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Laura Caitlin Page

Laura Caitlin Page

Associate Professor of Pediatrics
Pediatrics, Endocrinology
laura.page@duke.edu
PO Box 102820, Duke Pediatric Endocrinology, Durham, NC 27710
3000 Erwin Road, Suite 200, Durham, NC 27705

Selected Publications

Adaptive Responses in Severe Acute Malnutrition: Endocrinology, Metabolomics, Mortality, and Growth.

Journal Article Nutrients · September 4, 2025 Malnutrition afflicts millions of the world's children and predisposes to death from diarrhea and infectious diseases. Children with severe acute malnutrition (SAM) are at highest risk. Our review of the endocrinology and metabolomics of SAM implicates cri ... Full text Link to item Cite

Entrustable Professional Activities to Milestones Advisor for Pediatric Subspecialties: Developing a Comprehensive Approach to Competency-Based Assessment.

Journal Article Acad Pediatr · August 19, 2025 OBJECTIVE: This project sought to define the relationship between the Accreditation Council of Graduate Medical Education (ACGME) Milestones 2.0 and Entrustable Professional Activities (EPAs) for each of 15 pediatric subspecialties and create a novel tool ... Full text Link to item Cite

Pediatric Endocrinology Milestones 2.0-guide to their implementation.

Journal Article BMC Med Educ · December 20, 2023 The Milestones were initiated by the Accreditation Council for Graduate Medical Education (ACGME) to provide a framework for monitoring a trainee's progression throughout residency/fellowship. The Milestones describe stepwise skill progression through six ... Full text Link to item Cite

Hormonal Determinants of Growth and Weight Gain in the Human Fetus and Preterm Infant.

Journal Article Nutrients · September 18, 2023 The factors controlling linear growth and weight gain in the human fetus and newborn infant are poorly understood. We review here the changes in linear growth, weight gain, lean body mass, and fat mass during mid- and late gestation and the early postnatal ... Full text Link to item Cite

Successful Management of Cushing Syndrome From Ectopic ACTH Secretion in an Adolescent With Osilodrostat.

Journal Article JCEM Case Rep · July 2023 A previously healthy 11-year-old male was found to have a mass in the pancreatic head after several months of abdominal pain and jaundice. Pathology was consistent with a World Health Organization grade 2 pancreatic neuroendocrine tumor. He developed refra ... Full text Link to item Cite

Thyroid Nodules on Ultrasound in Children and Young Adults: Comparison of Diagnostic Performance of Radiologists' Impressions, ACR TI-RADS, and a Deep Learning Algorithm.

Journal Article AJR Am J Roentgenol · March 2023 BACKGROUND. In current clinical practice, thyroid nodules in children are generally evaluated on the basis of radiologists' overall impressions of ultrasound images. OBJECTIVE. The purpose of this article is to compare the diagnostic performance of radiolo ... Full text Link to item Cite

Endocrine disorders in infants, children, and adolescents

Chapter · January 1, 2023 Hormones are vital to life as they provide critical signals that impact multiple organ systems. In children, hormones not only maintain homeostasis but also support growth, neurodevelopment, and pubertal development. Thus, hormone dysfunction can have prof ... Full text Cite

Pharmacologic Weight Management in the Era of Adolescent Obesity.

Journal Article J Clin Endocrinol Metab · September 28, 2022 CONTEXT: Pediatric obesity is a serious health problem in the United States. While lifestyle modification therapy with dietary changes and increased physical activity are integral for the prevention and treatment of mild to moderate obesity in youth, only ... Full text Link to item Cite

Sustained Impact of a Pediatric Resident-Led Patient Safety Council.

Journal Article J Patient Saf · December 1, 2021 OBJECTIVES: The aim of the study was to evaluate the impact of a resident-led patient safety council. This study measured change in resident perceptions and knowledge of safety issues for 3 years, as well as behavioral choices to participate in patient saf ... Full text Link to item Cite

An endocrine perspective on menstrual suppression for adolescents: achieving good suppression while optimizing bone health.

Journal Article J Pediatr Endocrinol Metab · November 25, 2021 Suppression of menstruation and/or ovarian function in adolescent girls may be desired for a variety of reasons. Numerous medical options exist. The choice of the appropriate modality for an individual patient depends on several factors based on difference ... Full text Link to item Cite

Management and Appropriate Use of Diazoxide in Infants and Children with Hyperinsulinism.

Journal Article J Clin Endocrinol Metab · December 1, 2020 BACKGROUND: The diagnosis of hypoglycemia and the use of diazoxide have risen in the last decade. Diazoxide is the only Food and Drug Agency-approved pharmacologic treatment for neonatal hypoglycemia caused by hyperinsulinism (HI). Recent publications have ... Full text Link to item Cite

Role of GLP-1 Receptor Agonists in Pediatric Obesity: Benefits, Risks, and Approaches to Patient Selection.

Journal Article Curr Obes Rep · December 2020 PURPOSE OF REVIEW: Effective treatments for pediatric obesity are limited. Glucagon-like peptide-1 receptor (GLP-1R) agonists have emerged as therapeutic agents for obesity in adults and have shown benefits outside of weight loss. Here we explore the evide ... Full text Link to item Cite

Ghrelin regulation of glucose metabolism.

Journal Article J Neuroendocrinol · July 2019 Ghrelin and its receptor, the growth hormone secretagogue receptor 1a (GHSR1a), are implicated in the regulation of glucose metabolism via direct actions in the pancreatic islet, as well as peripheral insulin-sensitive tissues and the brain. Although many ... Full text Open Access Link to item Cite

The Association Between Pediatric Faculty Factors and Resident Physician Ratings of Teaching Effectiveness.

Journal Article Glob Pediatr Health · 2019 Background. Faculty factors not inherently related to teaching effectiveness can influence teaching ratings. No studies have focused on pediatric faculty who possess unique differences from general medical faculty. Methods. We designed a retrospective obse ... Full text Link to item Cite

Interaction of GLP-1 and Ghrelin on Glucose Tolerance in Healthy Humans.

Journal Article Diabetes · October 2018 Emerging evidence supports the importance of ghrelin to defend against starvation-induced hypoglycemia. This effect may be mediated by inhibition of glucose-stimulated insulin secretion as well as reduced insulin sensitivity. However, administration of ghr ... Full text Link to item Cite

Gastrointestinal hormones and the control of food intake and energy metabolism

Chapter · January 1, 2018 Gastrointestinal (GI) hormones are increasingly recognized for their roles in the control of appetite and obesity. In this chapter, we review selected regulatory factors secreted from the gut including ghrelin, glucagon-like peptide 1 (GLP-1), cholecystoki ... Full text Cite

Fetal and Neonatal Thyroid Physiology

Chapter · January 1, 2018 Thyroid hormone is critical to fetal and neonatal neurodevelopment. The tight control of fetal exposure to thyroid hormone begins early in gestation, as the placental thyroid hormone transporters facilitate passage of maternal thyroxine into fetal blood. W ... Full text Cite

Early-Onset Obesity Caused by Monogenic Disorders

Journal Article Current Pediatrics Reports · September 1, 2017 Purpose of Review: Obesity is a common problem encountered daily by pediatricians. Although most obesity results from an “obesogenic” environment, single gene mutations in the hypothalamic leptin-melanocortin pathway may cause severe hyperphagia and early- ... Full text Cite

Acute administration of acyl, but not desacyl ghrelin, decreases blood pressure in healthy humans.

Journal Article Eur J Endocrinol · February 2017 OBJECTIVE: To compare the effects of acyl ghrelin (AG) and desacyl ghrelin (DAG) on blood pressure (BP), heart rate (HR) and other autonomic parameters in healthy humans and to elucidate the hormonal mechanisms through which AG could exert its cardiovascul ... Full text Link to item Cite

Screening for hormonal, monogenic, and syndromic disorders in obese infants and children.

Journal Article Pediatr Ann · September 2014 The prevalence of pediatric obesity in the United States is nearly 17%. Most cases are "exogenous", resulting from excess energy intake relative to energy expenditure over a prolonged period of time. However, some cases of obesity are "endogenous", associa ... Full text Link to item Cite

An intracellular role for ABCG1-mediated cholesterol transport in the regulated secretory pathway of mouse pancreatic beta cells.

Journal Article J Clin Invest · July 2010 Cholesterol is a critical component of cell membranes, and cellular cholesterol levels and distribution are tightly regulated in mammals. Recent evidence has revealed a critical role for pancreatic beta cell-specific cholesterol homeostasis in insulin secr ... Full text Link to item Cite

A test of receiver perceptual performance: European starlings' ability to detect asymmetry in a naturalistic trait

Journal Article Animal Behaviour · August 1, 2008 There has been substantial interest in whether birds use small degrees of asymmetry (fluctuating asymmetry, FA) in visual communication. However, there is a scarcity of experimental evidence for the visual role of FA. Hence, there is still much debate as t ... Full text Cite

High levels of environmental noise erode pair preferences in zebra finches: implications for noise pollution

Journal Article Animal Behaviour · September 1, 2007 Male-female pair bonds are common to most bird species, and these bonds affect fundamental aspects of mating systems and the strength of selection, for example, by limiting extrapair paternity. Therefore, understanding factors that strengthen and erode pai ... Full text Cite

Deconstructing Pompe disease by analyzing single muscle fibers: to see a world in a grain of sand..

Journal Article Autophagy · 2007 Autophagy is a major pathway for delivery of proteins and organelles to lysosomes where they are degraded and recycled. We have previously shown excessive autophagy in a mouse model of Pompe disease (glycogen storage disease type II), a devastating myopath ... Full text Link to item Cite