Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., Chinese Academy of Medical Sciences (China) 2009
• Research
• 

  Selected Grants

  • HUMAN GENETIC VARIATION REGULATING SALMONELLA HOST-PATHOGEN INTERACTIONS AND DISEASE SUSCEPTIBILITY awarded by National Institutes of Health 2015 - 2025
  • Human Genetic Variation Regulating Transcriptional Response and Cellular Susceptibility to Influenza awarded by National Institutes of Health 2021 - 2022
  • Regulation of Salmonella virulence by interspecies methylthioadenosine signaling awarded by National Institutes of Health 2019 - 2022
  • SALMONELLA HIJACKING OF STAT3 AND CONSEQUENCES FOR DISEASE awarded by National Institutes of Health 2019 - 2021
  • AN ATLAS OF SHARED GENETIC ARCHITECTURE CONNECTING CELL BIOLOGY AND HUMAN DISEASE awarded by National Institutes of Health 2018 - 2021
  • Human Genetic Variance and Cellular Responses to Sexually Transmitted Infections awarded by University of Maryland, Baltimore 2015 - 2020
  • Human Genetic Variance and Cellular Responses to Sexually Transmitted Infections awarded by University of Maryland 2009 - 2019
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Schott, Benjamin H., Alejandro L. Antonia, Liuyang Wang, Kelly J. Pittman, Barbara S. Sixt, Alyson B. Barnes, Raphael H. Valdivia, and Dennis C. Ko. “Modeling of variables in cellular infection reveals CXCL10 levels are regulated by human genetic variation and the Chlamydia-encoded CPAF protease.” Sci Rep 10, no. 1 (October 26, 2020): 18269. https://doi.org/10.1038/s41598-020-75129-y.
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    • Xie, Longxiang, Liuyang Wang, Wan Zhu, Jing Zhao, and Xiangqian Guo. “Editorial: Bioinformatics Tools (and Web Server) for Cancer Biomarker Development.” Front Oncol 10 (2020): 599085. https://doi.org/10.3389/fonc.2020.599085.
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    • Zhang, Yang, Poorva Mudgal, Liuyang Wang, Haiyang Wu, Na Huang, Peter B. Alexander, Zhixian Gao, Nan Ji, and Qi-Jing Li. “T cell receptor repertoire as a prognosis marker for heat shock protein peptide complex-96 vaccine trial against newly diagnosed glioblastoma.” Oncoimmunology 9, no. 1 (2020): 1749476. https://doi.org/10.1080/2162402X.2020.1749476.
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    • Zhang, Yue, Yang Xu, Hao Chen, Liuyang Wang, Kangquan Yin, and Fang K. Du. “Comparative Genomic Analysis Reveals the Mechanism Driving the Diversification of Plastomic Structure in Taxaceae Species.” Front Genet 10 (2019): 1295. https://doi.org/10.3389/fgene.2019.01295.
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    • Yang, Fan, Peng Xiao, Chang-Xiu Qu, Qi Liu, Liu-Yang Wang, Zhi-Xin Liu, Qing-Tao He, et al. “Allosteric mechanisms underlie GPCR signaling to SH3-domain proteins through arrestin.” Nat Chem Biol 14, no. 9 (September 2018): 876–86. https://doi.org/10.1038/s41589-018-0115-3.
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    • Wang, Liuyang, Kelly J. Pittman, Jeffrey R. Barker, Raul E. Salinas, Ian B. Stanaway, Graham D. Williams, Robert J. Carroll, et al. “An Atlas of Genetic Variation Linking Pathogen-Induced Cellular Traits to Human Disease.” Cell Host Microbe 24, no. 2 (August 8, 2018): 308-323.e6. https://doi.org/10.1016/j.chom.2018.07.007.
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    • Jaslow, Sarah L., Kyle D. Gibbs, W Florian Fricke, Liuyang Wang, Kelly J. Pittman, Mark K. Mammel, Joshua T. Thaden, et al. “Salmonella Activation of STAT3 Signaling by SarA Effector Promotes Intracellular Replication and Production of IL-10.” Cell Rep 23, no. 12 (June 19, 2018): 3525–36. https://doi.org/10.1016/j.celrep.2018.05.072.
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    • Cai, Zhenyuan, Liuyang Wang, Xiaoying Song, Somnath Tagore, Xiangfeng Li, Huihua Wang, Jiarui Chen, et al. “Adaptive Transcriptome Profiling of Subterranean Zokor, Myospalax baileyi, to High- Altitude Stresses in Tibet.” Sci Rep 8, no. 1 (March 16, 2018): 4671. https://doi.org/10.1038/s41598-018-22483-7.
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    • Antonia, Alejandro L., Liuyang Wang, and Dennis C. Ko. “A real-time PCR assay for quantification of parasite burden in murine models of leishmaniasis.” Peerj 6 (2018): e5905. https://doi.org/10.7717/peerj.5905.
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    • Corona, Erik, Liuyang Wang, Dennis Ko, and Chirag J. Patel. “Systematic detection of positive selection in the human-pathogen interactome and lasting effects on infectious disease susceptibility.” Plos One 13, no. 5 (2018): e0196676. https://doi.org/10.1371/journal.pone.0196676.
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    • Alvarez, Monica I., Luke C. Glover, Peter Luo, Liuyang Wang, Elizabeth Theusch, Stefan H. Oehlers, Eric M. Walton, et al. “Human genetic variation in VAC14 regulates Salmonella invasion and typhoid fever through modulation of cholesterol.” Proc Natl Acad Sci U S A 114, no. 37 (September 12, 2017): E7746–55. https://doi.org/10.1073/pnas.1706070114.
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    • Sun, Sheng, Vikas Yadav, R Blake Billmyre, Christina A. Cuomo, Minou Nowrousian, Liuyang Wang, Jean-Luc Souciet, et al. “Fungal genome and mating system transitions facilitated by chromosomal translocations involving intercentromeric recombination.” Plos Biol 15, no. 8 (August 2017): e2002527. https://doi.org/10.1371/journal.pbio.2002527.
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    • Lotterhos, K. E., D. C. Card, S. M. Schaal, L. Wang, C. Collins, and B. Verity. “Composite measures of selection can improve the signal-to-noise ratio in genome scans.” Methods in Ecology and Evolution 8, no. 6 (June 1, 2017): 717–27. https://doi.org/10.1111/2041-210X.12774.
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    • Galarza-Muñoz, Gaddiel, Farren B. S. Briggs, Irina Evsyukova, Geraldine Schott-Lerner, Edward M. Kennedy, Tinashe Nyanhete, Liuyang Wang, et al. “Human Epistatic Interaction Controls IL7R Splicing and Increases Multiple Sclerosis Risk.” Cell 169, no. 1 (March 23, 2017): 72-84.e13. https://doi.org/10.1016/j.cell.2017.03.007.
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    • Wang, Liuyang, Emily R. Ko, James J. Gilchrist, Kelly J. Pittman, Anna Rautanen, Matti Pirinen, J Will Thompson, et al. “Human genetic and metabolite variation reveals that methylthioadenosine is a prognostic biomarker and an inflammatory regulator in sepsis.” Sci Adv 3, no. 3 (March 2017): e1602096. https://doi.org/10.1126/sciadv.1602096.
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    • Oehlers, Stefan H., Maria Vega Flores, Christopher J. Hall, Liuyang Wang, Dennis C. Ko, Kathryn E. Crosier, and Philip S. Crosier. “A whole animal chemical screen approach to identify modifiers of intestinal neutrophilic inflammation.” Febs J 284, no. 3 (February 2017): 402–13. https://doi.org/10.1111/febs.13976.
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    • Verity, Robert, Caitlin Collins, Daren C. Card, Sara M. Schaal, Liuyang Wang, and Katie E. Lotterhos. “minotaur: A platform for the analysis and visualization of multivariate results from genome scans with R Shiny.” Mol Ecol Resour 17, no. 1 (January 2017): 33–43. https://doi.org/10.1111/1755-0998.12579.
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    • Li, Kexin, Huihua Wang, Zhenyuan Cai, Liuyang Wang, Qinqin Xu, Matěj Lövy, Zhenlong Wang, and Eviatar Nevo. “Sympatric speciation of spiny mice, Acomys, unfolded transcriptomically at Evolution Canyon, Israel.” Proc Natl Acad Sci U S A 113, no. 29 (July 19, 2016): 8254–59. https://doi.org/10.1073/pnas.1608743113.
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    • Li, Kexin, Liuyang Wang, Binyamin A. Knisbacher, Qinqin Xu, Erez Y. Levanon, Huihua Wang, Milana Frenkel-Morgenstern, et al. “Transcriptome, genetic editing, and microRNA divergence substantiate sympatric speciation of blind mole rat, Spalax.” Proc Natl Acad Sci U S A 113, no. 27 (July 5, 2016): 7584–89. https://doi.org/10.1073/pnas.1607497113.
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    • Pittman, Kelly J., Luke C. Glover, Liuyang Wang, and Dennis C. Ko. “The Legacy of Past Pandemics: Common Human Mutations That Protect against Infectious Disease.” Plos Pathog 12, no. 7 (July 2016): e1005680. https://doi.org/10.1371/journal.ppat.1005680.
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    • Jaslow, Sarah, Liuyang Wang, and Dennis Ko. “Contribution to Virulence of a Novel Anti-inflammatory Effector in Salmonella enterica.” Open Forum Infect Dis 2, no. Suppl 1 (December 2015): 693. https://doi.org/10.1093/ofid/ofv131.68.
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    • Redelings, Benjamin D., Seiji Kumagai, Andrey Tatarenkov, Liuyang Wang, Ann K. Sakai, Stephen G. Weller, Theresa M. Culley, John C. Avise, and Marcy K. Uyenoyama. “A Bayesian Approach to Inferring Rates of Selfing and Locus-Specific Mutation.” Genetics 201, no. 3 (November 2015): 1171–88. https://doi.org/10.1534/genetics.115.179093.
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    • Wang, Liuyang, Stefan H. Oehlers, Scott T. Espenschied, John F. Rawls, David M. Tobin, and Dennis C. Ko. “CPAG: software for leveraging pleiotropy in GWAS to reveal similarity between human traits links plasma fatty acids and intestinal inflammation.” Genome Biol 16 (September 15, 2015): 190. https://doi.org/10.1186/s13059-015-0722-1.
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    • Chen, Yuan, Anastasia P. Litvintseva, Aubrey E. Frazzitta, Miriam R. Haverkamp, Liuyang Wang, Charles Fang, Charles Muthoga, Thomas G. Mitchell, and John R. Perfect. “Comparative analyses of clinical and environmental populations of Cryptococcus neoformans in Botswana.” Mol Ecol 24, no. 14 (July 2015): 3559–71. https://doi.org/10.1111/mec.13260.
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    • Meng, Lihua, Gang Chen, Zhonghu Li, Yongping Yang, Zhengkun Wang, and Liuyang Wang. “Refugial isolation and range expansions drive the genetic structure of Oxyria sinensis (Polygonaceae) in the Himalaya-Hengduan Mountains.” Sci Rep 5 (May 27, 2015): 10396. https://doi.org/10.1038/srep10396.
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    • Janoušek, Václav, Pavel Munclinger, Liuyang Wang, Katherine C. Teeter, and Priscilla K. Tucker. “Functional organization of the genome may shape the species boundary in the house mouse.” Mol Biol Evol 32, no. 5 (May 2015): 1208–20. https://doi.org/10.1093/molbev/msv011.
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    • Gao, Dahai, Dennis C. Ko, Xinmin Tian, Guang Yang, and Liuyang Wang. “Expression Divergence of Duplicate Genes in the Protein Kinase Superfamily in Pacific Oyster.” Evol Bioinform Online 11, no. Suppl 1 (2015): 57–65. https://doi.org/10.4137/EBO.S30230.
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    • Han, Xinwei, Yuan Chen, Liuyang Wang, Wenwen Fang, Ning Zhang, and Qiyun Zhu. “RNA: An Expanding View of Function and Evolution.” Evol Bioinform Online 11, no. Suppl 1 (2015): 77–79. https://doi.org/10.4137/EBO.S38105.
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    • Wang, Lei, Zhengkun Wang, Jianbing Chen, Chunyan Liu, Wanlong Zhu, Liuyang Wang, and Lihua Meng. “De Novo Transcriptome Assembly and Development of Novel Microsatellite Markers for the Traditional Chinese Medicinal Herb, Veratrilla baillonii Franch (Gentianaceae).” Evol Bioinform Online 11, no. Suppl 1 (2015): 39–45. https://doi.org/10.4137/EBO.S20942.
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    • Zhou, Zhili, Huancheng Ma, Kevin Lin, Youjie Zhao, Yuan Chen, Zhi Xiong, Liuyang Wang, and Bin Tian. “RNA-seq Reveals Complicated Transcriptomic Responses to Drought Stress in a Nonmodel Tropic Plant, Bombax ceiba L.” Evol Bioinform Online 11, no. Suppl 1 (2015): 27–37. https://doi.org/10.4137/EBO.S20620.
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    • Kass, David H., Václav Janoušek, Liuyang Wang, and Priscilla K. Tucker. “The uncharacterized gene 1700093K21Rik and flanking regions are correlated with reproductive isolation in the house mouse, Mus musculus.” Mamm Genome 25, no. 5–6 (June 2014): 223–34. https://doi.org/10.1007/s00335-014-9506-2.
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    • Janoušek, Václav, Liuyang Wang, Ken Luzynski, Petra Dufková, Martina M. Vyskočilová, Michael W. Nachman, Pavel Munclinger, Miloš Macholán, Jaroslav Piálek, and Priscilla K. Tucker. “Genome-wide architecture of reproductive isolation in a naturally occurring hybrid zone between Mus musculus musculus and M. m. domesticus.” Mol Ecol 21, no. 12 (June 2012): 3032–47. https://doi.org/10.1111/j.1365-294X.2012.05583.x.
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    • Wang, Liuyang, Ken Luzynski, John E. Pool, Václav Janoušek, Petra Dufková, Martina M. Vyskočilová, Katherine C. Teeter, et al. “Measures of linkage disequilibrium among neighbouring SNPs indicate asymmetries across the house mouse hybrid zone.” Mol Ecol 20, no. 14 (July 2011): 2985–3000. https://doi.org/10.1111/j.1365-294X.2011.05148.x.
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    • JIA, DON G‐R U. I., TEN G‐L I. A. N. G. LIU, LI U‐Y A. N. G. WANG, DAN G‐W E. I. ZHOU, and JIA N‐Q U. A. N. LIU. “Evolutionary history of an alpine shrub Hippophae tibetana (Elaeagnaceae): allopatric divergence and regional expansion.” Biological Journal of the Linnean Society. Linnean Society of London 102, no. 1 (January 2011): 37–50. https://doi.org/10.1111/j.1095-8312.2010.01553.x.
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    • Tang, Li-Zhou, Liu-Yang Wang, Zhen-Yuan Cai, Tong-Zuo Zhang, Hai-Xin Ci, Gong-Hua Lin, Jian-Ping Su, and Jian-Quan Liu. “Allopatric divergence and phylogeographic structure of the plateau zokor (Eospalax baileyi), a fossorial rodent endemic to the Qinghai-Tibetan Plateau.” Journal of Biogeography 37, no. 4 (April 2010): 657–68. https://doi.org/10.1111/j.1365-2699.2009.02232.x.
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    • Wang, L. Y., Y. X. Kou, G. L. Wu, and Y. J. Wang. “Development and characterization of novel microsatellite markers isolated from potentilla fruticosa L. (Rosaceae), and cross-species amplification in its sister species-Potentilla glabra L.” Conservation Genetics Resources 1, no. 1 (December 1, 2009): 51–53. https://doi.org/10.1007/s12686-009-9012-0.
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    • Tian, Bin, Ruirui Liu, Liuyang Wang, Qiang Qiu, Kangming Chen, and Jianquan Liu. “Phylogeographic analyses suggest that a deciduous species (Ostryopsis davidiana Decne., Betulaceae) survived in northern China during the Last Glacial Maximum.” Journal of Biogeography 36, no. 11 (November 2009): 2148–55. https://doi.org/10.1111/j.1365-2699.2009.02157.x.
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    • Wang, L. Y., P. B. Pelser, B. Nordenstam, and J. Q. Liu. “Strong incongruence between the ITs phylogeny and generic delimitation in the Nemosenecio-Sinosenecio-Tephroseris assemblage (Asteraceae: Senecioneae).” Botanical Studies 50, no. 4 (October 1, 2009): 435–42.
    • Wang, Liu-Yang, Hiroshi Ikeda, Teng-Liang Liu, Yu-Jin Wang, and Jian-Quan Liu. “Repeated range expansion and glacial endurance of Potentilla glabra (Rosaceae) in the Qinghai-Tibetan plateau.” J Integr Plant Biol 51, no. 7 (July 2009): 698–706. https://doi.org/10.1111/j.1744-7909.2009.00818.x.
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    • Wang, Liuyang, Richard J. Abbott, Wei Zheng, Ping Chen, Yujin Wang, and Jianquan Liu. “History and evolution of alpine plants endemic to the Qinghai-Tibetan Plateau: Aconitum gymnandrum (Ranunculaceae).” Mol Ecol 18, no. 4 (February 2009): 709–21. https://doi.org/10.1111/j.1365-294X.2008.04055.x.
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    • Zheng, Wei, Liuyang Wang, Lihua Meng, and Jianquan Liu. “Genetic variation in the endangered Anisodus tanguticus (Solanaceae), an alpine perennial endemic to the Qinghai-Tibetan Plateau.” Genetica 132, no. 2 (February 2008): 123–29. https://doi.org/10.1007/s10709-007-9154-5.
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