Scholars@Duke
Lauren Covert

Lauren Covert

Assistant Professor of Pediatrics
Pediatrics, Rheumatology

Selected Publications

Interferon-β-Induced Injury During Pediatric Muscle Differentiation: Insight Into Juvenile Dermatomyositis Pathogenesis.

Journal Article ACR Open Rheumatol · October 22, 2024 OBJECTIVE: Juvenile dermatomyositis (JDM) involves up-regulated type I interferons (IFNs), including IFNβ, yet pathologic mechanisms remain poorly understood. We aimed to characterize the functional and structural effects of IFNβ on in vitro human pediatri ... Full text Link to item Cite

Genetic changes from type I interferons and JAK inhibitors: clues to drivers of juvenile dermatomyositis.

Journal Article Rheumatology (Oxford) · September 1, 2024 OBJECTIVE: To better understand the pathogenesis of juvenile dermatomyositis (JDM), we examined the effect of the cytokines type I interferons (IFN I) and JAK inhibitor drugs (JAKi) on gene expression in bioengineered pediatric skeletal muscle. METHODS: My ... Full text Link to item Cite

Effect of type I interferon on engineered pediatric skeletal muscle: a promising model for juvenile dermatomyositis.

Journal Article Rheumatology (Oxford) · January 4, 2024 OBJECTIVE: To investigate pathogenic mechanisms underlying JDM, we defined the effect of type I IFN, IFN-α and IFN-β, on pediatric skeletal muscle function and expression of myositis-related proteins using an in vitro engineered human skeletal muscle model ... Full text Link to item Cite