Laura Eloise Rupprecht

Journal Article Nat Biotechnol · June 2024 Progress in understanding brain-viscera interoceptive signaling is hindered by a dearth of implantable devices suitable for probing both brain and peripheral organ neurophysiology during behavior. Here we describe multifunctional neural interfaces that com ... Full text Link to item Cite

Evaluation of Flavor Effects on Oral Nicotine Liking and/or Disliking Using the Taste Reactivity Test in Rats.

Journal Article Nicotine Tob Res · March 26, 2022 INTRODUCTION: Tobacco product flavors may change the sensory properties of nicotine, such as taste and olfactory cues, which may alter nicotine reward and aversion and nicotine taking behavior. The hedonic or aversive value of a taste stimulus can be evalu ... Full text Link to item Cite

The preference for sugar over sweetener depends on a gut sensor cell.

Journal Article Nat Neurosci · February 2022 Guided by gut sensory cues, humans and animals prefer nutritive sugars over non-caloric sweeteners, but how the gut steers such preferences remains unknown. In the intestine, neuropod cells synapse with vagal neurons to convey sugar stimuli to the brain wi ... Full text Link to item Cite

The nerve not taken.

Journal Article Cell Metab · March 2, 2021 Nutrients entering the gut influence our brains through uncharacterized circuits. In this issue of Cell Metabolism, Goldstein et al. (2021) show hypothalamic neurons responding, via distinct neural paths, to nutrients infused in different intestinal segmen ... Full text Link to item Cite

Neuropod Cells: The Emerging Biology of Gut-Brain Sensory Transduction.

Journal Article Annu Rev Neurosci · July 8, 2020 Guided by sight, scent, texture, and taste, animals ingest food. Once ingested, it is up to the gut to make sense of the food's nutritional value. Classic sensory systems rely on neuroepithelial circuits to convert stimuli into signals that guide behavior. ... Full text Link to item Cite

Examining the role of muscarinic M5 receptors in VTA cholinergic modulation of depressive-like and anxiety-related behaviors in rats.

Journal Article Neuropharmacology · July 2020 Acetylcholine is implicated in mood disorders including depression and anxiety. Increased cholinergic tone in humans and rodents produces pro-depressive and anxiogenic-like effects. Cholinergic receptors in the ventral tegmental area (VTA) are known to med ... Full text Link to item Cite

Nicotine Self-administration Is Not Increased in the Methylazoxymethanol Acetate Rodent Model of Schizophrenia.

Journal Article Nicotine Tob Res · February 6, 2020 INTRODUCTION: Patients with schizophrenia (SCZ) smoke at a rate of 4-5 times higher than the general population, contributing to negative health consequences in this group. One possible explanation for this increased smoking is that individuals with SCZ fi ... Full text Link to item Cite

Cholinergic Receptor Blockade in the VTA Attenuates Cue-Induced Cocaine-Seeking and Reverses the Anxiogenic Effects of Forced Abstinence.

Journal Article Neuroscience · August 10, 2019 Drug relapse after periods of abstinence is a common feature of substance abuse. Moreover, anxiety and other mood disorders are often co-morbid with substance abuse. Cholinergic receptors in the ventral tegmental area (VTA) are known to mediate drug-seekin ... Full text Link to item Cite

Basic Science and Public Policy: Informed Regulation for Nicotine and Tobacco Products.

Journal Article Nicotine Tob Res · June 7, 2018 INTRODUCTION: Scientific discoveries over the past few decades have provided significant insight into the abuse liability and negative health consequences associated with tobacco and nicotine-containing products. While many of these advances have led to th ... Full text Link to item Cite

Self-administered nicotine increases fat metabolism and suppresses weight gain in male rats.

Journal Article Psychopharmacology (Berl) · April 2018 RATIONALE: The ability of nicotine to suppress body weight is cited as a factor impacting smoking initiation and the failure to quit. Self-administered nicotine in male rats suppresses weight independent of food intake, suggesting that nicotine increases e ... Full text Link to item Cite

Animal Research on Nicotine Reduction: Current Evidence and Research Gaps.

Journal Article Nicotine Tob Res · September 1, 2017 UNLABELLED: A mandated reduction in the nicotine content of cigarettes may improve public health by reducing the prevalence of smoking. Animal self-administration research is an important complement to clinical research on nicotine reduction. It can fill r ... Full text Link to item Cite

Self-administered nicotine differentially impacts body weight gain in obesity-prone and obesity-resistant rats.

Journal Article Physiol Behav · July 1, 2017 Obesity and tobacco smoking represent the largest challenges to public health, but the causal relationship between nicotine and obesity is poorly understood. Nicotine suppresses body weight gain, a factor impacting smoking initiation and the failure to qui ... Full text Link to item Cite

Repeated administration of an acetylcholinesterase inhibitor attenuates nicotine taking in rats and smoking behavior in human smokers.

Journal Article Transl Psychiatry · March 28, 2017 Full text Link to item Cite

Reducing nicotine exposure results in weight gain in smokers randomised to very low nicotine content cigarettes.

Journal Article Tob Control · March 2017 BACKGROUND: The Food and Drug Administration can reduce the nicotine content in cigarettes to very low levels. This potential regulatory action is hypothesised to improve public health by reducing smoking, but may have unintended consequences related to we ... Full text Link to item Cite

Characterizing the relationship between increases in the cost of nicotine and decreases in nicotine content in adult male rats: implications for tobacco regulation.

Journal Article Psychopharmacology (Berl) · December 2016 BACKGROUND: A large reduction in the nicotine content of cigarettes may benefit public health by reducing the rate and the prevalence of smoking. A behavioral economics framework suggests that a decrease in nicotine content may be considered an increase in ... Full text Link to item Cite

Self-Administered Nicotine Suppresses Body Weight Gain Independent of Food Intake in Male Rats.

Journal Article Nicotine Tob Res · September 2016 INTRODUCTION: The action of nicotine to suppress body weight is often cited as a factor impacting smoking initiation and the failure to quit. Despite the weight-suppressant effects of nicotine, smokers and nonsmokers report equal daily caloric intake. The ... Full text Link to item Cite

Adolescent Rats Self-Administer Less Nicotine Than Adults at Low Doses.

Journal Article Nicotine Tob Res · September 2016 INTRODUCTION: Although nearly 90% of current smokers initiated tobacco use during adolescence, little is known about reinforcement by nicotine in adolescents. Researchers are currently investigating whether a potential public health policy setting a tobacc ... Full text Link to item Cite

Effects of Monoamine Oxidase Inhibition on the Reinforcing Properties of Low-Dose Nicotine.

Journal Article Neuropsychopharmacology · August 2016 The Food and Drug Administration (FDA) has the authority to regulate cigarette smoke constituents, and a reduction in nicotine content might benefit public health by reducing the prevalence of smoking. Research suggests that cigarette smoke constituents th ... Full text Link to item Cite

Repeated administration of an acetylcholinesterase inhibitor attenuates nicotine taking in rats and smoking behavior in human smokers.

Journal Article Transl Psychiatry · January 19, 2016 Tobacco smoking remains the leading cause of preventable death worldwide and current smoking cessation medications have limited efficacy. Thus, there is a clear need for translational research focused on identifying novel pharmacotherapies for nicotine add ... Full text Link to item Cite

Hindbrain GLP-1 receptor mediation of cisplatin-induced anorexia and nausea.

Journal Article Physiol Behav · January 1, 2016 While chemotherapy-induced nausea and vomiting are clinically controlled in the acute (<24 h) phase following treatment, the anorexia, nausea, fatigue, and other illness-type behaviors during the delayed phase (>24 h) of chemotherapy are largely uncontroll ... Full text Link to item Cite

Effects of MAO inhibition and a combination of minor alkaloids, β-carbolines, and acetaldehyde on nicotine self-administration in adult male rats.

Journal Article Drug Alcohol Depend · October 1, 2015 INTRODUCTION: Although nicotine is the primary reinforcing constituent in cigarettes, there is evidence that other constituents in cigarette smoke may interact with nicotine to reinforce smoking behavior. METHODS: The present experiments investigated wheth ... Full text Link to item Cite

Obese Smokers as a Potential Subpopulation of Risk in Tobacco Reduction Policy.

Journal Article Yale J Biol Med · September 2015 Smoking and obesity represent the largest challenges to public health. There is an established inverse relationship between body mass index (BMI) and smoking, but this relationship becomes more complicated among obese smokers. Smokers with higher BMI consu ... Link to item Cite

Behavioral mechanisms underlying nicotine reinforcement.

Journal Article Curr Top Behav Neurosci · 2015 Cigarette smoking is the leading cause of preventable deaths worldwide, and nicotine, the primary psychoactive constituent in tobacco, drives sustained use. The behavioral actions of nicotine are complex and extend well beyond the actions of the drug as a ... Full text Link to item Cite

Donepezil, an acetylcholinesterase inhibitor, attenuates nicotine self-administration and reinstatement of nicotine seeking in rats.

Journal Article Addict Biol · July 2014 Nicotine craving and cognitive impairments represent core symptoms of nicotine withdrawal and predict relapse in abstinent smokers. Current smoking cessation pharmacotherapies have limited efficacy in preventing relapse and maintaining abstinence during wi ... Full text Link to item Cite

The food intake-suppressive effects of glucagon-like peptide-1 receptor signaling in the ventral tegmental area are mediated by AMPA/kainate receptors.

Journal Article Am J Physiol Endocrinol Metab · December 1, 2013 Glucagon-like peptide-1 receptor (GLP-1R) activation in the ventral tegmental area (VTA) is physiologically relevant for the control of palatable food intake. Here, we tested whether the food intake-suppressive effects of VTA GLP-1R activation are mediated ... Full text Link to item Cite

Hindbrain GLP-1 receptor-mediated suppression of food intake requires a PI3K-dependent decrease in phosphorylation of membrane-bound Akt.

Journal Article Am J Physiol Endocrinol Metab · September 15, 2013 Glucagon-like peptide-1 (GLP-1) receptors (GLP-1R) expressed in the nucleus tractus solitarius (NTS) are physiologically required for the control of feeding. Recently, NTS GLP-1R-mediated suppression of feeding was shown to occur via a rapid PKA-induced su ... Full text Link to item Cite

Amylin receptor signaling in the ventral tegmental area is physiologically relevant for the control of food intake.

Journal Article Neuropsychopharmacology · August 2013 The ability of amylin, a pancreatic β-cell-derived neuropeptide, to promote negative energy balance has been ascribed to neural activation at the area postrema. However, despite amylin binding throughout the brain, the possible role of amylin signaling at ... Full text Link to item Cite

Galantamine, an acetylcholinesterase inhibitor and positive allosteric modulator of nicotinic acetylcholine receptors, attenuates nicotine taking and seeking in rats.

Journal Article Neuropsychopharmacology · September 2012 Current smoking cessation pharmacotherapies have limited efficacy in preventing relapse and maintaining abstinence during withdrawal. Galantamine is an acetylcholinesterase inhibitor that also acts as a positive allosteric modulator of nicotinic acetylchol ... Full text Link to item Cite

The role of nausea in food intake and body weight suppression by peripheral GLP-1 receptor agonists, exendin-4 and liraglutide.

Journal Article Neuropharmacology · April 2012 The FDA-approved glucagon-like-peptide-1 receptor (GLP-1R) agonists exendin-4 and liraglutide reduce food intake and body weight. Nausea is the most common adverse side effect reported with these GLP-1R agonists. Whether food intake suppression by exendin- ... Full text Link to item Cite

GLP-1 neurons in the nucleus of the solitary tract project directly to the ventral tegmental area and nucleus accumbens to control for food intake.

Journal Article Endocrinology · February 2012 Central glucagon-like-peptide-1 (GLP-1) receptor activation reduces food intake; however, brain nuclei and mechanism(s) mediating this effect remain poorly understood. Although central nervous system GLP-1 is produced almost exclusively in the nucleus of t ... Full text Link to item Cite