Lori Ann Orlando
Professor of Medicine
Dr. Lori A. Orlando, MD MHS MMCI is a Professor of Medicine and Director of the Precision Medicine Program in the Center for Applied Genomics and Precision Medicine at Duke University. She attended Tulane Medical Center for both medical school (1994-1998) and Internal Medicine residency (1998-2000). There she finished AOA and received a number of awards for teaching and clinical care from the medical school and the residency programs, including the Musser-Burch-Puschett award in 2000 for academic excellence. After completing her residency, she served as Chief Medical Resident in Internal Medicine (2001) and then completed a Health Services Research Fellowship at Duke University Medical Center (2002-2004). In 2004 she also received her MHS from the Clinical Research Training Program at Duke University and joined the academic faculty at Duke. In 2005 she received the Milton W. Hamolsky Award for Outstanding Junior Faculty by the Society of General Internal Medicine. Her major research interests are decision making and patient preferences, implementation research, risk stratification for targeting preventive health services, and decision modeling. From 2004-2009 she worked with Dr. David Matchar in the Center for Clinical Heath Policy Research (CCHPR), where she specialized in decision modeling, decision making, and technology assessments. In 2009 she began working with Dr. Geoffrey Ginsburg in what is now the Center for Applied Genomics and Precision Medicine (CAGPM) and in 2014 she became the director of the Center’s Precision Medicine Program. Since joining the CAGPM she has been leading the development and implementation of MeTree, a patient-facing family health history based risk assessment and clinical decision support program designed to facilitate the uptake of risk stratified evidence-based guidelines. MeTree was designed to overcome the major barriers to collecting and using high quality family health histories to guide clinical care and has been shown to be highly effective when integrated into primary care practices. This effort started with the Genomic Medicine Model, a multi-institutional project, whose goal was to implement personalized medicine in primary care practices. The success of that project has led to funding as part of NHGRI’s IGNITE (Implementing Genomics in Clinical Practice) network. She is currently testing methods for integrating patient preferences and decision making processes into clinical decision support recommendations for patients and providers to facilitate management of patients’ risk for chronic disease using mHealth and other behavioral interventions.
Current Research Interests
Current Appointments & Affiliations
- Professor of Medicine, Medicine, General Internal Medicine, Medicine 2021
- Associate Director of Duke Center for Applied Genomics and Precision Medicine, Duke Center for Applied Genomics and Precision Medicine, Medicine 2014
Contact Information
- 102906, Aesthetic Center 2nd Floor, Durham, NC 27705
- 3475 Erwin Rd, 2nd Floor Aesthetics Bldg, Durham, NC 27705
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orlan002@duke.edu
(919) 660-6606
- Background
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Education, Training, & Certifications
- M.M.C.i., Duke University, Fuqua School of Business 2019
- Fellow in General Internal Medicine, Medicine, Duke University 2002 - 2004
- M.H.S., Duke University 2004
- Chief Medical Resident, Medicine, Tulane University 2001 - 2002
- Medical Resident, Medicine, Tulane University 1998 - 2001
- M.D., Tulane University 1998
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Previous Appointments & Affiliations
- Associate Professor of Medicine, Medicine, General Internal Medicine, Medicine 2014 - 2021
- Assistant Professor of Medicine, Medicine, General Internal Medicine, Medicine 2013
- Assistant Professor of Medicine, Medicine, General Internal Medicine, Medicine 2006 - 2013
- Associate in the Department of Medicine, Medicine, General Internal Medicine, Medicine 2004 - 2006
- Recognition
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In the News
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FEB 15, 2022 Center for Applied Genomics and Precision Medicine -
NOV 1, 2018 Duke Health News -
MAR 4, 2016 Duke Today -
MAR 4, 2016 -
NOV 19, 2014
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- Expertise
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Subject Headings
- Adult
- Arthroscopy
- Cardiovascular Diseases
- Cohort Studies
- Comorbidity
- Cytochrome P-450 CYP2D6
- Decision Making, Computer-Assisted
- Decision Support Systems, Clinical
- Decision Support Techniques
- Decision Trees
- Electronic Health Records
- Evidence-Based Medicine
- False Negative Reactions
- False Positive Reactions
- Family
- Family Health
- Female
- Gene Expression Profiling
- Genetic Testing
- Genetic Variation
- Genetics, Medical
- Genomics
- Genotype
- Health Care Costs
- Health Services
- Health Services Accessibility
- Health Services Needs and Demand
- Health Services Research
- Health Surveys
- Individualized Medicine
- Internet
- Male
- Markov Chains
- Medical History Taking
- Medical Records Systems, Computerized
- Monte Carlo Method
- North Carolina
- Osteoarthritis
- Patient education
- Pedigree
- Pharmacogenetics
- Physical Examination
- Physicians, Primary Care
- Polymorphism, Genetic
- Primary Health Care
- Quality of Life
- Quality-Adjusted Life Years
- Risk Assessment
- Risk Factors
- Rupture
- Rupture, Spontaneous
- Sensitivity and Specificity
- Shoulder Dislocation
- Time Factors
- Total Quality Management
- Treatment Outcome
- United States
- Research
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Selected Grants
- Deploying a genomic-medicine risk assessment model for diverse primary care populations and settings awarded by National Institutes of Health 2021 - 2026
- Engaging Multidisciplinary Health System Stakeholders to Create a Process for Implementing Machine-Learning Enabled Clinical Decision Support awarded by National Institutes of Health 2022 - 2024
- Building and Deploying a Genomic-Medicine Risk Assessment Model for Diverse Primary Care Populations. awarded by National Institutes of Health 2018 - 2023
- Postdoctoral Training in Genomic Medicine Research awarded by National Institutes of Health 2017 - 2023
- The Electronic Medical Records and Genomics (eMERGE) Genomic Risk Assessment and Management Network-Coordinating Center awarded by Vanderbilt University Medical Center 2020 - 2023
- Implementing Pharmacogenomics in Diverse Health Care Systems awarded by National Institutes of Health 2021 - 2022
- Improving identification and healthcare for patients with Inherited Cancer Syndromes: Evidence-based EMR implementation using a web-based computer platform awarded by Vanderbilt University Medical Center 2019 - 2022
- VGER, The Vanderbilt Genome-Electronic Records Project awarded by Vanderbilt University Medical Center 2018 - 2020
- Implementation, Adoption, and Utility of Family History in Diverse Care Settings awarded by National Institutes of Health 2013 - 2019
- VA Metree Subaward awarded by Durham Veterans Affairs Medical Center 2016 - 2019
- Genome Medical Pilot awarded by Genome Medical, Inc 2017
- Comparative Effectiveness Reveiws for MMA Section 1013 awarded by Agency for Healthcare Research and Quality 2005 - 2008
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External Relationships
- MeTree&You
- Publications & Artistic Works
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Selected Publications
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Books
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Henrich, V. C., Orlando, L. A., & Shirts, B. H. (2020). Managing Health in the Genomic Era: A Guide to Family Health History and Disease Risk (pp. 1–221). https://doi.org/10.1016/C2017-0-01313-7Full Text
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Academic Articles
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Voils, C. I., Coffman, C. J., Wu, R. R., Grubber, J. M., Fisher, D. A., Strawbridge, E. M., … Goldstein, K. M. (2022). A Cluster Randomized Trial of a Family Health History Platform to Identify and Manage Patients at Increased Risk for Colorectal Cancer. J Gen Intern Med. https://doi.org/10.1007/s11606-022-07787-9Full Text Link to Item
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Cavallari, L. H., Cicali, E., Wiisanen, K., Fillingim, R. B., Chakraborty, H., Myers, R. A., … IGNITE Pragmatic Trials Network, . (2022). Implementing a pragmatic clinical trial to tailor opioids for acute pain on behalf of the IGNITE ADOPT PGx investigators. Clin Transl Sci, 15(10), 2479–2492. https://doi.org/10.1111/cts.13376Full Text Link to Item
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Eadon, M. T., Cavanaugh, K. L., Orlando, L. A., Christian, D., Chakraborty, H., Steen-Burrell, K.-A., … GUARDD-US Investigators, . (2022). Design and rationale of GUARDD-US: A pragmatic, randomized trial of genetic testing for APOL1 and pharmacogenomic predictors of antihypertensive efficacy in patients with hypertension. Contemp Clin Trials, 119, 106813. https://doi.org/10.1016/j.cct.2022.106813Full Text Link to Item
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Livingood, W. C., Bautista, M. A. B., Smotherman, C., Azueta, D., Coleman, J., Grewal, R., … Scuderi, C. (2022). Comparative study of different SES neighborhood clinics for health literacy and internet access. Digit Health, 8, 20552076221123716. https://doi.org/10.1177/20552076221123715Full Text Link to Item
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Yoon, S., Goh, H., Fung, S. M., Tang, S., Matchar, D., Ginsburg, G. S., … Wu, R. R. (2021). Experience and Perceptions of a Family Health History Risk Assessment Tool among Multi-Ethnic Asian Breast Cancer Patients. J Pers Med, 11(10). https://doi.org/10.3390/jpm11101046Full Text Open Access Copy Link to Item
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Levy, K. D., Blake, K., Fletcher-Hoppe, C., Franciosi, J., Goto, D., Hicks, J. K., … Ginsburg, G. S. (2021). Correction: Opportunities to implement a sustainable genomic medicine program: lessons learned from the IGNITE Network. Genet Med, 23(10), 2020. https://doi.org/10.1038/s41436-020-01054-0Full Text Link to Item
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Chung, W. K., Brothers, K., Bradbury, A., Chanprasert, S., Orlando, L., Torkamani, A., … Ramos, E. M. (2021). Genomic medicine implementation protocols in the PhenX Toolkit: tools for standardized data collection. Genet Med, 23(9), 1783–1788. https://doi.org/10.1038/s41436-021-01183-0Full Text Link to Item
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Sperber, N. R., Dong, O. M., Roberts, M. C., Dexter, P., Elsey, A. R., Ginsburg, G. S., … Orlando, L. A. (2021). Strategies to Integrate Genomic Medicine into Clinical Care: Evidence from the IGNITE Network. J Pers Med, 11(7). https://doi.org/10.3390/jpm11070647Full Text Link to Item
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Bylstra, Y., Lim, W. K., Kam, S., Tham, K. W., Wu, R. R., Teo, J. X., … Tan, P. (2021). Correction to: Family history assessment significantly enhances delivery of precision medicine in the genomics era. Genome Med, 13(1), 109. https://doi.org/10.1186/s13073-021-00916-9Full Text Link to Item
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Ginsburg, G. S., Cavallari, L. H., Chakraborty, H., Cooper-DeHoff, R. M., Dexter, P. R., Eadon, M. T., … IGNITE PTN, . (2021). Establishing the value of genomics in medicine: the IGNITE Pragmatic Trials Network. Genet Med, 23(7), 1185–1191. https://doi.org/10.1038/s41436-021-01118-9Full Text Open Access Copy Link to Item
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Schneider, T. M., Eadon, M. T., Cooper-DeHoff, R. M., Cavanaugh, K. L., Nguyen, K. A., Arwood, M. J., … Kannry, J. L. (2021). Multi-Institutional Implementation of Clinical Decision Support for APOL1, NAT2, and YEATS4 Genotyping in Antihypertensive Management. J Pers Med, 11(6). https://doi.org/10.3390/jpm11060480Full Text Link to Item
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Fung, S. M., Wu, R. R., Myers, R. A., Goh, J., Ginsburg, G. S., Matchar, D., … Ngeow, J. (2021). Clinical implementation of an oncology-specific family health history risk assessment tool. Hered Cancer Clin Pract, 19(1), 20. https://doi.org/10.1186/s13053-021-00177-yFull Text Open Access Copy Link to Item
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Bylstra, Y., Lim, W. K., Kam, S., Tham, K. W., Wu, R. R., Teo, J. X., … Tan, P. (2021). Family history assessment significantly enhances delivery of precision medicine in the genomics era. Genome Med, 13(1), 3. https://doi.org/10.1186/s13073-020-00819-1Full Text Link to Item
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Lau, B. C., Hutyra, C. A., Streufert, B., Reed, S. D., Orlando, L. A., Huber, J. C., … Mather, R. C. (2020). Surgeon Applications of Patient Preferences in Treatment Decision Making for First-Time Anterior Shoulder Dislocation. Orthop J Sports Med, 8(12), 2325967120966145. https://doi.org/10.1177/2325967120966145Full Text Open Access Copy Link to Item
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Orlando, L. A., Wu, R. R., Myers, R. A., Neuner, J., McCarty, C., Haller, I. V., … Ginsburg, G. S. (2020). At the intersection of precision medicine and population health: an implementation-effectiveness study of family health history based systematic risk assessment in primary care. Bmc Health Services Research, 20(1), 1015. https://doi.org/10.1186/s12913-020-05868-1Full Text
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Luvsantseren, S., Whirl-Carrillo, M., Sangkuhl, K., Shin, N., Wen, A., Empey, P., … Palaniappan, L. (2020). Variant Interpretation in Current Pharmacogenetic Testing. J Pers Med, 10(4). https://doi.org/10.3390/jpm10040204Full Text Link to Item
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Levy, K. D., Blake, K., Fletcher-Hoppe, C., Franciosi, J., Goto, D., Hicks, J. K., … Ginsburg, G. S. (2020). Correction: Opportunities to implement a sustainable genomic medicine program: lessons learned from the IGNITE Network. Genet Med, 22(10), 1730. https://doi.org/10.1038/s41436-020-0911-5Full Text Link to Item
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Orlando, L. A., Sperber, N. R., Voils, C., Nichols, M., Myers, R. A., Wu, R. R., … IGNITE Network, . (2020). Correction: Developing a common framework for evaluating the implementation of genomic medicine interventions in clinical care: the IGNITE Network's Common Measures Working Group. Genet Med, 22(10), 1729. https://doi.org/10.1038/s41436-020-0910-6Full Text Link to Item
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Wu, R. R., Sultana, R., Bylstra, Y., Jamuar, S., Davila, S., Lim, W. K., … Tan, P. (2020). Evaluation of family health history collection methods impact on data and risk assessment outcomes. Prev Med Rep, 18, 101072. https://doi.org/10.1016/j.pmedr.2020.101072Full Text Link to Item
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Haga, S. B., & Orlando, L. A. (2020). The enduring importance of family health history in the era of genomic medicine and risk assessment. Per Med, 17(3), 229–239. https://doi.org/10.2217/pme-2019-0091Full Text Open Access Copy Link to Item
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Bylstra, Y., Lim, W. K., Kam, S., Tham, K. W., Wu, R. R., Teo, J. X., … Tan, P. (2020). Family History Assessment Significantly Enhances Delivery of Precision Medicine in the Genomics Era. https://doi.org/10.1101/2020.01.29.926139Full Text
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Neuner, J., Dimmock, D., Kirschner, A. L. P., Beaudry, H., Paradowski, J., & Orlando, L. (2020). Results and Lessons of a Pilot Study of Cascade Screening for Familial Hypercholesterolemia in US Primary Care Practices. J Gen Intern Med, 35(1), 351–353. https://doi.org/10.1007/s11606-019-05485-7Full Text Link to Item
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Goldstein, K. M., Fisher, D. A., Wu, R. R., Orlando, L. A., Coffman, C. J., Grubber, J. M., … Voils, C. I. (2019). An electronic family health history tool to identify and manage patients at increased risk for colorectal cancer: protocol for a randomized controlled trial. Trials, 20(1), 576. https://doi.org/10.1186/s13063-019-3659-yFull Text Link to Item
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Ginsburg, G. S., Wu, R. R., & Orlando, L. A. (2019). Family health history: underused for actionable risk assessment. Lancet, 394(10198), 596–603. https://doi.org/10.1016/S0140-6736(19)31275-9Full Text Link to Item
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Peterson, J. F., Roden, D. M., Orlando, L. A., Ramirez, A. H., Mensah, G. A., & Williams, M. S. (2019). Building evidence and measuring clinical outcomes for genomic medicine. Lancet, 394(10198), 604–610. https://doi.org/10.1016/S0140-6736(19)31278-4Full Text Link to Item
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Ginsburg, G. S., Horowitz, C. R., & Orlando, L. A. (2019). What will it take to implement genomics in practice? Lessons from the IGNITE Network. Per Med, 16(4), 259–261. https://doi.org/10.2217/pme-2019-0021Full Text Link to Item
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Levy, K. D., Blake, K., Fletcher-Hoppe, C., Franciosi, J., Goto, D., Hicks, J. K., … Ginsburg, G. S. (2019). Correction: Opportunities to implement a sustainable genomic medicine program: lessons learned from the IGNITE Network. Genet Med, 21(7), 1670. https://doi.org/10.1038/s41436-018-0280-5Full Text Link to Item
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Zebrowski, A. M., Ellis, D. E., Barg, F. K., Sperber, N. R., Bernhardt, B. A., Denny, J. C., … Kimmel, S. E. (2019). Qualitative study of system-level factors related to genomic implementation. Genet Med, 21(7), 1534–1540. https://doi.org/10.1038/s41436-018-0378-9Full Text Link to Item
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Horowitz, C. R., Orlando, L. A., Slavotinek, A. M., Peterson, J., Angelo, F., Biesecker, B., … Sanderson, S. C. (2019). The Genomic Medicine Integrative Research Framework: A Conceptual Framework for Conducting Genomic Medicine Research. Am J Hum Genet, 104(6), 1088–1096. https://doi.org/10.1016/j.ajhg.2019.04.006Full Text Link to Item
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Orlando, L. A., Voils, C., Horowitz, C. R., Myers, R. A., Arwood, M. J., Cicali, E. J., … Madden, E. B. (2019). IGNITE network: Response of patients to genomic medicine interventions. Mol Genet Genomic Med, 7(5), e636. https://doi.org/10.1002/mgg3.636Full Text Link to Item
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Hutyra, C. A., Smiley, S., Taylor, D. C., Orlando, L. A., & Mather, R. C. (2019). Efficacy of a Preference-Based Decision Tool on Treatment Decisions for a First-Time Anterior Shoulder Dislocation: A Randomized Controlled Trial of At-Risk Patients. Med Decis Making, 39(3), 253–263. https://doi.org/10.1177/0272989X19832915Full Text Link to Item
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Wu, R. R., Myers, R. A., Buchanan, A. H., Dimmock, D., Fulda, K. G., Haller, I. V., … Orlando, L. A. (2019). Effect of Sociodemographic Factors on Uptake of a Patient-Facing Information Technology Family Health History Risk Assessment Platform. Appl Clin Inform, 10(2), 180–188. https://doi.org/10.1055/s-0039-1679926Full Text Link to Item
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Levy, K. D., Blake, K., Fletcher-Hoppe, C., Franciosi, J., Goto, D., Hicks, J. K., … Ginsburg, G. S. (2019). Opportunities to implement a sustainable genomic medicine program: lessons learned from the IGNITE Network. Genet Med, 21(3), 743–747. https://doi.org/10.1038/s41436-018-0080-yFull Text Link to Item
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Wu, R. R., Myers, R. A., Sperber, N., Voils, C. I., Neuner, J., McCarty, C. A., … Orlando, L. A. (2019). Implementation, adoption, and utility of family health history risk assessment in diverse care settings: evaluating implementation processes and impact with an implementation framework. Genet Med, 21(2), 331–338. https://doi.org/10.1038/s41436-018-0049-xFull Text Link to Item
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Hutyra, C. A., Streufert, B., Politzer, C. S., Agaba, P., Rubin, E., Orlando, L. A., … Mather, R. C. (2019). Assessing the Effectiveness of Evidence-Based Medicine in Practice: A Case Study of First-Time Anterior Shoulder Dislocations. J Bone Joint Surg Am, 101(2), e6. https://doi.org/10.2106/JBJS.17.01588Full Text Link to Item
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Madhavan, S., Bullis, E., Myers, R., Zhou, C. J., Cai, E. M., Sharma, A., … Haga, S. B. (2019). Awareness of family health history in a predominantly young adult population. Plos One, 14(10), e0224283. https://doi.org/10.1371/journal.pone.0224283Full Text Link to Item
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Tillekeratne, L. G., Bodinayake, C., Nagahawatte, A., Kurukulasooriya, R., Orlando, L. A., Simmons, R. A., … Reed, S. D. (2019). Use of clinical algorithms and rapid influenza testing to manage influenza-like illness: a cost-effectiveness analysis in Sri Lanka. Bmj Glob Health, 4(2), e001291. https://doi.org/10.1136/bmjgh-2018-001291Full Text Link to Item
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Orlando, L. A., Sperber, N. R., Voils, C., Nichols, M., Myers, R. A., Wu, R. R., … Damschroder, L. J. (2018). Developing a common framework for evaluating the implementation of genomic medicine interventions in clinical care: the IGNITE Network's Common Measures Working Group. Genetics in Medicine : Official Journal of the American College of Medical Genetics, 20(6), 655–663. https://doi.org/10.1038/gim.2017.144Full Text
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Phillips, K. A., Deverka, P. A., Sox, H. C., Khoury, M. J., Sandy, L. G., Ginsburg, G. S., … Douglas, M. P. (2017). Making genomic medicine evidence-based and patient-centered: a structured review and landscape analysis of comparative effectiveness research. Genet Med, 19(10), 1081–1091. https://doi.org/10.1038/gim.2017.21Full Text Open Access Copy Link to Item
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Sperber, N. R., Carpenter, J. S., Cavallari, L. H., J Damschroder, L., Cooper-DeHoff, R. M., Denny, J. C., … Orlando, L. A. (2017). Challenges and strategies for implementing genomic services in diverse settings: experiences from the Implementing GeNomics In pracTicE (IGNITE) network. Bmc Med Genomics, 10(1), 35. https://doi.org/10.1186/s12920-017-0273-2Full Text Open Access Copy Link to Item
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Streufert, B., Reed, S. D., Orlando, L. A., Taylor, D. C., Huber, J. C., & Mather, R. C. (2017). Understanding Preferences for Treatment After Hypothetical First-Time Anterior Shoulder Dislocation: Surveying an Online Panel Utilizing a Novel Shared Decision-Making Tool. Orthop J Sports Med, 5(3), 2325967117695788. https://doi.org/10.1177/2325967117695788Full Text Open Access Copy Link to Item
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Wu, R. R., Myers, R. A., Hauser, E. R., Vorderstrasse, A., Cho, A., Ginsburg, G. S., & Orlando, L. A. (2017). Impact of Genetic Testing and Family Health History Based Risk Counseling on Behavior Change and Cognitive Precursors for Type 2 Diabetes. J Genet Couns, 26(1), 133–140. https://doi.org/10.1007/s10897-016-9988-zFull Text Open Access Copy Link to Item
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Orlando, L. A., Wu, R. R., Myers, R. A., Buchanan, A. H., Henrich, V. C., Hauser, E. R., & Ginsburg, G. S. (2016). Clinical utility of a Web-enabled risk-assessment and clinical decision support program. Genet Med, 18(10), 1020–1028. https://doi.org/10.1038/gim.2015.210Full Text Open Access Copy Link to Item
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Henrich, V. C., & Orlando, L. A. (2016). Family health history: an essential starting point for personalized risk assessment and disease prevention. Per Med, 13(5), 499–510. https://doi.org/10.2217/pme-2016-0007Full Text Link to Item
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Weitzel, K. W., Alexander, M., Bernhardt, B. A., Calman, N., Carey, D. J., Cavallari, L. H., … IGNITE Network, . (2016). The IGNITE network: a model for genomic medicine implementation and research. Bmc Med Genomics, 9, 1. https://doi.org/10.1186/s12920-015-0162-5Full Text Open Access Copy Link to Item
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Wu, R. R., Myers, R. A., McCarty, C. A., Dimmock, D., Farrell, M., Cross, D., … Family Health History Network, . (2015). Protocol for the "Implementation, adoption, and utility of family history in diverse care settings" study. Implement Sci, 10, 163. https://doi.org/10.1186/s13012-015-0352-8Full Text Open Access Copy Link to Item
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Wu, R. R., & Orlando, L. A. (2015). Implementation of health risk assessments with family health history: barriers and benefits. Postgrad Med J, 91(1079), 508–513. https://doi.org/10.1136/postgradmedj-2014-133195Full Text Link to Item
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Buchanan, A. H., Christianson, C. A., Himmel, T., Powell, K. P., Agbaje, A., Ginsburg, G. S., … Orlando, L. A. (2015). Use of a patient-entered family health history tool with decision support in primary care: impact of identification of increased risk patients on genetic counseling attendance. J Genet Couns, 24(1), 179–188. https://doi.org/10.1007/s10897-014-9753-0Full Text Link to Item
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Gallagher, P., King, H. A., Haga, S. B., Orlando, L. A., Joy, S. V., Trujillo, G. M., … Vorderstrasse, A. (2015). Patient beliefs and behaviors about genomic risk for type 2 diabetes: implications for prevention. J Health Commun, 20(6), 728–735. https://doi.org/10.1080/10810730.2015.1018563Full Text Open Access Copy Link to Item
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Mather, R. C., Garrett, W. E., Cole, B. J., Hussey, K., Bolognesi, M. P., Lassiter, T., & Orlando, L. A. (2015). Cost-effectiveness analysis of the diagnosis of meniscus tears. Am J Sports Med, 43(1), 128–137. https://doi.org/10.1177/0363546514557937Full Text Open Access Copy Link to Item
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Bartlett, G., Rahimzadeh, V., Longo, C., Orlando, L. A., Dawes, M., Lachaine, J., … Issa, A. M. (2014). The future of genomic testing in primary care: the changing face of personalized medicine. Per Med, 11(5), 477–486. https://doi.org/10.2217/pme.14.36Full Text Link to Item
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Beadles, C. A., Ryanne Wu, R., Himmel, T., Buchanan, A. H., Powell, K. P., Hauser, E., … Orlando, L. A. (2014). Providing patient education: impact on quantity and quality of family health history collection. Fam Cancer, 13(2), 325–332. https://doi.org/10.1007/s10689-014-9701-zFull Text Link to Item
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Li, J. H., Joy, S. V., Haga, S. B., Orlando, L. A., Kraus, W. E., Ginsburg, G. S., & Voora, D. (2014). Genetically guided statin therapy on statin perceptions, adherence, and cholesterol lowering: a pilot implementation study in primary care patients. J Pers Med, 4(2), 147–162. https://doi.org/10.3390/jpm4020147Full Text Link to Item
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Orlando, L. A., Wu, R. R., Beadles, C., Himmel, T., Buchanan, A. H., Powell, K. P., … Ginsburg, G. S. (2014). Implementing family health history risk stratification in primary care: impact of guideline criteria on populations and resource demand. Am J Med Genet C Semin Med Genet, 166C(1), 24–33. https://doi.org/10.1002/ajmg.c.31388Full Text Link to Item
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Wu, R. R., Himmel, T. L., Buchanan, A. H., Powell, K. P., Hauser, E. R., Ginsburg, G. S., … Orlando, L. A. (2014). Quality of family history collection with use of a patient facing family history assessment tool. Bmc Fam Pract, 15, 31. https://doi.org/10.1186/1471-2296-15-31Full Text Link to Item
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Mather, R. C., Hug, K. T., Orlando, L. A., Watters, T. S., Koenig, L., Nunley, R. M., & Bolognesi, M. P. (2014). Economic evaluation of access to musculoskeletal care: the case of waiting for total knee arthroplasty. Bmc Musculoskelet Disord, 15, 22. https://doi.org/10.1186/1471-2474-15-22Full Text Open Access Copy Link to Item
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Wu, R. R., Himmel, T. L., Buchanan, A. H., Powell, K. P., Hauser, E. R., Ginsburg, G. S., … Orlando, L. A. (2014). Quality of family history collection with use of a patient facing family history assessment tool. Bmc Family Practice, 15(1). https://doi.org/10.1186/1471-2296-15-31Full Text
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Cho, A. H., & Orlando, L. A. (2013). Clinical Implementation of Genomic Medicine in Primary Care, 1, 295–305. https://doi.org/10.1016/B978-0-12-382227-7.00025-2Full Text
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Wu, R. R., Orlando, L. A., Himmel, T. L., Buchanan, A. H., Powell, K. P., Hauser, E. R., … Ginsburg, G. S. (2013). Patient and primary care provider experience using a family health history collection, risk stratification, and clinical decision support tool: a type 2 hybrid controlled implementation-effectiveness trial. Bmc Fam Pract, 14, 111. https://doi.org/10.1186/1471-2296-14-111Full Text Link to Item
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Vorderstrasse, A. A., Cho, A., Voils, C. I., Orlando, L. A., & Ginsburg, G. S. (2013). Clinical utility of genetic risk testing in primary care: the example of Type 2 diabetes. Per Med, 10(6), 549–563. https://doi.org/10.2217/pme.13.47Full Text Link to Item
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Orlando, L. A., Henrich, V. C., Hauser, E. R., Wilson, C., Ginsburg, G. S., & Genomedical Connection, . (2013). The genomic medicine model: an integrated approach to implementation of family health history in primary care. Per Med, 10(3), 295–306. https://doi.org/10.2217/pme.13.20Full Text Link to Item
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Orlando, L. A., Buchanan, A. H., Hahn, S. E., Christianson, C. A., Powell, K. P., Skinner, C. S., … Henrich, V. C. (2013). Development and validation of a primary care-based family health history and decision support program (MeTree). N C Med J, 74(4), 287–296.Link to Item
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Powell, K. P., Christianson, C. A., Hahn, S. E., Dave, G., Evans, L. R., Blanton, S. H., … Henrich, V. C. (2013). Collection of family health history for assessment of chronic disease risk in primary care. N C Med J, 74(4), 279–286.Link to Item
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Orlando, L. A., Hauser, E. R., Christianson, C., Powell, K. P., Buchanan, A. H., Chesnut, B., … Ginsburg, G. (2011). Protocol for implementation of family health history collection and decision support into primary care using a computerized family health history system. Bmc Health Serv Res, 11, 264. https://doi.org/10.1186/1472-6963-11-264Full Text Open Access Copy Link to Item
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Haga, S. B., Carrig, M. M., O’Daniel, J. M., Orlando, L. A., Killeya-Jones, L. A., Ginsburg, G. S., & Cho, A. (2011). Genomic risk profiling: attitudes and use in personal and clinical care of primary care physicians who offer risk profiling. J Gen Intern Med, 26(8), 834–840. https://doi.org/10.1007/s11606-011-1651-7Full Text Link to Item
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Orlando, L. A., Belasco, E. J., Patel, U. D., & Matchar, D. B. (2011). The chronic kidney disease model: a general purpose model of disease progression and treatment. Bmc Med Inform Decis Mak, 11, 41. https://doi.org/10.1186/1472-6947-11-41Full Text Open Access Copy Link to Item
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Orlando, L. A., Hauser, E. R., Christianson, C., Powell, K. P., Buchanan, A. H., Agbaje, A. B., … Ginsburg, G. (2011). WHAT'S THE IMPACT? CLINICAL VALIDITY AND UTILITY OF METREE, AN ELECTRONIC FAMILY HISTORY COLLECTION AND DECISION SUPPORT TOOL FOR PRIMARY CARE. Journal of General Internal Medicine, 26, S35–S36.Link to Item
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Mather, R. C., Orlando, L. A., Henderson, R. A., Lawrence, J. T. R., & Taylor, D. C. (2011). A predictive model of shoulder instability after a first-time anterior shoulder dislocation. J Shoulder Elbow Surg, 20(2), 259–266. https://doi.org/10.1016/j.jse.2010.10.037Full Text Link to Item
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Watters, T. S., Browne, J. A., Orlando, L. A., Wellman, S. S., Urbaniak, J. R., & Bolognesi, M. P. (2011). Cost-effectiveness analysis of free vascularized fibular grafting for osteonecrosis of the femoral head. J Surg Orthop Adv, 20(3), 158–167.Link to Item
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Orlando, L. A., & Orlando, R. C. (2010). Anatomy, embryology, and congenital malformations of the esophagus and stomach, 3–8.
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Mather, R. C., Watters, T. S., Orlando, L. A., Bolognesi, M. P., & Moorman, C. T. (2010). Cost effectiveness analysis of hemiarthroplasty and total shoulder arthroplasty. J Shoulder Elbow Surg, 19(3), 325–334. https://doi.org/10.1016/j.jse.2009.11.057Full Text Link to Item
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Kawamoto, K., Orlando, L. A., Voora, D., Lobach, D. F., Joy, S., Cho, A., & Ginsburg, G. S. (2009). Evaluation of the PharmGKB knowledge base as a resource for efficiently assessing the clinical validity and utility of pharmacogenetic assays. Amia Annu Symp Proc, 2009, 307–311.Link to Item
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Orlando, L. A., & Orlando, R. C. (2009). Dilated intercellular spaces as a marker of GERD. Curr Gastroenterol Rep, 11(3), 190–194. https://doi.org/10.1007/s11894-009-0030-6Full Text Link to Item
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Abernethy, A. P., Raman, G., Balk, E. M., Hammond, J. M., Orlando, L. A., & Wheeler, J. L. (2009). Erratum: Reliability of compendia methods for off-label oncology indications (Ann Intern Med. (2009) 150, (336-43)). Annals of Internal Medicine, 150(8), 571.
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Abernethy, A. P., Raman, G., Balk, E. M., Hammond, J. M., Orlando, L. A., Wheeler, J. L., … McCrory, D. C. (2009). Systematic review: reliability of compendia methods for off-label oncology indications. Ann Intern Med, 150(5), 336–343. https://doi.org/10.7326/0003-4819-150-5-200903030-00107Full Text Link to Item
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Matchar, D. B., McCrory, D. C., Orlando, L. A., Patel, M. R., Patel, U. D., Patwardhan, M. B., … Gray, R. N. (2008). Systematic review: comparative effectiveness of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers for treating essential hypertension. Ann Intern Med, 148(1), 16–29. https://doi.org/10.7326/0003-4819-148-1-200801010-00189Full Text Link to Item
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Thakur, M., Grossman, I., McCrory, D. C., Orlando, L. A., Steffens, D. C., Cline, K. E., … Matchar, D. B. (2007). Review of evidence for genetic testing for CYP450 polymorphisms in management of patients with nonpsychotic depression with selective serotonin reuptake inhibitors. Genet Med, 9(12), 826–835. https://doi.org/10.1097/gim.0b013e31815bf98fFull Text Link to Item
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Orlando, L. A., Lenard, L., & Orlando, R. C. (2007). Chronic hypergastrinemia: causes and consequences. Dig Dis Sci, 52(10), 2482–2489. https://doi.org/10.1007/s10620-006-9419-3Full Text Link to Item
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Patel, M. R., Hurwitz, L. M., Orlando, L., McCrory, D. C., Sanders, G. D., Matchar, D. B., … Medicare Coverage Advisory Commission, . (2007). Noninvasive imaging for coronary artery disease: a technology assessment for the Medicare Coverage Advisory Commission. Am Heart J, 153(2), 161–174. https://doi.org/10.1016/j.ahj.2006.10.023Full Text Link to Item
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Matchar, D. B., Thakur, M. E., Grossman, I., McCrory, D. C., Orlando, L. A., Steffens, D. C., … Gray, R. N. (2007). Testing for cytochrome P450 polymorphisms in adults with non-psychotic depression treated with selective serotonin reuptake inhibitors (SSRIs). Evid Rep Technol Assess (Full Rep), (146), 1–77.Link to Item
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Orlando, L. A., Owen, W. F., & Matchar, D. B. (2007). Relationship between nephrologist care and progression of chronic kidney disease. N C Med J, 68(1), 9–16.Link to Item
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Orlando, L. A., & Matchar, D. B. (2005). Chronic kidney disease: Relationship of nephrologist involvement and disease course. Journal of Investigative Medicine, 53(1), S313–S314.Link to Item
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Orlando, L. A., Kulasingam, S. L., & Matchar, D. B. (2004). Meta-analysis: the detection of pancreatic malignancy with positron emission tomography. Aliment Pharmacol Ther, 20(10), 1063–1070. https://doi.org/10.1111/j.1365-2036.2004.02266.xFull Text Link to Item
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Orlando, L. A., & Orlando, R. C. (2004). Pathophysiology of GERD: Esophageal epithelial defense. Practical Gastroenterology, 28(7).
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Orlando, L. A., & Matchar, D. B. (2004). When to stress over triptans: a Markov analysis of cardiovascular risk in migraine treatment. Headache, 44(7), 652–660. https://doi.org/10.1111/j.1526-4610.2004.04123.xFull Text Link to Item
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Orlando, L., & Orlando, R. C. (2002). Review and assessment of pharmacologic management strategies for reflux esophagitis. Formulary, 37(3), 140–146.
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Book Sections
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Orlando, L. A., & Wu, R. R. (2022). Family health history and health risk assessment in oncology. In Genomic and Precision Medicine: Oncology, Third Edition (pp. 71–83). https://doi.org/10.1016/B978-0-12-800684-9.00021-6Full Text
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Orlando, L. A., & Wu, R. R. (2018). Family Health History and Health Risk Assessment For Cardiovascular Disease in Health Care. In Genomic and Precision Medicine: Cardiovascular Disease: Third Edition (pp. 1–16). https://doi.org/10.1016/B978-0-12-801812-5.00016-0Full Text
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Bregendahl, M. E., Orlando, L. A., & Palaniappan, L. (2017). Health Risk Assessments, Family Health History, and Predictive Genetic/Pharmacogenetic Testing. In Genomic and Precision Medicine: Primary Care: Third Edition (pp. 75–88). https://doi.org/10.1016/B978-0-12-800685-6.00003-5Full Text
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Orlando, L. A., & Wu, R. R. (2017). Family Health History and Health Risk Assessment in Health Care. In Genomic and Precision Medicine: Foundations, Translation, and Implementation: Third Edition (pp. 189–204). https://doi.org/10.1016/B978-0-12-800681-8.00013-XFull Text
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Orlando, L. A., & cho, A. H. (2012). Clinical Implementation of Genomic Medicine in Primary Care. In G. S. ginsburg & H. willard (Eds.), Genomic and Personalized Medicine. San Diego, CA: Academic Press.
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Conference Papers
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Song, E. J., O’Connell, B., Sullivan, B., Myers, R. A., Rakhra-Burris, T. K., Parish, A., … Garman, K. (2021). Family History Screening Tool Reveals Gaps in Colorectal Cancer Screening and Surveillance. In American Journal of Gastroenterology (Vol. 116, pp. S119–S120).Link to Item
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Verduin, T. L., Robinson, S., Stein, C. R., McGregor, K. A., Zhao, C., Driscoll, K., … Egger, H. L. (2018). 23.4 Creating Early-Childhood Research Tools That Families Want to Use: The When to Wonder Platform. In Journal of the American Academy of Child &Amp; Adolescent Psychiatry (Vol. 57, pp. S34–S35). Elsevier BV. https://doi.org/10.1016/j.jaac.2018.07.148Full Text
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Orlando, L. A., Wu, R. R., Buchanan, A., Myers, R. A., & Ginsburg, G. S. (2018). THE INTERSECTION OF POPULATION HEALTH AND PRECISION MEDICINE: EMPLOYING TECHNOLOGY TO OPTIMIZE RISK ASSESSMENT IN PRIMARY CARE. In Journal of General Internal Medicine (Vol. 33, pp. S362–S362). Denver, CO: SPRINGER.Link to Item
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Wu, R. R., Himmel, T., Myers, R. A., Hauser, E., Vorderstrasse, A., Ginsburg, G., & Orlando, L. A. (2015). EFFECT OF FAMILY HISTORY AND GENETIC RISK COUNSELLING FOR TYPE 2 DIABETES ON PERCEPTIONS OF RISK AND CONTROL: SECONDARY ANALYSIS OF A RANDOMIZED CONTROLLED TRIAL. In Journal of General Internal Medicine (Vol. 30, pp. S55–S55). Toronto, CANADA: SPRINGER.Link to Item
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Wu, R. R., Himmel, T., Buchanan, A., Powell, K., Hauser, E., Agbaje, A. B., … Orlando, L. A. (2013). IMPACT OF A FAMILY HISTORY COLLECTION TOOL, METREE (c), IN IDENTIFYING INDIVIDUALS AT HIGH-RISK FOR CANCER AND THROMBOSIS. In Journal of General Internal Medicine (Vol. 28, pp. S101–S101). Denver, CO: SPRINGER.Link to Item
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Wu, R. R., Himmel, T., Powell, K., Hauser, E., Agbaje, A. B., Henrich, V., … Orlando, L. A. (2013). USABILITY OF A FAMILY HEALTH HISTORY AND CLINICAL DECISION SUPPORT TOOL FOR PATIENTS AND PRIMARY CARE PROVIDERS. In Journal of General Internal Medicine (Vol. 28, pp. S233–S233). Denver, CO: SPRINGER.Link to Item
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Orlando, L. A., & Matchar, D. B. (2005). Chronic kidney disease: Relationship of nephrologist involvement and disease course. In Journal of General Internal Medicine (Vol. 20, pp. 62–62). New Orleans, LA: BLACKWELL PUBLISHING.Link to Item
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Orlando, L. A., & Matcher, D. B. (2003). When to stress over triptans: A Markov analysis of cardiovascular risk and migraine treatment. In Journal of General Internal Medicine (Vol. 18, pp. 165–165). VANCOUVER, CANADA: BLACKWELL PUBLISHING INC.Link to Item
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Orlando, L. A., & Matchar, D. B. (2003). When to stress over triptans: A Markov analysis of cardiovascular risk and migraine treatment. In Journal of Investigative Medicine (Vol. 51, pp. S297–S297). CARMEL, CALIFORNIA: B C DECKER INC.Link to Item
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- Scholarly, Clinical, & Service Activities
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Outreach & Engaged Scholarship
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