Scholars@Duke

• Background
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  Duke Appointment History

  • Assistant Research Professor of Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2019 - 2021
• Research
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  Selected Grants

  • Human Genetic Variance and Cellular Responses to Sexually Transmitted Infections awarded by University of Maryland 2009 - 2019
• Publications & Artistic Works
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  Selected Publications

  • Academic Articles

    • Wang, L., Balmat, T. J., Antonia, A. L., Constantine, F. J., Henao, R., Burke, T. W., … Ko, D. C. (2021). An atlas connecting shared genetic architecture of human diseases and molecular phenotypes provides insight into COVID-19 susceptibility. Genome Med, 13(1), 83. https://doi.org/10.1186/s13073-021-00904-z
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    • Wang, L., Balmat, T. J., Antonia, A. L., Constantine, F. J., Henao, R., Burke, T. W., … Ko, D. C. (2020). An atlas connecting shared genetic architecture of human diseases and molecular phenotypes provides insight into COVID-19 susceptibility. Medrxiv. https://doi.org/10.1101/2020.12.20.20248572
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    • Schott, B. H., Antonia, A. L., Wang, L., Pittman, K. J., Sixt, B. S., Barnes, A. B., … Ko, D. C. (2020). Modeling of variables in cellular infection reveals CXCL10 levels are regulated by human genetic variation and the Chlamydia-encoded CPAF protease. Sci Rep, 10(1), 18269. https://doi.org/10.1038/s41598-020-75129-y
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    • Xie, L., Wang, L., Zhu, W., Zhao, J., & Guo, X. (2020). Editorial: Bioinformatics Tools (and Web Server) for Cancer Biomarker Development. Frontiers in Oncology, 10, 599085. https://doi.org/10.3389/fonc.2020.599085
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    • Zhang, Y., Mudgal, P., Wang, L., Wu, H., Huang, N., Alexander, P. B., … Li, Q.-J. (2020). T cell receptor repertoire as a prognosis marker for heat shock protein peptide complex-96 vaccine trial against newly diagnosed glioblastoma. Oncoimmunology, 9(1), 1749476. https://doi.org/10.1080/2162402X.2020.1749476
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    • Zhang, Y., Xu, Y., Chen, H., Wang, L., Yin, K., & Du, F. K. (2019). Comparative Genomic Analysis Reveals the Mechanism Driving the Diversification of Plastomic Structure in Taxaceae Species. Frontiers in Genetics, 10, 1295. https://doi.org/10.3389/fgene.2019.01295
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    • Yang, F., Xiao, P., Qu, C.-X., Liu, Q., Wang, L.-Y., Liu, Z.-X., … Wang, J. (2018). Allosteric mechanisms underlie GPCR signaling to SH3-domain proteins through arrestin. Nature Chemical Biology, 14(9), 876–886. https://doi.org/10.1038/s41589-018-0115-3
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    • Wang, L., Pittman, K. J., Barker, J. R., Salinas, R. E., Stanaway, I. B., Williams, G. D., … Ko, D. C. (2018). An Atlas of Genetic Variation Linking Pathogen-Induced Cellular Traits to Human Disease. Cell Host Microbe, 24(2), 308-323.e6. https://doi.org/10.1016/j.chom.2018.07.007
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    • Jaslow, S. L., Gibbs, K. D., Fricke, W. F., Wang, L., Pittman, K. J., Mammel, M. K., … Ko, D. C. (2018). Salmonella Activation of STAT3 Signaling by SarA Effector Promotes Intracellular Replication and Production of IL-10. Cell Rep, 23(12), 3525–3536. https://doi.org/10.1016/j.celrep.2018.05.072
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    • Cai, Z., Wang, L., Song, X., Tagore, S., Li, X., Wang, H., … Nevo, E. (2018). Adaptive Transcriptome Profiling of Subterranean Zokor, Myospalax baileyi, to High- Altitude Stresses in Tibet. Scientific Reports, 8(1), 4671. https://doi.org/10.1038/s41598-018-22483-7
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    • Antonia, A. L., Wang, L., & Ko, D. C. (2018). A real-time PCR assay for quantification of parasite burden in murine models of leishmaniasis. Peerj, 6, e5905. https://doi.org/10.7717/peerj.5905
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    • Corona, E., Wang, L., Ko, D., & Patel, C. J. (2018). Systematic detection of positive selection in the human-pathogen interactome and lasting effects on infectious disease susceptibility. Plos One, 13(5), e0196676. https://doi.org/10.1371/journal.pone.0196676
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    • Alvarez, M. I., Glover, L. C., Luo, P., Wang, L., Theusch, E., Oehlers, S. H., … Ko, D. C. (2017). Human genetic variation in VAC14 regulates Salmonella invasion and typhoid fever through modulation of cholesterol. Proc Natl Acad Sci U S A, 114(37), E7746–E7755. https://doi.org/10.1073/pnas.1706070114
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    • Sun, S., Yadav, V., Billmyre, R. B., Cuomo, C. A., Nowrousian, M., Wang, L., … Heitman, J. (2017). Fungal genome and mating system transitions facilitated by chromosomal translocations involving intercentromeric recombination. Plos Biol, 15(8), e2002527. https://doi.org/10.1371/journal.pbio.2002527
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    • Lotterhos, K. E., Card, D. C., Schaal, S. M., Wang, L., Collins, C., & Verity, B. (2017). Composite measures of selection can improve the signal-to-noise ratio in genome scans. Methods in Ecology and Evolution, 8(6), 717–727. https://doi.org/10.1111/2041-210X.12774
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    • Galarza-Muñoz, G., Briggs, F. B. S., Evsyukova, I., Schott-Lerner, G., Kennedy, E. M., Nyanhete, T., … Garcia-Blanco, M. A. (2017). Human Epistatic Interaction Controls IL7R Splicing and Increases Multiple Sclerosis Risk. Cell, 169(1), 72-84.e13. https://doi.org/10.1016/j.cell.2017.03.007
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    • Wang, L., Ko, E. R., Gilchrist, J. J., Pittman, K. J., Rautanen, A., Pirinen, M., … Ko, D. C. (2017). Human genetic and metabolite variation reveals that methylthioadenosine is a prognostic biomarker and an inflammatory regulator in sepsis. Sci Adv, 3(3), e1602096. https://doi.org/10.1126/sciadv.1602096
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    • Oehlers, S. H., Flores, M. V., Hall, C. J., Wang, L., Ko, D. C., Crosier, K. E., & Crosier, P. S. (2017). A whole animal chemical screen approach to identify modifiers of intestinal neutrophilic inflammation. Febs J, 284(3), 402–413. https://doi.org/10.1111/febs.13976
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    • Verity, R., Collins, C., Card, D. C., Schaal, S. M., Wang, L., & Lotterhos, K. E. (2017). minotaur: A platform for the analysis and visualization of multivariate results from genome scans with R Shiny. Molecular Ecology Resources, 17(1), 33–43. https://doi.org/10.1111/1755-0998.12579
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    • Li, K., Wang, H., Cai, Z., Wang, L., Xu, Q., Lövy, M., … Nevo, E. (2016). Sympatric speciation of spiny mice, Acomys, unfolded transcriptomically at Evolution Canyon, Israel. Proceedings of the National Academy of Sciences of the United States of America, 113(29), 8254–8259. https://doi.org/10.1073/pnas.1608743113
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    • Li, K., Wang, L., Knisbacher, B. A., Xu, Q., Levanon, E. Y., Wang, H., … Nevo, E. (2016). Transcriptome, genetic editing, and microRNA divergence substantiate sympatric speciation of blind mole rat, Spalax. Proceedings of the National Academy of Sciences of the United States of America, 113(27), 7584–7589. https://doi.org/10.1073/pnas.1607497113
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    • Pittman, K. J., Glover, L. C., Wang, L., & Ko, D. C. (2016). The Legacy of Past Pandemics: Common Human Mutations That Protect against Infectious Disease. Plos Pathog, 12(7), e1005680. https://doi.org/10.1371/journal.ppat.1005680
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    • Jaslow, S., Wang, L., & Ko, D. (2015). Contribution to Virulence of a Novel Anti-inflammatory Effector in Salmonella enterica. Open Forum Infect Dis, 2(Suppl 1), 693. https://doi.org/10.1093/ofid/ofv131.68
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    • Redelings, B. D., Kumagai, S., Tatarenkov, A., Wang, L., Sakai, A. K., Weller, S. G., … Uyenoyama, M. K. (2015). A Bayesian Approach to Inferring Rates of Selfing and Locus-Specific Mutation. Genetics, 201(3), 1171–1188. https://doi.org/10.1534/genetics.115.179093
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    • Wang, L., Oehlers, S. H., Espenschied, S. T., Rawls, J. F., Tobin, D. M., & Ko, D. C. (2015). CPAG: software for leveraging pleiotropy in GWAS to reveal similarity between human traits links plasma fatty acids and intestinal inflammation. Genome Biol, 16, 190. https://doi.org/10.1186/s13059-015-0722-1
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    • Chen, Y., Litvintseva, A. P., Frazzitta, A. E., Haverkamp, M. R., Wang, L., Fang, C., … Perfect, J. R. (2015). Comparative analyses of clinical and environmental populations of Cryptococcus neoformans in Botswana. Mol Ecol, 24(14), 3559–3571. https://doi.org/10.1111/mec.13260
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    • Meng, L., Chen, G., Li, Z., Yang, Y., Wang, Z., & Wang, L. (2015). Refugial isolation and range expansions drive the genetic structure of Oxyria sinensis (Polygonaceae) in the Himalaya-Hengduan Mountains. Scientific Reports, 5, 10396. https://doi.org/10.1038/srep10396
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    • Janoušek, V., Munclinger, P., Wang, L., Teeter, K. C., & Tucker, P. K. (2015). Functional organization of the genome may shape the species boundary in the house mouse. Molecular Biology and Evolution, 32(5), 1208–1220. https://doi.org/10.1093/molbev/msv011
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    • Gao, D., Ko, D. C., Tian, X., Yang, G., & Wang, L. (2015). Expression Divergence of Duplicate Genes in the Protein Kinase Superfamily in Pacific Oyster. Evol Bioinform Online, 11(Suppl 1), 57–65. https://doi.org/10.4137/EBO.S30230
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    • Han, X., Chen, Y., Wang, L., Fang, W., Zhang, N., & Zhu, Q. (2015). RNA: An Expanding View of Function and Evolution. Evolutionary Bioinformatics Online, 11(Suppl 1), 77–79. https://doi.org/10.4137/ebo.s38105
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    • Wang, L., Wang, Z., Chen, J., Liu, C., Zhu, W., & Meng, L. (2015). De Novo Transcriptome Assembly and Development of Novel Microsatellite Markers for the Traditional Chinese Medicinal Herb, Veratrilla baillonii Franch (Gentianaceae). Evolutionary Bioinformatics Online, 11(Suppl 1), 39–45. https://doi.org/10.4137/ebo.s20942
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    • Zhou, Z., Ma, H., Lin, K., Zhao, Y., Chen, Y., Xiong, Z., … Tian, B. (2015). RNA-seq Reveals Complicated Transcriptomic Responses to Drought Stress in a Nonmodel Tropic Plant, Bombax ceiba L. Evolutionary Bioinformatics Online, 11(Suppl 1), 27–37. https://doi.org/10.4137/ebo.s20620
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    • Kass, D. H., Janoušek, V., Wang, L., & Tucker, P. K. (2014). The uncharacterized gene 1700093K21Rik and flanking regions are correlated with reproductive isolation in the house mouse, Mus musculus. Mammalian Genome : Official Journal of the International Mammalian Genome Society, 25(5–6), 223–234. https://doi.org/10.1007/s00335-014-9506-2
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    • Janoušek, V., Wang, L., Luzynski, K., Dufková, P., Vyskočilová, M. M., Nachman, M. W., … Tucker, P. K. (2012). Genome-wide architecture of reproductive isolation in a naturally occurring hybrid zone between Mus musculus musculus and M. m. domesticus. Molecular Ecology, 21(12), 3032–3047. https://doi.org/10.1111/j.1365-294x.2012.05583.x
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    • Wang, L., Luzynski, K., Pool, J. E., Janoušek, V., Dufková, P., Vyskočilová, M. M., … Tucker, P. K. (2011). Measures of linkage disequilibrium among neighbouring SNPs indicate asymmetries across the house mouse hybrid zone. Molecular Ecology, 20(14), 2985–3000. https://doi.org/10.1111/j.1365-294x.2011.05148.x
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    • JIA, D. O. N. G. U. I., LIU, T. E. N. G. I. A. N. G., WANG, L. I. U. A. N. G., ZHOU, D. A. N. G. E. I., & LIU, J. I. A. N. U. A. N. (2011). Evolutionary history of an alpine shrub Hippophae tibetana (Elaeagnaceae): allopatric divergence and regional expansion. Biological Journal of the Linnean Society. Linnean Society of London, 102(1), 37–50. https://doi.org/10.1111/j.1095-8312.2010.01553.x
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    • Tang, L.-Z., Wang, L.-Y., Cai, Z.-Y., Zhang, T.-Z., Ci, H.-X., Lin, G.-H., … Liu, J.-Q. (2010). Allopatric divergence and phylogeographic structure of the plateau zokor (Eospalax baileyi), a fossorial rodent endemic to the Qinghai-Tibetan Plateau. Journal of Biogeography., 37(4), 657–668. https://doi.org/10.1111/j.1365-2699.2009.02232.x
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    • Wang, L. Y., Kou, Y. X., Wu, G. L., & Wang, Y. J. (2009). Development and characterization of novel microsatellite markers isolated from potentilla fruticosa L. (Rosaceae), and cross-species amplification in its sister species-Potentilla glabra L. Conservation Genetics Resources, 1(1), 51–53. https://doi.org/10.1007/s12686-009-9012-0
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    • Tian, B., Liu, R., Wang, L., Qiu, Q., Chen, K., & Liu, J. (2009). Phylogeographic analyses suggest that a deciduous species (Ostryopsis davidiana Decne., Betulaceae) survived in northern China during the Last Glacial Maximum. Journal of Biogeography., 36(11), 2148–2155. https://doi.org/10.1111/j.1365-2699.2009.02157.x
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    • Wang, L. Y., Pelser, P. B., Nordenstam, B., & Liu, J. Q. (2009). Strong incongruence between the ITs phylogeny and generic delimitation in the Nemosenecio-Sinosenecio-Tephroseris assemblage (Asteraceae: Senecioneae). Botanical Studies, 50(4), 435–442.
    • YIN, H.-J., WANG, L.-Y., GAO, Q., GAO, D.-H., ZHANG, D.-Y., & LIU, J.-Q. (2009). cDNA Library Construction and Expressed Sequence Tags(ESTs) Analyses of an Alpine Plant Species Gentiana officinalis(Gentianaceae). Acta Botanica Yunnanica, 31(2), 146–152. https://doi.org/10.3724/sp.j.1143.2009.08181
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    • Wang, L.-Y., Ikeda, H., Liu, T.-L., Wang, Y.-J., & Liu, J.-Q. (2009). Repeated range expansion and glacial endurance of Potentilla glabra (Rosaceae) in the Qinghai-Tibetan plateau. Journal of Integrative Plant Biology, 51(7), 698–706. https://doi.org/10.1111/j.1744-7909.2009.00818.x
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    • Wang, L., Abbott, R. J., Zheng, W., Chen, P., Wang, Y., & Liu, J. (2009). History and evolution of alpine plants endemic to the Qinghai-Tibetan Plateau: Aconitum gymnandrum (Ranunculaceae). Molecular Ecology, 18(4), 709–721. https://doi.org/10.1111/j.1365-294x.2008.04055.x
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    • Li, X., Wang, L., Yang, H., & Liu, J. (2008). Confirmation of natural hybrids between Gentiana straminea and G. siphonantha (Gentianaceae) based on molecular evidence. Frontiers of Biology in China, 3(4), 470–476. https://doi.org/10.1007/s11515-008-0076-0
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    • Zheng, W., Wang, L., Meng, L., & Liu, J. (2008). Genetic variation in the endangered Anisodus tanguticus (Solanaceae), an alpine perennial endemic to the Qinghai-Tibetan Plateau. Genetica, 132(2), 123–129. https://doi.org/10.1007/s10709-007-9154-5
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  • Book Sections

    • Tucker, P. K., Wang, L., Luzynski, K., & Teeter, K. (2012). Linkage disequilibrium approaches for detecting hybrid zone movement: A study of the house mouse hybrid zone in southern bavaria. In Evolution of the House Mouse (pp. 504–518). https://doi.org/10.1017/CBO9781139044547.022
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