
Awarded by National Institutes of Health ·
2017 - 2019
Drug Abuse: Discovering Ligands for Pertinent GPCRs
Research
Co-Principal Investigator ·
Awarded by National Institutes of Health ·
2010 - 2019
A Cancer Rainbow Mouse for Simultaneous Assessment of Multiple Oncogenes
Research
Co Investigator ·
Awarded by National Institutes of Health ·
2015 - 2018
Screening and identification of beta-arrestin biased dopamine receptor ligands for PD symptom therapy.
Research
Consultant ·
Awarded by Michael J. Fox Foundation for Parkinson's Research ·
2016 - 2016
Beta-arrestin Regulation of Ghrelin Signaling in Modulating Addictive Behavior
Research
Principal Investigator ·
Awarded by National Institutes of Health ·
2014 - 2016
Novel high-throughput screening for modifiers of TorsinA pathology
Research
Collaborator ·
Awarded by National Institutes of Health ·
2013 - 2015
A Cancer Rainbow Mouse for the Simultaneous Assessment of Multiple Oncogenes
Research
Co Investigator ·
Awarded by National Institutes of Health ·
2012 - 2015
Discovering Ligands for a5-a3-b4 Nicotinic Acetylcholine Receptors.
Research
Co-Principal Investigator ·
Awarded by National Institutes of Health ·
2010 - 2014
Small molecule screen to enhance epithelial repair
Research
Co Investigator ·
Awarded by National Institutes of Health ·
2011 - 2012
Small Molecule Agonsists for the Neurotensin 1 Receptor
Research
Principal Investigator ·
Awarded by National Institutes of Health ·
2009 - 2012
Drug Abuse: Discovering Ligands for Pertinent GPCRs
Research
Co Investigator ·
Awarded by National Institutes of Health ·
2006 - 2010
Innovative Assays for Oncogenic Hedgehog Signaling
Research
Co Investigator ·
Awarded by National Institutes of Health ·
2006 - 2010
Dopamine Receptors: Characterization And Regulation
Research
Assistant Research Professor ·
Awarded by National Institutes of Health ·
1983 - 2008
Molecular fingerprinting of GPCR ligands in Cancer
Research
Principal Investigator ·
Awarded by National Institutes of Health ·
2004 - 2006
Zeiss LSM510 META confocal-fluorescence spectroscopy
Equipment
Director ·
Awarded by National Institutes of Health ·
2003 - 2004
Same
Research
Principal Investigator ·
Awarded by National Institutes of Health ·
1999 - 2004
Mechanisms Of Beta2-Adrenergic Receptor Internalization
Research
Principal Investigator ·
Awarded by National Institutes of Health ·
1996 - 1999
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